Clinical trials: Critically Ill Patients
Critical Illness
Effect of Protocolized Magnesium Replacement on Mortality and Atrial Fibrillation in Critically Ill Patients
In patients with critical illness, such as severe infections, heart attacks, or respiratory failure, most intensive care units (ICUs) measure magnesium levels and give supplemental doses of magnesium when levels are below certain…
- Trial name
- MAGNOLIA (NCT07173855)
- Testing
- Magnesium sulfate administration, Magnesium oxide, Magnesium glucoheptonate
- Where
- 6 sites in Canada
- Volunteers
- 3,853 people
- Sponsor
- Scarborough General Hospital
Critical Illness, Acute Kidney Injury
Use of EBPT in Critically Ill Patients With AKI and/or Multiorgan Failure
The use of extracorporeal blood purification therapies (EBPT) is becoming increasingly widespread worldwide in everyday clinical practice, particularly in the critical care setting.
- Conditions
- Critical Illness, Acute Kidney Injury, Sepsis, Systemic Inflammatory Response Syndrome
- Trial name
- NCT04033224
- Testing
- Commercial membrane for Extracorporeal Blood Purification Therapy (EBPT)
- Where
- 15 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- Careggi Hospital
Sodium Balance
Comparing Sodium to Fluid Balance in Predicting Respiratory Dysfunction in Critically Ill Septic Patients
Critically ill septic patients are at risk of positive sodium balance due to inadvertent excess administration, which may be over twice the daily requirement of sodium for healthy individuals This research will estimate sodium…
- Trial name
- NCT06771869
- Testing
- Sodium balance
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Severe Acute Respiratory Infection
Viral Etiology of Severe Acute Respiratory InFection in CriticallY Ill Patients Registry
SARI is a major public health problem in Saudi Arabia and leads to considerable morbidity and mortality. Most SARI-related mortality occurs in patients admitted to ICUs across the country.
- Trial name
- VERIFY (NCT06627166)
- Where
- Saudi Arabia
- Volunteers
- 13 people
- Sponsor
- King Abdullah International Medical Research Center
Covid19, Thromboembolism
Dosing of Thromboprophylaxis and Mortality in Critically Ill COVID-19 Patients
The aim of the study is to associate dose of thromboprophylaxis with outcome in critically ill COVID-19 patients. This will be done by associating dose of thromboprophylaxis with 28-day mortality, survival outside ICU…
- Trial name
- NCT04593654
- Testing
- Dose of tinzaparin or dalteparin
- Where
- Sweden
- Volunteers
- 257 people
- Sponsor
- Karolinska Institutet
Post Intensive Care Unit Syndrome
Long-term Follow up in Survivors of Critical Illness
Survivors of critical illness may suffer from persistent physical, cognitive and mental impairments, such as muscle weakness, dysfunction in the memory and executive domains, post-traumatic stress disorders, depression, and…
- Trial name
- NCT04608994
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Severe Sepsis, Organ Dysfunction Syndrome
Effect of Docosahexaenoic Acid on the Inflammatory Response and Clinical Outcomes From Surgical Patients
The purpose of this study is to evaluate if enteral docosahexaenoic acid (DHA) administration attenuates the inflammatory cytokines and improve clinical outcomes in neonates who underwent cardiovascular surgery
- Trial name
- DHA-IRCO (NCT01049529)
- Testing
- Docosahexaenoic acid
- Where
- Mexico
- Volunteers
- 55 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Critically Ill Patients
The Estimation of Abdominal Pressure by the Bladder and Gastric Pressure
The investigators aim to compare the bladder pressure to the gastric pressure in critically ill patients.
- Trial name
- NCT00143494
- Testing
- measurement of abdominal pressure
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Policlinico Hospital
Respiratory Failure
Sedation Management in Pediatric Patients Supported on Mechanical Ventilation
The purpose of this two-year project is to pilot test an intervention to change sedation management in pediatric patients supported on mechanical ventilation for acute respiratory failure in the pediatric intensive care unit…
- Trial name
- NCT00142766
- Testing
- Nurse Implemented Goal-Directed Comfort Algorithm
- Where
- 3 sites in United States
- Volunteers
- 245 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Critical Illness, Safety Issues
TraceBook: the Clinical Proof of Concept on the Intensive Care.
The effectiveness of current checklists is hampered by lack of acceptance and compliance. Recently, a new type of checklist with dynamic properties has been created to provide more specific checklist items for each individual…
- Trial name
- TraceBook (NCT03599856)
- Testing
- TraceBook
- Where
- Netherlands
- Volunteers
- 408 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Focus of the Study:Protein Binding Characteristics of Voriconazole.
Plasma Protein Binding Characteristics of Voriconazole
The purpose of this study is to investigate the influence of hypoalbuminemia on the protein binding characteristics of the antifungal drug voriconazole in ICU patients.
- Trial name
- NCT01812473
- Testing
- Blood sampling
- Where
- Belgium
- Volunteers
- 35 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hemodynamically Stable, Critical Illness
Comparing USCOM and Echocardiographic Hemodynamic Measurements in Children (CUE Study)
The primary objective of this study is to evaluate the agreement between hemodynamic measurements obtained using the Ultrasound Cardiac Output Monitor (USCOM®; USCOM Ltd., Sydney, Australia), and reference standards as determined…
- Trial name
- NCT02083172
- Testing
- Ultrasound Cardiac Output Monitor and 2 D-Echo
- Where
- Canada
- Volunteers
- 78 people
- Sponsor
- McMaster University
Pediatric Acute Respiratory Distress Syndrome (PARDS), Pediatric Respiratory Diseases
IPV and Lung Compliance in Invasively Ventilated Children
The goal of this observational study is to determine if Intrapulmonary Percussive Ventilation (IPV) improves lung compliance in children receiving conventional invasive mechanical ventilation.
- Conditions
- Pediatric Acute Respiratory Distress Syndrome (PARDS), Pediatric Respiratory Diseases, Lung Compliance
- Trial name
- NCT06836050
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health