Clinical trials: Craniofacial Surgery
Craniosynostoses, Pain, Postoperative
Scalp Block Decreases Pain and Side Effects
Postoperative analgesia after corrective surgery of paediatric craniosynostosis is crucial in term of short and long-term outcomes.
- Trial name
- NCT04133467
- Testing
- scalp block
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Unilateral Cleft Lip and Palate, Cleft Lip
Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients
The purpose of this study is to evaluate which surgical protocol for treating Unilateral Cleft Lip and Palate (UCLP), a single or two stage repair ( with hard palate late closure) will have less impact in mid facial growth.
- Conditions
- Unilateral Cleft Lip and Palate, Cleft Lip, Cleft Palate, Developmental Disabilities
- Trial name
- NCT02329509
- Testing
- two stage palate surgical repair, One stage Palate Surgical repair
- Volunteers
- 64 people
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Maxilla; Hypoplasia
Transverse Maxillary Expansion With a Segmental Le Fort I Osteotomy or Surgically Assisted Rapid Maxillary Expansion (SARME)
To assess transverse dental and skeletal expansion and stability after SLFIO with no fixation of the palatal vault compared to stabilization of the palatal vault with an autogenous bone block graft or fixation of the palatal…
- Trial name
- NCT03511989
- Testing
- Bone borne distractor, Tooth borne distractor, Segmental LF1 Osteotomy group 1
- Where
- Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Craniosynostoses
Burosumab and 1-25 (OH) Vitamin D on Human Osteoblasts
FGF23 is the cornerstone of phosphate / calcium / vitamin D metabolism: it is synthesized mainly by osteocytes and acts as a phosphaturizing agent, inhibitor of dihydroxyvitamin D, and inhibitor of synthesis and secretion of PTH…
- Trial name
- HYPO-BLASTES (NCT04159675)
- Testing
- osteoblast biology study
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Children With Craniosynostoses
Nautilus: Dynamic Craniotomy; New Surgical Technique and Preliminary Results
Being the craniostenoses sutural basically a disease, the fact that the brain being trapped in an enclosure that does not have complacency required to accompany their growth constitutes the challenge of treatment, which aims to…
- Trial name
- Nautilus (NCT01672619)
- Testing
- dynamic craniotomy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Nucleo de Plastica Avancada
Wounds and Injuries, Wound Infection
Long Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
This study will evaluate the use of free autologous dermal fat grafting (also called free dermal fat autografting) to treat complex craniofacial wounds that have failed standard treatment and to understand how well these grafts…
- Conditions
- Wounds and Injuries, Wound Infection, Facial Bones Fracture, Soft Tissue Injuries
- Trial name
- FTFDT2 (NCT03880188)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dufresne, Craig, MD, PC
Post Craniotomy Surgery, Cancer
The Management of Postoperative Craniotomy Pain in Pediatric Patients
The purpose of this prospective, clinical observational trial is to assess the incidence of pain (and analgesia), methods of pain assessment (and by whom), prescribed analgesics, methods of analgesic delivery, and patient/parent…
- Conditions
- Post Craniotomy Surgery, Cancer, Epilepsy, Vascular Malformations
- Trial name
- NCT01576601
- Where
- 3 sites in United States
- Volunteers
- 81 people
- Sponsor
- Johns Hopkins University
Surgical Complication, Paresthesia
Trial of Bilateral Sagittal Split Osteotomy Induced Paresthesia Using Ultrasonic vs. Reciprocating Saw Instrumentation
The aim of this prospective study is to analyze the postoperative paresthesias experienced in patients who undergo bilateral sagittal split osteotomies (BSSO) using an ultrasonic saw, versus a reciprocating saw.
- Conditions
- Surgical Complication, Paresthesia, Fracture, Nerve Injury
- Trial name
- NCT05205616
- Testing
- Sonopet ultrasonic saw, Reciprocating saw
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cleft Palate Children
Length of Hospital Stay and Postoperative Analgesic Requirements After Introduction of a Specific Maxillary Nerve Block in Children Undergoing Cleft Palate Surgery
Cleft lip and palate (CLP) is one of the most common congenital malformations and requires repeated surgical correction during childhood.
- Trial name
- NCT07279883
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
DiGeorge Syndrome, Congenital Heart Defects
Infection in DiGeorge Following CHD Surgery
We propose a retrospective review of patients with DiGeorge syndrome having undergone cardiac surgery to evaluate the incidence of blood stream and/or surgical site infection.
- Trial name
- NCT00278005
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Children's Healthcare of Atlanta
Dentofacial Deformity
Lower Laser Therapy in Orthognathics Surgery
This study will examine the use of lower laser therapy to reduce edema and pain in orthognathics surgery.
- Trial name
- NCT01530100
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Goias
Recovery After Cleft Palate Surgery
Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery
A cleft deformity of the lip and/or palate is one of the commonest major birth defects. Primary surgery of cleft palates (CP) varies according to the different surgical teams.
- Trial name
- NCT02923869
- Testing
- Levobupivacaine, Bupivacaine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Cleft Lip and Palate, Maxillary Hypoplasia
Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better?
Cleft lip and palate patients normally present with a sunken face due to collapse in the middle part of the face and inability of the upper and lower teeth to meet during chewing.
- Trial name
- NCT00930124
- Testing
- Orthognathic surgery, Distraction osteogenesis
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Cleft Palate
Efficacy of Oral Versus Intravenous Acetaminophen for Primary Pediatric Cleft Palate Repair
The purpose of this investigator-initiated study is to determine whether acetaminophen is an effective pain reliever for primary cleft palate repair in children and possesses opioid sparing effects.
- Trial name
- NCT01500109
- Testing
- Oral acetaminophen, Ofirmev®, Opioid only
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Loma Linda University
Wound; Head, Multiple, Wound; Head, Scalp
Short Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
This study will evaluate the use of free autologous dermal fat grafting (also called free dermal fat autografting) to treat complex craniofacial wounds that have failed standard treatment and to understand how well these grafts…
- Conditions
- Wound; Head, Multiple, Wound; Head, Scalp, Wound; Head, Wound Infection
- Trial name
- FTFDT3 (NCT03872544)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dufresne, Craig, MD, PC
Cleft Lip, Cleft Palate
Primary Palatoplasty in Pediatric Patients - A Retrospective Review of Surgical Outcomes
Children who are born with cleft palate need surgery in order to correct the problem. The surgery is needed because the defect allows food to leak into the nose.
- Trial name
- NCT01380171
- Where
- United States
- Volunteers
- 1,295 people
- Sponsor
- Children's Healthcare of Atlanta
Mandibular Hypoplasia, Relapse
Evaluation of Early Relapse After Mandibular Lengthening Surgery
The goal of this study is to evaluate whether the use of a bone graft substitute at the osteotomy site will result in better stability and diminish early relapse after mandibular lengthening surgery.
- Trial name
- NCT03710512
- Testing
- Bilateral sagittal split osteotomy
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitair Ziekenhuis Brussel
Orthognathic Surgery, Dentofacial Deformities
Development and Validation of an Automated Three-dimensional Cephalometry Method
This study is aimed to develop and assess the validity of an algorithm for automated three-dimensional cephalometry.
- Trial name
- AutoCEPH-3D (NCT04464252)
- Where
- France
- Volunteers
- 453 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Craniofacial Abnormalities, Maxillofacial Abnormalities
3D Imaging of Hard and Soft Tissue in Orthognathic Surgery
The primary objective of this clinical trial is to assess the influence of orthognathic surgery on facial soft tissue, such as changes (volume, linear, angular) of facial hard and soft tissue, in three dimensions, so enabling the…
- Conditions
- Craniofacial Abnormalities, Maxillofacial Abnormalities, Cleft Lip, Cleft Palate
- Trial name
- NCT00285714
- Testing
- 3D stereophotogrammetric imaging, 3D CT-imaging with cone-beam CT, Case report form
- Where
- 3 sites in Netherlands
- Volunteers
- 450 people
- Sponsor
- Radboud University Medical Center
Noonan Syndrome
Link Between Abnormal Bleeding and Coagulation Disorders in Noonan Syndromes
Noonan syndrome is a relatively rare genetic disorder, affecting around 1 in every 1,000 to 2,500 children born. Patients often have a tendency to bleed more easily, particularly from the skin or mucocutaneous tissue (such as…
- Trial name
- PlatNoon (NCT07259135)
- Testing
- Reuse of routine clinical and biological data
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Bordeaux