Clinical trials: Coronary Microvascular Disease
XIAP Deficiency, NLRC4-MAS
Therapeutic Use of Tadekinig Alfa in NLRC4 Mutation and XIAP Deficiency As Open Label Extension
This is an open-label extension study for patients previously enrolled in the AB2 Bio Ltd. ongoing Phase III clinical trial NLRC4/XIAP.2016.001 (IND N° 127953).
- Trial name
- NCT03512314
- Testing
- Tadekinig alfa
- Where
- 11 sites in United States, Canada and 1 more
- Volunteers
- 11 people
- Sponsor
- AB2 Bio Ltd.
Syndrome X
Syndrome X and Endothelial Dysfunction
Cardiac syndrome X is characterized by angina, positve stress test, and patent coronary angiography, and its probable mechanism is microvascular dysfunction associated with endothelial dysfunction.
- Trial name
- NCT00190086
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
X-linked Lymphoproliferative Syndrome Type 2 (XLP-2)
A Single-patient Clinical Trial of MAS825 in a Patient With XIAP Deficiency
MAS825 is a bi-specific IgG1 monoclonal antibody that simultaneously targets IL-1 beta and IL-18, thereby neutralizing both cytokines that are thought to be integral to the pathogenesis of XLP-2.
- Trial name
- NCT06309823
- Testing
- MAS825
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- The Hospital for Sick Children
Cardiovascular Diseases, Coronary Disease
Genetics of the Metabolic Syndrome in Japanese Americans
To investigate the genetic influence of candidate gene polymorphisms on risk factors for the metabolic insulin resistance syndrome in Japanese American sibships and kindreds.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Insulin Resistance
- Trial name
- NCT00005374
- Sponsor
- University of Washington
Ischemia, Myocardial, Non-Obstructive Coronary Atherosclerosis
INOCA-NA a Local Prospective Registry
The present study has the following objectives: 1. To investigate the prevalence of INOCA in patients referring for a clinically indicated coronary angiography (CA) c/o Division of Cardiology - Federico II University Hospital; 2.
- Conditions
- Ischemia, Myocardial, Non-Obstructive Coronary Atherosclerosis, Microcirculatory Status, Coronary Microvascular Dysfunction (CMD)
- Trial name
- INOCA-NA (NCT06588244)
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Federico II University
Autism, Autism Spectrum Disorder
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Autism
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding autism.
- Conditions
- Autism, Autism Spectrum Disorder, Autistic Disorder, Autism, Akinetic
- Trial name
- NCT04100863
- Testing
- No Intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Metabolic Syndrome X
Study of Chronic Degenerative Diseases
The prevalence of obesity and type 2 diabetes mellitus (DM) in children have been increasing in parallel at an alarming rate. In particular, the increasing prevalence of type 2 DM is attributable to genetic factors, clinical…
- Trial name
- NCT02495961
- Where
- Mexico
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Asociación Científica Latina A.C.
Metabolic Syndrome X
OPUS School Meal Study
The aim of this randomized crossover study, is to investigate the effect of school meals based on a sustainable New Nordic Diet on growth, learning abilities, well-being, sleep quality, physical activity and risk markers of…
- Trial name
- NCT01457794
- Testing
- School meals based on the principles of the New Nordic Diet
- Where
- Denmark
- Volunteers
- 834 people, healthy volunteers welcome
- Sponsor
- Arne Astrup
Chagas Cardiomyopathy
Microvascular Endothelial Function in a Cohort of Patients With the Cardiac Form of Chronic Chagas Disease.
The present study aims to evaluate the microvascular endothelial function of a single centre cohort of patients with the cardiac form of Chagas disease, and to search for associations with clinical and laboratory variables.
- Trial name
- NCT03524768
- Testing
- skin laser speckle contrast imaging and video-capillaroscopy
- Where
- Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Peripheral Artery Disease, Coronary Disease
Evaluation of Patients With Known or Suspected Heart Disease
In this study researchers will admit and evaluate patients with known or suspected heart disease referred to the Cardiology Branch of the National Heart, Lung, and Blood Institute (NHLBI).
- Conditions
- Peripheral Artery Disease, Coronary Disease, Diabetes and Heart Failure, Dilated Cardiomyopathy
- Trial name
- NCT00001313
- Where
- 2 sites in United States
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases, Microvascular Complications
Non-invasive Microvascular Assessment in Individuals at High Risk of Cardiovascular Disease From the SCAPIS2 Study
Microvascular dysfunction, particularly endothelial dysfunction, is increasingly recognized as a key mechanism underlying various cardiovascular diseases (CVD), including heart failure, ischemic heart disease, atherosclerosis…
- Trial name
- NCT07359768
- Where
- Sweden
- Volunteers
- 900 people
- Sponsor
- HJN Sverige AB/Neko Health
MINOCA, STEMI
Retinal OCTA for Microvascular Dysfunction Evaluation and Outcome Prediction in MINOCA Patients
The aim of this study is to evaluate microvascular dysfunction through OCTA in MINOCA patients. In order to better understand the condition, OCTA will also be performed in two matched patient groups: healthy controls and ACS…
- Conditions
- MINOCA, STEMI, Normal
- Trial name
- REVEAL (NCT07055152)
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Pisa
XIAP Deficiency
Quercetin in Patients With XIAP (X-linked Inhibitor of Apoptosis) Deficiency
The purpose of the study is to evaluate safety and tolerability of oral quercetin in reducing inflammation in male patients with XIAP deficiency.
- Trial name
- NCT07433621
- Testing
- Quercetin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Coronary Arteriosclerosis, Coronary Heart Disease
Analysis of Human Coronary Aspirate
During elective percutaneous coronary intervention (PCI), both proximal and distal protection devices are used. The distal occlusion protection device temporarily occludes the vessel distal to the lesion during the intervention…
- Conditions
- Coronary Arteriosclerosis, Coronary Heart Disease, No Reflow Phenomenon
- Trial name
- AHCA (NCT01430884)
- Testing
- Aspirated Coronary Blood
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Universität Duisburg-Essen
ST Segment Elevation Myocardial Infarction
Early Prediction of QFR in STEMI-I
The study intends to provide important data on whether the noval method using quantitative flow ratio could predict microvascular dysfunction.
- Trial name
- EARLYmyo-QFR-I (NCT03780335)
- Testing
- Computation of quantitative flow ratio
- Volunteers
- 162 people
- Sponsor
- RenJi Hospital
Alport Syndrome, X-Linked, Alport Syndrome, Autosomal Recessive
EXACT Study: A Blinded Study in Patients With Alport Syndrome to Evaluate Exaluren Efficacy and Safety
This is a randomized, double-Blind, placebo-controlled study to evaluate the efficacy and safety of exaluren in Alport Syndrome patients with nonsense mutations in COL4A3/4/5 genes.
- Trial name
- NCT07523581
- Testing
- Exaluren
- Where
- 11 sites in United States, United Kingdom
- Volunteers
- 24 people
- Sponsor
- Eloxx Pharmaceuticals, Inc.
Congenital Heart Disease
International Multicenter Outcomes of Transcatheter Pulmonary Flow Restrictors in Congenital and Acquired Heart Disease
The international multicenter registry aims to collect real-world data on clinical outcomes and evaluate the net clinical success of transcatheter microvascular plug (MVP)-based pulmonary flow restrictors (PFRs) in patients with…
- Trial name
- RESTRICT (NCT07791069)
- Testing
- Transcatheter pulmonary flow restriction
- Where
- 5 sites in France, Germany and 3 more
- Volunteers
- 150 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Psychotic Disorders, Bipolar Disorder
Comparison of Aripiprazole Versus Higher Metabolic Risk Antipsychotic Drugs on Adiposity Using MRI
The purpose of this study is to compare abdominal weight gain and fat distribution in people taking aripiprazole versus risperidone or quetiapine, to people not taking any of these antipsychotic medications.
- Conditions
- Psychotic Disorders, Bipolar Disorder, Metabolic Syndrome X
- Trial name
- CALM (NCT01739127)
- Testing
- Aripiprazole, Risperidone/Quetiapine
- Where
- Canada
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
ST Segment Elevation Myocardial Infarction
Early Prediction of QFR in STEMI-Pharmaco-invasice
The study intends to provide important data on whether the noval method using quantitative flow ratio could predict microvascular dysfunction.
- Trial name
- EARLYmyoQFR-PI (NCT04220736)
- Testing
- Computation of quantitative flow ratio
- Where
- China
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
Myocardial Infarction, Gender
Barts-MINOCA Registry
The last 15 years the introduction of primary angioplasty has radically improved outcomes for acute myocardial infarction (AMI).
- Conditions
- Myocardial Infarction, Gender, Coronary Microvascular Disease
- Trial name
- NCT04440761
- Testing
- Observation only
- Where
- United Kingdom
- Volunteers
- 3,000 people
- Sponsor
- Queen Mary University of London