Clinical trials: Controls
Group 1: Healthy Controls, Group 2: Stable CF
Assessment of CFTR-Modulator Treatment in Cystic Fibrosis Lung Disease Using Novel Structural and Functional MRI
This is a prospective, longitudinal observational study conducted at The Hospital for Sick Children (SickKids). The purpose of this study is to evaluate the ability of MRI to detect changes in lung structure and function in CF…
- Conditions
- Group 1: Healthy Controls, Group 2: Stable CF, Group 3: CF Participants Anticipated to Receive CFTR-modulator Therapy, Group 4: 4-8 yo CF Participants Starting Triple Combination Modulator Therapy
- Trial name
- NCT04391322
- Where
- Canada
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Stroke, Balance; Distorted
Limits of Stability in Sitting in Healthy Controls and Participants Post Stroke
In this cross-sectional study we will compare the limits of stability in non-ambulatory participants post stroke compared to healthy controls.
- Trial name
- NCT04171401
- Testing
- In-patient stroke rehabilitation.
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Biliary Disease
Common Bile Duct Pressures in Patients With and Without Cholelithiasis
Objective. To measure the pressures of the common bile duct in patients with and without cholelithiasis and relating them to the presence of pancreatobiliary reflux. Summary Background Data.
- Trial name
- NCT04025645
- Testing
- MEASUREMENT OF COMMON BILE DUCT PRESSURES
- Volunteers
- 87 people
- Sponsor
- Hospital de La Serena
Asthma, Cystic Fibrosis
Breath Analysis in Children by New Point-of-care Instruments
In this study new hand-held devices for measuring exhaled breath will be tested in children with asthma, CF, and healthy controls. Main objectives will be feasibility and discriminative value of these techniques.
- Trial name
- NCT03377686
- Testing
- inflammation markers in exhaled breath
- Where
- Netherlands
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Childhood Obesity
Brain Activation and Satiety in Children: Functional Magnetic Resonance Imaging
BASIC fMRI is a prospective single center intervention trial using fMRI imaging in 9-11 year old obese male and females pre and post family-based behavioral treatment of 24 weeks duration to determine the relationship between…
- Trial name
- BASIC-FMRI (NCT02484976)
- Testing
- Family Based Behavioral Treatment
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Duchenne Muscular Dystrophy
Study to Assess the Safety, Tolerability, and Efficacy of Viltolarsen in Ambulant and Non-Ambulant Boys With DMD (Galactic53)
This is a phase II, open-label study where weekly doses of 80 mg/kg viltolarsen is administered intravenously over a 48-week treatment period to ambulant and non-ambulant DMD patients over the age of 8 years.
- Trial name
- NCT04956289
- Testing
- Viltolarsen
- Where
- 8 sites in United States, China and 4 more
- Volunteers
- 20 people
- Sponsor
- NS Pharma, Inc.
Adolescent Pregnancy, Preeclampsia and Eclampsia
Blood Pressure in Adolescents With PReclampsia and Eclampsia.
Levels of blood pressure in adolescents with preeclampsia and eclampsia: Multicenter case-control study (Latin America). Maternities in Latin America: Two hospitals in Panama, one hospital in Mexico, one hospital in El Salvador…
- Trial name
- ADPRE (NCT03360240)
- Where
- 8 sites in Bolivia, Colombia and 4 more
- Volunteers
- 1,050 people
- Sponsor
- Complejo Hospitalario Dr. Arnulfo Arias Madrid
Allergic Rhinitis, Asthma
Comparative Real World Effectiveness of SQ Sublingual Immunotherapy (SLIT)-Tablets vs. Controls in Allergic Rhinitis and Asthma
To assess the impact of SQ SLIT-tablets (SQ Grass SLIT-tablet and SQ HDM SLIT-tablet) in Danish and Swedish allergic rhinitis (AR) patients, with or without asthma, between 2007-2020.
- Conditions
- Allergic Rhinitis, Asthma, Allergy
- Trial name
- RELY (NCT05476484)
- Testing
- SQ SLIT-tablet
- Where
- Denmark
- Volunteers
- 46,196 people
- Sponsor
- ALK-Abelló A/S
PCD
NIOX VERO Nasal Application in Primary Ciliary Dyskinesia
This is a multi-centre, single visit clinical investigation involving patients with known PCD vs. age matched healthy volunteers. This study involves 1 visit which will last one (1) to two (2) hours.
- Trial name
- NCT02622061
- Where
- 5 sites in United States, Denmark and 2 more
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Aerocrine AB
Obstructive Sleep Apnea Syndrome
Cytokine Profiles in Children With Obstructive Sleep Apnea
The purpose of this study is to compare the cytokine profile of tonsillar and peripheral blood mononuclear cells in patients with obstructive sleep apnea (OSA) and to compare the blood mononuclear cell cytokine secretion profile…
- Trial name
- NCT00456573
- Testing
- tonsillectomy
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Anorexia Nervosa
Characteristics of Intensity and Dependence to Physical Activity in Anorexia Nervosa
Etude d'épidémiologie clinique multicentrique (IMM), naturalistique, comparant un échantillon clinique à un échantillon de témoins issus de la population générale.
- Trial name
- HAP-AM (NCT02165982)
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Institut Mutualiste Montsouris
Osteoarthritis of the CMC-1 Joint
TRACE - Thumb Base Replacement Arthroplasty for Osteoarthritis.
Osteoarthritis in the base of the thumb is one of the most common forms of hand arthritis. It usually appears in middle age, particularly in women, and can cause significant pain and loss of function.
- Trial name
- TRACE (NCT07178223)
- Testing
- Arthroplasty CMC-1
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Karolinska Institutet
ALL (Acute B-Lymphoblastic Leukemia), AML (Acute Myeloid Leukemia)
PRAISE-IR Versus CIBMTR Controls
The rationale to conduct this RWE study is to provide data to support the safety of CD34 selected grafts versus T replete PBSC transplants to address concerns about increased TRM in CD34 selected graft recipients.
- Conditions
- ALL (Acute B-Lymphoblastic Leukemia), AML (Acute Myeloid Leukemia), MDS (Myelodysplastic Syndrome)
- Trial name
- NCT07717164
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Miltenyi Biomedicine GmbH
Peripheral Nerve Diseases
Mechanisms of Neuropathic Pain: Investigation by Contact Heat Evoked Potential
In order to clarify the normal components of thermal and painful evoked potentials by heat in normal subjects of both genders and different age group, to clarify the effect of specific anatomy in pain transduction, transmission…
- Trial name
- NCT00173420
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Biliary Atresia, Intrahepatic Cholestases
Intestinal Microbiome Composition in Infants With Biliary Atresia (BA)
A prospective observational study in infants with biliary atresia and controls to determine whether the composition of the intestinal microbiome is specific for biliary atresia will be conducted.
- Conditions
- Biliary Atresia, Intrahepatic Cholestases, Normal Controls
- Trial name
- BA (NCT03890536)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Left Ventricular Non-compaction Cardiomyopathy, Left Ventricular Failure
Value of Cardiac Magnetic Resonance (CMR) Derived Parameters for Diagnosing Left Ventricular Non-compaction Cardiomyopathy
Left ventricular non-compaction (LVNC) is a rare cardiomyopathy characterized by numerous excessively prominent left ventricular (LV) trabeculation and deep intertrabecular recesses communicating with the ventricular cavity and…
- Conditions
- Left Ventricular Non-compaction Cardiomyopathy, Left Ventricular Failure, Left Ventricular Hypertrophy
- Trial name
- NCT01481298
- Where
- Germany
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Type 1 Diabetes Mellitus
Gastrointestinal Symptoms in Children With Type 1 Diabetes
This cross-sectional study aims to assess the frequency and types of gastrointestinal symptoms in children with type 1 diabetes mellitus compared with age- and sex-matched healthy controls.
- Trial name
- NCT07845175
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Assiut University
Williams Syndrome, Induced Pluripotent Stem Cell (Ips Cell)
A Case-Control Observational Study of Peripheral Blood-Derived iPSC Models to Investigate Oligodendrocyte Lineage Development in Children With Williams Syndrome and Healthy Controls
This study aims to collect peripheral blood samples from children with Williams syndrome (WS) and healthy children, establish a cell line of induced pluripotent stem cells (iPSCs) derived from the subjects, and further induce and…
- Trial name
- NCT07537374
- Testing
- one-time peripheral blood collection
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Hypohidrotic Ectodermal Dysplasia
Characterization of Sweat Gland Function in Patients With Recessively Inherited Hypohidrotic Ectodermal Dysplasia
Hypohidrotic ectodermal dysplasia (HED) is a complex genetic disorder characterized by lack of sweat glands, sparse hair, and missing or malformed teeth.
- Trial name
- NCT01109290
- Where
- Germany
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University Hospital Erlangen
Mitochondrial Myopathies
Niacin Supplementation in Healthy Controls and Mitochondrial Myopathy Patients
The most frequent form of adult-onset mitochondrial disorders is mitochondrial myopathy, often manifesting with progressive external ophthalmoplegia (PEO), progressive muscle weakness and exercise intolerance.
- Trial name
- NiaMIT (NCT03973203)
- Testing
- Niacin
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Helsinki