Clinical trials: Condition
Breast Neoplasms
Randomized Phase II Trial of Anastrozole Plus Metronomic Tegafur-uracil as Neo-adjuvant Therapy in Postmenopausal Breast Cancer
The Aim of this study is to validate a treatment of anastrozole in combination with tegafur-uracil as pre-operative therapy for postmenopausal primary breast cancer.
- Trial name
- Neo-ACET BC (NCT01262274)
- Testing
- Anastrozole, Anastrozole plus tegafur-uracil
- Where
- Japan
- Volunteers
- 57 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Meningococcal Meningitis, Measles
Study of the Safety of Menactra® Vaccine When Administered With Other Pediatric Vaccines to Healthy Toddlers
This clinical trial will evaluate the safety of two injections of Menactra® Vaccine in subjects at 9 months and at 12 months of age when the second dose is given concomitantly with other pediatric vaccines routinely administered…
- Conditions
- Meningococcal Meningitis, Measles, Mumps, Rubella
- Trial name
- NCT00483574
- Testing
- Menactra®: Meningococcal Polysaccharide Diphtheria Toxoid Conjugate, Measles-mumps-rubella-varicella vaccine, Routine paediatric vaccine - Pneumococcal conjugate (PCV)
- Where
- 79 sites in United States, Chile
- Volunteers
- 1,378 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Type 1 Diabetes, New Onset
A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes
This multi-center randomized controlled trial will assess the safety and efficacy of ATG followed by either adalimumab or verapamil in preserving insulin secretion 2 years from randomization in persons aged 9 to <21 with…
- Trial name
- WAVE T1D (NCT07061574)
- Testing
- Anti-thymocyte globulin (ATG), verapamil extended-release capsule, Adalimumab
- Where
- 11 sites in United States
- Volunteers
- 120 people
- Sponsor
- City of Hope Medical Center
Sepsis, Infections
Bacillus Cereus Invasive Infections in Preterm Neonates Hospitalized in French Hospitals
Background. Bacillus cereus group (Bc) comprises twenty-six closely related species of spore-forming environmental bacteria. Recently, increased sepsis and septic shock caused by Bc were reported in preterm neonates (PN), and the…
- Trial name
- NCT06973174
- Testing
- Premature neonates with invasive infection caused by Bacillus cereus
- Where
- 13 sites in France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Pre-Eclampsia
Measuring Practice Pattern Changes and Clinical Utility of a Novel Test for Preeclampsia
This study will collect high-quality data on how practicing obstetricians across the U.S. currently manage patients showing signs and/or symptoms of preeclampsia and how the results of Progenity's test change clinical decision…
- Trial name
- NCT04204018
- Testing
- Experimental Arm
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Qure Healthcare, LLC
OBESITY
Molecules Associated with Pediatric Obesity
Childhood obesity is linked to obesity in adulthood and causes severe problems, particularly due to its relationship with metabolic syndrome, diabetes, cancer, and cardiovascular diseases.
- Trial name
- Thesis (NCT06775990)
- Testing
- Blood sample
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Anxiety, Digital Eye Strain
Reducing Eye Strain and Anxiety Using a Digital Intervention During Online Learning Class Recess Among Children at Home: A Randomized Controlled Trial
The primary aim of the current study is to conduct a cluster-randomized control trial to evaluate the effectiveness of a novel digital intervention in reducing anxiety and digital eye strain compared to usual care among Chinese…
- Trial name
- RESILIENT (NCT04309097)
- Testing
- Digital intervention, Information-only intervention
- Where
- China
- Volunteers
- 954 people
- Sponsor
- Sun Yat-sen University
Brain Injuries, Congenital Heart Disease
Protecting Brains and Saving Futures - the PBSF Protocol
Background: Multiple neonatal disorders are associated with risks of neurological injury. Thus, management of these infants should involve a coordinated approach to permit early diagnosis with improved clinical care.
- Conditions
- Brain Injuries, Congenital Heart Disease, Newborn Morbidity, Intraventricular Hemorrhage
- Trial name
- PBSF (NCT03786497)
- Where
- 2 sites in Brazil
- Volunteers
- 2,268 people
- Sponsor
- Protecting Brains Saving Futures
Metabolic Syndrome, Insulin Resistance
FTO rs9939609 and PPARy rs1801282 Polymorphisms in Mexican Adolescents
Background and Aims: The presence of the FTO rs9939609 and PPARy rs1801282 polymorphisms suggests changes in energy metabolism; this variation may be responsible for the development of various diseases including obesity.
- Trial name
- NCT02886013
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Asociación Científica Latina A.C.
Parkinson's Disease
Motor Cortex Stimulation for Parkinson's Disease
Deep Brain Stimulation represents the golden standard for surgical treatment of Parkinson disease (PD), but it is not optimally effective for controlling every motor sign and adverse events are not so infrequent Therefore, other…
- Trial name
- NCT00637260
- Testing
- Motor cortex stimulation on., motor cortex stimulation off
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Catholic University, Italy
Cardiac Arrest
Improving Defibrillation Pad Position
Manufacturer's diagrams showing defibrillation pad positioning (as used on public access defibrillators) are anatomically incorrect and are likely to lead to poor position of defibrillation pads, with reduced defibrillation…
- Trial name
- NCT03476720
- Testing
- Pad positioning according to a manufacturer's diagram
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Glioma
The Role of Gene Changes in Brain Tumor Formation and Growth
This study will examine tissue from gliomas (a type of brain tumor) removed during surgery for gene mutations, or changes, thought to be involved in tumor formation and growth.
- Trial name
- NCT00059020
- Where
- United States
- Volunteers
- 344 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Concussion, Brain, TBI
Collaborative Care Model for the Treatment of Persistent Symptoms After Concussion Among Youth
SPECIFIC AIMS While post-concussive symptoms following sports-related concussion are typically transient and resolve spontaneously within two weeks of concussive injury, 14% or more of youth who sustain concussion experience…
- Conditions
- Concussion, Brain, TBI, Depression, Anxiety
- Trial name
- NCT03034720
- Testing
- Collaborative Care
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Seattle Children's Hospital
Appendiceal Cancer
Surgical Outcome and Predictors of Overall Survival of Stage I-III Appendiceal Adenocarcinoma
A few studies investigated the predictors of overall survival in appendiceal adenocarcinoma. A SEER database analysis of 1404 patients with appendiceal adenocarcinoma found that older age, T4 tumors, N1-2 stage, poorly…
- Trial name
- NCT05452382
- Testing
- Partial colecctomy, Hemicolectomy
- Where
- United States
- Volunteers
- 2,607 people
- Sponsor
- Mansoura University
Bacteremia
Surveillance of AMR in DRC
This study addresses knowledge gaps regarding antimicrobial resistance (AMR) in sub-Saharan Africa, focusing on evaluating the feasibility of AMR surveillance and enhancing local research capacity.
- Trial name
- SARKIN (NCT06821282)
- Where
- Democratic Republic of the Congo
- Volunteers
- 210 people
- Sponsor
- University of Oxford
Parkinson Disease
Asymmetric Subthalamic Deep Brain Stimulation for Axial Motor Dysfunction in Parkinson's Disease
This single-center, randomized, quadruple-blinded, double-crossover comparative efficacy trial will study the effects of unilateral 50% voltage reduction in axial motor dysfunction for patients with Parkinson's disease that…
- Trial name
- NCT03462082
- Testing
- Asymmetric STN-DBS
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of Toronto
Anxiety, Depression
Examining the Effects of an Improvisation Group
This study is taking place to examine the preliminary effects of improvisational therapy (improv group) on social anxiety for youth at the Youth Wellness Centre (YWC). The improv group will run for 12-weeks as a drop-in group.
- Conditions
- Anxiety, Depression, Self Concept Alteration, Social Support
- Trial name
- NCT03147924
- Testing
- Improvisation Group
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
HIV Infection
Analytical Treatment Interruption (ATI) to Assess the Immune System's Ability to Control HIV in Participants Who Became HIV-infected During the HVTN 703/HPTN 081 AMP Study
The purpose of this study is to learn whether having the AMP Study antibody (called VRC01) in a person's body might help their immune system control HIV better, even without HIV medication called antiretroviral therapy or ART, if…
- Trial name
- NCT04860323
- Testing
- Analytical Treatment Interruption
- Where
- 11 sites in Botswana, Malawi and 2 more
- Volunteers
- 13 people
- Sponsor
- HIV Vaccine Trials Network
Melanoma, Meningioma
T Cell Receptor Immunotherapy Targeting NY-ESO-1 for Patients With NY-ESO-1 Expressing Cancer
Background: The National Cancer Institute (NCI) Surgery Branch has developed an experimental therapy for treating patients with cancer that involves taking white blood cells from the patient, growing them in the laboratory in…
- Conditions
- Melanoma, Meningioma, Breast Cancer, Non-Small Cell Lung Cancer
- Trial name
- NCT01967823
- Testing
- Anti-NY ESO-1 mTCR PBL, Cyclophosphamide, Fludarabine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Cancer Institute (NCI)
Burn Injury
Effects of Non-Invasive Vagus Nerve Stimulation in Adolescent Burn Patients
This study will evaluate the effects of non-invasive vagus nerve stimulation in adolescents aged 12 to 18 years who have burn injuries.
- Trial name
- NCT07566923
- Testing
- Non-Invasive Vagus Nerve Stimulation, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Fenerbahce University
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