Clinical trials: Detection
Inherited Retinal Degeneration Associated With RPGR Mutations, Inherited Retinal Degeneration Associated With Biallelic RPE65 Mutations
Monitoring and Early Detection of Treatable Inherited RETinal Disease in Children and Adolescents
The goals of this observational study are to develop and train artificial intelligence (AI) algorithms using multimodal imaging to identify patients with inherited retinal degeneration (IRD) caused by Retinal Pigment Epithelium…
- Trial name
- MEDIRET (NCT07901907)
- Where
- 3 sites in United States, Germany and 1 more
- Volunteers
- 4,887 people, healthy volunteers welcome
- Sponsor
- University College, London
Colorectal Polyp
The Accuracy of Human Endoscopic Detection of Submucosal Invasive Cancer in Colorectal Polyps
Colorectal cancer (CRC) is a leading cause of death in the Western world. It can be effectively prevented by removal of pre-malignant polyps (polypectomy) during colonoscopy.
- Trial name
- NCT05191095
- Where
- Belgium
- Volunteers
- 82 people
- Sponsor
- University Hospital, Ghent
Light Fluorescence Device
Clinical Effectiveness of(VistaProof)in Comparison With ICDAS-II & Histological Validation for Detecting Occlusal Caries
a diagnostic accuracy study control trial is to be held to evaluate the Clinical performance of quantitative light fluorescence based device (Vistacam Proof) in comparison with the visual examination and histological validation…
- Trial name
- NCT03940170
- Testing
- vistacam proof, ICDASII, fissurotomy
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Mohamed samy El-sayed
Melanoma
War on Melanoma™ Public Health & Education Campaign
This trial studies how well a health educational campaign works in increasing early detection of melanoma in Oregon. The health educational campaign may provide information to help people learn about the early signs of melanoma.
- Trial name
- NCT04611568
- Testing
- Educational Intervention, Health Education, Media Campaign
- Where
- United States
- Volunteers
- 75,000 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute
Pre-eclampsia, Pregnancy
IMproved PRegnancy Outcome by Early Detection
The overall objective of the IMPROvED project is to develop a sensitive, specific, high-throughput and economically viable early pregnancy screening test for preeclampsia.
- Conditions
- Pre-eclampsia, Pregnancy, Pregnancy, High-risk, Pregnancy Complications
- Trial name
- IMPROvED (NCT01891240)
- Where
- 6 sites in Ireland, Netherlands and 2 more
- Volunteers
- 5,000 people
- Sponsor
- Louise Kenny
Colorectal Adenoma, Colorectal Polyp
EndoRings Colonoscopy vs Standard Colonoscopy
The study aims to compare the results between a standard colonoscopy to a colonoscopy with an attachment on the distal end of the colonoscope.
- Conditions
- Colorectal Adenoma, Colorectal Polyp, Colon Cancer
- Trial name
- NCT03418662
- Testing
- EndoRings device
- Where
- United States
- Volunteers
- 592 people, healthy volunteers welcome
- Sponsor
- Indiana University
Portal Hypertension, Cirrhosis
Esophageal Capsule Endoscopy in Children
The portal hypertension (PHT) is the main complication in patients presenting with cirrhosis. It can be the direct cause of bleeding by rupture of the esophageal or gastric varices and can also contribute to the development of…
- Trial name
- PREVOCAP (NCT01551966)
- Testing
- Wireless esophageal capsule endoscopy ( PillCam Eso2)
- Where
- 7 sites in France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Delirium
Delirium Detection in Pediatric Intensive Care Unit Through a French Translation of the CAPD : a French Monocentric Observational Study
The purpose of this study is to introduce delirium detection and try to determine the prevalence of delirium in Pediatric Intensive Care Unit (PICU) using a validated tool : the Cornell Assessment of Pediatric Delirium (CAPD) for…
- Trial name
- DeliReP (NCT04954261)
- Testing
- CAPD
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Distress Syndrome in Children
Assessment of Airway Opening Pressure in Invasively Ventilated Children
Acute respiratory distress syndrome (ARDS) in children is associated with significant morbidity and mortality. Current studies seek to individualize the management of children by defining several phenotypes, based until now…
- Trial name
- AOP-KID (NCT07262541)
- Testing
- Measurement of airway opening pressure
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Autism Spectrum Disorder, Neurodevelopmental Disorders
A Smart Toy for Motor Function and Early Assessment of Children With Possible Autism
Autism diagnostic referrals across the UK have doubled within the last five years. Covid-19 has further delayed diagnostic pathways, while innovation has not kept pace in assisting clinical teams with low cost, fast, and…
- Trial name
- Tangiball (NCT04980677)
- Testing
- Tangiball
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Sussex Community NHS Foundation Trust
Apnea of Prematurity
Detection of CardioRespiratory Events Using Acoustic Monitoring in Preterm Infants on CPAP
This is an observational, proof-of-concept, feasibility study where 50 preterm infants with gestational age < 32+0 weeks will be recruited from the neonatal intensive care unit (NICU) at the Montreal Children's Hospital.
- Trial name
- DREAM (NCT05196646)
- Testing
- Respiratory Acoustic Sensors, Nasal thermistor, Respiratory Inductive Plethysmography
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Ischemic Stroke, Brain Tumor
Confounding Factors in the Detection of Intracranial Hemorrhage With the Infrascanner
The investigators prospectively want to use the Infrascanner in patients with ischemic stroke, patients with brain surgery, patients with brain tumors, patients with intracranial hemorrhage and patients with a normal CT scan of…
- Conditions
- Ischemic Stroke, Brain Tumor, Brain Surgery, Intracranial Hemorrhage
- Trial name
- NCT02809651
- Testing
- Infrascanner
- Where
- Belgium
- Volunteers
- 89 people
- Sponsor
- Ziekenhuis Oost-Limburg
Neurologic Disorder
Intracorporeal Nanocomposites and Neurological Disorders in Fulgurates (FulgurnanoF)
Objective: To demonstrate the presence of bioresistant intracorporeal carbon-based nanocomposites in subjects exposed to a fulguration, in the immediate aftermath of this fulguration and 24 months (+/- 6 months) after the…
- Trial name
- Fulgurnano (NCT04380194)
- Testing
- nano-composite screening
- Where
- 5 sites in France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
COVID-19
Evaluation of Molecular Point-of-care Xpert® Xpress SARS-CoV-2 Detection Implementation in Resource-limited Settings
This study evaluated the diagnostic accuracy and effectiveness of POC viral load (VL) assay in improving the availability of SARS-CoV-2 detection for COVID-19 patient management in decentralised healthcare facilities of…
- Trial name
- EXPERT-CoV-2 (NCT05514886)
- Testing
- Gene Expert molecular Point-of-Care (POC) (Xpert® Xpress SARS-CoV-2/Flu/RSV test
- Where
- Tanzania
- Volunteers
- 3,429 people
- Sponsor
- National Institute for Medical Research, Tanzania
Down Syndrome, Obstructive Sleep Apnea of Newborn
Early Detection and Treatment of Obstructive Sleep Apnoea in Infants With Down Syndrome
Interventional, comparative, open-label, single-center study to demonstrate that early (from 6 months of age) and systematic (every 6 months) screening for Obstructive Sleep Apnoea (OSA) by polysomnography (PSG) in infants with…
- Trial name
- RESPIRE21 (NCT03210675)
- Testing
- Polysomnography (PSG)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Institut Jerome Lejeune
Prostate Cancer
Choline PET/CT vs. MeAIB PET/CT in Prostate Cancer
Prostate cancer is currently the leading newly diagnosed cancer in the industrialized world. Treatment of prostate cancer is highly dependent on the stage of the disease.
- Trial name
- NCT02232672
- Testing
- Choline PET/CT and MeAIB PET/CT
- Where
- Denmark
- Sponsor
- Odense University Hospital
Atherosclerosis, Peripheral Vascular Disease
Magnetic Resonance Imaging to Detect Blood Vessel Inflammation in Patients Undergoing Peripheral Balloon Angioplasty
This study will examine the use of magnetic resonance imaging (MRI) in detecting blood vessel inflammation. The results of this study may later be applied to diagnosing inflammation of arteries in patients with atherosclerosis…
- Trial name
- NCT00004549
- Testing
- Magnetic resonance imaging
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Plasmodium Knowlesi Infection
Molecular Diagnostic Methods for Detection of Plasmodium Knowlesi
This study aims to determine the sensitivity, specificity, and practical value of two new molecular diagnostic assays compared to a more classical nested molecular diagnostic assay and the routine microscopy (both of which are…
- Trial name
- NCT03988296
- Where
- 3 sites in Malaysia
- Volunteers
- 116 people
- Sponsor
- Duke University
Invasive Pulmonary Aspergillosis, Invasive Fungal Disease
LFD of Aspergillus Antigen in Paediatrics
Many children and young people are at risk of invasive fungal disease (IFD), such as those who have had a haematopoietic stem cell transplants, those with an immune deficiency or those who are prescribed immunosuppressive drugs…
- Trial name
- LFD-AsPaeds (NCT05569824)
- Testing
- Lateral-flow Device
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- St George's University Hospitals NHS Foundation Trust
Teledentistry
Accuracy of Teledentistry for Diagnosis and Treatment Need in Dental Caries Detection Versus Clinical Examination on a Group of Egyptian Children: A Diagnostic Accuracy Study
The aim of this study is to assess the accuracy of teledentistry for diagnosis and treatment need in dental caries detection versus clinical examination on a group of Egyptian children.
- Trial name
- NCT06600360
- Testing
- Teledentistry
- Volunteers
- 102 people
- Sponsor
- Cairo University
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