Clinical trials: Craniosynostoses
Craniosynostoses, Pain, Postoperative
Scalp Block Decreases Pain and Side Effects
Postoperative analgesia after corrective surgery of paediatric craniosynostosis is crucial in term of short and long-term outcomes.
- Trial name
- NCT04133467
- Testing
- scalp block
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Craniosynostosis
Osteogenic Profiling of Tissue From Children With Craniosynostosis
The primary objectives of this study are to procure human temporalis muscle, subcutaneous adipose (fat), and bone tissue samples from children with craniosynostosis, to grow cells from these tissues in vitro, to evaluate the…
- Trial name
- NCT00773643
- Testing
- biopsy
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- University of Pittsburgh
Craniosynostoses
Burosumab and 1-25 (OH) Vitamin D on Human Osteoblasts
FGF23 is the cornerstone of phosphate / calcium / vitamin D metabolism: it is synthesized mainly by osteocytes and acts as a phosphaturizing agent, inhibitor of dihydroxyvitamin D, and inhibitor of synthesis and secretion of PTH…
- Trial name
- HYPO-BLASTES (NCT04159675)
- Testing
- osteoblast biology study
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Children With Craniosynostoses
Nautilus: Dynamic Craniotomy; New Surgical Technique and Preliminary Results
Being the craniostenoses sutural basically a disease, the fact that the brain being trapped in an enclosure that does not have complacency required to accompany their growth constitutes the challenge of treatment, which aims to…
- Trial name
- Nautilus (NCT01672619)
- Testing
- dynamic craniotomy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Nucleo de Plastica Avancada
Craniostenosis
Multimodal Mechanical, Tissue, Architectural, and Histological Evaluation of the Bone and Sutures of the Parietal Bone in an Infant With Craniosynostosis.
The human skull is a complex structure that protects the underlying tissues, including the brain. Certain rare conditions and diseases, such as craniosynostosis-which affects 1 in 2,000 to 2,500 children-impair these functions…
- Trial name
- CRANIOMECA (NCT07650981)
- Testing
- Biological sample, bones sample and questionaires.
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
Plagiocephaly
Postural Assessment in Plagiocephaly
The positional plagiocephaly is a condition involving craniofacial asymmetry. The purpose of this study is to evaluate the spine, the posture and the psychomotor state in children who were diagnosed with infant plagiocephaly.
- Trial name
- NCT01989286
- Testing
- Assessment
- Where
- Spain
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Craniosynostosis, Strabismus
Ocular Characteristics in Patients With Craniosynostosis
Craniosynostosis are cranial deformations due to the premature closure of one or more cranial sutures. These deformations affect approximately one in 2.500 births.
- Conditions
- Craniosynostosis, Strabismus, Intracranial Hypertension, Amblyopia
- Trial name
- COPACA (NCT06928727)
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Optic Nerve Sheath Diameter
Optic Nerve Sheath Diameter in Craniosynostosis
Changes of optic nerve sheath diameter after position changes
- Trial name
- ONSD (NCT03131245)
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Hypovolemia, Craniosynostoses
Bedside Resources to Gauge Intravascular Volume Status
The goal if this study is to employ the CardioQ-Esophageal Aortic Doppler probe to define fluid responders from non-responders among infants undergoing cranial vault reconstruction for craniosynostosis.
- Trial name
- NCT03915587
- Testing
- CardioQ-EDM and CipherOx-CRI
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Colorado, Denver
Craniosynostosis Repair, Untethering of Cord
The Effect of Gender on the Consumption of Pain Medication in Infants Undergoing Craniosynostosis Repair or Untethering of Cord in ITU
Postoperative pain is a major concern in routine management of children admitted to pediatric intensive care treatment. There are significant negative physiological and psychological ramifications of postoperative pain such as…
- Trial name
- NCT01996163
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Marfan Syndrome, Turner Syndrome
National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions
The National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) was initiated in 2006 by the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of…
- Conditions
- Marfan Syndrome, Turner Syndrome, Ehlers-Danlos Syndrome, Loeys-Dietz Syndrome
- Trial name
- GenTAC (NCT01322165)
- Where
- 7 sites in United States
- Volunteers
- 3,706 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Craniosynostoses
Craniosynostosis :Surgical Treatment Modalities and Outcome
Aim of study: 1. To evaluate outcome of cases( cosmoses and cognition) after Craniosynostosis surgery 2. - To ascertain intra- and postoperative complications
- Trial name
- NCT05511168
- Testing
- Craniostnostosis surgery
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hydrocephalus in Children, Epilepsy
Myelin Imaging Changes In Patients With Neurosurgical Diseases
Investigate myelin alterations in patients with neurosurgical diseases
- Conditions
- Hydrocephalus in Children, Epilepsy, Craniosynostoses, Traumatic Brain Injury
- Trial name
- McDESPOT (NCT03698838)
- Testing
- McDESPOT
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Memorial Healthcare System
Craniosynostoses, Synostosis
Craniofacial Imaging With 3D MRI: an Alternative to Ionising Radiation
Craniosynostosis is a condition where infants are born with or subsequently develop an abnormally shaped skull. The skull develops from plates of bone separated from each other by growth lines (sutures).
- Conditions
- Craniosynostoses, Synostosis, Skull Deformity
- Trial name
- NCT04695938
- Testing
- MRI
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Cambridge
Craniofacial Differences
Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences
This study will describe the use of an intervention, developed by an organization called Positive Exposure, to improve self-perceptions among adolescents and young adults who may encounter the stigma, or negative effect, of…
- Trial name
- NCT00340964
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Plagiocephaly, Brachycephaly
Monitoring System for Cranial Orthoses
This is a study which investigates the wear time and fit of a cranial remolding orthosis (a standard-of-care treatment where an infant wears a custom helmet to help reshape their head as they grow).
- Conditions
- Plagiocephaly, Brachycephaly, Deformational Plagiocephaly, Deformational Posterior Plagiocephaly
- Trial name
- NCT06425172
- Testing
- Cranial Remolding Orthosis
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Texas Southwestern Medical Center
Craniosynostosis, Sagittal, Scaphocephaly
Examination of Neuromotor Development of Cases Diagnosed with Scaphocephaly
It's an observational study. Purpose of the study: To evaluate the neuromotor development of scaphocephaly cases. 21 infants diagnosed with scaphocephaly aged 2-17 months were included.
- Conditions
- Craniosynostosis, Sagittal, Scaphocephaly, Developmental Delay
- Trial name
- NCT06294626
- Testing
- Group 1
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Acıbadem Atunizade Hospital
Plagiocephaly, Nonsynostotic, Brachycephaly
Effects of Corrective Helmet Therapy on Cervical Motion and Thermoregulation in Children With Positional Deformities
The purpose of the study is to examine how cranial helmet therapy may affect neck movement and body temperature regulation in children with positional head deformity.
- Trial name
- NCT07201324
- Testing
- cranial helmet therapy - observational
- Volunteers
- 270 people
- Sponsor
- Wroclaw University of Health and Sport Sciences
Craniosynostoses
EPBONF : Evaluation of the Safety and Effectiveness of a Medical Device Aimed at Guiding Orbito-naso-frontal Band Surgery, for the Treatment of Craniostenoses
Craniostenosis is a congenital disorder caused by early fusion of the cranial sutures between the skull bones, resulting in orbito-naso-frontal deformities.
- Trial name
- EPBONF (NCT06366178)
- Testing
- BONFIX system
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Craniosynostosis
Efficacy of Amicar for Children Having Craniofacial Surgery
The purpose of this study is to determine whether Amicar (ε-aminocaproic acid) is effective in reducing blood loss in children undergoing craniofacial reconstruction surgery.
- Trial name
- NCT02229968
- Testing
- Amicar (ε-aminocaproic acid), normal saline
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Children's National Research Institute