Clinical trials: Development Disorder, Child
Language Development Disorders
Kindergarten Children Acquiring Words Through Storybook Reading
Children with Specific Language Impairment (SLI) are slower to learn new words than their peers, placing them at risk for academic failure.
- Trial name
- KAWStory (NCT03586479)
- Testing
- Interactive storybook reading
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Kansas
Autism, Childhood Autism
Galantamine Versus Placebo in Childhood Autism
Autism is a severe neurodevelopmental disorder that affects up to 16 in 10,000 individuals. It is a pervasive developmental disorder affecting social, communicative, and compulsive/repetitive behaviors characterized by…
- Trial name
- NCT00252603
- Testing
- Galantamine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Transcranial Direct Current Stimulation, Autistic Spectrum Disorder
Cumulative and Booster Effects of Multisession Prefrontal tDCS in ASD Adolescents
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by disturbances in communication, poor social skills, and aberrant behavior.
- Conditions
- Transcranial Direct Current Stimulation, Autistic Spectrum Disorder, Electroencephalography
- Trial name
- NCT06272669
- Testing
- Active-tDCS
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- The Hong Kong Polytechnic University
Mental Disorders, Severe
Measuring Development of Brain Responses to Vocal Sounds in Babies of Mums With Mental Illness
CAPRI-Voc examines the differences in how speech and environmental sounds are processed in the infant brain as they grow from 9 to 12 months.
- Trial name
- CAPRI-Voc (NCT04350294)
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Osteogenesis Imperfecta
Pediatric Safety Follow-up Study of Prior Treatment With Romosozumab for Osteogenesis Imperfecta
The primary objective of this trial is to evaluate the safety of romosozumab in participants with osteogenesis imperfecta (OI) that have completed Study 20200105, regardless of whether they received investigational product…
- Trial name
- NCT07366086
- Testing
- Vitamin D, Calcium
- Where
- 4 sites in United States, Germany and 1 more
- Volunteers
- 71 people
- Sponsor
- Amgen
Hypomineralization Molar Incisor
Laser Therapy and Flouride Therapy in Desensibilization Hypomineralized Teeth
To investigate the efficacy of laser therapy associated with fluorotherapy in the desensibitization of hypomineralized teeth in children 8 to 12 years of age. A randomized blinded clinical trial will be conducted.
- Trial name
- LTAFTIDHT (NCT03823170)
- Testing
- Laser therapy, Fluorotherapy, Laser therapy and Fluorotherapy
- Where
- Brazil
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Universidade Ceuma
Dental Caries Extending to Pulp, Molar Incisor Hypomineralization
Vital Pulp Therapy in Carious Teeth With Hypomineralization
Vital pulp therapy (VPT) is a general term for multiple procedures (indirect pulp cap, direct pulp cap and pulpotomy) all directed toward preserving pulp vitality and enable complete root development in immature teeth.
- Trial name
- NCT03735069
- Testing
- IPT (Indirect pulp treatment), Cvek/partial pulpotomy, Cervical pulpotomy
- Where
- Jordan
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Anesthesia, Neurotoxicity
A Study to Compare the Long-term Outcomes After Two Different Anaesthetics
There is considerable evidence that most general anaesthetics modulate brain development in animal studies. The impact is greater with longer durations of exposure and in younger animals.
- Conditions
- Anesthesia, Neurotoxicity, Child Development
- Trial name
- TREX (NCT03089905)
- Testing
- Sevoflurane, Remifentanil, Dexmedetomidine
- Where
- 21 sites in United States, Australia and 2 more
- Volunteers
- 450 people
- Sponsor
- Murdoch Childrens Research Institute
Vestibular Disorder
Vestibular Function and Motor Development in Small Children
Infants and toddlers with and without vestibular impairment will be tested blinded by pediatric physiotherapist with different age adequate motor scales in order to find out pathological motor patterns specifically associated to…
- Trial name
- NCT07079488
- Testing
- Motor proficiency scales
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Autism Spectrum Disorder
Characterization of (A)Typical Sensorimotor Pathways in Individuals With Autism
The goal of this interventional study is to understand whether sensorimotor skills could represent an endophenotype for autism, i.e.
- Trial name
- MovAUT (NCT07389720)
- Testing
- clinical assessment, Neuropsychological examination, Neurophysiological evaluation
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Autistic Disorder
Study of Fluoxetine in Autism
The purpose of this study is to assess the effect of fluoxetine orally dissolving tablets (ODT) on the repetitive behaviors core domain in children and adolescents with Autistic Disorder.
- Trial name
- SOFIA (NCT00515320)
- Testing
- Fluoxetine
- Where
- 17 sites in United States
- Volunteers
- 158 people
- Sponsor
- Neuropharm
Fractures in Children, Apophysitis
Total Genotype Score, Growth, Maturation and Loading Exposure as Risk Factors for Injury in Elite Male Youth Football
A total genotype risk score was generated based on the findings of previous research for non-contact injury, non-contact muscle injury, tendon injury, ligament injury, fracture injury and apophysitis injury.
- Conditions
- Fractures in Children, Apophysitis, Muscle Strain, Ligament Injury
- Trial name
- NCT05220969
- Testing
- Total Genotype Risk Score
- Where
- 2 sites in United Kingdom
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- St Mary's University College
Dyslexia, Developmental
Neural Mechanisms of Successful Intervention in Children With Dyslexia
Dyslexia, an impairment in accurate or fluent word recognition, is the most common learning disability affecting roughly ten percent of children.
- Trial name
- NCT04323488
- Testing
- Lindamood-Bell Seeing Stars
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Stanford University
Autism, Autism Spectrum Disorder High-Functioning
PRT for Adolescents With High Functioning Autism
The purpose of this study is to identify improvement in behavioral and social function and changes in the brain following Pivotal Response Treatment (PRT) for Adolescents in highly verbal adolescents with autism spectrum disorder…
- Conditions
- Autism, Autism Spectrum Disorder High-Functioning, Developmental Disability, Child Development
- Trial name
- NCT05987761
- Testing
- PRT for Adolescents
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Stanford University
Autism Spectrum Disorder
Therapeutic Issues for Autism
This study aimed to show the effects of hyperbaric oxygen therapy and/or Risperidone in improving symptoms of autism
- Trial name
- NCT03887754
- Testing
- Risperidone, hyperbaric oxygen therapy, Non specific Multivitamin
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Minia University
Autism Spectrum Disorder
Piloting an Enhanced Protocol of Occupational Therapy in an Equine Environment for Youth With Autism
The purpose of this study is to learn about occupational therapy for youth with autism in a traditional clinic environment, and in an equine environment.
- Trial name
- NCT04482088
- Testing
- Occupational Therapy in an Equine Environment, Occupational Therapy in a Clinic (OTC)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Colorado State University
Vascular Malformations
Development of a Specific Scale of Life'Quality for Children With Low-flow Vascular Malformations
The low-flow malformations include venous and lymphatic malformations. The malformation often affects the skin and can extend deep to the muscles and bone, as well as to deep organs.
- Trial name
- MVFL (NCT03440827)
- Testing
- Focus Group
- Where
- 3 sites in France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Specific Phobia, Social Anxiety Disorder
Virtual Reality for Youth Phobias
The purpose of this study is to examine the effectiveness of virtual reality (VR) delivered exposure therapy for youth with phobias or social anxiety, with and without autism spectrum disorder.
- Conditions
- Specific Phobia, Social Anxiety Disorder, Autism Spectrum Disorder
- Trial name
- NCT05839431
- Testing
- Virtual Reality for Youth Phobias
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Miami
Autism, ASD
Medical Cannabis Registry and Pharmacology
The overall goals of this research is to describe the 1) natural history of current use and disposition of medical cannabis products including Cannabidiol (CBD) products, being administered to children as standard of care for the…
- Trial name
- Med Can Autism (NCT03699527)
- Testing
- Multiple questionnaires administered
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- Children's Hospital of Philadelphia
Down Syndrome
Efficacy Assessment of Systematic Treatment With Folinic Acid and Thyroid Hormone on Psychomotor Development of Down Syndrome Young Children
Evaluation of the following in very young children with Down syndrome: the efficacy of systematic treatment with L-thyroxine at controlled doses (clinically and by ultrasensitive thyreostimulating hormone (TSH) assay), the…
- Trial name
- ACTHYF (NCT01576705)
- Testing
- thyroid hormone and folinic acid
- Where
- France
- Volunteers
- 175 people
- Sponsor
- Institut Jerome Lejeune