Clinical trials: Critical Care Medicine
Critical Laboratory Values, Drug Laboratory Interactions
Effect of an Automated Paging System on Response to Critical Laboratory Values
Patients in hospitals may develop serious problems that are detected by blood tests. It is very important for the physicians to be notified of these abnormal blood tests as soon as possible.
- Conditions
- Critical Laboratory Values, Drug Laboratory Interactions, Drug Drug Interactions
- Trial name
- NCT00469924
- Testing
- Real Time Clinical Alerting
- Where
- Canada
- Volunteers
- 271 people
- Sponsor
- Sunnybrook Health Sciences Centre
Critical Illness
Clinical Trial on Individual Characteristics Affecting Pain Drug Therapy in Neonates
Children differ from adults with respect to growth and development but also immaturity of various pharmacological mechanisms. Dosing schemes in children are usually derived in an empirical manner from clinical trials in adult…
- Trial name
- NeoPopGen (NCT02426463)
- Testing
- propofol, oxycodone
- Where
- Finland
- Volunteers
- 80 people
- Sponsor
- Turku University Hospital
Tetanus
Multicenter Study of Tetanus Patients in Fujian Province of China
Background: Tetanus is a life-threatening disease in developing countries, and accompanied by a high mortality rate. China is the world's largest developing country, and Fujian Province is a typical coastal province in China with…
- Trial name
- NCT04165928
- Where
- China
- Volunteers
- 95 people
- Sponsor
- Fujian Provincial Hospital
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Lung Cancer
A Study to Evaluate Guideline Adoption Through Quality Improvement Project (QIP) in Pulmonary and Critical Care Medicine (PCCM) Department
This is a cluster randomized controlled trial with PCCM department in each site being the cluster. Fifty-four sites' PCCM departments will be randomized to the QIP arm versus control arm in 2:1 allocation ratio.
- Trial name
- LC PCCM QIP (NCT06484972)
- Volunteers
- 1,728 people
- Sponsor
- China-Japan Friendship Hospital
Acute Renal Injury
Dialyzing Wisely - Improving the Delivery of Acute Renal Replacement Therapy to Albertans
Implementation of an evidence-based and best practices acute RRT pathway aiming to decrease acute RRT program and healthcare systems costs while improving important patient-reported outcomes.
- Trial name
- NCT05186636
- Testing
- KPI reports, Prescriber reports
- Where
- 15 sites in Canada
- Volunteers
- 9,348 people
- Sponsor
- University of Alberta
Chronic Kidney Disease, Pneumonia
Proton Pump Inhibitor Use is Associated With High Risk of Pneumonia in Chronic Kidney Disease Patients
Chronic kidney disease is a severe medical problem in Taiwan public health issue, which the highest incidence and prevalence rate in the world.Proton pump inhibitors may increase the risk of pneumonia appearance, which were…
- Trial name
- NCT01588886
- Volunteers
- 9,000 people
- Sponsor
- Far Eastern Memorial Hospital
Death
Advance Directives and End-of-life Decision Making in Intensive Care Medicine in Germany
Description of the decision making process as well as the practices of end of life care in an ICU of a German university hospital during the period when changes of German legislation occurred.
- Trial name
- NCT01294189
- Where
- Germany
- Volunteers
- 224 people
- Sponsor
- Charite University, Berlin, Germany
Major Injury
Perioperative Research Into Memory: Cognitive Outcome Following Major Burns
The long term survival of patients who require admission to critical care (CC) following a major burn injury (MBI) continues to improve with advanced clinical management.
- Trial name
- PRiMe (NCT03470844)
- Testing
- Face-to-face neurocognitive tests, Psychological screening, fMRI
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Critical Care Medicine, Transportation of Patients
Pediatric Intensive Care Transport Registry
The aim is to establish a nationwide registry for pediatric intensive care transports in Germany. The project aims to describe and analyse the need for, and current practice of, specialised transports.
- Conditions
- Critical Care Medicine, Transportation of Patients, Pediatrics
- Trial name
- PIT Registry (NCT07070258)
- Where
- 2 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- Philipps University Marburg
Septic Shock
Pilot Study for the SQUEEZE Trial
The purpose of the SQUEEZE Trial is to determine which fluid resuscitation strategy results in the best outcomes for children treated for suspected or confirmed septic shock.
- Trial name
- SQUEEZE (NCT01973907)
- Testing
- Fluid Sparing Resuscitation Strategy
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- McMaster Children's Hospital
Red Blood Cell Transfusions
Implementation of Red Blood Cell Transfusion Recommendations in the Pediatric Intensive Care Unit
Evidence demonstrates that the risks of red blood cell transfusions outweigh benefits in many patients who are hospitalized in the pediatric intensive care unit with increased risk of organ dysfunction, infection, delirium, and…
- Trial name
- TRIP (NCT07108374)
- Testing
- Implementation strategies to increase use of transfusion recommendations
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Stanford University
Septic Shock
SQUEEZE Trial: A Trial to Determine Whether Septic Shock Reversal is Quicker in Pediatric Patients Randomized to an Early Goal Directed Fluid Sparing Strategy vs. Usual Care
The purpose of the SQUEEZE Trial is to determine which fluid resuscitation strategy results in the best outcomes for children treated for suspected or confirmed septic shock.
- Trial name
- SQUEEZE (NCT03080038)
- Testing
- Fluid Sparing Resuscitation Strategy
- Where
- 8 sites in Canada
- Volunteers
- 406 people
- Sponsor
- McMaster University
Critical Illness, Ultrasound
Core Competencies in General Intensive Care Ultrasound (GenIUS): a Delphi Study
This study using a Delphi methodology, and involving international experts, will help define a training curriculum for core competencies for general intensive care ultrasound practice.
- Conditions
- Critical Illness, Ultrasound, POCUS, Training
- Trial name
- NCT07917988
- Testing
- Delphi procedure
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Hospital General Universitario de Castellón
Drug Withdrawal Symptoms, Critical Care
Tapering of Analgosedation and Occurrence of Withdrawal Syndrome in Paediatric Intensive Care Treatment
The study is a prospective interventional study with three main aims: 1. Describe the frequency and severity of withdrawal syndrome in a population of paediatric intensive care patients. 2.
- Conditions
- Drug Withdrawal Symptoms, Critical Care, Child
- Trial name
- ASWISPIC (NCT02952846)
- Testing
- Algorithm for tapering og analgosedation
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Oslo University Hospital
Medical Education, ICU
Case-Based Learning for Bedside Lung Ultrasound Teaching in ICU
This single-center randomized controlled study aims to evaluate the effectiveness of Case-Based Learning (CBL) compared with traditional teaching in clinical training of bedside lung ultrasound (BLUE) for emergency medicine…
- Conditions
- Medical Education, ICU, Emergency Medicine, Lung Ultrasound
- Trial name
- NCT07594470
- Testing
- Case-Based Learning (CBL), Traditional lecture-based teaching
- Where
- China
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum
Nutritional and Metabolic Management of Toxidermia Patients Requiring Intensive Care (TEN Metabolism)
Retrospective observational cohort study including all patients admitted for toxidermia (Lyell syndrome, Stevens-Johnson Syndrome (SJS), or other extensive skin destruction) to the Burn unit of the adult ICU of the Lausanne burn…
- Trial name
- TEN metabolism (NCT05320653)
- Testing
- Medical nutrition
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Acute Lung Injury, Acute Respiratory Distress Syndrome
Effects and Safety of Infusion of Low-Doses of Methylprednisolone in Early ALI and ARDS in Children
The purpose of this study is to investigate the effects of prolonged low-dose methylprednisolone infusion on pulmonary function (LIS and ventilation-free days), extra pulmonary organ function (PMODS score), inflammatory markers …
- Trial name
- PEDALI (NCT01757899)
- Testing
- Methylprednisolone Arm, Sterile Saline Arm
- Where
- Brazil
- Sponsor
- Universidade Federal do Rio de Janeiro
Sepsis
Early PREdiction of Severe Sepsis I (ExPRES-Sepsis I) Study
Between 6 and 16% of patients presenting to hospital emergency departments have infections, with half of these having signs of systemic inflammation (known as 'sepsis').
- Trial name
- ExPRES (NCT02188992)
- Where
- 3 sites in United Kingdom
- Volunteers
- 401 people
- Sponsor
- University of Edinburgh
Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome)
RECOMMEND Platform Trial
The goal of this platform trial is to determine the efficacy, safety and cost-effectiveness of various interventions in patients with acute cardiorespiratory failure requiring extracorporeal membrane oxygenation (ECMO) The main…
- Conditions
- Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome), Intensive Care Medicine, Cardiac Arrest (CA)
- Trial name
- RECOMMEND (NCT06526533)
- Testing
- Liberal RBC Transfusion, Restrictive RBC Transfusion
- Where
- 3 sites in Australia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Australian and New Zealand Intensive Care Research Centre