Clinical trials: Development, Child
Autism Spectrum Disorder
Multisensory Room in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a complex neurological development with onset in infancy or early childhood. Atypical sensory processing has been widely reported in ASD, and recent literature suggest that this abnormality…
- Trial name
- NCT06184802
- Testing
- TAU+Multisensory room, TAU
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Osteogenesis Imperfecta
Multicenter,Single-arm Study to Evaluate Efficacy, Safety, & Pharmacokinetics of Denosumab in Children w/ OI
This is a prospective, multicenter, single-arm study in children 2 to 17 years of age with OI to evaluate efficacy and safety of denosumab.
- Trial name
- OI (NCT02352753)
- Testing
- Denosumab
- Where
- 49 sites in United States, Australia and 11 more
- Volunteers
- 153 people
- Sponsor
- Amgen
Bone Diseases, Developmental
Developing a COMputerised Bone Age Tool
The Greulich and Pyle technique (G\&P) is that most commonly used to assess bone age in children, particularly in the context of suspected skeletal dysplasia.
- Trial name
- COMBAT1 (NCT02617901)
- Testing
- Left hand DXA
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Autism
Prebiotic Intervention for Autism Spectrum Disorders
The purpose of this study is to determine the effect of a prebiotic (BGOS) on gut microbiota and metabolites in children with autism spectrum disorders.
- Trial name
- NCT02720900
- Testing
- B-GOS, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Clasado Limited
Weight-Estimation
Can Habitus Adapted Length Based Body Weight Estimation be Improved by Adding Further Parameters?
The purpose of this prospective single center study is to investigate if the accuracy of length based body weight estimation by the already investigated algorithm (CLAWAR) can be improved by adding another parameter.
- Trial name
- Including MUC (NCT02930928)
- Testing
- Accuracy of weight estimation
- Where
- Switzerland
- Volunteers
- 495 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
General Population of Children Aged 3 to 5 Years Old
Early Development of Academic Skills in the Classroom
This is a two-arm cluster randomized controlled trial. The two arms will be: 1) Intervention group, where the stimulation program will be implemented; and 2) Comparison group (active).
- Trial name
- JAPI (NCT05224700)
- Testing
- JAPI, Painting group
- Volunteers
- 754 people, healthy volunteers welcome
- Sponsor
- University of Talca
Autism Spectrum Disorder, Sleep Disorder
Evaluating the Effects of Tasimelteon in Individuals With Autism Spectrum Disorder (ASD) and Sleep Disturbances
This is a multicenter, open-label study to evaluate the efficacy and safety of a daily single oral dose of tasimelteon in treating sleep disturbances in pediatric and adult participants with ASD.
- Conditions
- Autism Spectrum Disorder, Sleep Disorder, Neurological Disorder, Sleep Disturbance
- Trial name
- NCT05361707
- Testing
- Tasimelteon Oral Capsule, Tasimelteon Liquid Suspension
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Vanda Pharmaceuticals
Preterm Birth
Interdisciplinary E-health Based Follow-up of Preterm Born Children
The aim of the study is to assess mental and somatic symptoms of preterm born children at the ages of 2, 5 and 10 by a multidisciplinary team and to evaluate an app that screens for these symptoms.
- Trial name
- NeoUp (NCT06345664)
- Testing
- Diagnostics and intervention recommendations
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Short Stature, Growth Hormone Deficiency
The IGFBP-3 Stimulation Test: A New Tool for the Diagnosis of Growth Hormone Deficiency in Children.
This project is designed to answer the question: Is there an acute IGFBP-3 response in normal children? Our specific hypothesis states that under the influence of growth hormone secretagogues, intact IGFBP-3 molecule will undergo…
- Trial name
- NCT00235599
- Testing
- IGFBP-3 Stimulation Test
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Autism Spectrum Disorder
Exergaming on Hand Dexterity In Autistic Children
Through this study we aim to determine the effect of Exergaming on bimanual hand dexterity in Autistic children. This randomized controlled trial will recruit a sample of 20 autistic children as per the inclusion and exclusion…
- Trial name
- NCT05475132
- Testing
- Exergaming, Conventional Dexterity Exercises
- Where
- 2 sites in Pakistan
- Volunteers
- 20 people
- Sponsor
- Riphah International University
Autism-Spectrum Disorder, Conduct Disorder
Investigating the Specificity of Neural Correlates for Emotion Processing Deficits in Conduct Disorder and Autism Spectrum Disorders
This study is 1. to investigate the differential and shared neural underpinnings of facial emotion processing within Conduct disorder (CD) and Autism-Spectrum disorder (ASD) and 2.
- Trial name
- NCT04324099
- Testing
- neuroimaging session (with simultaneously acquired eye-tracking), Questionnaire (for children) assessing traumatic experiences (Childhood trauma questionnaire (CTQ)), Social and Health Assessment (SAHA) questionnaire (for children)
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Hearing Loss, Language Development
Improving Outcomes Using Technology for Children Who Are DHH
This study evaluates the efficacy of using augmentative and alternative communication (AAC) technology for enhancing language development in children who are deaf or hard of hearing.
- Conditions
- Hearing Loss, Language Development, Social Behavior
- Trial name
- NCT02998164
- Testing
- augmentative and alternative communication technology, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 154 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Marfan Syndrome
Cardiorespiratory and Muscular Rehabilitation of Children and Young Adults With Marfan Syndrome.
Marfan syndrome (MFS) is a rare genetic disease (1/5000) characterized by the association of ocular impairment, cardiovascular disease and musculoskeletal disease.
- Trial name
- Marfanpower (NCT03236571)
- Testing
- Rehabilitation program
- Where
- France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Toulouse
Autism Spectrum Disorder
Investigation of Brain Plasticity in Autism Spectrum Disorders
Individuals with autism spectrum disorders (ASD) commonly experience variances in tactile behaviors, such as hypersensitivity to light touch stimuli, altered texture discrimination, and hyporesponsivity to pain.
- Trial name
- NCT04706364
- Testing
- Neuropsychological Testing, (Optional) Saliva Collection, Sensory Testing
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Stunted Growth, Stunting
Child Growth and Development in East London
The overarching objective of this research is to detect poor growth and delayed development early in childhood by developing an automated growth-screening algorithm.
- Conditions
- Stunted Growth, Stunting, Growth Disorders, Child Development
- Trial name
- CGDEL (NCT05419336)
- Where
- United Kingdom
- Volunteers
- 558 people
- Sponsor
- Queen Mary University of London
Osteogenesis Imperfecta
Osteogenesis Imperfecta and Balance
Osteogenesis Imperfecta (OI), also known as brittle bone disease, is a group of genetic disorders that mainly affect the bones. It results in bones that break easily. Its severity may be mild to severe.
- Trial name
- NCT06010134
- Testing
- Physical Therapy Program
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- South Valley University
Child Development, Child Language
The Pittsburgh Study Early Childhood
The Early Childhood Collaborative of The Pittsburgh Study is a community-partnered, county-wide implementation of programs for children and families from birth through formal school entry to address real-world challenges that…
- Conditions
- Child Development, Child Language, Child Behavior Problem, Parenting
- Trial name
- TPS-ECC (NCT05444205)
- Testing
- Text4Baby or Bright by Text Referral, Nurture Program Warm Referral, Video Interaction Project
- Where
- 5 sites in United States
- Volunteers
- 2,546 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Autism, Autism Spectrum Disorder
SenseToKnow Autism Screening Device Validation Study
This is a pivotal, prospective, double-blind, study to evaluate the sensitivity and specificity of the SenseToKnow device for the detection of autism spectrum disorder in children 16-36 months of age.
- Trial name
- NCT05874466
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Duke University
Gut Microbiome, Neurocognitive Correlates of Eating Habits
Tiny Tummies - A Milk Study
This is a 12-month, 2-arm randomized controlled trial (n=150) examining whether toddlers randomized at 12 months of age to 1.5 cup-equivalents/day of cow's milk-based dairy versus oat milk-based dairy, and followed to 24 months…
- Conditions
- Gut Microbiome, Neurocognitive Correlates of Eating Habits, Infants and Young Children, Sleep
- Trial name
- NCT07839156
- Testing
- Daily cow's milk products, Daily Oat Milk Exposure
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Autism Spectrum Disorder
Early Intervention, Supervision, Quality and Outcome in ASD
The objective of this study is to examine the significance of knowledge of autism spectrum disorder (ASD), and early intensive behavioral intervention, as well as trust in EIBI, adequate assessment of EIBI quality, and EIBI…
- Trial name
- NCT03196713
- Testing
- Early Intensive Behavioral Intervention
- Where
- Sweden
- Volunteers
- 34 people
- Sponsor
- Karolinska Institutet
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