Clinical trials: Cystic Fibrosis (CF), open to volunteers
Cystic Fibrosis (CF)
A Precision Medicine Approach to Assess Protein Function Loss and the Potential for CFTR Function Restoration in Cystic Fibrosis and Related Disorders
This multicenter translational research study integrates diagnostic analyses and ex-vivo functional testing to support future clinical trials evaluating the safety and efficacy of CFTR modulator treatments in individuals with…
- Trial name
- VALPERPRO-CFTR (NCT07889973)
- Where
- 3 sites in Italy
- Volunteers
- 165 people
- Sponsor
- Istituto Giannina Gaslini
Cystic Fibrosis (CF), Cystic Fibrosis Lung Disease
SPutum Induction and Nebuliser deviCEs for Patients With CF
The goal of the SPICE-CF feasibility trial is to learn whether it is feasible to recruit and retain people with cystic fibrosis (CF) who are unable to produce sputum spontaneously in a study comparing two different nebuliser…
- Trial name
- SPICE-CF (NCT07879651)
- Testing
- Sputum induction
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Cystic Fibrosis (CF)
Pharmacokinetics of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis
The goal of this clinical trial is to support the development of personalized therapy tailored to each patient's individual characteristics.
- Trial name
- NCT07809867
- Testing
- Elexacaftor, Tezacaftor, Ivacaftor, Ivacaftor (VX-770)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Giannina Gaslini
Cystic Fibrosis, Non-CF Bronchiectasis
Regional Phenotyping of CF and Non-CF Bronchiectasis
The Investigators propose to study pediatric subjects who are diagnosed with cystic fibrosis (CF) and patients with non-CF bronchiectasis, with the goal of developing markers of CF lung disease severity, progression, and therapy…
- Trial name
- NCT04793867
- Testing
- Xenon
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Exocrine Pancreatic Insufficiency (EPI), Cystic Fibrosis (CF)
Phase 2 Study to Assess the Safety and Efficacy of ANG003
In this study, ANG003, a pancreatic enzyme replacement therapy (PERT; commonly called "enzymes"), is being investigated as a potential treatment for exocrine pancreatic insufficiency (EPI).
- Trial name
- NCT07450547
- Testing
- ANG003 Dose A, ANG003 Dose B, Creon
- Where
- 27 sites in United States
- Volunteers
- 113 people
- Sponsor
- Anagram Therapeutics, Inc.
Cystic Fibrosis (CF), Mucoviscidosis
Environmental Reservoirs of Non-tuberculous Mycobacteria in Cystic Fibrosis Households
This multicenter, non-interventional case-control study investigates whether household environmental reservoirs, particularly water systems, are associated with non-tuberculous mycobacterial (NTM) infections in people with cystic…
- Conditions
- Cystic Fibrosis (CF), Mucoviscidosis, Non-Tuberculous Mycobacteria, Mycobacterium Abscessus Infection
- Trial name
- NTMecoCF (NCT07369414)
- Testing
- Multi-modal NTM diagnostic including PCR, WGS, culture
- Where
- 2 sites in Germany
- Volunteers
- 120 people
- Sponsor
- Research Center Borstel
Cystic Fibrosis (CF)
Autogenic Drainage Versus Mechanical Percussion in Children With Cystic Fibrosis
The goal of this clinical trial is to compare the effects of autogenic drainage and mechanical percussion on lung function, dyspnea, and quality of life in children with cystic fibrosis.
- Trial name
- ADMP-CF (NCT07729787)
- Testing
- Autogenic Drainage, Mechanical Percussion
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Cystic Fibrosis (CF)
Rethinking Early Airway Clearence Therapies
The REACT trial consists of two parallel, randomized studies; the Hypertonic Saline Study and the Dornase Alfa Study. Health outcomes among people with cystic fibrosis (CF) have been steadily improving, most recently with the…
- Trial name
- REACT (NCT07696338)
- Testing
- As-needed hypertonic saline (HS), Twice daily hypertonic saline (HS), As-needed dornase alfa (DA)
- Where
- 39 sites in United States, Canada
- Volunteers
- 405 people
- Sponsor
- Nicole Hamblett
Cystic Fibrosis Related Diabetes, Cystic Fibrosis (CF)
Verapamil Effect in Cystic Fibrosis-related Dysglycemia
The investigators are conducting a pilot open-label pre/post interventional trial in adolescents and adults with cystic fibrosis (CF) and abnormal glucose tolerance or early CF-related diabetes mellitus (CFRD) to assess the…
- Conditions
- Cystic Fibrosis Related Diabetes, Cystic Fibrosis (CF), Abnormal Glucose Tolerance
- Trial name
- NCT07688070
- Testing
- Verapamil Hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Rhode Island Hospital
Cystic Fibrosis (CF)
TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age
This is a longitudinal, observational epidemiological study designed to estimate the prevalence of depression, anxiety, and behavior problems in children ages 18 months through 11 years with cystic fibrosis (CF).
- Trial name
- TIDES 2 (NCT07048574)
- Where
- 13 sites in United States
- Volunteers
- 600 people
- Sponsor
- State University of New York at Buffalo
Cystic Fibrosis (CF), Cystic Fibrosis Gastrointestinal Disease
Gastrointestinal Response of Pediatric Cystic Fibrosis Patients on Mediterranean Diet
There is no study to date that has evaluated the impact or effect of a Mediterranean diet in children with CF. The goal of this study would be to help provide better guidance around questions the investigators, as CF care…
- Trial name
- MedDietCF (NCT07223255)
- Testing
- Mediterranean diet
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cystic Fibrosis (CF), New Diagnostics
Study to Enable New Diagnostics for Pulmonary Microbes in People With CF
Sputum culture has been the best approach to detect harmful bacteria in the lungs of people with cystic fibrosis (CF). With the widespread use of new CF therapies (like Trikafta and Alyftrak), it is more difficult for people with…
- Trial name
- SEND-CF (NCT07312734)
- Where
- 9 sites in United States
- Volunteers
- 300 people
- Sponsor
- Chris Goss
Cystic Fibrosis (CF)
Home Air Pollution in Children With Cystic Fibrosis Study
Cystic Fibrosis (CF) is a devastating chronic pulmonary disease that continues to cause significant morbidity and mortality despite great advances in therapies.
- Trial name
- HEROIC-CF (NCT07665203)
- Volunteers
- 200 people
- Sponsor
- Seattle Children's Hospital
Cystic Fibrosis (CF)
Personalized Mobile Health Platform to Promote Physical Activity in Adolescents and Young Adults With Cystic Fibrosis
The goal of this clinical trial is to help adolescents and young adults between the ages of 13-25 with Cystic Fibrosis (CF), medically stable, able to speak and read English, and are not experiencing a CF - related exacerbation…
- Trial name
- NUDGE (NCT06616857)
- Testing
- NUDGE, Education
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Nemours Children's Clinic
Cystic Fibrosis (CF), Pulmonary Exacerbation
Pharmacokinetics of Antibiotics in Patients With Cystic Fibrosis Trated With Elexacaftor/Tezacaftor/Ivacaftor (ETI)
Cystic fibrosis (CF) is associated with major pharmacokinetic and pharmacodynamic alterations affecting antibiotic exposure, including changes in absorption, distribution, metabolism, and elimination.
- Conditions
- Cystic Fibrosis (CF), Pulmonary Exacerbation, Respiratory Infection Bacterial
- Trial name
- PKCF (NCT07629986)
- Testing
- No intervention assigned
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Fondation Ildys
Cystic Fibrosis (CF)
Ensuring Access to Optimal Therapy in CF: The ENACT Study
This clinical trial is examining the action and effects of several new drugs in the treatment of cystic fibrosis in children. In addition, several genetic factors are examined.
- Trial name
- ENACT (NCT07148739)
- Testing
- Elexacaftor / Ivacaftor / Tezacaftor, therapeutic drug monitoring
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Cystic Fibrosis (CF), Chronic Kidney Disease(CKD)
Kidney Function in People With Cystic Fibrosis in the Era of HEMT
The purpose of this study is to find out what causes kidney disease in people with CF. The investigators will study biomarkers in the blood and urine that can either predict who is at risk or detect kidney damage early before it…
- Conditions
- Cystic Fibrosis (CF), Chronic Kidney Disease(CKD), Acute Kidney Injury
- Trial name
- NCT06595420
- Where
- 3 sites in United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Cystic Fibrosis (CF)
MAGNIFY - Pulmonary Magnetic Resonance Imaging for Cystic Fibrosis
This research study is looking at new ways of measuring the function of the lungs in patients with cystic fibrosis. This study is using the most advanced methods for measuring lung function including 2 tests called hyperpolarised…
- Trial name
- MAGNIFY (NCT07192679)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Cystic Fibrosis (CF)
Exercises' Effect on Muscle Strength, Aerobic Capacity and Respiratory Functions in Cystic Fibrosis
This research aims to evaluate the effects of upper and lower limb exercises on muscle strength and pulmonary function in children diagnosed with CF.
- Trial name
- NCT07508904
- Testing
- Arm Cycle Ergometry, Leg Cycle Ergometry
- Where
- Pakistan
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Cystic Fibrosis (CF), Cystic Fibrosis in Children
Physical Impairments in Children With Cystic Fibrosis
It is aimed to reveal impairments regarding urinary incontinence, dyspnea, muscle strength, functional capacity or quality of life in children and adolescents with cystic fibrosis compared to healthy children and adolescents.
- Trial name
- NCT06984679
- Testing
- Physical Evaluations in Children with Cystic Fibrosis, Physical Evaluations in Healthy Children
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Izmir Democracy University