Clinical trials: Connective Tissue Disorders
Skin Condition, Dermatology
Application of the Belle.AI Dermatological Image Reference System for Patient Diagnosis in an Active Clinical Setting
The goal of this research study is to test a new, investigational tool that uses artificial intelligence (AI) to help primary care providers assess skin conditions.
- Conditions
- Skin Condition, Dermatology, Dermatology/Skin - Other
- Trial name
- NCT06724627
- Testing
- Dermatology/Skin - Other
- Where
- United States
- Volunteers
- 263 people
- Sponsor
- BelleTorus Corporation
Breast Neoplasms, Breast Cancer
Assessment of Breast Cancer Response to Neoadjuvant Anthracycline-based Chemotherapy by FDG-PET and Molecular Markers
A correlation between early changes in the tumor maximum standardized uptake value (SUVmax) on FDG-PET after one or two cycles of neoadjuvant chemotherapy (NAC) and the pathological response after 6 to 8 cycles has been…
- Trial name
- NCT02600442
- Testing
- non interventional study
- Where
- France
- Volunteers
- 168 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cancer
Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation
RATIONALE: Giving itraconazole or fluconazole may be effective in preventing infections in patients undergoing peripheral stem cell or bone marrow transplantation.
- Trial name
- NCT00003883
- Testing
- fluconazole, itraconazole
- Where
- 2 sites in United States
- Volunteers
- 578 people
- Sponsor
- Fred Hutchinson Cancer Center
Dermatitis, Atopic
Tacrolimus Ointment Pharmacokinetics in Infants With Atopic Dermatitis
The purpose of this study is to estimate the systemic exposure to tacrolimus in infants with atopic dermatitis after repeated application of tacrolimus ointment.
- Trial name
- NCT00535691
- Testing
- Tacrolimus Ointment 0.03%
- Where
- 8 sites in Canada, Finland and 3 more
- Volunteers
- 53 people
- Sponsor
- Astellas Pharma Inc
Ewing Sarcoma, Neuroblastoma
Phase 2 STIR Trial: Haploidentical Transplant and Donor Natural Killer Cells for Solid Tumors
The investigators hypothesize that this Phase 2 cellular and adoptive immunotherapy study using human leukocyte antigen (HLA)-haploidentical hematopoietic cell transplantation (HCT) followed by an early, post-transplant infusion…
- Conditions
- Ewing Sarcoma, Neuroblastoma, Rhabdomyosarcoma, Osteosarcoma
- Trial name
- STIR (NCT02100891)
- Testing
- Allogeneic HCT, Donor NK Cell Infusion
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Monica Thakar
Moderate to Severe Plaque Psoriasis
A Study to Assess the Pharmacokinetics, Safety, and Efficacy of Two Doses of Bimekizumab in Adolescent Study Participants With Moderate to Severe Plaque Psoriasis
The purpose of the study is to assess th pharmacokinetics (PK) of bimekizumab administered subcutaneously (sc) in adolescents with moderate to severe plaque psoriasis (PSO).
- Trial name
- BE CONNECTED (NCT04718896)
- Testing
- bimekizumab
- Where
- 11 sites in United States, Canada and 2 more
- Volunteers
- 41 people
- Sponsor
- UCB Biopharma SRL
Breast Neoplasms
Efficacy Study of an Educational Program for Decision Support for Breast Cancer
The purpose of this study is to develop and test an informative computer-based program to help women in making good choices among options for treating early stage breast cancer.
- Trial name
- H-6019 (NCT00473096)
- Testing
- Informed breast cancer surgical treatment
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Baylor College of Medicine
Dupuytren Disease
Ultrasound Features of Dupuytren's Disease
Dupuytren's disease (DD) is a benign and progressive condition that affects the palmar aponeurosis with a very high global incidence.
- Trial name
- Micro in DD (NCT06956027)
- Testing
- Ultrasound assesment, ROM measurement
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Diaper Rash
A Clinical Study to Assess the Efficacy and Safety of a Healing Ointment on Diaper Rash
The goal of this clinical trial is to assess the efficacy and safety of a Healing Ointment in infants 2-24 months with mild to moderate diaper rash.
- Trial name
- NCT06015217
- Testing
- "Cetaphil Healing Ointment"
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Juvenile Idiopathic Arthritis
Internet Self-Management Program With Telephone Support for Adolescents With Arthritis
This study will evaluate the feasibility of "Teens Taking Charge: Managing Arthritis On-line" intervention that will help adolescents with arthritis to better manage their disease and improve their health-related quality of life…
- Trial name
- NCT01011179
- Testing
- Teens Taking Charge, Self-Management
- Where
- 4 sites in Canada
- Volunteers
- 46 people
- Sponsor
- The Hospital for Sick Children
Basal Tryptasemia
Serum Basal Tryptase Levels in Healthy Children
The National REference Center for MASTocytosis (CEREMAST), located at the Necker-Enfants Malades Hospital, is particularly interested in two groups of rare diseases whose common point is excessive activation of mast cells…
- Trial name
- KID-Tryp (NCT05323188)
- Testing
- Tryptase dosage
- Where
- France
- Volunteers
- 402 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atopic Dermatitis / Eczema
To Evaluate the in Use Tolerance of E45 Eczema Repair Emollient in Babies and Children With (Very(Dry/Atopic Skin
The investigation will evaluate, under dermatological control, the cutaneous in-use tolerance of E45 Eczema Repair Emollient with two or three times daily application, over a period of two weeks on children and babies with…
- Trial name
- NCT02857062
- Testing
- E45 Eczema Repair Emollient
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
Osteosarcoma, Ewing Sarcoma
Dietary Habits, Metabolome, Immune Profile and Microbiota in Patients With Bone Sarcoma
Osteosarcoma and Ewing sarcoma treatment has not changed in the last 30 years. For other types of cancer the epidemiologic and prognostic correlations between dietary behavior, lifestyle and metabolic alterations (i.e.obesity…
- Trial name
- Metabol-Sarc (NCT04735289)
- Testing
- EPIC-COS Food Frequency Questionnaire diet Evaluation, Metabolome, Microbiota, Lymphocytes subpopulations
- Where
- 7 sites in Italy
- Volunteers
- 810 people, healthy volunteers welcome
- Sponsor
- Istituto Ortopedico Rizzoli
Dermatophyte Infection, Terbinafine Adverse Reaction
Comparison of Efficacy of Double Dose Oral Terbinafine Vs Itraconazole in Treatment of Dermatophyte Infections of Skin.
Study would be conducted to compare the efficacy and safety of double than usual dose oral terbinafine versus itraconazole in treatment of dermatophyte infections of skin in patient presenting at dermatology department of Pak…
- Conditions
- Dermatophyte Infection, Terbinafine Adverse Reaction, Itraconazole Adverse Reaction
- Trial name
- NCT04880980
- Testing
- Terbinafine Pill, Itraconazole capsule
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Pak Emirates Military Hospital
Human Papilloma Virus Infection Type 11, Human Papilloma Virus Infection Type 16
HPV Vaccination: Evaluation of Reminder Prompts for Doses 2 & 3
Randomized, 2-arm observational study. The 2 arms (randomized at the level of health care provider) will be: 1. usual practice; 2.
- Conditions
- Human Papilloma Virus Infection Type 11, Human Papilloma Virus Infection Type 16, Human Papilloma Virus Infection Type 18, Human Papilloma Virus Infection Type 6
- Trial name
- NCT02558803
- Testing
- Simple Reminder
- Where
- 5 sites in United States
- Volunteers
- 1,305 people
- Sponsor
- Regenstrief Institute, Inc.
Sarcoma, Central Nervous System Tumor
Dendritic Cell-based Immunotherapy for Advanced Solid Tumours of Children and Young Adults
Phase I/II, open, prospective clinical trial, historically controlled. The objective is to evaluate the safety and, as a secondary measure, the efficacy of an experimental treatment based on a cellular therapy (vaccination with…
- Trial name
- DEND/TIA (NCT02496520)
- Testing
- dendritic cells, Surgery as needed by the patient´s tumor and stage, Chemotherapy as needed by the patient´s tumor and stage
- Where
- Spain
- Volunteers
- 6 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Rheumatoid Arthritis
A Study to Observe Characteristics of Rheumatoid Arthritis in Patients Using Infliximab (Study P04250)
This 14-week non-interventional study will observe patients with rheumatoid arthritis (RA) who are being treated with infliximab for the first time, in order to learn about their disease characteristics.
- Trial name
- REMARK (NCT00705289)
- Testing
- Infliximab
- Volunteers
- 728 people
- Sponsor
- Merck Sharp & Dohme LLC
Atopic Dermatitis, Psoriasis
Analytical Validation of Wrist-Based Assessment of Nocturnal Scratch in Atopic Dermatitis and Psoriasis
Pruritis is a common symptom in patients with atopic dermatitis and psoriasis. Patients with atopic dermatitis and psoriasis often report pruritis-associated sleep impairments and scratching behaviors during nighttime and the…
- Trial name
- DECODE-Scratch (NCT06448689)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- ActiGraph L.L.C
Psoriasis
Randomized Double-Blind Placebo-Controlled Trial Using Recombinant Human Interleukin-10 for Moderate-to-Severe Psoriasis
Several studies have documented an essential role for interleukin-10 (IL-10) in preventing prolonged and exaggerated immune responses to antigens and irritants.
- Trial name
- NCT00001797
- Testing
- Recombinant human interleukin-10
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- National Cancer Institute (NCI)
Lung Diseases, Lymphangiomyomatosis
Lymphangioleiomyomatosis (LAM) Registry
To establish a registry of individuals with LAM by forming a consortium of six clinical centers and referring physicians who treat LAM patients.
- Trial name
- NCT00005486
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
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