Clinical trials: Corneal Crosslinking
Keratoconus, Ectasia
UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia
The primary objective of this study is to evaluate two different ultraviolet (UV) dosing regimens for corneal collagen cross linking to slow the progressive changes in corneal curvature in eyes with progressive keratoconus or…
- Conditions
- Keratoconus, Ectasia, Corneal Ectasia
- Trial name
- NCT01325298
- Testing
- UV-X Light, Riboflavin
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Mercy Center for Corrective Eye Surgery
Keratoconus, Corneal Ectasia
Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Riboflavin/Dextran or Riboflavin/Methylcellulose
This study is being conducted to evaluate the safety and efficacy of isotonic riboflavin for corneal collagen crosslinking for keratoconus and corneal ectasia.
- Trial name
- CXL (NCT04897503)
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Cornea and Laser Eye Institute
Keratoconus, Ectasia
Progressive Keratoconus or Ectasia Treatment Plan
Keratoconus and pellucid marginal degenerations are genetically based ocular conditions and post surgical ectasia is an iatrogenic condition.
- Trial name
- NCT01384773
- Testing
- Riboflavin Solution, UV-X Illumination System
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stephen Trokel
Pain, Postoperative, Pain, Chronic
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
- Conditions
- Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury
- Trial name
- NCT04439552
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Keratoconus
Evaluation of Topical Riboflavin Exposed to UVA Radiation and Implantation of Corneal Ring
The purpose of this study is to postpone the corneal transplantation in keratoconus and promote the stiffness of the cornea across the riboflavin-UVA corneal collagen crosslinking , and after, corneal ring surgery.
- Trial name
- NCT00832897
- Testing
- Corneal collagen crosslinking
- Where
- Brazil
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Keratoconus, Corneal Ectasia
Transepithelial (Epi-on) Corneal Collagen Crosslinking to Treat Keratoconus and Corneal Ectasia
Corneal collagen crosslinking (CXL) has been demonstrated as an effective method of reducing progression of both keratoconus and corneal ectasia after surgery, as well as possibly decreasing the steepness of the cornea in these…
- Trial name
- NCT04905108
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Cornea and Laser Eye Institute
Keratoconus
McNeel Eye Center Corneal Crosslinking Study
This study will investigate the effectiveness in treating keratoconus, pellucid marginal degeneration and post LASIK iatrogenic ectasia utilizing fluence rates and treatment times of Corneal Cross Linking other than the original…
- Trial name
- NCT02921009
- Testing
- Crosslinking using UV light of two different fluence rates
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- McNeel Eye Center
Keratoconus, Keratoconus, Unstable
Epi-On Corneal Crosslinking for Keratoconus
Epithelium-On Corneal Crosslinking for Keratoconus.
- Trial name
- NCT03245853
- Testing
- Riboflavin 5'-Phosphate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Comprehensive EyeCare of Central Ohio