Clinical trials: Couples
HIV Infections
Male Partner Involvement in the Prevention of MTCT of HIV
The study aims to invite male sexual partners to attend antenatal clinic with their pregnant partners to either acquire pregnancy information or undergo voluntary counselling and testing for HIV.
- Trial name
- NCT00405990
- Testing
- Voluntary counselling and HIV testing in ANC for PMTCT, VCT
- Where
- South Africa
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Violence, Gender-Based, Violence, Domestic
Responsible Engaged and Loving (REAL) Fathers Intervention Evaluation
The goal of this stepped-wedge cluster randomized control trial is to assess whether a Ugandan community-based intervention for young fathers (ages 18-25 years) of children ages 0-3 years impacts fathers' knowledge, attitudes…
- Conditions
- Violence, Gender-Based, Violence, Domestic, Violence, Sexual, Violence, Physical
- Trial name
- NCT06100679
- Testing
- Responsible Engaged and Loving (REAL) Fathers Initiative
- Where
- 4 sites in Uganda
- Volunteers
- 4,728 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Pregnancy
Influence of Sperm With Large Nuclear Vacuole on ICSI Outcomes
Current research on sperm morphology has been directed towards the dysmorphisms of the sperm head. A new technique based on the motile sperm organelle morphology examination (MSOME) allows the detection of sperm with large…
- Trial name
- NCT01727947
- Testing
- MSOME
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sapientiae Institute
Behavior and Behavior Mechanisms
Couple & Family Contexts
The purpose of this study is to understand the factors that lead to adolescent sexual risk behavior by investigating both the family contexts and romantic relationships that influence adolescent couples' decision-making.
- Trial name
- CFC (NCT01631721)
- Where
- United States
- Volunteers
- 2,960 people, healthy volunteers welcome
- Sponsor
- New York University
Human Immunodeficiency Virus
Testing Strategies for Couple Engagement in PMTCT and Family Health in Kenya
This study will test the efficacy and cost-effectiveness of an interdependence theory-based couples intervention in Kenya that reaches pregnant women and male partners through home visits by male-female pairs of lay health…
- Trial name
- Jamii Bora (NCT03547739)
- Testing
- Home visits, HIV Self-testing
- Where
- Kenya
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
HIV/AIDS
Demand Creation for Couples' HIV Counseling and Testing
This study aims at assessing the effect of a demand-creation intervention on couples' HIV counseling and testing (couples' HCT) uptake among married couples who have never tested together as a couple.
- Trial name
- NCT02492061
- Testing
- Demand creation for couples' HCT
- Volunteers
- 3,076 people, healthy volunteers welcome
- Sponsor
- Makerere University
HIV
Home-based Partner Education and Testing (HOPE) Study
The purpose of this study is to investigate the impacts of home-based couple HIV-testing and counseling and male partner education on partner HIV testing and other critical maternal and infant health outcomes during pregnancy and…
- Trial name
- HOPE (NCT01784783)
- Testing
- HOPE Intervention, INVITE Intervention
- Where
- Kenya
- Volunteers
- 601 people, healthy volunteers welcome
- Sponsor
- University of Washington
Pregnancy, Postpartum Period
The Effect of Sexual Education-Counseling According to PLISSIT Model of Couples' Sexual Functions During Pregnancy and Postpartum
Sexuality is a natural part of human life at every stage of life. It is a multidimensional phenomenon influenced by biological, psychological, social, interpersonal and cultural factors.
- Conditions
- Pregnancy, Postpartum Period, Sexual Dysfunction, PLISSIT Model
- Trial name
- NCT06762301
- Testing
- sexual education and counseling, Routine clinical care
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Coronary Heart Disease (CHD)
Couples Coping With Coronary Heart Disease
The main purpose of this study is to examine the contribution of personality traits to marital satisfaction and well -being among couples coping with Coronary Heart Disease (CHD) and couples from the general population, and to…
- Trial name
- psychocardio (NCT01315834)
- Where
- Israel
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
HIV
A Couple-Based Relationship Strengthening HIV Intervention for Young Parents
This study seeks to develop, implement, and assess an innovative 15-session couple-based intervention to be delivered in a group format to young parents that aims to strengthen relationships and reduce HIV risk.
- Trial name
- NCT01643005
- Testing
- Relationship Strengthening HIV Prevention Intervention, Parenting Program Intervention
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yale University
Mental Health Issue, Gender Equality
Pathways to Improved Adolescent Mental Health in Conflict Affected Families
The study combined a youth-friendly economic empowerment program (Rabbits for Resilience (RFR) with a gender equality couple curriculum program (HIKA) to advance knowledge on the combined and synergistic impact of structural…
- Trial name
- NCT05763719
- Testing
- Rabbits for Resilience (RFR) + HIKA, Rabbits for Resilience (RFR) only, HIKA Healthy Relationship Program
- Where
- United States
- Volunteers
- 3,024 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Posttraumatic Stress Disorder
Couple HOPES (Helping Overcome PTSD and Enhance Satisfaction)
Posttraumatic stress disorder (PTSD) is a common and disabling condition associated with intimate relationship problems and mental health problems in partners of those with PTSD.
- Trial name
- HOPES (NCT04231578)
- Testing
- Couple HOPES Guided, Internet-Delivered, Self-Help Intervention
- Where
- Canada
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Toronto Metropolitan University
Human Immunodeficiency Virus
Acceptability, Feasibility and Impact of Oral HIV Self-testing for Partner Testing Among Kenyan Adolescent Girls Aged 15-19 Years: A Randomized Controlled Trial
This randomized controlled trial will assess the feasibility, acceptability and impact of the provision of multiple oral-fluid based HIV self-test kits to HIV-negative adolescents aged 15-19 years to promote HIV testing among…
- Trial name
- NCT04805112
- Testing
- Provision of multiple self-tests
- Where
- Kenya
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Unintended Pregnancy, Family Planning
Efficacy Testing of a Multi-Level Family Planning Intervention
The goal of this cluster randomized controlled trial is to learn if the multi-level, community-based family planning intervention, known as the Family Health=Family Wealth (FH=FW) program, can improve family planning outcomes in…
- Trial name
- NCT06923189
- Testing
- Family Planning Intervention, Water, Sanitation, and Hygiene (WASH) Intervention
- Where
- Uganda
- Volunteers
- 1,464 people, healthy volunteers welcome
- Sponsor
- Boston College
Partner HIV Testing, Couple HIV Counseling
Couple-oriented Prenatal HIV Counseling in Low and Medium HIV Prevalence Countries
ANRS 12127 Prenahtest is an intervention trial conducted in four countries (Cameroon, Dominican Republic, Georgia and India), where pregnant women are randomized during prenatal care to receive either standard post-test HIV…
- Conditions
- Partner HIV Testing, Couple HIV Counseling, Couple Communication, HIV Incidence
- Trial name
- Prenahtest (NCT01494961)
- Testing
- Couple-oriented post-test HIV counseling
- Where
- 4 sites in Cameroon, Dominican Republic and 2 more
- Volunteers
- 1,943 people, healthy volunteers welcome
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Intimate Partner Violence (IPV)
Familia Imara: A Parenting Program to Reduce Family Violence in Tanzania
This cluster-randomized controlled trial will evaluate the effectiveness, implementation, and scalability of Familia Imara, a group-based, couples-focused, community health worker (CHW)-delivered parenting program, on reducing…
- Trial name
- NCT07574567
- Testing
- Familia Imara
- Where
- Tanzania
- Volunteers
- 6,216 people, healthy volunteers welcome
- Sponsor
- Saini Das
Substance Use, HIV Infections
Expanding the Potential of Couples HIV Testing: Adjunct Modules to Reduce Drug Use Among Vulnerable Male Couples
This study utilizes a randomized controlled trial design to evaluate the efficacy of two intervention components for couples HIV testing and counseling (CHTC): a communication skills training video and a substance use module.
- Trial name
- 4Us (NCT05000866)
- Testing
- Communication skills training video, Drug use module
- Where
- 2 sites in United States
- Volunteers
- 484 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
Pregnancy
The Benefits of Intracytoplasmic Morphologically Selected Sperm Injection (IMSI) in Couples With Unexplained Infertility
The (motile sperm organelle morphology examination) MSOME allows the detection of sperm vacuoles that seems to be related to sperm DNA damage.
- Trial name
- NCT01729533
- Testing
- ICSI, IMSI
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sapientiae Institute
HIV/AIDS
Development of a Couple-Based Mobile Health Intervention for Enhancing HIV Care Engagement Outcomes (N'Gage)
HIV/AIDS among Black men is a US public health crisis, emphasizing the urgency for increased research focus and intervention development.
- Trial name
- N'Gage (NCT03100643)
- Testing
- mHealth N'Gage mobile application
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Knowledge, Attitudes, Practice
Assessment of Knowledge, Attitude and Practice of Eligible Couples Regarding Eugenics
A Descriptive study to assess the knowledge, attitude and practice regarding eugenics among eligible couples of selected area of Ambala, Haryana, India.
- Trial name
- NCT03237559
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)