Clinical trials: Critically Ill Child
Critically Ill
New Stable Isotope Method to Determine Protein Requirements in Critically Ill Children
The need for certain components of food (i.e. protein) for critically ill children is not clear. It is important to have critically ill children fed adequately to prevent that their condition becomes worse or that recovery takes…
- Trial name
- NCT01511354
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Texas A&M University
Critical Illness, Enteral Feeding Intolerance
Evaluation of Enteral Nutrition in Critically Ill Children
The aim of this study was to evaluate the effect of calorie and enteral feeding timing on survival in critically ill children receiving inotropic, vasopressor and inodilatory supplements.
- Trial name
- NCT04013893
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Cukurova University
Pediatric Asthma, Critical Illness
Azithromycin for Critical Asthma - Pediatrics
The CR-AZI Study will assess the immunomodulatory effects of Azithromycin for pediatric Critical Asthma.
- Trial name
- CR-AZI Kids (NCT06223828)
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins All Children's Hospital
Bloodstream Infection Due to Central Venous Catheter, Central Line-associated Bloodstream Infections
Chlorhexidine Bathing in Critically Ill Children
Central line-associated bloodstream infections are associated with increased mortality, morbidity, and length of hospital stay. The incidence has decreased significantly with the strict implementation of preventive bundle cares…
- Trial name
- NCT05995080
- Testing
- clorhexidine gluconate bathing
- Where
- Turkey (Türkiye)
- Volunteers
- 247 people
- Sponsor
- Istanbul Medeniyet University
Hypoglycemia Non Diabetics, Emergencies
SugarFACT - Sugar Requirements For African Children Trial
The purpose of this study is to evaluate the impact of dextrose administration in severely sick children admitted to hospital with low-glycaemia. The problem: Mortality in children remains high in sub-Saharan African hospitals.
- Conditions
- Hypoglycemia Non Diabetics, Emergencies, Pediatric ALL, Critical Illness
- Trial name
- NCT02989675
- Testing
- 10% dextrose
- Where
- 2 sites in Malawi
- Volunteers
- 410 people
- Sponsor
- Helena Hildenwall
Circadian Dysrhythmia, Sleep Disturbance
PICU-related Sleep and Circadian Dysregulation Pilot Study
A single center pilot trial investigating the feasibility of using actigraphy and salivary melatonin levels to measure the sleep and circadian rhythm of critically ill children aged 3 to 6 years old.
- Conditions
- Circadian Dysrhythmia, Sleep Disturbance, Critical Illness, Children, Only
- Trial name
- NCT06505447
- Testing
- Daytime light exposure, Daytime restricted feeding
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- State University of New York at Buffalo
Deep Venous Thrombosis
Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Trial
The purpose of this phase 2a, multi-center, randomized controlled study, is to explore the efficacy of early prophylaxis against catheter-associated deep venous thrombosis (CADVT) in critically ill children.
- Trial name
- CRETE (NCT03003390)
- Testing
- Enoxaparin
- Where
- 6 sites in United States
- Volunteers
- 51 people
- Sponsor
- Yale University
Pediatric Critical Illness, Critical Illness
Tissue Penetration of Antibiotics in CriTically Ill Children
This clinical study evaluates the extent to which three commonly administered beta-lactam antibiotics (piperacillin-tazobactam, meropenem, and amoxicillin-clavulanic acid) penetrate tissue in critically ill pediatric patients.
- Trial name
- TACTIC (NCT07822243)
- Testing
- Pharmacokinetic sampling (Microdialysis and blood sampling)
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- University Hospital, Ghent
Delirium
Polypharmacy-related Adverse Events in Critically Ill Children
The purpose of this study is to learn how 2 medications (fentanyl and dexmedetomidine) affect how sick children think and interact with their environments.
- Trial name
- NCT03293927
- Testing
- Fentanyl, Dexmedetomidine
- Where
- United States
- Sponsor
- Duke University
Sepsis
Vitamin A Status in Critically Ill Children With Sepsis and Its Association With Illness Severity
The primary purpose of this study is to assess the status of vitamin A in critically ill children with sepsis and its association with the ill severity.
- Trial name
- NCT03598127
- Where
- China
- Volunteers
- 300 people
- Sponsor
- West China Hospital
Lung Collapse
Brochoscopic Intervention Versus Conventional Management in Acute Lung Collapse in the Pediatric Intensive Care Unit
This prospective RCT at Cairo University Children Hospitals enrolls critically ill pediatric patients (intubated, NIV, or post-extubation) with lung atelectasis unresponsive to 48 hours of conventional recruitment.
- Trial name
- picu (NCT07383129)
- Testing
- bronchoscope, chest physiotherapy and suction
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Cairo University
Staphylococcal Infection
Safety and Efficacy of Mupirocin in Eradicating Colonization With S. Aureus in Critically Ill Infants
The objective of this trial is 1) to evaluate the safety and clinical acceptability of a 5-day course of mupirocin applied every 8 hours (± 2 hours) to the nares, umbilical and perianal areas of infants residing in the ICU.
- Trial name
- NCT01827358
- Testing
- Mupirocin calcium
- Where
- 6 sites in United States
- Volunteers
- 155 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Dexmedetomidine, Mechanical Ventilation Complication
DOSE Trial of Opioid Sparing Effect
Multicenter, double blind randomized controlled trial of fentanyl vs. fentanyl + dexmedetomidine as the initial regimen for maintenance of sedation in mechanically-ventilated, critically ill children.
- Conditions
- Dexmedetomidine, Mechanical Ventilation Complication, Critically Ill
- Trial name
- DOSE (NCT03938857)
- Testing
- Fentanyl, Dexmedetomidine
- Where
- 19 sites in United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Pediatric Intensive Care Unit, Pediatric Immuno-hematology Department
Population Pharmacokinetics of Anti-infectives in Critically Ill Children
Concentrations and effects of anti-infectives in critically ill children are unpredictable and the risk of under-exposure may be associated with poor clinical outcomes.
- Trial name
- OPTIMOME (NCT02539407)
- Testing
- Pharmacokinetics
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Output
Validation of Minimally Invasive Ultrasound Indicator Dilution Technique in Critically Ill Children
A novel method to measure cardiac index based on ultrasound indicator dilution technology (UIDT) has been developed by Transonic Systems Inc. (Ithaca, NY, USA).
- Trial name
- NCT00852254
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Transonic Systems Inc.
Enteral Nutrition, Feeding Intolerance
Evaluation of Status of Early Reached Target Enteral Nutrition and IFABP as Biomarker of Feeding Intolerance in Critically Ill Children
Stage 1 - Evaluation of Status of Early Reached Target Enteral Nutrition in critically ill children in the PICU (ERTEN in PICU).
- Conditions
- Enteral Nutrition, Feeding Intolerance, Intestinal Fatty Acid Binding Protein
- Trial name
- ERTENIFABPICU (NCT02598375)
- Testing
- Feeding intolerance
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Gazi University
Hemodynamically Stable, Critical Illness
Comparing USCOM and Echocardiographic Hemodynamic Measurements in Children (CUE Study)
The primary objective of this study is to evaluate the agreement between hemodynamic measurements obtained using the Ultrasound Cardiac Output Monitor (USCOM®; USCOM Ltd., Sydney, Australia), and reference standards as determined…
- Trial name
- NCT02083172
- Testing
- Ultrasound Cardiac Output Monitor and 2 D-Echo
- Where
- Canada
- Volunteers
- 78 people
- Sponsor
- McMaster University
Critical Illness
Early Rehabilitation in Critically Ill Children Pilot Study
Critically ill patients are often confined to bedrest, because of the nature of their illness. However, it has now been shown that prolonged bedrest and immobility, particularly in critically ill adults and children, can lead to…
- Trial name
- WeeHab in PCCU (NCT01531816)
- Testing
- Early Rehabilitation intervention
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Emergencies, mHealth
Feasibility and Efficacy of Ambulance-Based m-Health for Pediatric Emergencies (FEAMER) Trial
Investigators hypothesize that in a low-resource setting, linking ambulances that transport acutely ill children to a remote pediatric emergency physician using a simple audio-video device will improve the quality of these…
- Conditions
- Emergencies, mHealth, Child Health, Critical Illness
- Trial name
- FEAMER (NCT07027813)
- Testing
- Telemedicine, Control
- Where
- 3 sites in Pakistan
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Critical Illness
Timing of Initiation of Parenteral Nutrition for Critically Ill Children
Parenteral Nutrition (PN) is prescribed to children with a non functioning gut. Timing of initiation of PN for critically ill children is a hotly issue.
- Trial name
- TPN (NCT04693143)
- Testing
- A randomized controlled open-label clinical trial.
- Volunteers
- 140 people
- Sponsor
- Menoufia University