Clinical trials: Debility
Acute Myeloid Leukemia (AML)
Luveltamab Tazevibulin (STRO-002) in Infants and Children < 12 Years of Age With Relapsed/Refractory CBFA2T3::GLIS2 AML
This trial will evaluate whether luveltamab tazevibulin is well tolerated and active against a rare form of AML carrying a particular genetic abnormality called CBFA2T3::GLIS2 that arises in infants and children.
- Trial name
- NCT06679582
- Testing
- Luveltamab tazevibulin
- Where
- 36 sites in United States, Austria and 7 more
- Volunteers
- 1 people
- Sponsor
- Sutro Biopharma, Inc.
Hypermobility, Joint, Muscle Weakness
"Core" Muscle Endurance, Upper Extremity Muscle Strength, Grip Strength, and Hand-eye Coordination in Generalized Joint Hypermobility
Every individual with joint hypermobility may not apply to a health institution because they do not have a complaint that will affect their daily life.
- Conditions
- Hypermobility, Joint, Muscle Weakness, Coordination Lack
- Trial name
- NCT05896722
- Testing
- Core muscle endurance, Upper extremity muscle strength, Grip strength
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Pompe's Disease
Pompe Prevalence Study in Patients With Muscle Weakness Without Diagnosis
An international consensual group recommends confirming the diagnosis of the Pompe disease after a dried blood spot (DBS) with a dosage of the enzymatic activity in other tissue.
- Trial name
- POPS (NCT00830583)
- Testing
- blood test
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Leg Pain, Peripheral Nerve Discontinuities
Effect of Nerve Stimulation on Sciatic Nerve Injury Pediatric Patients
Brief Summary The goal of this study is to learn if Faradic Nerve Stimulation (FNS) can help children recover from a condition called Post-Injection Sciatic Nerve Injury (PISNI).
- Conditions
- Leg Pain, Peripheral Nerve Discontinuities, Muscle Weakness, Sciatic Nerve Compression
- Trial name
- PISNI (NCT06781060)
- Testing
- Faradic Nerve Stimulation Therapy+Standard Physiotherapy, Physiotherapy Standard Treatment with TENS machine therapy
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Azeem Hospital, Multan
Cerebral Palsy, Weakness
Use of Surface Electromyography Biofeedback to Improve Reaching in Children With Cerebral Palsy
A newly-developed device for biofeedback of surface EMG will be used to either increase or decrease activity in the muscles of children with poor reaching due to cerebral palsy.
- Conditions
- Cerebral Palsy, Weakness, Hypertonia
- Trial name
- NCT00473161
- Testing
- surface EMG biofeedback
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern California
ICU Acquired Weakness, Weaning Failure
Predictors of Prognosis in Patients With Critical Illness.
Recently, intensive care unit acquired weakness (ICUAW) has become a hotspot issue in the patients with critical illness. The symptoms of ICUAW, including sensory impairment and muscle atrophy, may lead to poor quality of life…
- Conditions
- ICU Acquired Weakness, Weaning Failure, Quality of Life
- Trial name
- NCT04914065
- Testing
- Regular care in the surgery intensive care unit
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Taoyuan General Hospital
Anterior Cruciate Ligament Reconstruction, Regional Anesthesia, Saphenous Nerve Block
Comparing Subsartorial Saphenous Nerve Blocks With and Without Dexamethasone for Anterior Cruciate Ligament Reconstruction
For patients undergoing Anterior Cruciate Ligament reconstruction surgery, the postoperative period can be a painful experience without adequate pain management.
- Trial name
- NCT01586806
- Testing
- Bupivacaine Only, Bupivacaine with 1 mg of Dexamethasone, Bupivacaine with 4 mg of Dexamethasone
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- Hospital for Special Surgery, New York
Infant Development, Hemiplegia
CIMT and taVNS for Hemiplegia in Infants
Newborns who are born premature or suffer brain injury at birth are at risk for motor problems that may cause weakness in reaching and grasping on one side of the body.
- Conditions
- Infant Development, Hemiplegia, Constraint Induced Movement Therapy
- Trial name
- NCT05101707
- Testing
- transcutaneous auricular vagus nerve stimulation, Constraint induced movement therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Medical University of South Carolina
ICU Acquired Weakness
Development of an Early Warning Model for Intensive Care Unit-Acquired Weakness in Mechanically Ventilated Children
Acquired weakness (AW) is a common complication among patients in the Intensive Care Unit (ICU). It is a systemic muscle weakness and dysfunction associated with critical illness, often related to prolonged bed rest, mechanical…
- Trial name
- NCT07150637
- Testing
- ICU-AW
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Children's Hospital of Fudan University
Cerebral Palsy
Study Assessing High-Frequency Chest Wall Oscillation (HFCWO) in Preventing Pulmonary Exacerbations
To asssess efficacy of airway clearance provided by Vest therapy (HFCWO) in the reduction of respiratory exacerbations requiring hospitalization or antibiotic utilization in patients with muscle weakness and restrictive lung…
- Trial name
- NCT00739310
- Testing
- Vest Treatment (high frequency chest wall oscillation)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Hill-Rom
Muscle Weakness, Sports Performance
Light Therapy and Electrical Stimulation on Functional Performance in Volleyball Athletes
Background: Volleyball players constantly perform vertical jumps, the higher the height of the jump is better sports performance of these players. Several methods have been tested to improve jumping performance in these players.
- Trial name
- NCT02443701
- Testing
- Exercise, LASER, NMES
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Centro de Traumatologia do Esporte
Epidermolysis Bullosa
Improve Adherence to Weak or Strong Opioid Analgesics at the Time of Care in Children With Hereditary Epidermolysis Bullosa
Hereditary epidermolysis bullosa (HEB) are rare genodermatoses, clinically characterized by epithelial and subepithelial fragility leading to the formation of blisters and spontaneous erosions on skin at the slightest contact…
- Trial name
- ODEB (NCT04853667)
- Testing
- Interview
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiomyopathy, Hypertrophic
The Role of Heart Stiff and Weak Atrium on Exercise Capacity in Patients With Hypertrophic Cardiomyopathy
This study will examine how heart stiffness and a weak atrium affect exercise capacity and symptoms in patients with hypertrophic cardiomyopathy (HCM).
- Trial name
- NCT00074880
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Neurologic Diseases, Hemiparesis
NuroSleeve Powered Brace & Stimulation System to Restore Arm Function
The purpose of this study is to investigate if a person with weakness or paralysis in one or both arms, can use the NuroSleeve combined powered arm brace (orthosis) and muscle stimulation system to help restore movement in one…
- Conditions
- Neurologic Diseases, Hemiparesis, Quadriplegia, Muscular Dystrophies
- Trial name
- NCT04798378
- Testing
- Neurosleeve
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Duchenne Muscular Dystrophy With Mutations Amenable to PBGENE-DMD
PBGENE-DMD Phase 1/2a Safety and Preliminary Efficacy Study in Duchenne Muscular Dystrophy (FUNCTION-DMD)
The purpose of this Phase 1/2a trial is to evaluate the safety, tolerability, and preliminary efficacy of PBGENE-DMD in patients with DMD harboring mutations amenable to excision of exons 45-55.
- Trial name
- NCT07429240
- Testing
- PBGENE-DMD (IV)
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Precision BioSciences, Inc.
Muscle Weakness, Smartphone Addiction
Effect of Scapular Stabilization Exercises on Scapular Muscles Strength and Kyphosis Index in Smartphone Users
This study will be conducted to investigate the effect of scapular stabilization exercises on scapular muscles strength (serratus anterior, lower fibers of trapezius, rhomboid major and minor), pain intensity level and kyphosis…
- Trial name
- NCT05437367
- Testing
- Scapular Stabilization exercises, Postural correction exercises
- Where
- Egypt
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Cairo University
Neuromuscular Disease
Diagnostic Evaluation of Patients With Neuromuscular Disease
The objectives of this protocol are to: 1) screen patients with various neuromuscular disorders and facilitate their entry into appropriate research protocols; 2) help resolve puzzling diagnostic neuromuscular problems and train…
- Trial name
- NCT00015470
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Neuromuscular Diseases in Children
Mechanical Insufflation -Exsufflation in Children With NMD and Weak Cough
Neuromuscular diseases (NMD) in children are severe, possibly life-threatening orphan conditions. The children are vulnerable and often subject to rapid deterioration of pulmonary function due to impaired ability to clear airway…
- Trial name
- NCT04081116
- Testing
- Symmetric settings (high pressures/fast rate), Asymmetric settings (Pi<Pe/Ti>Te), Preinclusion settings
- Where
- 4 sites in Norway
- Volunteers
- 77 people
- Sponsor
- Oslo University Hospital
Cerebral Palsy, Muscle Hypertonia
Hypertonia in Patients With Cerebral Palsy
This study will classify types of hypertonia in patients with cerebral palsy and determine if the classifications are reasonable in relation to the functional task of walking. Hypertonia is an abnormal increase in muscle tension.
- Trial name
- NCT00123708
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Severe Muscle Atrophy, Muscle Weakness
BFRT for Severe Lower Extremity Muscle Atrophy
Muscle weakness or atrophy is a common condition following acute and chronic musculoskeletal injuries. Strength training is an imperative component in clinical rehabilitation of musculoskeletal injuries.
- Trial name
- BFRT (NCT04357184)
- Testing
- Blood flow restriction training
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Cincinnati Sportsmedicine Research and Education Foundation