Clinical trials: Cutaneous Scars
Leg Injuries, Ankle Injuries
Medico Economic Evaluation of Dermal Substitute Integra® for Coverage of Inferior Limb Traumatic Skin Loss
Comparison of 2 techniques of surgery on patients with inferior limb traumatic wounds: the innovative technique Integra® and the technique of reference: the flap surgery.
- Conditions
- Leg Injuries, Ankle Injuries, Foot Injuries
- Trial name
- INTEGRA® (NCT00906672)
- Testing
- INTEGRA®, Flap technique
- Where
- 7 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Bordeaux
Scleroderma, Keloids
UVA1 Light for Treatment of Scleroderma and Similar Conditions
The purpose of this investigation is to evaluate the effectiveness of an investigational device which is similar in appearance to a "tanning bed" but which emits ultraviolet irradiation of a specific wavelength known as UVA1.
- Conditions
- Scleroderma, Keloids, Other Fibrosing Conditions
- Trial name
- NCT00476801
- Testing
- German manufactured UVA1 light emitting device
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Michigan
Cutaneous Leishmaniasis, Scar
Cosmetic Outcome of Leishmaniasis Scar After WR279396 Application
Primary Objectives: Assess whether CL (caused by Leishmaniasis major) lesions treated with WR279396 improved the cosmetic outcome compared with no treatment (natural healing)
- Trial name
- SCAR (NCT00490230)
- Testing
- WR 279396
- Where
- Tunisia
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Burns
Study With an Autologous Dermo-epidermal Skin Substitute for the Treatment of Burns in Adults and Adolescents
This phase IIb trial aims to evaluate the efficacy and safety of EHSG-KF (synonym denovoSkin) in comparison to meshed STSG in adults and adolescents with partial deep dermal and full thickness burns.
- Trial name
- NCT03227146
- Testing
- EHSG-KF, STSG
- Where
- 6 sites in Italy, Netherlands and 1 more
- Volunteers
- 14 people
- Sponsor
- CUTISS AG
Cleft Lip, Nose; Anomaly
Outcome of Alar Base Support in Unilateral Secondary Cleft Lip and Nasal Deformity Repair With Dermal Roll Flap
Dermal Roll flap for alar base support
- Conditions
- Cleft Lip, Nose; Anomaly, Repair, Flap Design
- Trial name
- Dermal Roll (NCT07624643)
- Testing
- surgery
- Where
- Pakistan
- Volunteers
- 45 people
- Sponsor
- King Edward Medical University
Keloid, Scleroderma
UVA1 Light for Scleroderma and Similar Conditions
The purpose of this investigation is to evaluate the effectiveness of high-dose UVA1 irradiation in the treatment of fibrosing conditions of the skin, e.g., keloid (a thick scar from growth of fibrous tissue), scleroderma…
- Conditions
- Keloid, Scleroderma, Scars, Granuloma Annulare
- Trial name
- NCT00476697
- Testing
- German manufactured UVA1 emitting light system
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Michigan
Burns, Burn Scar
Dermal Substitution in Pediatric Burns
The standard treatment of deep dermal to full thickness burns is surgical removal of the burn followed by skin transplantation. Dermal substitutes are increasingly used in the treatment of deep burns to replace lost dermis.
- Trial name
- GlyPeB (NCT05309720)
- Testing
- Glyaderm
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Cutaneous Groves
Cicatrix Cream in Cutaneous Groves
The purpose of the study is to assess the effect of CICATRIX (Asian Gotu Kola or Pennywort) usage in the treatment of cutaneous grooves. The duration of this phase 2 clinical trial will be 4 months.
- Trial name
- NCT01018212
- Testing
- Cicatrix cream
- Where
- Cuba
- Volunteers
- 50 people
- Sponsor
- Catalysis SL
Burn Injury, Soft Tissue Injury
Phase I Study for Autologous Dermal Substitutes and Dermo-epidermal Skin Substitutes for Treatment of Skin Defects
The purpose of this study is the evaluation of the safety of autologous tissue-engineered dermal substitutes "denovoDerm" (first arm) and dermo-epidermal skin substitutes "denovoSkin" (second arm) transplanted onto the wound bed…
- Conditions
- Burn Injury, Soft Tissue Injury, Skin Necrosis, Scars
- Trial name
- NCT02145130
- Testing
- denovoDerm, denovoSkin
- Where
- 2 sites in Switzerland
- Volunteers
- 12 people
- Sponsor
- University of Zurich
Scar
Tissue-engineered Skin Graft Repair of Autologous Scar Dermal Scaffolds
Hypertrophic scar is an inevitable outcome of wound repair. It affects the appearance and some scar contracture often leads to joint dysfunction.Patients have low quality of life, long treatment cycle, heavy social burden and…
- Trial name
- NCT04389164
- Testing
- Tissue-engineered skin grafts of autologous scar dermal scaffolds
- Where
- China
- Volunteers
- 226 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Keloid, Scleroderma, Localized
Ultraviolet B (UVB) Light Therapy in the Treatment of Skin Conditions With Altered Dermal Matrix
This research study will evaluate the effectiveness of high dose UVB light therapy in the treatment of keloid (or hypertrophic scar), scleroderma, acne keloidalis nuchae, old burn scars, granuloma annulare or related conditions.
- Conditions
- Keloid, Scleroderma, Localized, Acne Keloidalis, Scars
- Trial name
- NCT00129428
- Testing
- UVB Irradiation
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Michigan
SCAR
An Exploratory Study of Genetic and Clinical Factors for Serious Skin Reactions Among Users of Eslicarbazepine Acetate
The reason for this study is to understand if people with certain genes are predisposed to develop severe skin reactions after they are administered Eslicarbazepine Acetate.
- Trial name
- NCT02520557
- Testing
- Blood or Saliva
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Sumitomo Pharma America, Inc.
Drug Hypersensitivity
Evaluation of TNF-α Blockade Effect in Patients With Severe Cutaneous Adverse Drug Reactions
Severe skin adverse drug reactions can result in death. Toxic epidermal necrolysis (TEN) has the highest mortality (30-35%); Stevens-Johnson syndrome and transitional forms correspond to the same syndrome, but with less extensive…
- Trial name
- NCT01276314
- Testing
- anti- TNF-a, Prednisolone
- Where
- Taiwan
- Volunteers
- 135 people
- Sponsor
- Chang Gung Memorial Hospital
Gout Initiating Urate-loweringUrate-lowering Therapy, Gout Arthritis
HLA-B*58:01-Guided Therapy for Gout: Effectiveness, Safety, and Cost-Effectiveness
Severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS), are rare but life-threatening complications that…
- Conditions
- Gout Initiating Urate-loweringUrate-lowering Therapy, Gout Arthritis, Gout and Hyperuricemia
- Trial name
- HLA-SCREEN (NCT07369622)
- Testing
- HLA-B*58:01 Genotyping, Allopurinol Tablet, Febuxostat
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Haiphong University of Medicine and Pharmacy
Burns
Study With an Autologous Dermo-epidermal Skin Substitute for the Treatment of Burns in Children
This phase IIb trial aims to evaluate the efficacy and safety of EHSG-KF (synonym denovoSkin) in comparison to meshed STSG in children with partial deep dermal and full thickness burns.
- Trial name
- NCT03229564
- Testing
- EHSG-KF, STSG
- Where
- 4 sites in Italy, Netherlands and 1 more
- Volunteers
- 12 people
- Sponsor
- CUTISS AG
Burn Scar, Burn Wound
Post-Operative Use of FS2 to Mitigate Scarring in Burn Patients
The goal of this study is to see how an ingredient called kynurenic acid (which we named "FS2") affects scar formation in people with burn injuries that need skin graft surgery.
- Trial name
- NCT06807021
- Testing
- IP1 control cream (Vehicle base), IP2 - 0.5% w/w FS2
- Where
- 2 sites in Canada
- Volunteers
- 70 people
- Sponsor
- Birch BioMed Inc