Clinical trials: Delirium
Mechanically Ventilated, Critically Ill Children
Sedation Efficacy of Dexmedetomidine Versus Midazolam in Critically Ill Ventilated Children
There is a significant lack of adequately powered randomized clinical trial (RCT) data to determine the comparative safety and effectiveness of sedative treatments in pediatric patients.
- Trial name
- NCT04082767
- Testing
- Precedex, Midazolam
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Douglas Fraser
Low Flow Anesthesia, Sevoflurane
Low Flow Anesthesia in Children Undergoing Strabismus Surgery
Emergence agitation (EA) involves restlessness, disorientation, excitation, non-purposeful movement, inconsolability, thrashing, and incoherence during early recovery from general anesthesia.
- Conditions
- Low Flow Anesthesia, Sevoflurane, Strabismus, Emergence Delirium
- Trial name
- LFA in child (NCT06560268)
- Testing
- Sevoflurane; In our study, the effects of sevoflurane in different FGFs administered in children undergoing strabismus surgery on EA and anesthetic agent consumption will be investigated.
- Volunteers
- 150 people
- Sponsor
- Cukurova University
Paediatric Anesthesia Emergence Delirium
Evaluation and Implementation of the "Paediatric Anesthesia Emergence Delirium Scale" (PAED) in the PACU in Children Under 14 Years of Age
The goal of this study is to determine the incidence and characteristics of Emergence Delirium (ED) in children aged 0 - 13 undergoing general anesthesia and being taken care of at the paediatric PACU of the Charité Campus…
- Trial name
- NCT02358278
- Where
- Germany
- Volunteers
- 821 people
- Sponsor
- Charite University, Berlin, Germany
Delirium
Lived Experiences and Impact of Delirium in Critically Ill Children: a Qualitative Study
The investigators aim to conduct a qualitative study evaluating the long and short-term recollection and experiences of critically ill children with delirium as well as collect the lived experience of the caregiver and healthcare…
- Trial name
- NCT04168515
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Postoperative Confusion, Postoperative Delirium
Autonomous Nervous System Regulated Paediatric Anaesthesia With Dexmedetomidine or Placebo
The goal of this randomized, double blinded study is to examine in children whether postoperative agitation can be reduced. The main question it aims to answer is Will optimized, monitor guided analgesic treatment and…
- Conditions
- Postoperative Confusion, Postoperative Delirium, Postoperative Pain, Acute, Postoperative Complications
- Trial name
- ANNA (NCT05785689)
- Testing
- Dexmedetomidine
- Where
- Denmark
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Delirium
Pediatric Delirium Screening in the PICU Via EEG
Delirium in the pediatric intensive care unit (PICU) is a serious problem that has recently attracted much attention. This study will evaluate the use of electroencephalogram (EEG) for delirium screening in the PICU.
- Trial name
- PEDEEGO (NCT04846023)
- Testing
- aEEG via vEEGix
- Volunteers
- 220 people
- Sponsor
- St. Justine's Hospital
Delirium
Vitamin D Level and Emergence Delirium in Children
In our study, we aimed to evaluate the relationship between vitamin D levels and postoperative delirium in children who had undergone tonsillectomy and/or adenoidectomy.
- Trial name
- NCT05076162
- Testing
- PAED
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people
- Sponsor
- Aydin Adnan Menderes University
Tonsillectomy
Dexmedetomidine as a Rapid Bolus in Children for Emergence Agitation
To Determine The Efficacy of a Rapid Bolus Injection of Dexmedetomidine on the Incidence of Emergence Agitation in Anesthetized Children and the Cardiovascular Profile of a Rapid Bolus Injection of Dexmedetomidine.
- Trial name
- NCT01528891
- Testing
- Dexmedetomidine
- Where
- 2 sites in United States
- Volunteers
- 418 people
- Sponsor
- Peter Davis
Agitation, Postoperative Agitation
Effect of Daily Screen Time on Postoperative Emergence Delirium in Children Aged 2-11 Years
This prospective observational study aims to evaluate the association between daily screen exposure duration and postoperative emergence delirium in children aged 2 to 11 years undergoing elective lower abdominal surgery.
- Trial name
- NCT07552896
- Testing
- Daily Screen Exposure Duration
- Where
- Turkey (Türkiye)
- Volunteers
- 288 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Emergence Agitation After Desflurane Anesthesia
Gabapentin Oral Solution in Decreasing Desflurane Associated Emergence Agitation
to study the effect of oral gabapentin (5 mg/kg) on emergence agitation after desflurane anesthesia in pediatrics undergoing starbismus surgery
- Trial name
- NCT03347916
- Testing
- Gabapentin Oral Solution [Neurontin]
- Where
- Kuwait
- Volunteers
- 75 people
- Sponsor
- Kuwait Specialized Eye Center
Stem Cell Transplant Complications, Delirium
Delirium in Children Undergoing Stem Cell Transplantation
Children undergoing stem cell transplants are at risk for delirium, a temporary change in thinking and behavior. This study will define delirium rates, risk factors, and outcomes.
- Trial name
- NCT04937400
- Testing
- Daily screening for delirium
- Where
- 6 sites in United States, Canada
- Volunteers
- 1,040 people
- Sponsor
- Weill Medical College of Cornell University
Oral Melatonin, Nebulized Dexmedetomidine
Oral Melatonin Versus Nebulized Dexmedetomidine on Emergence Agitation in Children Undergoing Adenotonsillectomy
This study aims to compare the efficacy of using oral Melatonin versus nebulized Dexmedetomidine in limitation of emergence agitation in children undergoing adenotonsillectomy.
- Conditions
- Oral Melatonin, Nebulized Dexmedetomidine, Emergence Agitation, Children
- Trial name
- NCT07345715
- Testing
- Normal saline, Oral melatonin syrup, Nebulized dexmedetomidine
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Tanta University
Perioperative Anxiety, Emergence Delirium
The Effects of Familiar Toy and Parental Presence Combination on Perioperative Pediatric Anxiety
This study will evaluate the effect of presence of favorite toy and parent during perioperative period on pediatric anxiety and emergence delirium.
- Trial name
- NCT06459089
- Testing
- Selection of the parent according to children preference, Bringing the favorite toy of the children that will accompany the child during their perioperative period
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Karaman Training and Research Hospital
Comparison of the Effects of Propofol and Nasal Dexmedetomidine
Propofol vs. Nasal Dexmedetomidine in Pediatric Agitation and Delirium
Dental pain and anxiety are quite common in pediatric patients. However, due to children's inability to express their fears and lack of knowledge about the procedures to be performed, these symptoms have often been misunderstood…
- Trial name
- NCT06466915
- Testing
- Dexmedetomidine, Propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Baskent University Ankara Hospital
Emergence Delirium, Strabismus
Methadone for Emergence Delirium in Children Undergoing Outpatient Strabismus Surgery
Strabismus surgery for children is a very common procedure, with a high incidence of emergence delirium in the recovery room. Pain is often implicated in delirium.
- Trial name
- NCT03778372
- Testing
- Methadone
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Cardiovascular Surgery
Tranexamic Acid Dose and Confusion After Cardiac Surgery
Delirium is one of the most common complications after cardiac surgery and occurs with an incidence of 3 - 70%. Both predisposing factors (age, diabetes, severity of cardiac disease, atrial fibrillation) and precipitating factors…
- Trial name
- NCT05966012
- Testing
- Tranexamic acid
- Where
- United Kingdom
- Volunteers
- 5,000 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Emergence Agitation, Pain
Can Acetaminophen Given 1-2 Hours to Children Before Ear Tube Surgery Reduce Agitation After Anesthesia?
Emergence agitation (EA) occurs in up to 67% of pediatric patients after anesthesia for bilateral myringotomy tubes (BMT, "ear tubes").
- Trial name
- NCT01737593
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Emergence Agitation
Propofol Versus Dexmedetomidine Effect on Prevention Emergence Agitation
The goal of this clinical trial is to compare Propofol versus Dexmedetomidine in children undergoing squint surgery. The main question it aims to answer is: Which drug is more effective in preventing the appearance of Emergence…
- Trial name
- NCT06312618
- Testing
- Propofol, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Critical Illness, Post Intensive Care Unit Syndrome
pEEG Monitoring Effect on Delirium, Ventilator Days, and PICS
The goal of this multi-site observational study is to compare delirium rates, days on mechanical ventilation, and Post Intensive Care Syndrome (PICS) rates in adult Intensive Care Unit (ICU) patients.
- Conditions
- Critical Illness, Post Intensive Care Unit Syndrome, Post Intensive Care Syndrome, Mechanical Ventilation Complication
- Trial name
- NCT06019078
- Testing
- SedLine
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Fraser Health
Emergence Delirium
Dexmedetomidine-Midazolam vs. Ketamine-Midazolam on Emergence Delirium
Fifty children undergoing heart catheterization without local anesthesia in the skin will be randomly divided into two groups. Group DM (Dexmedetomidine + Midazolam) and Group KM (Ketamine + Midazolam)
- Trial name
- NCT07427446
- Testing
- Dexmedetomidine and Midazolam, Ketamine and Midazolam
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Kasr El Aini Hospital