Clinical trials: Contrast Agent, open to volunteers
Contrast Enhanced Ultrasound, Ultrasonic Diagnosis
International Delphi Study to Develop Standardized Quality Criteria and a Rating Tool for Liver CEUS Image Quality Assessment
This study aims to establish international consensus-based quality criteria for contrast-enhanced ultrasound (CEUS) examinations of the liver and to develop a standardized tool for assessing CEUS image and examination quality.
- Conditions
- Contrast Enhanced Ultrasound, Ultrasonic Diagnosis, Liver
- Trial name
- ICON LiverCEUS (NCT07656181)
- Where
- Switzerland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Bern
Myopia, Child Myopia Progression
Effect of MiYOSMART iQ Spectacle Lenses on Myopia Progression in Children
This prospective, single-center study aims to evaluate the efficacy and safety of MiYOSMART iQ spectacle lenses with DIMS (Defocus Incorporated Multiple Segments) and Triple Enhanced Design (TED) technology in slowing myopia…
- Trial name
- NCT07387159
- Testing
- MiYOSMART iQ spectacle lenses
- Where
- Russia
- Volunteers
- 70 people
- Sponsor
- Hoya Lens Rus LLC
Clear Cell Renal Cell Carcinoma, Prognostic Cancer Model
Contrast-enhanced CT-based Deep Learning Model for Preoperative Prediction of Disease-free Survival (DFS) in Localized Clear Cell Renal Cell Carcinoma (ccRCC)
This study aims to preoperatively predict DFS of patients with localised ccRCC using a deep learning prognostic model based on enhanced contrast CT images, validate it's predictive ability in multicentre data and compare it's…
- Conditions
- Clear Cell Renal Cell Carcinoma, Prognostic Cancer Model, Recurrent Renal Cell Cancer
- Trial name
- NCT06088134
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Mingzhao Xiao
Chronic Constipation, Slow Transit Constipation
MSOT and MRI for Non-invasive Assessment of Intestinal Transit Time in Children With Chronic Bowel Emptying Disorders
The project presented here is a monocentric clinical study conducted by the Pediatric Surgery and Pediatrics departments of the University Hospital Erlangen.
- Conditions
- Chronic Constipation, Slow Transit Constipation, Intestinal Transit Disorder, Hirschsprungs Disease
- Trial name
- NCT06911749
- Testing
- MSOT with ICG, MRI
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Dr. med. Sonja Diez
Cardiovascular Diseases, Microvascular Complications
Non-invasive Microvascular Assessment in Individuals at High Risk of Cardiovascular Disease From the SCAPIS2 Study
Microvascular dysfunction, particularly endothelial dysfunction, is increasingly recognized as a key mechanism underlying various cardiovascular diseases (CVD), including heart failure, ischemic heart disease, atherosclerosis…
- Trial name
- NCT07359768
- Where
- Sweden
- Volunteers
- 900 people
- Sponsor
- HJN Sverige AB/Neko Health
Tumor
Clinical Application Value of Deep Learning-Based "Opportunistic Screening" for Malignant Tumors on Routine Non-Contrast Chest-Abdomen-Pelvis CT
This study aims to develop and validate a deep learning-based opportunistic multi-cancer screening system using routine non-contrast chest-abdomen-pelvis CT examinations, including CHANCE-Breast, CHANCE-Liver, CHANCE-Kidney, and…
- Trial name
- NCT07639567
- Where
- China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Lian Yang
Healthy Nutrition, Healthy Diet
Baylor Infant and Toddler Biomarker of Nutrition Study
Young children rely on their foods and drinks for the nutrients they need to grow, like energy, protein, vitamins, and minerals.
- Trial name
- BITBONS (NCT05869760)
- Testing
- Carotenoid Intake, Serum carotenoid concentrations
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Diabetes Mellitus
Assessing Diabetic Foot Ulcer Microcirculation With High-frequency Contrast Enhanced Ultrasound
The objective of this observational study is to investigate and validate the utility of high-frame-rate ultrasound imaging technology for dynamic observation of the blood perfusion process at the site of ulcer wounds in…
- Trial name
- NCT06309082
- Testing
- Amputation, Debridement
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
VUR - Vesicoureteric Reflux
Diagnosing Vesicoureteric Reflux in Children by Direct Isotope Cystography and Contrast Enhanced Voiding Ultrasonography
The purpose of this study is to examine the applicability of contrast enhanced voiding ultrasonography in diagnosing vesicoureteral reflux (VUR) in pediatric patients compared to direct isotope cystography.
- Trial name
- NCT06138080
- Testing
- Contrast-enhanced voiding ultrasonography (CEVUS), Direct isotope cystography
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Turku University Hospital
Developmental Dysplasia of the Hip
Intraoperative Contrast-Enhanced Ultrasound Evaluation of Blood Flow at the Time of Surgical Hip Reduction for DDH
This study evaluates the feasibility and utility of contrast-enhanced ultrasound to provide real-time assessment of blood flow to the femoral head in infants undergoing surgical reduction for developmental dysplasia of the hip.
- Trial name
- NCT03107520
- Testing
- Intraoperative contrast-enhanced ultrasound (CEUS), Lumason
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Children's Hospital of Philadelphia
Non Mass Breast Lesions
Diagnostic Accuracy of Multiparametric Dynamic Contrast Enhanced Magnetic Resonance Imaging in Improving Detection of Ultrasound Non-mass Breast Lesions According to ACR BI-RADS v2025
this study aims To evaluate the diagnostic performance of Ultrasound (US) in correlation with Dynamic Magnetic Resonance Imaging (MRI) for the assessment, characterization, and evaluation of non-mass breast lesions.
- Trial name
- NCT07679308
- Testing
- multiparametric DCE- MRI and US for all patients
- Volunteers
- 60 people
- Sponsor
- Sohag University
Pituitary Adenoma, Cushing Disease
Evaluation of Intraoperative Contrast Enhanced Ultrasound for the Identification of Pituitary Adenoma in Cushing's Disease Compared to Other Pituitary Tumors
This pilot and feasibility study aims to combine recent advances in ultrasound imaging, specifically an endonasal transducer array and contrast enhanced ultrasound, to offer an intraoperative image-guided solution for…
- Trial name
- NCT07335315
- Testing
- Contrast enhanced pituitary magnetic resonance imaging (MRI), Contrast enhanced ultrasound, Non-Contrast Ultrasound
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Mayo Clinic
Head and Neck Squamous Cell Carcinoma
The Value of CEUS in Assessing the Response of Cervical Lymph Nodes After NACI for HNSCC
The head and neck squamous cell carcinoma is the sixth most common malignant tumor worldwide. For patients with locally advanced head and neck cancer, neoadjuvant therapy is recommended before surgery, including neoadjuvant…
- Trial name
- NCT06727162
- Testing
- Contrast-Enhanced Ultrasound
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Hydrocephalus in Infants, Hydrocephalus Acquired
CEUS Evaluation of Hydrocephalus in Neonates and Infants
Hydrocephalus affects up to 2 out of every 500 births and results in long-term disability in up to 78% of those affected. The standard treatment of hydrocephalus is cerebrospinal fluid (CSF) diversion via placement of an invasive…
- Trial name
- NCT06693752
- Testing
- Sulfur Hexafluoride Lipid Type A Microspheres 25 mg Injection Powder for Suspension [LUMASON]
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital of Philadelphia
No Disease or Condition is Being Studied
French Contrast Versus Oregon Circuit Training in Competitive Football Players
This randomized, two-arm, parallel-group clinical trial is designed to compare French Contrast Training (FCT) with Oregon Circuit Training (OCT) for improving explosive strength, lower-limb power, and agility in competitive…
- Trial name
- FCT-OCT (NCT07865702)
- Testing
- French Contrast Training, Oregon Circuit Training
- Where
- Pakistan
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Superior University
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)
The main purpose of this study is to evaluate the efficacy and safety of lebrikizumab in participants with chronic rhinosinusitis and nasal polyps treated with intranasal corticosteroids. The study will last about 18 months.
- Trial name
- NCT06338995
- Testing
- LY3650150, Standard therapy for INCS
- Where
- 202 sites in United States, Argentina and 18 more
- Volunteers
- 510 people
- Sponsor
- Eli Lilly and Company
Perinatal Asphyxia, Hypothermia Treatment
Quantification of Brain and Kidney Perfusion Before, During, and After Hypothermia Treatment in Neonates With Perinatal Asphyxia Using Contrast-enhanced Ultrasound
In this clinical study vascular dynamics in the neonatal brain and kidney will be monitored by CUES and ULM before, during and after hypothermia treatment in neonates with asphyxia.
- Conditions
- Perinatal Asphyxia, Hypothermia Treatment, Gestational Age Min. 36SSW
- Trial name
- NCT06611254
- Testing
- Contrast enhanced ultrasound imaging (CEUS) and post processing with ULM
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Neonatal Hypoxic Ischemic Encephalopathy, Neonatal Stroke
Neonatal Brain Ultrasound With CEUS and Elastography
The aim of our study is to investigate changes of brain perfusion and elasticity in neonates during the time that a neonate is adapting to live outside the womb and during diseases that are suspected to affect neonatal brain…
- Conditions
- Neonatal Hypoxic Ischemic Encephalopathy, Neonatal Stroke, Neonatal Encephalopathy, Unspecified
- Trial name
- NCT05648812
- Testing
- Brain contrast enhanced ultrasound, brain ultrasound elastography, Sulfur Hexafluoride
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Turku University Hospital
Hepatic Malignant Tumors, Hepatic Perfusion Disorders
Correlation Between CEUS Identification of Nodular HPD on CE-MRI and Hepatic Malignant Lesions
Hepatic malignant tumors are a category of diseases with high incidence and mortality rates worldwide, including various types such as primary hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), and liver…
- Trial name
- NCT06816212
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Retinoblastoma
Can Pretreatment MRI be Used to Predict Intra-arterial Chemotherapy Response in Retinoblastoma?
Retinoblastoma is the most frequent intraocular tumor in children and represents 6% of all pediatric cancers before the age of 5 years-old. The outcome is now excellent with 95 to 97% of 5-years survival rate.
- Trial name
- PREDIR (NCT03267459)
- Testing
- Dynamic contrast-enhanced MRI
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild