Clinical trials: Deep Carious Lesion
Deep Dental Caries
Randomized Clinical Trial for Primary Molar Pulpotomy, Biodentine Vs Formocresol-ZOE
This is a RCT that will compare the clinical and radiographic success of pulpotomies on primary molars between the traditional technique (Formocresol/ZOE) and the new technique with Biodentine.
- Trial name
- NCT02201498
- Testing
- Pulpotomies with Formocresol/OZE and Biodentine
- Where
- Canada
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
Dental Caries in Children
Experimental Research on Deep Carious Lesion Treatment of Molars
Maintaining dental pulp vitality is crucial for tooth preservation and functionality. Untreated dental caries may lead to pulp necrosis and infection, affecting children's growth and well-being.
- Trial name
- VITAPULP (NCT03626740)
- Testing
- TheraCal, MTA
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Carol Davila University of Medicine and Pharmacy
Deep Caries
Multicenter Trial Comparing One-step Partial Caries Removal to Complete Caries Removal for the Treatment of Deep Carious Lesions in Permanent Teeth. (DECAT : DEep CAries Treatment).
This clinical trial is a national multicenter randomized controlled trial performed in parallel groups aiming to validate a treatment that preserves pulp vitality of mature permanent posterior teeth through partial removal of…
- Trial name
- DECAT (NCT02286388)
- Testing
- A one-step partial caries removal procedure for the treatment of deep carious lesions in posterior permanent teeth., A complete caries removal procedure for the treatment of deep carious lesions in posterior permanent teeth., The application of an antibacterial dental adhesive (ClearfilTM SE Protect, Kuraray Dental).
- Where
- 15 sites in France
- Volunteers
- 464 people
- Sponsor
- Hospices Civils de Lyon
Deep Carious Lesion, Indirect Pulp Treatment
Light Cured Resin Modified Calcium Silicate Versus Light Cured Calcium Hydroxide in Indirect Pulp Treatment of Primary Molars
The objective of this study is to explore if light cured resin modified Calcium silicate could result in better clinical and radiographic success if compared to light cured Calcium hydroxide when used in indirect pulp capping…
- Trial name
- NCT03791255
- Testing
- Calcium silicate liner, Calcium hydroxide liner
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Cairo University
Caries, Dental
Alternative Treatment of Deep Carious Lesions Based on Biological Evidences
The purpose of this study is to evaluate the success rate of alternative treatment of deep carious lesions in asymptomatic primary teeth with no clinical nor radiographic signs of pulpal inflammation.
- Trial name
- NCT00973089
- Testing
- Incomplete caries removal in primary teeth
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Caries,Dental, Crown of Tooth With Poor Contour
Clinical and Radiographical Evaluation of CAD-CAM Crowns With and Without Deep Margin Elevation
Deep margin elevation (DME) is a non-invasive restorative technique to relocate the deep cervical margin to a supragingival position using resin composite.
- Conditions
- Caries,Dental, Crown of Tooth With Poor Contour, Broken Teeth, Survival, Prosthesis
- Trial name
- NCT06114030
- Testing
- Deep margin elevation with composite resin and Lithium disilicate glass-ceramic crowns
- Where
- United Arab Emirates
- Volunteers
- 560 people
- Sponsor
- University of Sharjah
Deep Caries, Ozone
Influence of Ozone Application in Stepwise Excavation Procedure of Primary Molars With Deep Carious Lesion
Purpose: The purpose of this study was to investigate the clinical and microbiological effectiveness of the ozone application in stepwise excavation of primary molars.
- Trial name
- NCT03737201
- Testing
- ozone, chlorhexidine digluconate, Control
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Caries; Dentin
SMART With Different Modifications in Asymptomatic Deep Carious Lesions of Primary Molars.
This study aimed to evaluate the clinical success of the 'Silver Modified Atraumatic Restorative Technique '(SMART) with different modifications in asymptomatic deep carious lesions of primary molars.
- Trial name
- NCT06645860
- Testing
- SDF+KI+LED Light 20s, SDF+KI
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Deep Caries, Pulp Exposure, Dental
Selective Removal to Soft Dentine vs Selective Removal to Firm Dentine for Deep Posterior Caries Lesions
Removal of infected dentin contaminated with bacteria and remaining affected dentin detected as firm is the conventional strategy for the management of cavitated caries lesions.
- Conditions
- Deep Caries, Pulp Exposure, Dental, Dental Caries
- Trial name
- NCT04052685
- Testing
- Selective removal to soft dentin (SRSD), Selective removal to firm dentine (SRFD)
- Where
- Turkey (Türkiye)
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- burcu gözetici
Reversible Pulpitis, Deep Carious Lesions
Comparative Evaluation of Calcium Silicate-doped Treated Dentin Matrix and Mineral Trioxide Aggregate as Miniature Pulpotomy Biomaterials in Deep Carious Lesions
AIM: To compare the efficacy of a Novel calcium silicate doped treated dentin matrix and Mineral Trioxide aggregate as biomaterials for miniature pulpotomy.
- Trial name
- hTDM (NCT07302438)
- Testing
- Calcium Silicate doped treated dentin matrix for miniature pulpotomy (CaSi+hTDM MP)., Mineral Trioxide Aggregate (MTA) for Miniature Pulpotomy
- Where
- 2 sites in India
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences
Vital Pulp Therapy
Diagnostic Biomarkers to Correlate Molecular Changes and Inflammatory Cascade in the Dental Pulp.
This study aimed to evaluate the molecular changes that occur within the pulp tissue during inflammation and its correlation with vital pulp therapy with its different treatment modalities (Direct pulp capping, Partial Pulpotomy…
- Trial name
- NCT05464797
- Testing
- Pulp therapy, Cytokines level in pulpal blood.
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Dental Caries
Selective or Stepwise Removal of Deep Caries
Background: For treating deep caries lesions, selective or stepwise, i. e. one- and two-step incomplete excavation seems advantageous compared with complete caries removal.
- Trial name
- NCT02232828
- Testing
- Selective removal, Stepwise removal
- Where
- 4 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Pulpitis - Irreversible
Pulpotomy vs Root Canal Treatment for Teeth With Symptomatic Irreversible Pulpitis
This study is a randomised controlled trial for complete pulpotomy as an alternative to root canal treatment for teeth with clinical diagnosis of symptomatic irreversible pulpitis (i.e.
- Trial name
- NCT05964933
- Testing
- Complete Pulpotomy, Pulpectomy and Root Canal Treatment
- Where
- Singapore
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Deep Carious Lesions
SDF Modified Hall Technique Vs. Conventional Pulpotomy for Management of Carious Primary Molars
Dental caries in primary teeth is considered the most common oral disease of childhood and it has been investigated in many places throughout the world.
- Trial name
- NCT05240365
- Testing
- SDF modified Hall technique, Conventional pulpotomy and stainless steel crown
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Sondos Naserallah
Dental Caries
Partial Removal of Caries Dentines
The aim of this multicenter randomized controlled clinical trial is to evaluate the effectiveness of an alternative treatment for deep caries lesions in Public Health Services.
- Trial name
- PRCD (NCT00887952)
- Testing
- Partial removal of carious dentine, Stepwise excavation
- Where
- 2 sites in Brazil
- Volunteers
- 329 people
- Sponsor
- Federal University of Rio Grande do Sul
Dental Caries
Effect of aPDT on Deep Caries in Permanent Tooth
The aim of this study is to assess the clinical effect of aPDT on deep caries in permanent teeth. Half of the deep caries will receive aPDT disinfect in restorative treatment procedure, while the other half will receive sodium…
- Trial name
- NCT02929914
- Testing
- Local anesthesia and rubber dam isolation, Incomplete caries removal and microbiological samples collection, Dentin washed with sodium 0.9% saline
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fujian Medical University
Dental Caries in Children, Tooth Diseases
Hall Technique or Modified Hall Technique of Deep Carious Lesions in Primary Molars
The purpose of this randomized clinical trial is to compare the clinical/radiographic success of Hall technique and modified Hall technique in the treatment of primary molars with deep dentine carious lesions in children…
- Conditions
- Dental Caries in Children, Tooth Diseases, Tooth Demineralization, Stomatognathic Diseases
- Trial name
- NCT05220865
- Testing
- Hall Technique, Modified Hall Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Deep Caries
Treatment of Primary Molars With Deep Caries Using Silver Diamine Fluoride
Untreated dental caries is a worldwide pandemic (Edelstein, 2006). Due to limited financial resources, poor access to basic oral care, and the high cost of restorative treatment, children of low-income nations have their general…
- Trial name
- NCT03563534
- Testing
- Silver Diamine Fluoride, Glass Ionomer
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Caries, Reversible Pulpitis
Management of Deep Carious Lesions in Adults
Dental caries is one of the most prevalent non-communicable disease. However, despite its prevalence there is no consensus on how much caries to remove prior to placing a restoration to achieve optimal outcomes.
- Trial name
- NCT05144711
- Testing
- Selective caries excavation, Non selective caries excavation
- Where
- Jordan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Pulp Exposure, Dental, Deep Dental Caries
Effects of Total and Selective Caries Removal - Requiring or Avoiding Vital Pulp Therapy - on Pulp Vitality and Postoperative Pain in Deep Carious Mature Permanent Teeth: A Split-Mouth Clinical Study
The effect of selective caries cleaning and total caries cleaning on pulp health and post operative pain in teeth with deep caries will be investigated.
- Trial name
- NCT07041905
- Testing
- Total Caries Removal, Selective Caries Removal
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Cukurova University