Clinical trials: Coronavirus Infection
COVID-19 Infection
Novel Point-of-Care Diagnostic Test for SARS-CoV-2 (COVID-19)
This study investigates a new diagnostic test in detecting SARS-CoV-2, the virus that causes the disease COVID-19. This may help to improve testing for COVID-19.
- Trial name
- END CoV-2 (NCT04513990)
- Testing
- Biospecimen Collection, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Covid19
COVID-19 and Acute Invasive Fungal Rhinosinusitis
Data for acute invasive rhinosinusitis was obtained from the Otorhinolaryngology departments at our tertiary hospital at the period from January 2017 to December 2020.
- Trial name
- NCT04809480
- Testing
- Fungal rhinosinusitis
- Volunteers
- 56 people
- Sponsor
- Al-Azhar University
SARS-CoV Infection, Covid19
A Study to Evaluate the Efficacy, Immune Response, and Safety of a COVID-19 Vaccine in Adults ≥ 18 Years With a Pediatric Expansion in Adolescents (12 to<18 Years) at Risk for SARS-CoV-2
This is a phase 3, randomized, observer-blinded, placebo-controlled study to evaluate the efficacy, safety, and immunogenicity of SARS-CoV-2 rS with Matrix-M1 adjuvant in adult participants and adolescent participants.
- Trial name
- NCT04611802
- Testing
- SARS-CoV-2 rS/Matrix-M1 Adjuvant (Initial Vaccination Period), SARS-CoV-2 rS/Matrix-M1 Adjuvant (Crossover Vaccination period), SARS-CoV-2 rS/Matrix-M1 Adjuvant (Booster Vaccination)
- Where
- 154 sites in United States, Mexico and 1 more
- Volunteers
- 33,000 people, healthy volunteers welcome
- Sponsor
- Novavax
COVID-19
Trial to Evaluate Efficacy and Safety of Nitazoxanide in the Treatment of Mild or Moderate COVID-19
Trial to Evaluate Efficacy and Safety of Nitazoxanide in the Treatment of Mild or Moderate COVID-19
- Trial name
- NCT04486313
- Testing
- Nitazoxanide, Vitamin Super B-Complex
- Where
- 2 sites in United States
- Volunteers
- 935 people
- Sponsor
- Romark Laboratories L.C.
Treat and Prevent Covid-19 Infection
Safety and Immunity of Covid-19 aAPC Vaccine
In December 2019, viral pneumonia (Covid-19) caused by a novel beta-coronavirus (SARS-CoV-2) broke out in Wuhan, China. Some patients rapidly progressed and suffered severe acute respiratory failure and died, making it imperative…
- Trial name
- NCT04299724
- Testing
- Pathogen-specific aAPC
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
COVID-19
Pharmacokinetics, Pharmacodynamics, and Safety of Single-dose Sotrovimab in High-risk Pediatric Participants With Mild to Moderate COVID-19
This Phase 2b study will evaluate the pharmacokinetics (PK), pharmacodynamics (PD) and safety of sotrovimab in pediatric participants from birth to less than (<)18 years old with mild-to-moderate Coronavirus Disease-2019…
- Trial name
- COMET-PACE (NCT05124210)
- Testing
- Sotrovimab
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- GlaxoSmithKline
COVID19
ABC Science Collaborative Registry Study
The ABC Registry is associated with Pro00107943 and provides a resource for collecting information on members of school communities both regionally in North and South Carolina, as well as nationally in the United States (U.S.)…
- Trial name
- NCT04781218
- Volunteers
- healthy volunteers welcome
- Sponsor
- Duke University
COVID-19, SARS-CoV-2 Infection
Clinical Characteristics and Outcomes of Pediatric COVID-19
Rationale: The clinical manifestations of SARS-CoV-2 infection in children are poorly characterized. Preliminary findings indicate that they may be atypical.
- Conditions
- COVID-19, SARS-CoV-2 Infection, Pediatric ALL, Pneumonia, Viral
- Trial name
- PERN-COVID-19 (NCT04330261)
- Testing
- Exposure (not intervention) - SARS-CoV-2 infection
- Where
- Canada
- Volunteers
- 10,610 people
- Sponsor
- University of Calgary
COVID-19
Retrospective Study for Identificatiopn of a Link Between Doxycycline and COVID-19 Treatment
A new coronavirus, the third documented animal-to-human passage, emerged in Wuhan , China in the last quarter of 2019. Acne patients on doxycycline escaped seasonal viruses, showing the interest of this antibiotic as a possible…
- Trial name
- DOXY-COVID (NCT05445479)
- Testing
- Doxycycline
- Sponsor
- Nantes University Hospital
COVID-19, Asymptomatic Pregnant
COVID-19 PCR Test Results in Asymptomatic Pregnants
In order to prevent contamination from the pregnant women hospitalized in this clinic, the RT-PCR test is performed from the oropharyngeal and nasal swab sample taken before hospitalization.
- Trial name
- NCT04410939
- Testing
- Reverse transcription polymerase chain reaction
- Where
- Turkey (Türkiye)
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
COVID-19
POC Study to Evaluate the Performance of the AcuVid COVID-19 Rapid Antigen Saliva Test
The AcuVid COVID-19 Rapid Antigen Saliva Test is a lateral flow immunoassay to detect SARS-CoV-2 nucleocapsid antigens in human saliva specimens from individuals suspected of COVID-19 by their healthcare provider within the first…
- Trial name
- NCT05119530
- Testing
- AcuVid COVID-19 Rapid Antigen Saliva Test
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Therma Bright Inc
COVID-19, Hematopoietic Stem Cell Transplantation
A Study to Evaluate the Safety and Efficacy of COVID-19 Convalescent Plasma (CCP) Transfusion to Prevent COVID-19 in Adult Recipients Following Hematopoietic Stem Cell Transplantation
The study is to evaluate the safety and efficacy of COVID-19 convalescent plasma (CCP) transfusion to prevent COVID-19 in adult recipients following hematopoietic stem cell transplantation.
- Trial name
- NCT05904067
- Testing
- COVID Convalescent Plasma
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
COVID-19
A Study to Understand is the COVID-19 Vaccine BNT162b2 is Safe in Indonesia People
The purpose of this study is to characterize descriptively the BNT162b2 vaccination safety experience among the Indonesian people.
- Trial name
- NCT05621239
- Testing
- BNT162b2
- Where
- Indonesia
- Volunteers
- 260 people
- Sponsor
- Pfizer
Covid19
Rapid Diagnosis of COVID-19 by Chemical Analysis of Exhaled Air
Since the start of 2020, the new SARS-CoV-2 coronavirus is causing a real global health crisis. In France, nasopharyngeal swabs are used to obtain the sample needed for respiratory infection screening.
- Trial name
- COVIDAIR (NCT04706039)
- Testing
- Performance evaluation (sensitivity and specificity) for COVID-19 diagnosis of the Vocus PTR-TOF process
- Where
- France
- Volunteers
- 4,600 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Antigen Rapid Diagnostic Tests for Community Identification of Severe Acute Respiratory Syndrome Coronavirus 2
Background: Background: Testing with antigen-detecting rapid diagnostic tests (Ag-RDTs), including in asymptomatic individuals, has the potential to promptly identify more Severe Acute Respiratory Syndrome Coronavirus 2…
- Trial name
- NCT05458557
- Testing
- Rapid Antigen Testing
- Where
- Kenya
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
Invasive Group A Beta-Haemolytic Streptococcal Disease
Severe Group A Streptococcus Infections in Paris, France, 2018-2023
Streptococcus pyogenes, commonly referred to as Group A Streptococcus (GAS), has the ability to induce a diverse range of illnesses.
- Trial name
- IGASI (NCT06297122)
- Testing
- Collection of data from the patient's medical file
- Where
- France
- Volunteers
- 269 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cancer, Covid19
CCP Cancer UK Companion Study
Currently, there is extremely limited information regarding the risks posed by SARS-CoV-2 to patients with cancer. This study aims to understand the presentation, management and outcomes of patients with cancer.
- Trial name
- NCT04603105
- Where
- United Kingdom
- Volunteers
- 9,000 people
- Sponsor
- The Clatterbridge Cancer Centre NHS Foundation Trust
Pain, Chronic
PR-VR At-home Program During and After COVID-19
Poorly controlled chronic pain in teens can impact quality of life, increase opioid use and is a risk factor for developing chronic pain in adulthood.
- Trial name
- NCT04912817
- Testing
- Off the Shelf VR, Custom VR
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- The Hospital for Sick Children
Covid19
COVID-19 STAndard of Care in Sub-Saharan Africa
This study was conducted in three African countries on four COVID-19 care centers (CCCs). The CCCs were set up in collaboration with a medical NGO with long experience in recording and monitoring data for cohorts and clinical…
- Trial name
- COVISTA (NCT04885543)
- Where
- 3 sites in Burkina Faso, Guinea
- Volunteers
- 2,495 people
- Sponsor
- Alliance for International Medical Action
COVID-19 Pandemic
Animation Supported COVID-19 Education
Introduction: The COVID-19 epidemic and related mutations, which affect the whole world, continue to increase globally. In particular, this crisis adversely affects school-age children's quality of life.
- Trial name
- COVID-19 (NCT05633485)
- Testing
- Animation-Supported Education
- Where
- Turkey (Türkiye)
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Siirt University
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