Clinical trials: DBS
Parkinson's Disease
Deep Brain Stimulation for Visuomotor Function in Parkinson's Disease
Inability to align and refocus the eyes on the objects at different depths, i.e., vergence impairment, frequently affects the quality of life in patients with Parkinson's disease.
- Trial name
- DBS visuomotor (NCT05400499)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Tourette Syndrome
Deep Brain Stimulation in Forel's H Field in Tourette's Syndrome
Tourette's Syndrome (TS) is a neurodevelopmental disease characterized tics that start before the age of 18 years. About 5% of cases do not respond to drug treatment and can be classified as refractory and in these cases surgical…
- Trial name
- NCT04342754
- Testing
- Deep Brain Stimulation (DBS)
- Where
- Brazil
- Volunteers
- 8 people
- Sponsor
- University of Sao Paulo General Hospital
TOR1A, PANK2
Deep Brain Stimulation (DBS) MatchMaker
DBS Matchmaker (https://www.dbsmatchmaker.com) is a platform designed to connect clinicians worldwide who are treating rare movement disorders with deep brain stimulation (DBS).
- Conditions
- TOR1A, PANK2, HPRT1, EIF2AK2
- Trial name
- DBSMatchMaker (NCT06912841)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Boston Children's Hospital
Motor Disorders, Psychiatric Disorder
Electroencephalographic Monitoring in Patients Treated by Deep Brain Stimulation
This protocol aims to develop the use of behavioral and electroencephalographic measures during cognitive tasks in patients treated with deep brain stimulation during the stimulation parameters adjustments.
- Trial name
- EEG-DBS (NCT03114748)
- Testing
- EEG, DBS switched OFF and ON
- Volunteers
- 60 people
- Sponsor
- University Hospital, Grenoble
Movement Disorders
Evaluation of Diffusion MRI as a Tool in Planning Deep Brain Stimulation (DBS)
The purpose of this study is to explore the relationship between deep brain stimulation implantation site and DTI (diffusion tensor imaging) derived measures for the region and later compare this to the clinical treatment…
- Trial name
- NCT01975532
- Volunteers
- 13 people
- Sponsor
- University of Aarhus
Epilepsy, Drug Resistant
Enhancing Epilepsy Management With Precision Deep Brain Stimulation
The goal of this study is to evaluate the effectiveness of objective neural response feedback on deep brain stimulation (DBS) programming for drug-resistant epilepsy in a prospective observational cohort study.
- Trial name
- EPI-BOOST (NCT06364085)
- Testing
- Neuromodulation programming
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Nova Scotia Health Authority
Binge Eating Disorder, Obesity
Binge Eating Disorder and Obesity : Functional MRI Study
Obesity, defined as BMI> 30kg / m2, is a major public health problem, with devastating medical and psychological consequences. 30% of obese suffer from BED type of eating disorders.
- Trial name
- BED (NCT02868619)
- Testing
- Functional MRI, ADO-BEDS scale, R-CMAS scale
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Dystonia, Generalized Primary Dystonia
Deep Brain Stimulation for Cervical Dystonia
This study will evaluate the effectiveness of deep brain stimulation (DBS) in treating primary generalized dystonia. Patients with dystonia have muscle spasms that cause uncontrolled twisting and repetitive movement or abnormal…
- Trial name
- NCT00105430
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Major Depressive Disorder
Amygdala and dLPFC MRI-TIS for Depression in Adolescents
The study utilizes a non-invasive deep brain stimulation (temporal interference, TI) technique primarily targeting the amygdala to preliminarily explore the clinical efficacy and potential mechanisms of MRI-compatible TI…
- Trial name
- NCT06452849
- Testing
- Nervio-X
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University
Parkinson Disease, Essential Tremor
Deep Brain Stimulation (DBS) Retrospective Outcomes Study
The primary objective of this study is to characterize real-world clinical outcomes of Deep Brain Stimulation (DBS) using retrospective review of de-identified patient records.
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia
- Trial name
- NCT03664609
- Testing
- Deep Brain Stimulation
- Where
- 20 sites in United States, Belgium and 4 more
- Volunteers
- 5,000 people
- Sponsor
- Boston Scientific Corporation
Tourette Syndrome
Multimodal Electrophysiological Study of Cortico-subcortical Biomarkers of Tics in Tourette Syndrome
Tourette syndrome (TS) is a complex neurodevelopmental disorder characterized by the occurrence of involuntary movements (motor tics) and vocalizations (phonic tics).
- Trial name
- BioTic (NCT06909656)
- Testing
- Multimodal electrophysiological recordings
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Bordeaux
Parkinson Disease
Clinical Evaluation of the Infinity Deep Brain Stimulation System
The purpose of this post-market study is to characterize the clinical performance of the Infinity Deep Brain Stimulation (DBS) system, including the Implantable Pulse Generator (IPG), directional DBS leads, extensions, iPad…
- Trial name
- PROGRESS (NCT02989610)
- Testing
- Omnidirectional stimulation, Directional stimulation
- Where
- 41 sites in United States, Australia and 6 more
- Volunteers
- 234 people
- Sponsor
- Abbott Medical Devices
Refractory Epilepsy
Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Refractory Epilepsy
Evaluate the long-term clinical effectiveness and safety of the PINS Deep Brain Stimulation to patients with refractory epilepsy.
- Trial name
- ANT-DBS-RE (NCT02602899)
- Testing
- PINS'Deep Brain Stimulator device
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Dystonia
Chronic Outcome Monitoring for DBS in Dystonia
Dystonia is a severe movement disorder involving increased muscular activity and can be very variable. To date, the treatment of dystonia is challenging.
- Trial name
- COMMED (NCT07244549)
- Where
- 3 sites in Germany
- Volunteers
- 25 people
- Sponsor
- Charite University, Berlin, Germany
HIV/AIDS
Can Undetectable (Viral Load) = Untransmissible (Virus) Change the Life Course of Adolescents Living in Africa
The scientific breakthrough related to Undetectable (viral load) = Untransmissible (virus) has had a major impact on motivation to take up and adhere to antiretroviral therapy among people living with HIV all over the world.
- Trial name
- NCT05278559
- Where
- Zimbabwe
- Volunteers
- 300 people
- Sponsor
- Centre for Sexual Health and HIV/AIDS Research Zimbabwe
Dystonia
Pallidal Stimulation in Patients With Post-anoxic and Idiopathic Dystonia
Bilateral pallidal stimulation is effective in the treatment of patients with generalised idiopathic dystonia. The aim of this study is to evaluate the efficacy of bilateral pallidal stimulation in patients with post-anoxic…
- Trial name
- NCT00169338
- Testing
- Deep brain stimulation
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Marie-laure Welter
Tourette Syndrome
Observational Database on Deep Brain Stimulation in Tourette Syndrome
Within an ongoing deep brain stimulation (DBS) program for Tourette syndrome (TS) at the Department of Neurology, Pitié-Salpêtrière Hospital, Paris/France, the investigator team plans to evaluate patients pre-operatively and then…
- Trial name
- POSTSTIC (NCT04449068)
- Testing
- Neurological and neuropsychological Follow-up after deep brain stimulation, EEG recordings
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dystonia
SUNDYS: A Multicenter, Randomized, Double-blind, Sham-controlled, Parallel-group Trial
Dystonia is a group of movement disorders characterized by twisting, repetitive movements, or abnormal postures caused by involuntary muscle contractions and is characterized by a young age of onset and a high disability rate.
- Trial name
- SUNDYS (NCT04650958)
- Testing
- Deep brain stimulation
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Ruijin Hospital
Parkinson's Disease
Managing Changes in Life After Deep Brain Stimulation for Parkinson's Disease
Parkinson's disease is a chronic progressive neurological disorder. Symptoms are tremor, slowness in movement, rigidity and postural instability.
- Trial name
- NCT01681641
- Testing
- A psycho-social intervention
- Where
- 3 sites in Denmark
- Volunteers
- 32 people
- Sponsor
- University of Aarhus
Parkinson Disease, Deep Brain Stimulation
Comparison of Outcomes in Asleep and Awake DBS With a Directional Electrode
To compare the clinical outcome of patients with Parkinson's disease (PD) treated with directional deep brain (dDBS) stimulation undergoing subthalamic deep brain stimulation operation (STN-DBS) under general anesthesia versus…
- Trial name
- NCT04287465
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Hospital District of Helsinki and Uusimaa