Clinical trials: Developmental Disorder
Molar Incisor Hypomineralization
Evaluation of the Effectiveness of Various Desensitizing Treatment Protocols
The objective of this research was to evaluate the clinical success of desensitization treatments using four different materials in the first permanent molars (FPMs) affected by MIH.
- Trial name
- NCT07085689
- Testing
- Sodium Fluoride Varnish (5%), Silver diamine fluoride- potassium iodide, Aqueous Silver Fluoride
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Hacettepe University
Language Disorders
A Comparison of Language Intervention Programs
Brief Summary: Nearly 7% of elementary school children present with difficulties learning and using language. Unfortunately, language impairments are often long lasting and may have serious social, academic, and vocational…
- Trial name
- NCT00033150
- Testing
- Fast ForWord, Computer Assisted Language Intervention, Individual Language Intervention
- Where
- 2 sites in United States
- Volunteers
- 216 people
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Developmental and Epileptic Encephalopathy 1
A Clinical Trial for Participants With DEE to Assess Efficacy, Safety, Tolerability, and PK of Relutrigine
A Phase 3, Randomized, Multi-Center, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Relutrigine in Participants with Developmental and Epileptic…
- Trial name
- EMERALD (NCT07010471)
- Testing
- 1.0mg/kg/day PRAX-562, 1.5mg/kg/day PRAX-562
- Where
- 11 sites in United States, Australia and 1 more
- Volunteers
- 160 people
- Sponsor
- Praxis Precision Medicines
Intellectual Disability
Research and Characterization of New Genes Involved in Intellectual Disability
Intellectual disability (ID) occurs in 2 to 3 % of the general population but the cause is identified only in 30 to 60% of cases.
- Trial name
- GeneDefi (NCT01867554)
- Testing
- gene analysis
- Where
- France
- Volunteers
- 8,500 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Autism Spectrum Disorder, Social Communication Disorder
Virtual Group Social ABCs - Multi-site Randomized Controlled Trial
The goal of this randomized control trial is to test the efficacy of the Social ABCs 6 week, group-based model using a virtual delivery platform.
- Conditions
- Autism Spectrum Disorder, Social Communication Disorder, Autism or Autistic Traits, Autism Spectrum Disorder With Impaired Functional Language
- Trial name
- NCT05663970
- Testing
- VG Social ABCs
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Mucopolysaccharidosis I, Mucopolysaccharidosis II
Clinical Trial of Growth Hormone in MPS I, II, and VI
The purpose of this study is to determine whether growth hormone is a safe and effective treatment for short stature in children with Mucopolysaccharidosis type I, II, and VI.
- Conditions
- Mucopolysaccharidosis I, Mucopolysaccharidosis II, Mucopolysaccharidosis VI
- Trial name
- NCT00748969
- Testing
- Somatropin (DNA origin)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Dental Caries, Tooth Hypomineralization
Zirconia and Bioflx Crowns for Primary Anterior Teeth
This parallel-group randomized controlled trial will compare the clinical performance of prefabricated zirconia and Bioflx crowns for restoring primary maxillary anterior teeth in children aged 3 to 5 years.
- Trial name
- NCT07691905
- Testing
- Zirconia Crown, Bioflx Crown
- Where
- Vietnam
- Volunteers
- 120 people
- Sponsor
- Hue University of Medicine and Pharmacy
Atrial Fibrillation (AF), Premature Atrial Complexes
Leveraging AI-ECG Technology for Early Notification and Tracking of AF Development
Our study aimed to use an AF-predict AI-ECG alert system to help physicians identify patients who need to wear a continuous cardiac rhythm monitor for new diagnoses of atrial fibrillation (AF), atrial flutter (AFL), or atrial…
- Conditions
- Atrial Fibrillation (AF), Premature Atrial Complexes, Atrial Arrhythmias, Artificial Intelligence (AI)
- Trial name
- LATENT (NCT06847932)
- Testing
- AF-predict AI-ECG alert system guided management
- Where
- Taiwan
- Volunteers
- 14,726 people
- Sponsor
- National Defense Medical Center, Taiwan
Autism Spectrum Disorder
Fatty Acid Supplementation in Children With ASD (Study 2)
The objective of the protocol is to test the impact of Omega 3-6 on pre-specified biological signatures (IL-1β, IL-2, and IFNγ) and to correlate changes in the biological signatures with changes in ASD symptoms.
- Trial name
- NCT04312932
- Testing
- LCPUFA Oil Supplement
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Sarah Keim
Turner Syndrome, Hypogonadism
Estrogen Treatment (Oral vs. Patches) in Turner Syndrome
The study attempts to evaluate if the way of administering estrogen, the principal female hormone, via patches or orally, affects the way estrogen works in girls with Turner Syndrome.
- Conditions
- Turner Syndrome, Hypogonadism, Premature Ovarian Failure
- Trial name
- NCT00140998
- Testing
- 17 beta estradiol
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Nemours Children's Clinic
Pompe Disease, Glycogen Storage Disease II
Pompe Telemedicine Developmental Study
The primary purpose of this study is to: Document the developmental outcomes of individuals with Pompe disease treated with long-term enzyme-replacement therapy (ERT) through school-age (ages 6-18) using measures of cognitive…
- Trial name
- NCT02950298
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Duke University
Autism Spectrum Disorder
Culturally Adapted Play-Based Behavioural Intervention for Autism
This study compared Culturally Adapted Play-Based Behavioural Intervention (PPBI) and Applied Behaviour Analysis (ABA) for children with Autism Spectrum Disorder (ASD) in semi-rural Tamil Nadu through a double-blinded randomized…
- Trial name
- NCT06859541
- Testing
- Culturally Adapted Play-Based Behavioural Intervention, Applied Behaviour Analysis
- Where
- India
- Volunteers
- 56 people
- Sponsor
- Saveetha University
Autism
Examining the Effects of Group Versus Individual Based Exercise Program on Balance and Coordination in Children With Autism
This study compared the effects of group-based versus individual-based exercise programs on balance and coordination in children aged 3-12 years who were diagnosed with Autism Spectrum Disorder (ASD) Level 1.
- Trial name
- NCT07799051
- Testing
- Individual based, Group Based Exercise
- Where
- Pakistan
- Volunteers
- 16 people
- Sponsor
- Ibadat International University, Islamabad
Turner Syndrome
Turner Syndrome Prenatal Diagnosis Study
The goal of this study is to compare the features of Turner syndrome in girls who are diagnosed before birth because of fetal concerns versus those who are diagnosed when their mother has an amniocentesis for another reason.
- Trial name
- NCT01668251
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Seattle Children's Hospital
Molar Incisor Hypomineralization
Restoration of Permanent Molars Affected With (MIH) Using Composite Restorations or Preformed Metal Crowns
The aim of this study is to compare clinical outcome of using direct esthetic composite restorations in managing MIH cases and the use of preformed metal crowns.
- Trial name
- NCT04658602
- Testing
- Preformed stainless steal crown cemented by glass ionomer lutting cement (Ketac cem,3M Espe)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Nada Mahmoud Abd El-Azim Mohamed
Retinal Disease, Bestrophinopathy
Stem Cell Models of Best Disease and Other Retinal Degenerative Diseases.
Background: Autosomal recessive bestrophinopathy (ARB) is one of 5 blinding eye diseases caused by mutations in the gene BEST1. These diseases, collectively termed "bestrophinopathies" include ARB, Best vitelliform macular…
- Conditions
- Retinal Disease, Bestrophinopathy, Best Vitelliform Macular Dystrophy, Adult Onset Vitelliform Macular Dystrophy
- Trial name
- NCT02162953
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Mayo Clinic
Achondroplasia
A Study Of Safety, Tolerability And Effectiveness Of Recifercept In Children With Achondroplasia
Approximately 63 participants will be randomized to one of three doses to receive Recifercept either Low Dose Medium Dose High Dose Participants will will attend the clinic at baseline and at Day 1, 4, 8, 15, 29 \& then Month 2…
- Trial name
- NCT04638153
- Testing
- Recifercept
- Where
- 16 sites in United States, Australia and 6 more
- Volunteers
- 60 people
- Sponsor
- Pfizer
Craniosynostosis, Muenke Syndrome
Clinical Study of Muenke Syndrome (FGFR3-Related Craniosynostosis)
This study will explore the range and type of medical and developmental problems in patients with Muenke syndrome, a condition that results when one or more of the suture between the bones of the skull close before birth.
- Trial name
- NCT00106977
- Where
- 2 sites in United States
- Volunteers
- 137 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Molar-Incisor Hypomineralization (MIH)
Nano Silver Fluoride and Photobiomodulation Therapy for Hypersensitivity and Pain in MIH-Affected Molars
Molar-incisor hypomineralization (MIH) is a developmental condition affecting primarily the first permanent molars and may be associated with post-eruptive enamel breakdown, hypersensitivity, and difficulties in achieving…
- Trial name
- NCT07826130
- Testing
- Nano Silver Fluoride, Photobiomodulation Therapy, Pre-appointment analgesics
- Volunteers
- 45 people
- Sponsor
- Ain Shams University
Breast Neoplasms, Neoplasms by Site
Studying Normal Breast Tissue and Cancer Risk
Breast cancer is the most common cancer among women in the United States. Breast cancer research has been hampered by the difficulty in collecting normal breast tissue.
- Conditions
- Breast Neoplasms, Neoplasms by Site, Neoplasms, Breast Diseases
- Trial name
- NCT00341692
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- National Cancer Institute (NCI)
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