Clinical trials: Corneal Ulcer
Acanthamoeba Keratitis
Parasitic Ulcer Treatment Trial Pilot
This is a study of optimal treatments for acanthamoeba keratitis. In the first part of the study, participants will be randomized to chlorhexidine monotherapy or chlorhexidine plus povidone iodine.
- Trial name
- NCT03484507
- Testing
- Chlorhexidine, Povidone-Iodine, Prednisolone Sodium Phosphate
- Where
- 2 sites in India
- Volunteers
- 49 people
- Sponsor
- University of California, San Francisco
Corneal Ulcer Caused by Acanthamoeba
Evaluation of Resveratrol and Its Loaded Nanoparticles on Acanthamoeba
Acanthamoeba is a free-living amoeba responsible for severe human infections. There are at least twenty-two different genotypes of Acanthamoeba (T1-T22).
- Trial name
- NCT07148752
- Volunteers
- 50 people
- Sponsor
- Assiut University
Keratitis
Microbiological Keratitis in a Countryside City of Brazil
The purpose of this study is to identify the predisposing factors, epidemiological features and clinical and microbiological diagnosis of infectious keratitis in two public referral centers of ophthalmology in a countryside city…
- Trial name
- NCT00949468
- Where
- Brazil
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Sao Jose do Rio Preto Medical School
Fungal Keratitis
Therapeutic Exploratory Study of Comparing Natamycin and Voriconazole to Treat Fungal Corneal Ulcer
We evaluated whether voriconazole is a superior treatment to natamycin for filamentous fungal keratitis in a randomized, masked, controlled trial.
- Trial name
- MUTT_TE (NCT00557362)
- Testing
- Natamycin 5%, Voriconazole, Corneal de-epithelialization
- Where
- 2 sites in India
- Volunteers
- 120 people
- Sponsor
- University of California, San Francisco
Bacterial Keratitis, Fungal Keratitis
The Antibiogram and Outcomes of Antimicrobial Regimens in Microbial Keratitis: A Prospective Cohort Study
This study is an observational prospective cohort study which aims to generate an antibiogram and to assess the clinical responses and outcomes of microbial keratitis patients, treated with empiric topical antimicrobial…
- Conditions
- Bacterial Keratitis, Fungal Keratitis, Mixed Bacterial and Fungal Keratitis, Microbial Keratitis
- Trial name
- NCT05655689
- Testing
- Moxifloxacin Ophthalmic 0.5% Ophthalmic Solution, Ceftazidime 5% + vancomycin 5%, Gentamicin 1.4% + vancomycin 5%
- Where
- Egypt
- Volunteers
- 123 people
- Sponsor
- Alexandria University
CNLDO - Congenital Nasolacrimal Duct Obstruction, Amblyopia
Improving the Follow up Rate for Pediatric Patients
Follow-up of pediatric patients is important for their regular ocular morbidity monitoring, especially for amblyopia management.
- Conditions
- CNLDO - Congenital Nasolacrimal Duct Obstruction, Amblyopia, Conjunctivitis, Eye Injuries
- Trial name
- NCT04837534
- Testing
- Counseling group, SMS and phone call reminder group
- Where
- Nepal
- Volunteers
- 264 people
- Sponsor
- Seva Foundation
Fungal Keratitis
A Clinical Trial of the Treatment of Fungal Corneal Ulcers With Povidone-Iodine
The purpose of this study is to determine the effectiveness of 1.25% povidone-iodine ophthalmic solution for the treatment of small to medium sized fungal corneal ulcers compared with an antifungal antibiotic.
- Trial name
- NCT00516399
- Testing
- povidone-iodine 1.25% ophthalmic solution, natamycin ophthalmic suspension, USP 5%
- Volunteers
- 78 people
- Sponsor
- University of California, Los Angeles
Corneal Ulcer, Eye Infections, Fungal
The Mycotic Ulcer Treatment Trial II: A Randomized Trial Comparing Oral Voriconazole vs Placebo
The purpose of this study is to determine if the addition of oral voriconazole to topical treatment regimens results in lower rates of perforation in severe fungal corneal ulcers.
- Trial name
- MUTTII (NCT00997035)
- Testing
- Voriconazole
- Where
- 7 sites in United States, India and 1 more
- Volunteers
- 240 people
- Sponsor
- University of California, San Francisco
Corneal Ulcer
The Asia Cornea Society Infectious Keratitis Study
Corneal diseases are a major cause of blindness worldwide, and corneal infections are a substantial cause of blindness in Asia. The aim of the Asia Cornea Society Infectious Keratitis Study (ACSIKS) is to study infectious…
- Trial name
- ACSIKS (NCT01560208)
- Where
- 11 sites in China, India and 6 more
- Volunteers
- 6,750 people
- Sponsor
- Asia Cornea Society
Corneal Ulcers, Cataract
The Application of Fibrin Glue (Tissucol Duo Quick) in External Eye Surgeries
The fibrin sealants are prepared from fibrinogen, thrombin, and sometimes factor XIII that have been purified from human plasma. Tissucol Duo Quick (Baxter, Vienna, Austria) is a kind of fibrin sealants with popular use.
- Conditions
- Corneal Ulcers, Cataract, Pterygium, Retinal Detachment
- Trial name
- NCT02138019
- Testing
- Fibrin Glue assisted external eye surgery, Fibrin glue
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Neurotrophic Corneal Ulcer, Neurotrophic Keratitis
Corneal Neurotization as a Treatment for Neurotrophic Keratopathy
The purpose of this study is to assess the efficacy of sural nerve transfer and cadaveric nerve graft to re-establish corneal sensation in patients with neurotrophic keratopathy.
- Conditions
- Neurotrophic Corneal Ulcer, Neurotrophic Keratitis, Cranial Nerve V Diseases
- Trial name
- NCT05809245
- Testing
- Corneal neurotization
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Stanford University
Corneal Ulcer
Corneal Ulcer Prevention Through Health Education
A community-randomized trial comparing villages randomized to receive an intervention consisting of a trained community health volunteer who brings patients to the nearest Vision Centers or Primary Health Care Centers for…
- Trial name
- CUP (NCT02284698)
- Testing
- Health Education
- Volunteers
- 98,207 people, healthy volunteers welcome
- Sponsor
- Aravind Eye Care System
Infected Corneal Ulcers, Bacterial Keratitis
A Clinical Trial of Povidone-Iodine for the Treatment of Bacterial Corneal Ulcers
Bacterial corneal ulcers are a leading cause of pediatric blindness in underdeveloped countries due to a lack of antibiotic availability and affordability, among other reasons.
- Conditions
- Infected Corneal Ulcers, Bacterial Keratitis, Corneal Ulcer, Childhood Blindness
- Trial name
- NCT00386958
- Testing
- Povidone-Iodine
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Infective Keratitis
Microbial Keratitis in Cairo University Hospitals
The aim of the study was to identify the incidence of infective keratitis presenting to the ophthalmology emergency department at Cairo University hospital, the risk factors and the bacterial/fungal spectrum causing the ulcers…
- Trial name
- NCT05387993
- Where
- Egypt
- Volunteers
- 85 people
- Sponsor
- Kasr El Aini Hospital
Herpes Simplex Keratitis
The Efficacy of Two Potential Diagnostic Assays for Herpes Simplex Keratitis (HSK)
The aim of this study is to compare the safety, specificity, sensitivity and ease of procedure of two potential diagnostic assays for HSV-1 detection in the cornea.
- Trial name
- NCT00357812
- Where
- 3 sites in United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Infectious Keratitis, Bacterial Keratitis
Collagen Cross-linking in Infectious Keratitis Trial
The purpose of this study is to evaluate the efficacy of collagen cross-linking for treatment of infectious keratitis.
- Conditions
- Infectious Keratitis, Bacterial Keratitis, Fungal Keratitis
- Trial name
- NCT01831206
- Testing
- Collagen cross-linking
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University
Acute Bacterial Corneal Ulcers, Bacterial Keratitis
Safety and Efficacy Study of Gatifloxacin Compared With Ciprofloxacin in Patients With Acute Bacterial Corneal Ulcers
This study evaluates the safety and efficacy of gatifloxacin 0.3% ophthalmic solution compared with ciprofloxacin 0.3% ophthalmic solution in patients with acute bacterial corneal ulcers
- Trial name
- NCT00651586
- Testing
- Gatifloxacin 0.3% ophthalmic solution, Ciprofloxacin 0.3% ophthalmic solution
- Where
- 2 sites in United States, India
- Volunteers
- 129 people
- Sponsor
- Allergan
Dry Eyes, Sjogren's Disease With Dry Eyes
Treating Dry Eyes and Corneal Ulcers With Fingerprick Autologous Blood
To investigate if fresh finger prick autologous blood (FAB) instead of serum from venesection, is a safe and effective treatment for dry eyes and corneal ulcers/ epithelial defects.
- Conditions
- Dry Eyes, Sjogren's Disease With Dry Eyes, Persistent Corneal Epithelial Defects, Chronic Corneal Ulcers
- Trial name
- FAB (NCT02153515)
- Testing
- Your own ( autologous) finger prick of blood produced with a diabetic lancet
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Bedford Hospital NHS Trust
Pterygium, Corneal Ulcer
The Application of Fibrin Glue in Ocular Surface Diseases
This clinical trial tries to use tissue fibrin glues (Tisseel) to treat various ocular surface diseases or surgeries, which includes pterygium surgery, corneal melting/perforation, Gunderson's flap, conjunctival laceration, and…
- Trial name
- NCT00155402
- Testing
- tissue fibrin glue application (Tisseel)
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Infectious Keratitis
Cross Linking for Treatment of Corneal Infection
This study is comparing 45 minute and 30 minute treatment durations with the UVX corneal cross linking system to treat corneal infections.
- Trial name
- NCT00912509
- Testing
- riboflavin, UVX Light
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Price Vision Group