Clinical trials: Deprescribing
Terminal Cancer
Towards Cancer Patient Empowerment for Optimal Use of Antithrombotic Therapy at the End of Life
Despite the fact that antithrombotic therapy (ATT) has little or even negative effects on the well-being of cancer patients during their last year of life, stopping ATT is rare in clinical practice.
- Trial name
- SERENITY (NCT05706740)
- Testing
- Physician survey on antithrombotic medication during end-of-life care in cancer patients
- Where
- 12 sites in Denmark, France and 6 more
- Volunteers
- 467 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Alzheimer Disease, Dementia
The Effect of De-Prescribing Antipsychotics on Health and Quality of Life for People With Dementia
This study aims to analyze how warning letters sent to physicians prescribing high levels of the antipsychotic quetiapine affected the health and quality of life of their patients with dementia.
- Conditions
- Alzheimer Disease, Dementia, Prescribing, Off-Label
- Trial name
- NCT05172687
- Testing
- Overprescribing letter to attributed physician
- Where
- 3 sites in United States
- Volunteers
- 336,460 people
- Sponsor
- Columbia University
Dementia, Behavior
Deprescribing Antipsychotics in Long-Term Care
Aggressive behaviours in long-term care (LTC) is a difficult health care issue to manage. One method that has been over-used is the prescription of antipsychotics for the behaviours and psychological symptoms of dementia (BPSD).
- Trial name
- NCT02958800
- Testing
- Intervention
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- McMaster University
Polypharmacy, Adverse Drug Reaction
Deprescribing of Symptomatic Medications in Rehabilitative or Subacute Care Patients
Deprescribing is a systematic method of withdrawing potentially inappropriate or unnecessary medications and is warranted in the elderly due to the high prevalence of polypharmacy.
- Trial name
- NCT03354845
- Testing
- Deprescribing intervention
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bright Vision Hospital
Polypharmacy, Inappropriate Prescribing
Opportunities and Limits to Deprescribing in Nursing Homes:Quality Circle Deprescribing Module
Older people residing in nursing homes (NH) are frequently polymedicated and often prescribed potentially inappropriate medications.
- Trial name
- OLD-NH-QC-DeMo (NCT03688542)
- Testing
- Quality Circle Deprescribing Module
- Where
- Switzerland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Anne Niquille
Polypharmacy
Feasibility Study of a Systematic Approach for Deprescribing of Statins and PPI's.
Deprescribing, the process of safely reducing or discontinuing unnecessary or harmful medication, has the potential to decrease polypharmacy and improve health outcomes.
- Trial name
- FeDeS+P (NCT04204590)
- Testing
- Deprescribing algorithm
- Where
- Netherlands
- Volunteers
- 75 people
- Sponsor
- Zuyderland Medisch Centrum
Inappropriate Prescribing, Primary Health Care
Deprescribing in Primary Health Care
Medications can help older adults but can also harm them. Frail older adults tend to have many health problems that require treatment, but are also at risk of harm from the medications prescribed.
- Conditions
- Inappropriate Prescribing, Primary Health Care, Polypharmacy
- Trial name
- NCT03903484
- Testing
- Deprescribing toolbox and intervention
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Medical Overuse, Inappropriate Prescribing
Engaging Patients to Promote Deprescribing
One mechanism to reduce potentially inappropriate medications is through deprescribing, a deimplementation-based approach to thoughtfully discontinue a medication a patient is currently prescribed.
- Conditions
- Medical Overuse, Inappropriate Prescribing, Deprescriptions
- Trial name
- NCT04294901
- Testing
- Direct to patient medication brochure
- Where
- 4 sites in United States
- Volunteers
- 5,946 people
- Sponsor
- VA Office of Research and Development