Clinical trials: Deep Brain Stimulation
Obsessive-Compulsive Disorder
Evaluating Unilateral Deep Brain Stimulation in Patients With Obsessive Compulsive Disorder
The investigators previously showed that deep brain stimulation (DBS) in the bed nucleus of the stria terminalis (BNST) reduces symptoms in patients with severe obsessive-compulsive disorder (OCD).
- Trial name
- NCT03894397
- Testing
- Electrical stimulation of the BNST
- Where
- Belgium
- Volunteers
- 9 people
- Sponsor
- KU Leuven
Parkinson's Disease
Deep Brain Stimulation Follow-up After 10 Years
The purpose of this study is to examine the long-term effect of Deep Brain Stimulation (DBS) for patients with Parkinson's Disease. We have data for patients operated with DBS since 1998.
- Trial name
- NCT01575132
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- University of Aarhus
Spinal Cord Stimulation, Deep Brain Stimulation
Implantable Systems Performance Registry
The Implantable Systems Performance Registry (ISPR) was developed to evaluate the long-term reliability and performance of market-released Medtronic Neuromodulation infusion and stimulation products.
- Conditions
- Spinal Cord Stimulation, Deep Brain Stimulation, Drug Infusion (Implantable Pumps), Sacral Neuromodulation
- Trial name
- ISPR (NCT00959296)
- Testing
- Various
- Where
- 50 sites in United States, Austria and 5 more
- Volunteers
- 10,981 people
- Sponsor
- MedtronicNeuro
Dystonia
Pallidal Stimulation in Patients With Post-anoxic and Idiopathic Dystonia
Bilateral pallidal stimulation is effective in the treatment of patients with generalised idiopathic dystonia. The aim of this study is to evaluate the efficacy of bilateral pallidal stimulation in patients with post-anoxic…
- Trial name
- NCT00169338
- Testing
- Deep brain stimulation
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Marie-laure Welter
Parkinson's Disease, Essential Tremor
RECHARGE Sub-Study to the Implantable Systems Performance Registry (ISPR)
The purpose of this study is to assess the recharge feature of the Activa RC System in patients who are receiving Deep Brain Stimulation (DBS) for Parkinson's Disease (PD), Essential Tremor (ET), or dystonia.
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia
- Trial name
- RECHARGE (NCT00998660)
- Testing
- Activa RC
- Where
- 11 sites in United States, Austria and 4 more
- Volunteers
- 100 people
- Sponsor
- MedtronicNeuro
Improving Accuracy of Implanting Stimulation Electrodes
Correlation of Tractography and Motor Evoked Potentials in Deep Brain Stimulation
The goal is to establish another anatomical referencing system in order to achieve an even higher accuracy when implanting stimulation electrodes.
- Trial name
- NCT03136302
- Testing
- Deep Brain Stimulation
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Dystonia, Epilepsy in Children
A Multicenter Pediatric Deep Brain Stimulation Registry
There is limited data on outcomes for children who have undergone deep brain stimulation (DBS) for movement disorders, and individual centers performing this surgery often lack sufficient cases to power research studies…
- Conditions
- Dystonia, Epilepsy in Children, Cerebral Palsy, Tourette Syndrome
- Trial name
- DBS-R (NCT06585618)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Children's Hospital
Epilepsy, Drug Resistant
Enhancing Epilepsy Management With Precision Deep Brain Stimulation
The goal of this study is to evaluate the effectiveness of objective neural response feedback on deep brain stimulation (DBS) programming for drug-resistant epilepsy in a prospective observational cohort study.
- Trial name
- EPI-BOOST (NCT06364085)
- Testing
- Neuromodulation programming
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Nova Scotia Health Authority
Epilepsy, Temporal Lobe
Hippocampal and Thalamic DBS for Bilateral Temporal Lobe Epilepsy
The study aims to compare the safety and effectiveness of deep brain stimulation of the hippocampus and the anterior nucleus of the thalamus for reducing the frequency of seizures in patients with bilateral temporal lobe epilepsy.
- Trial name
- NCT04164056
- Testing
- deep brain stimulation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Parkinson's Disease
L-dopa Versus Dopamine Agonists After Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease
Deep Brain Stimulation (DBS) of the Subthalamic nucleus (STN) is an established treatment for patients with advanced Parkinson's disease (PD).
- Trial name
- NCT02347059
- Testing
- L-dopa, Dopamine Agonists (pramipexole, ropirinole)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Toronto
Parkinson Disease
Behavior Addictions Improvement in Parkinson Disease's Patients Treated by Subthalamic Stimulation : Long Term Follow-up
Improvement of behavioral addictions in STN-DBS in PD: Long term follow-up
- Trial name
- PDdicted (NCT01705418)
- Volunteers
- 69 people
- Sponsor
- University Hospital, Grenoble
Parkinson's Disease (PD)
Closed-Loop Therapeutic Refinement Using Local Field Potentials in Parkinson's Disease
This multi-center pilot study compares conventional DBS (cDBS) and adaptive DBS (aDBS) in Parkinson's disease patients using the Medtronic Percept™ system.
- Trial name
- CTRL-PD (NCT07105280)
- Testing
- Optimized conventional DBS, Optimized adaptive DBS
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- HagaZiekenhuis
Obsessive-Compulsive Disorder
Psychiatric Neurosurgery (PNS) for Obsessive Compulsive Disorder (OCD): A Qualitative Analysis of Patient and Family Member Experiences
In this study the investigators will use semi-structured interviews to qualitatively analyse patient and family member experiences with either deep brain stimulation or other forms of psychiatric neurosurgery.
- Trial name
- NCT02537795
- Testing
- deep brain stimulation, anterior capsulotomy
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy
Stimulating Deep Brain Regions With a Magnetic Stimulator
The purpose of this study is to determine whether a special coil designed for magnetic stimulation of areas deep in the brain can affect mood and emotion in healthy volunteers.
- Trial name
- NCT00063245
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Binge Eating Disorder, Obesity
Binge Eating Disorder and Obesity : Functional MRI Study
Obesity, defined as BMI> 30kg / m2, is a major public health problem, with devastating medical and psychological consequences. 30% of obese suffer from BED type of eating disorders.
- Trial name
- BED (NCT02868619)
- Testing
- Functional MRI, ADO-BEDS scale, R-CMAS scale
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Epilepsy, Drug Resistant
Extreme Capsule Electrical Stimulation for Drug-resistant Focal Epilepsy
Evaluation of the Efficacy and Safety of Deep Brain Stimulation of the Extreme Capsule (EC) for the Treatment of Drug-Resistant Epilepsy
- Trial name
- NCT06663124
- Testing
- EC-DBS ON
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xuanwu Hospital, Beijing
Dystonia
Vercise™ DBS Dystonia Prospective Study
To compile characteristics of real-world outcomes of Boston Scientific Corporation's commercially approved VerciseTM Deep Brain Stimulation (DBS) Systems for the treatment of dystonia.
- Trial name
- NCT02686125
- Testing
- Deep Brain Stimulation (DBS)
- Where
- 36 sites in Belgium, Canada and 10 more
- Volunteers
- 300 people
- Sponsor
- Boston Scientific Corporation
Parkinson Disease
Safety and Efficacy of Adaptive Deep Brain Stimulation
The aim of this study is to assess the safety and the potential efficacy of personalized Local Field Potential (LFP)-based adaptive Deep Brain Stimulation (aDBS), using the implantable pulse generator (IPG) of the "AlphaDBS"…
- Trial name
- NCT04681534
- Testing
- AlphaDBS System
- Where
- 8 sites in Italy, Netherlands and 1 more
- Volunteers
- 15 people
- Sponsor
- Newronika
Parkinson's Disease
Feasibility Study to Evaluate Deep Brain Stimulation (DBS) Settings for the Treatment of Parkinson's Disease
The purpose of this study is to assess the cognitive performance in patients with advanced Parkinson's disease receiving Deep Brain Stimulation (DBS) with settings predetermined clinically to settings derived from a…
- Trial name
- SAGE (NCT01230151)
- Testing
- GUIDE software, Version 0.1, Clinically defined stimulation parameters
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Intelect Medical, Inc.
Parkinson's Disease, Movement Disorders
Imaging Blood Brain Imaging Dysfunction in Parkinson's Disease
The purpose of this study is to evaluate the blood brain barrier in the striatum of patients that have other types of movement disorders compared to patients with Parkinson's Disease that are receiving similar treatment, to…
- Trial name
- NCT02605161
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- Ottawa Hospital Research Institute