Clinical trials: Cost-Effectiveness
Human Immunodeficiency Virus
Package of Resources for Assisted Contact Tracing: Implementation, Costs, and Effectiveness
Having health workers assist HIV-infected persons with the recruitment and testing of their sexual contacts and biological children is an effective and efficient way of identifying additional HIV-infected persons in need of HIV…
- Trial name
- PRACTICE (NCT05343390)
- Testing
- Enhanced implementation package, Standard implementation package
- Where
- 33 sites in Malawi
- Volunteers
- 841 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
HIV, Hypertension
SEARCH SAPPHIRE Phase A: A Multisectoral Strategy to Address Persistent Drivers of the HIV Epidemic in East Africa
The randomized trials in this record will assess effectiveness, fidelity and cost of prevention and treatment interventions for HIV and hypertension with the objective of informing a population-based study of multi-sectored…
- Conditions
- HIV, Hypertension, Alcohol Drinking, Maternal Child Health
- Trial name
- SAPPHIRE PhA (NCT04810650)
- Testing
- Mobility Dynamic Treatment Intervention, Health Living Intervention for Heavy Alcohol Users, Hypertension Linkage
- Where
- 2 sites in Kenya, Uganda
- Volunteers
- 2,233 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Second Degree Burn
Evaluating the Cost-effectiveness, Efficacy, Safety and Tolerance of Mepilex® Ag Versus Silvadene®
The primary objective is to compare the incremental costs (direct and indirect) and benefits (healing outcomes, quality of life) of using foam silver dressing (Mepilex® Ag) to a Silver sulfadiazine 1% cream (Silvadene®) from the…
- Trial name
- NCT00742183
- Testing
- Mepilex, Silvadene
- Where
- 10 sites in United States
- Volunteers
- 100 people
- Sponsor
- Molnlycke Health Care AB
Childhood Asthma
Supervised Asthma Medication in Schools (SAMS)
The investigators hypothesize that school-based, direct supervision of daily controller therapy will result in more effective asthma control, as assessed by the Asthma Control Questionnaire than usual care.
- Trial name
- SAMS (NCT01997463)
- Testing
- Supervised asthma therapy in schools
- Where
- United States
- Volunteers
- 442 people
- Sponsor
- University of Arizona
Surgical Site Infections
The Skin Prep Study
The investigators propose a randomized controlled clinical trial to determine the comparative effectiveness of chlorhexidine-alcohol and iodine-alcohol preoperative skin preparation for preventing surgical site infections at…
- Trial name
- NCT01472549
- Testing
- Iodine-alcohol, Chlorhexidine-alcohol
- Where
- United States
- Volunteers
- 1,147 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Diabetes, Hypertension
Can Group Visits Improve Outcomes of Veterans With Diabetes
Background: Diabetes is a common, morbid and expensive disease among veterans. Achieving adequate glycemic control and blood pressure control can reduce the devastating complications of diabetes.
- Trial name
- NCT00286741
- Testing
- Diabetes Group Management Visits
- Where
- 2 sites in United States
- Volunteers
- 239 people
- Sponsor
- US Department of Veterans Affairs
Headache
A Cost Effective Treatment for Headache in Pregnancy When Acetaminophen Alone is Ineffective.
To determine if the intravenous administration of Metoclopramide and diphenhydramine in combination can effectively treat headaches in pregnant patients in those refractory to acetaminophen when compared to codeine
- Trial name
- MAD (NCT02295280)
- Testing
- Metoclopramide, Diphenhydramine, Codeine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- St. Louis University
Addiction
Evaluating Improvement Strategies in Addiction Treatment
Addiction treatment is often characterized by long delays between first contact and treatment as well as high no-show and drop out rates leading to unused capacity in apparently full agencies.
- Trial name
- NIATx 200 (NCT00934141)
- Testing
- Learning Session, Interest Circle Calls, Coaching
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Sexually Transmitted Infection, HIV/AIDS
Clinical Study of STI Screening to Prevent Adverse Birth and New-born Outcomes (Philani Ndiphile)
This study aims to evaluate different screening strategies to decrease the burden of Neisseria gonorrhoeae (NG), Chlamydia trachomatis (CT) and Trichomonas vaginalis (TV) among pregnant women, and reduce adverse birth outcomes.
- Conditions
- Sexually Transmitted Infection, HIV/AIDS, Cost-effectiveness, Birth Outcomes
- Trial name
- NCT04446611
- Testing
- First antenatal care + test-of-cure, First antenatal care + week 30-34 gestation (no test-of-cure)
- Where
- South Africa
- Volunteers
- 2,247 people, healthy volunteers welcome
- Sponsor
- Foundation for Professional Development (Pty) Ltd
Stroke
Interdisciplinary Team Approach to Stroke Rehabilitation in Home Care
As the population ages and the number of stroke survivors increases, information is needed to determine the best way of providing home care services for rehabilitation to stroke survivors and their caregivers while containing…
- Trial name
- NCT00463229
- Testing
- Interprofessional Team Approach
- Where
- Canada
- Volunteers
- 101 people
- Sponsor
- McMaster University
Learning Disability
Investigating the Clinical and Cost Effectiveness of Lycra Splinting
People with learning disabilities (LDs) experience high levels of health problems, including cerebral palsy, other problems associated with posture, movement and function, and injury (falls are the commonest cause of injury in…
- Trial name
- NCT02345512
- Testing
- Lycra Splinting Garment
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Glasgow Caledonian University
Osteosarcoma
Outpatient Administration of High Dose Methotrexate (HD MTX) in Patients With Osteosarcoma
The primary purpose of this study is to determine the safety and feasibility of delivering HDMTX in an outpatient setting.
- Trial name
- NCT01176981
- Testing
- High Dose Methotrexate
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- The Hospital for Sick Children
Neonatal Opioid Withdrawal Syndrome
Use of SVS Device to Improve Outcomes for Neonatal Opioid Withdrawal Syndrome.
Maternal use and addiction to opioids has resulted in an unprecedented rise in drug withdrawal complications in newborns known as neonatal opioid withdrawal syndrome (NOWS), also referred to as neonatal abstinence syndrome (NAS).
- Trial name
- NCT04834297
- Testing
- Prapela SVS mattress
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Tufts Medical Center
Severe Hemophilia A
Canadian Hemophilia Prophylaxis Study
Primary prophylaxis given less frequently initially, with the infusion frequency increased if needed (Escalating Dose Prophylaxis), is likely to be less expensive and associated with fewer complications than standard prophylaxis…
- Trial name
- CHPS (NCT01085344)
- Testing
- Recombinant Factor VIII (Advate/Helixate FS/KoegenateFS)
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- The Hospital for Sick Children
Dementia
D-CARE - The Dementia Care Study: A Pragmatic Clinical Trial of Health System-Based Versus Community-Based Dementia Care
D-CARE: The Dementia Care Study This pragmatic randomized clinical trial of 2150 persons with dementia and their caregivers, at four diverse clinical trial sites in the United States, compares the effectiveness and…
- Trial name
- D-CARE (NCT03786471)
- Testing
- Health System-based Dementia Care, Community-based Dementia Care, Usual Care
- Where
- 4 sites in United States
- Volunteers
- 2,176 people
- Sponsor
- University of California, Los Angeles
Venous Leg Ulcer
Diagnostics in the Leg Ulcer Pathway
This project aims to investigate 'The minimum diagnostic requirements for patients presenting to primary care with suspected venous ulcers.' In order to do this, the investigators intend to run a series of questionnaires with…
- Trial name
- NCT06181708
- Testing
- N/A - Questionnaire based study
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Atopic Dermatitis
Comparing Aquaphor to Atopiclair and EpiCeram in Children With Mild to Moderate Atopic Dermatitis
The purpose of this study is to compare the efficacy and cost effectiveness of Aquaphor Healing Ointment, Atopiclair and EpiCeram as a monotherapy in mild to moderate AD.
- Trial name
- NCT01093469
- Testing
- Atopiclair Nonsteroidal Cream, Aquaphor Healing Ointment, EpiCeram
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Wake Forest University Health Sciences
Congenital Heart Disease
Fibrinogen Concentrate vs Cryoprecipitate
One of the most common hemostatic derangements in pediatric open- heart surgery is an acute acquired hypofibrinogenemia. This compromises fibrin clot generation and platelet aggregation, resulting in increased bleeding and…
- Trial name
- NCT03014700
- Testing
- Fibrinogen Concentrate, Cryoprecipitate
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Stanford University
HIV/AIDS
Suubi4Her: Combination Intervention for Adolescent Girls Transitioning Into Adulthood in Uganda
This study examines the impact and cost associated with Suubi4Her, an innovative combination intervention that aims to prevent HIV risk behaviors among 15-17 year-old girls living in communities heavily affected by poverty and…
- Trial name
- NCT03307226
- Testing
- Youth Development Accounts (YDA), YDA + Multiple Family Groups (MFG)
- Where
- 2 sites in Uganda
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Postoperative Wound Infection
Study of the Efficacy of Plain Soap and Water Versus Alcohol-based Rubs for Surgical Hand Preparation
Surgical site infections (SSI) constitute a significant health-economic and clinical challenge. The investigators conducted a cluster-randomized, cross-over study to compare the efficacy of plain soap and water (PSW), used…
- Trial name
- NCT00987402
- Testing
- Plain soap and water (PSW), Alcohol-based hand rub (ABHR)
- Where
- Kenya
- Volunteers
- 3,317 people
- Sponsor
- University Hospital, Geneva