Clinical trials: Confusional State
Delirium, Withdrawal Syndrome
Early Rehabilitation in Critically Ill Children - The PICU Liber8 Study
This is a pilot quality improvement implementation study that will measure the impact of a rehabilitation bundle implementation on the outcomes of interest.
- Conditions
- Delirium, Withdrawal Syndrome, Hospital Acquired Condition, Critical Illness Myopathy
- Trial name
- PICULiber8 (NCT03573479)
- Testing
- PICU Liber8 Bundle
- Where
- 2 sites in Canada
- Volunteers
- 130 people
- Sponsor
- McMaster University
Critical Illness, Sedation Complication
Dexmedetomidine Cycling and Sleep in the Pediatric ICU
This is a study of mechanically ventilated pediatric intensive care unit (ICU) teenage patients and the effects of the medication dexmedetomidine on sleep, delirium, and sedation level.
- Conditions
- Critical Illness, Sedation Complication, Delirium
- Trial name
- NCT05003102
- Testing
- Dexmedetomidine Hydrochloride - Cycling, Fentanyl - PICU Standard, Dexmedetomidine Hydrochloride - PICU Standard
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Emergence Delirium, Anesthesia
Comparing the Efficacy of Propofol and Dexmedetomidine in Prevention of Emergence Agitation After Sevoflurane Anesthesia in Children
This is a clinical study for comparing the efficacy of two drugs i.e propofol and dexmedetomidine in prevention of a group of post operative abnormal behaviours that can occur after sevoflurane anesthesia in children and we will…
- Trial name
- NCT07799311
- Testing
- propofol 1mg/kg, Dexmedetomidine
- Where
- Pakistan
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Hip Osteoarthritis, Hip Arthroplasty Replacement
Virtual Reality for Intraoperative Anxiolysis and Postoperative Agitation in Elderely Hip Arthroplasty Patients
This study evaluates the effectiveness of Virtual Reality (VR) as a non-pharmacological intervention to reduce intraoperative anxiety and postoperative agitation in elderly patients undergoing elective hip arthroplasty under…
- Conditions
- Hip Osteoarthritis, Hip Arthroplasty Replacement, Emergence Delirium, Anesthesia, Emergence Agitation
- Trial name
- VR (NCT07705451)
- Testing
- immersive virtual reality, standard sedation
- Volunteers
- 40 people
- Sponsor
- Menoufia University
Strabismus, Delirium on Emergence
Efficacy of Single-Shot Dexmedetomidine Versus Placebo in Preventing Pediatric Emergence Delirium in Strabismus Surgery
This study is trying to see if using precedex pre-operatively prevents emergence delirium in pediatric (ages 1-7) patients undergoing strabismus surgery.
- Conditions
- Strabismus, Delirium on Emergence, Pediatric Disorders
- Trial name
- NCT01901588
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- NYU Langone Health
Delirium, Postoperative
Perioperative Risk Factors for Postoperative Delirium in Children
Despite recent advances in postoperative delirium research, the proportion of children with postoperative delirium is still high.
- Trial name
- NCT01032161
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Huazhong University of Science and Technology
Anesthesia Recovery, Pediatric Anesthesia
Recovery Trajectories After Propofol-Based Intravenous Anesthesia in Toddlers and Older Children
This observational study aims to compare how quickly and smoothly younger children (ages 3 to 6 years) recover from general anesthesia compared to older children (ages 6 to 12 years).
- Conditions
- Anesthesia Recovery, Pediatric Anesthesia, Total Intravenous Anesthesia
- Trial name
- NCT07766629
- Volunteers
- 64 people
- Sponsor
- Assiut University
Dementia, Cognitive Decline
Ammonia Levels and Cognitive Impairment
The purpose and objective of this study is to determine the prevalence of elevated ammonia levels in subjects with cognitive impairment, and to observe if treating the cause of the elevated ammonia level improves mental status.
- Conditions
- Dementia, Cognitive Decline, Cognitive Impairment, Developmental Delay
- Trial name
- NCT02059356
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Duke University
Sedation, Emergence Delirium
Nebulized Dexmedetomidine Combined With Ketamine Versus Nebulized Dexmedetomidine for Cleft Palate
To compare the efficacy of the pre-operative nebulization of a combination of dexmedetomidine and ketamine versus nebulization of dexmedetomidine alone for sedation and prevention of emergence delirium in children undergoing…
- Trial name
- NCT05821972
- Testing
- Nebulization of dexmedetomidine and ketamine, Nebulization of dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Postoperative Pain, Acute, Emergence Delirium
Comparing Ketamine and Fentanyl in Pediatric Tonsillectomy: Pain Control and Emergence Delirium Outcomes (KVFPT)
This study is designed to compare the effectiveness of two medications, ketamine and fentanyl, in managing pain and preventing delirium in children aged 3 to 8 years who are undergoing tonsillectomy and adenoidectomy surgery.
- Trial name
- KVFPT (NCT06630364)
- Testing
- ketamine, fentanyl
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people
- Sponsor
- Medipol University
Mechanically Ventilated, Critically Ill Children
Sedation Efficacy of Dexmedetomidine Versus Midazolam in Critically Ill Ventilated Children
There is a significant lack of adequately powered randomized clinical trial (RCT) data to determine the comparative safety and effectiveness of sedative treatments in pediatric patients.
- Trial name
- NCT04082767
- Testing
- Precedex, Midazolam
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Douglas Fraser
Delirium
Pediatric Delirium Screening in the PICU Via EEG
Delirium in the pediatric intensive care unit (PICU) is a serious problem that has recently attracted much attention. This study will evaluate the use of electroencephalogram (EEG) for delirium screening in the PICU.
- Trial name
- PEDEEGO (NCT04846023)
- Testing
- aEEG via vEEGix
- Volunteers
- 220 people
- Sponsor
- St. Justine's Hospital
Mechanical Ventilation, Sedation
Implementation of an Analgesia-sedation Algorithm in the Pediatric ICU to Reduce Benzodiazepine Use
The purpose of the study is to develop and implement an evidence-based analgesia-sedation algorithm in the pediatric intensive care unit (PICU) using quality improvement and implementation science methodology.
- Trial name
- NCT04263662
- Testing
- Analgesia-Sedation algorithm
- Where
- United States
- Volunteers
- 680 people
- Sponsor
- Boston Children's Hospital
S-ketamine, Esketamine
Safety and Efficacy Evaluation of S (+) - Ketamine in Children
A multicenter, randomized, open-label, active controlled pragmatic clinical trial that evaluates the safety and efficacy of S (+) -ketamine for postoperative acute pain in children in perioperative settings.
- Conditions
- S-ketamine, Esketamine, Acute Pain, Postoperative Pain
- Trial name
- NCT04834427
- Testing
- Conventional therapy + S (+)-Ketamine, Conventional therapy
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Chinese PLA General Hospital
Emergence Delirium, Strabismus
The Occurrence of Emergence Agitation in Pediatric Strabismus Surgery
The present trial conducted to demonstrate the administration of sugammadex as reversal of neuromuscular blockade agent reduces the incidence of emergence agitation (EA) comparing to neostigmine
- Conditions
- Emergence Delirium, Strabismus, Pediatric ALL
- Trial name
- NCT06035757
- Testing
- Bridion 200 MG in 2 ML Injection, Pyridostigmine Bromide 5 MG/ML
- Where
- South Korea
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Emergence Delirium, Preoperative Anxiety
Live Parent-Child Video Interaction and Cartoon Watching for Emergence Agitation in Children
Preoperative anxiety is common in preschool-aged children and may make anesthesia induction more difficult and contribute to agitation during recovery from general anesthesia.
- Trial name
- LIVE-CART Kids (NCT07689305)
- Testing
- Live Parent-Child Video Interaction, Cartoon Watching
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Izmir City Hospital
Preoperative Anxiety, Emergence Agitation
Effects of Nasal Administration of Dexmedetomidine on Pre-anesthesia Sedation, Intraoperative Brain Electrical Activity, and Incidence of Agitation During Recovery in Children
Pre - operative anxiety and emergence agitation are common issues among pediatric patients, which have various influences on the recovery progress and prognosis of children.
- Trial name
- NCT06896721
- Testing
- Preoperative sedation with dexmedetomidine was administered nasal before surgery, Preoperative sedation with normal saline was administered nasal before surgery
- Volunteers
- 627 people, healthy volunteers welcome
- Sponsor
- Fuzhou Hua
Emergency Delirium, Postoperative Delirium (POD)
Comparison of IV Dexmedetomidine Versus Clonidine Versus no Alpha 2 Agonist on Emergency Delirium, PACU Length of Stay and Time to Hospital Discharge in Children Undergoing (Adeno)Tonsillectomy: a Prospective Observational Study
Emergence delirium (ED) is a frequent complication in children undergoing general anesthesia, particularly following ENT procedures such as adenotonsillectomy.
- Conditions
- Emergency Delirium, Postoperative Delirium (POD), Adenotonsillectomy, Tonsillectomy
- Trial name
- CLONIDEX (NCT07913308)
- Testing
- Intravenous dexmedetomidine, Intravenous clonidine, Standard Anesthetic Care Without Alpha-2 Agonist
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitair Ziekenhuis Brussel
Emergence Delirium, Anesthesia, Child
Melatonin vs Midazolam in Children Undergoing Tonsillectomy
Used as a premedication to decrease anxiety (Caumo et al., 2007). Midazolam, though has several drawbacks (McCann and Kain, 2001). Hence, an alternative premedication to midazolam will definitely have a widespread appeal.
- Conditions
- Emergence Delirium, Anesthesia, Child, Anxiety, Midazolam Premedication
- Trial name
- NCT07336095
- Testing
- Melatonin group, Midazolam group, Control group
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Delirium - Postoperative, Sleep Problems
Preoperative Sleep Intervention on Postoperative Delirium in School-aged Children Undergoing Congenital Heart Surgery
This is a multicenter, randomized, controlled clinical trial aimed to determine whether preoperative sleep interventions could reduce the incidence of adverse outcomes, such as postoperative delirium, in sleep-disordered…
- Conditions
- Delirium - Postoperative, Sleep Problems, Congenital Heart Disease (CHD)
- Trial name
- NCT06879431
- Testing
- cognitive-behavioral intervention
- Where
- China
- Volunteers
- 544 people
- Sponsor
- Yan Fuxia