Clinical trials: Congenital Hernia
Sepsis, Congenital Diaphragmatic Hernia
Inflammatory Cytokine Quantification in Infants
This study proposes to quantify inflammatory cytokine profiles in three neonatal disease states, namely, neonatal sepsis, infants with a congenital diaphragmatic hernia defect, and infants suffering cardiopulmonary failure…
- Conditions
- Sepsis, Congenital Diaphragmatic Hernia, Neonatal Cardiopulmonary Failure
- Trial name
- NCT01155830
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- University of Utah
Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia
Palliative Care Needs of Children With Rare Diseases and Their Families
The palliative care needs of family caregivers of children with rare diseases and their children are largely unmet, including the need for support to prepare for future medical decision making.
- Conditions
- Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia, Asparagine Synthetase Deficiency, CHARGE Syndrome
- Trial name
- FACE-Rare (NCT06938542)
- Testing
- Family Centered pediatric palliative care for family caregivers of children with rare diseases.
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Gastroschisis
Silo Versus Primary Closure for Gastroschisis
The objective of this study is to scientifically evaluate two different closure strategies for gastroschisis to determine if there is a difference in the two approaches.
- Trial name
- NCT01506531
- Testing
- silo for gastroschisis, Primary closure of gastroschisis
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Children's Mercy Hospital Kansas City
Pediatric Postoperative Pain
Postoperative Pain After Pediatric Umbilical Hernia Repair
The purpose of this study is to compare the use of ultrasound-guided bilateral rectus sheath blocks to local infiltration of anesthetic agent in the surgical wound in a pediatric population of patients undergoing umbilical hernia…
- Trial name
- NCT01015053
- Testing
- bilateral ultrasound-guided rectus sheath block, Wound infiltration
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Boston Children's Hospital
Tracheo Esophageal Fistula, Congenital Diaphragmatic Hernia
Cerebral Blood Flow in Neonates During Thoracoscopic Surgeries
the aim of this study is to compare the effect of different modes of mechanical ventilation by using volume-controlled ventilation and pressure-controlled ventilation on cerebral blood flow monitored by cerebral oximetry during…
- Trial name
- NCT04507295
- Testing
- cerebral oximetry ( INVOS 5100 )
- Volunteers
- 30 people
- Sponsor
- Cairo University
Rare Diseases, Congenital Diaphragmatic Hernia
Intact Cord Resuscitation in CDH
Isolated CDH is a rare disease (1/3500) and displays a wide range of severity and outcome. Despite attempts to standardize the management of this disease at birth and during the first months of life, the mortality varies from 20…
- Trial name
- CHIC (NCT04429750)
- Testing
- Immediate umbilical cord clamping, intact cord resuscitation
- Where
- 3 sites in France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Lille
Congenital Diaphragmatic Hernia
Type of Material in Repair of Congenital Diaphragmatic Hernia
The objective of this study is to evaluate the use of 2 different types of biosynthetic material for the repair of congenital diaphragmatic hernia.
- Trial name
- NCT00257946
- Testing
- Repair of CDH w/SIS Gold, Repair of CDH w/Alloderm
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Children's Mercy Hospital Kansas City
NEC, Gastroschisis
Neokare Safety and Tolerability Assessment in Neonates With GI Problems
With an increasing body of evidence to support a causal link between drinking milk that contain cow's milk protein (CMP) and the development of gastrointestinal disturbance in infants, many clinicians avoid the use of CMP…
- Conditions
- NEC, Gastroschisis, Intestinal Perforation, Atresia, Intestinal
- Trial name
- NCT05293353
- Testing
- NeoKare Breast Milk Fortifier
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Hernia, DIaphragmatic, Congenital
Work of Breathing Description in Neonates With Congenital Diaphragmatic Hernia in NAVA and in Conventional Ventilation.
Congenital diaphragmatic hernia (CDH) is a congenital malformation associated with significant mortality and respiratory morbidity, particularly related to prolonged mechanical ventilation.
- Trial name
- NAVA-DIAPH (NCT03250793)
- Testing
- Physiologic study measuring work of breathing which can be estimated by the esophageal and trans-diaphragmatic pressure-time product obtained by an esophageal transducer
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Hospices Civils de Lyon
Gastroschisis
MEGA STUDY - Multicenter Evaluation of Gastroschisis Anomaly Study
The purpose of this observational study is to evaluate selected epidemiological aspects of gastroschisis (GS) and factors affecting health outcomes of newborns with this diagnosis in a population of fetuses with gastroschisis.
- Trial name
- MEGA (NCT07030309)
- Testing
- Gastroschisis
- Where
- 9 sites in Poland
- Volunteers
- 200 people
- Sponsor
- ResearchSkills
Hypospadia, Phimosis
Intelligence Changes Following Minor Surgery
Animal studies showed that many general anesthetics might result in neuron apoptosis and neurocognitive impairment in the developing brain. However results from human studies are conflicted.
- Conditions
- Hypospadia, Phimosis, Inguinal Hernia
- Trial name
- NCT01483313
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- RenJi Hospital
Congenital Inguinal Hernia
Laparoscopic Inguinal Hernia Repair in Infancy and Childhood
Aim of the study The aim of this study is to test the hypothesis that during laparoscopic hernia repair, disconnection of the hernial sac along with suture ligation of the neck is better than transperitoneal purse string suture…
- Trial name
- LIHR-2014 (NCT02239185)
- Testing
- Hernial sac ligation in continuity, Hernial sac disconnection
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Al-Azhar University
Gastroschisis
Early Feeds in Gastroschisis
This study aims to evaluate the feasibility of initiating early feeds in neonates with gastroschisis, a condition where infants are born with their intestines outside the body.
- Trial name
- GAIN (NCT06878950)
- Testing
- Early Feeding Protocol
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of California, Davis
Anesthesia, Spinal, Ambulatory Surgical Procedures
Spinal Anesthesia for Outpatient Abdominal Wall Surgery: Comparison of Bupivacaine, 2-chloroprocaine and Prilocaine
Considering fast-track principles, an ideal spinal anesthetic should have minimal complications and above all fast recovery so reducing in-hospital stay.
- Conditions
- Anesthesia, Spinal, Ambulatory Surgical Procedures, Hernia, Inguinal, Hernia, Umbilical
- Trial name
- spinal (NCT02813382)
- Testing
- Bupivacaine, Prilocaine, Chloroprocaine
- Volunteers
- 101 people
- Sponsor
- AZ St.-Dimpna Geel
Congenital Diaphragmatic Hernia, Congenital Diaphragmatic Eventration
Genetic Analysis of Congenital Diaphragmatic Disorders
The purpose of this study is to understand the genetic causes of congenital diaphragmatic disorders (CDD), namely congenital diaphragmatic hernia (CDH), eventration and hiatal hernia. Specifically, the investigators plan to: 1.
- Conditions
- Congenital Diaphragmatic Hernia, Congenital Diaphragmatic Eventration, Congenital Hiatal Hernia, Congenital Diaphragmatic Disorders
- Trial name
- NCT01243229
- Where
- 2 sites in United States
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- University of Utah
Congenital Diaphragmatic Hernia
Measurement of Lung Area at Chest Radiography to Define the Prognosis in Newborns With CDH
CDH represents a malformative disorder characterized by an incomplete diaphragm formation. This results in poor lung development (pulmonary hypoplasia), associated with altered vascularization of the lung (pulmonary…
- Trial name
- NeoAPACHE (NCT04396028)
- Testing
- data collection
- Where
- Italy
- Volunteers
- 85 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Gastroschisis
Multi-Centre Gastroschisis Interventional Study Across Sub-Saharan Africa
This study is a multi-centre interventional study at seven tertiary paediatric surgery centres in Ghana, Zambia, Malawi and Tanzania aimed at reducing mortality from gastroschisis.
- Trial name
- NCT03724214
- Testing
- Pre-hospital interventional care bundle, In-hospital interventional care bundle
- Where
- 9 sites in Canada, Ghana and 4 more
- Volunteers
- 235 people
- Sponsor
- King's College London
Hydrocele, Inguinal Hernia
The Caudal Space in Children: Ultrasound Evaluation
Caudal anesthesia is commonly employed in pediatrics to produce postoperative analgesia in low abdominal or urologic surgery. An exact understanding of the anatomy of the sacral area including sacral hiatus and surrounding…
- Conditions
- Hydrocele, Inguinal Hernia, Hypospadia, Cryptorchidism
- Trial name
- NCT01896076
- Testing
- ultrasound evaluation of caudal space
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Gastroschisis
Clinical and Biological Outcomes of Human Milk and Formula Intake After Gastroschisis Repair
The purpose of this study is to determine which type of food results in a shorter hospital stay and better overall outcome for babies born with gastroschisis.
- Trial name
- NCT02575846
- Testing
- Enteral Intake - Human Milk, Enteral Intake - Formula
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Duke University
Tethered Spinal Cord, Including Thickened Filum, Lipomas, Myelomeningocele and Meningocele
Inflammatory Response in Children Suffering From Tethered Cord
Embryologic phenomenons that lead to dysraphisms are known, but pathophysiology remains questioned. It is supposed not to be a simple mechanistic dysfunction, and other biological phenomenons are implied in spinal cord damaging.
- Trial name
- TETHERIC (NCT07611058)
- Testing
- CSF sampling during surgery
- Where
- France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Lille