Clinical trials: Condition
Primary Congenital Glaucoma, Goniotomy
Goniotomy in Primary Congenital Glaucoma
Brief Summary This is a multicenter cohort study designed to evaluate and compare the efficacy and safety of different surgical extents of goniotomy (GT) - specifically 120°, 240°, and 360° - in the treatment of Primary…
- Trial name
- NCT07550868
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Sun Yat-sen University
Myocardial Infarction, Comorbidity
Web-Enhanced Guideline Implementation for Post MI CBOC Patients
To assist busy primary care clinicians in VA Community Based Outpatient Clinics (CBOCs) in managing complex patients by providing a single, interactive, and personalized source of information regarding applicable guidelines for…
- Trial name
- VA MI Plus (NCT00126750)
- Testing
- VA MI Plus Interactive
- Where
- 41 sites in United States, Puerto Rico
- Volunteers
- 847 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Hepatitis B, Chronic
A Study of Entecavir in Pediatric Patients With Chronic Hepatitis B Virus (HBV)-Infection
The purpose of this clinical study is to determine the appropriate doses of entecavir to use in children and adolescents. Safety, tolerability and efficacy will also be studied
- Trial name
- NCT00423891
- Testing
- Entecavir
- Where
- 19 sites in United States, Argentina and 6 more
- Volunteers
- 64 people
- Sponsor
- Bristol-Myers Squibb
Schizophrenia, Psychosis
Aripiprazole Treatment of Prodromal Patients
We hypothesize that symptoms will improve in patients who meet diagnostic criteria for the schizophrenia prodrome when they are prescribed aripiprazole.
- Trial name
- NCT00237874
- Testing
- Aripiprazole
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Yale University
Shoulder Pain
Efficacy of Manual Therapy and Exercise in Patients With Shoulder Adhesive Capsulitis. A Randomized Clinical Trial.
The efficacy of manual therapy and therapeutic exercise in patients suffering from adhesive capsulitis of the shoulder will be studied.
- Trial name
- MTEAC (NCT02976974)
- Testing
- Manual therapy, Therapeutic exercise
- Where
- 3 sites in Spain
- Volunteers
- 30 people
- Sponsor
- University of Malaga
Sickle Cell Anemia, Malaria
Sulfadoxine- Pyrimethamine Versus Weekly Chloroquine for Malaria Prevention in Children With Sickle Cell Anemia
Malaria is fatal and increases the risk of death among children with sickle cell anemia. Chemoprophylaxis significantly improves quality of life in these children.
- Trial name
- NCT00399074
- Testing
- sulfadoxine pyrimethamine
- Where
- Uganda
- Volunteers
- 220 people
- Sponsor
- Makerere University
Anemia, Iron-Deficiency
Iron Deficiency Anemia in Twin Pregnancies
All pregnant women with twin pregnancies were given oral iron according to the current recommended dose. Blood routine and ferritin were monitored during pregnancy to understand the therapeutic effect of oral iron on iron…
- Trial name
- NCT04975074
- Testing
- Iron
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
SARS-CoV-2 Infection, COVID-19
A Study to Learn About New COVD-19 RNA Vaccine Candidates for New Variants in Healthy Individuals
The purpose of this clinical protocol is to learn about the safety, tolerability, and immunogenicity of new BNT162b2 RNA-based vaccine candidates targeting new variants of SARS-CoV-2 in healthy people.
- Trial name
- NCT05997290
- Testing
- BNT162b2 (Omi XBB.1.5), BNT162b2 (Omi JN.1), BNT162b2 (Omi KP.2)
- Where
- 37 sites in United States
- Volunteers
- 1,051 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Nephrotic Syndrome, Adolescent
The Selection of Initial Treatment Regimens for Adolescent Nephrotic Syndrome.
Given that the treatment strategy for adolescent PNS has a significant impact on growth and development, but there are few cases and a lack of clinical research, this study plans to collaborate with several domestic top-tier…
- Conditions
- Nephrotic Syndrome, Adolescent, Biopsy
- Trial name
- NCT07071597
- Testing
- Renal Biopsy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Nanjing Children's Hospital
Cystic Fibrosis
Cystic Fibrosis Treatment Adherence Cayston Proof-of-Concept Pilot Study
Real-world adherence to inhaled and oral therapies for cystic fibrosis (CF) patients remains discouragingly low, ranging between 31-53% for inhaled antibiotics and 41-72% for hypertonic saline.
- Trial name
- NCT02179710
- Testing
- Adherence dashboard motivational interviewing
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Landon Pediatric Foundation
Von Willebrand Disease (VWD), Acquired Von Willebrand Disease
Endothelial Colony-Forming Cells in Patients With VWD, AVWS and Healthy Subjects
The goal of this observational study is to learn how endothelial colony-forming cells (ECFCs) behave in people with von Willebrand disease (VWD), acquired von Willebrand syndrome (AVWS), and in healthy individuals.
- Trial name
- ECFCs/2022 (NCT07358013)
- Testing
- Blood sample collection for VWF measurements in plasma, Blood sample collection for ECFC isolation and characterization, Genetic testing of VWF
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Respiratory Insufficiency of Prematurity
Level of Continuous Positive Airway Pressure (CPAP) in Preterm Infants After Extubation (L-CPAP Study)
Despite widely used of nasal CPAP in preterm infants, uncertainties regarding aspects of its application remain. Clinical indications vary greatly between institutions, especially when combined with varieties of systems, devices…
- Trial name
- L-CPAP (NCT00636324)
- Testing
- Nasal CPAP, level 7 to 9 cmH2O, Nasal CPAP, level 4 to 6 cmH2O
- Volunteers
- 23 people
- Sponsor
- Hamilton Health Sciences Corporation
Eating Disorders
Feasibility and Acceptability of AVATAR Therapy in Eating Disorders.
This project will answer the overarching research question "What is the feasibility of developing and implementing AVATAR therapy to reduce the power of the eating disorder voice in patients with eating disorders?".
- Trial name
- NCT04778423
- Testing
- Avatar Therapy
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- King's College London
Depression, Unipolar
Adjunctive Bright Light Therapy in Adolescents With Depression and Eveningness
This study examines the efficacy of bright light therapy as a treatment for adolescents diagnosed with unipolar non-seasonal depression who exhibit an evening chronotype.
- Trial name
- NCT06973759
- Testing
- Bright light therapy, Dim red light
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- Chinese University of Hong Kong
Retinopathy of Prematurity, Pain, Procedural
Clonidine as Pain Relief During ROP Eye Examinations
Preterm infants are at risk of developing ROP (retinopathy of prematurity), an eye condition that can cause blindness. Preterm infants born before gestation week (GA) 30 are therefor screened regularly with eye examinations.
- Conditions
- Retinopathy of Prematurity, Pain, Procedural, Premature Infant Disease
- Trial name
- cloROP (NCT04902859)
- Testing
- Clonidine Oral Liquid Product, Sterile water
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Region Örebro County
Childhood Obesity
The ADAPT Trial: Adapting Evidence-Based Obesity Interventions in Community Settings
Evidence-based obesity treatment is inaccessible to most children in the United States. This lack of access is a source of health inequity, whereby children from rural and minority communities, who have the highest rates of…
- Trial name
- NCT06546696
- Testing
- Competency Based Approaches to Community Health (COACH)
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Secondary Hyperparathyroidism, End Stage Renal Disease
Safety and Effectiveness of Zemplar Injection in Decreasing iPTH Levels in Pediatric ESRD Subjects on Hemodialysis
The purpose of this study is to see if Zemplar, a vitamin D medication, safely and effectively decreases parathyroid hormone in children ages 2-20 with End Stage Renal Disease.
- Trial name
- NCT00053547
- Testing
- paricalcitol injection
- Where
- 6 sites in United States
- Volunteers
- 28 people
- Sponsor
- Abbott
Rhinitis, Rhinitis, Allergic
Short and Mid-term Repeatability of Active Anterior Rhinomanometry (AAR) Measurements in Paediatric Age
Longitudinal, observational study to assess the short-term (test re-test) and mid-term (within the span of 28 days) repeatability of active anterior rhinomanometry (AAR) measures on 4 parallel groups of children with different…
- Conditions
- Rhinitis, Rhinitis, Allergic, Rhinitis, Allergic, Seasonal, Rhinitis, Allergic, Perennial
- Trial name
- Rhino-Rep (NCT03286049)
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
Sleep Disorders
Validation of Home Sleep Testing (WP) Compared to an Overnight Sleep Testing in the Sleep Laboratory
Obstructive sleep apnea syndrome (OSAS) is considered to be a major public health problem. The prevalence of OSAS is estimated at 2% and 4% for adult women and men respectively, most of whom are undiagnosed and untreated.
- Trial name
- NCT01570738
- Where
- Israel
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Itamar-Medical, Israel
Anemia, Iron-deficiency
Effectiveness of Selling Micronutrient Sprinkles in Rural Kenya
The purpose of the study is to evaluate the effectiveness of household-based distribution of evidence-based health products and to measure the health impact of these combined interventions on a population basis.
- Trial name
- NICHE (NCT01088958)
- Testing
- Micronutrient powders (Sprinkles)
- Where
- Kenya
- Volunteers
- 7,200 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
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