Clinical trials: Developmental Disorder
Osteogenesis Imperfecta, Osteoporosis
REMS25: Study on the Use of REMS Technology in Diseases Commonly Associated With Reduced Bone Mineral Density (BMD)
This study evaluates bone mineral density (BMD) in pediatric patients aged 5-18 years with conditions negatively affecting bone health, using REMS (Radiofrequency Echographic Multi Spectrometry), a non-invasive and radiation-free…
- Conditions
- Osteogenesis Imperfecta, Osteoporosis, Hypogonadisms, Neoplasia
- Trial name
- NCT07412782
- Testing
- REMS
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Meyer Children's Hospital IRCCS
Developmental Disability
Self-identified Participation and Environment of Children With Disabilities
Picture My Participation (PmP) is a child self-report tool for children and adolescents with disabilities. The PmP uses pictures that enable children to identify participation frequencies, participation goals, and environmental…
- Trial name
- NCT04522518
- Testing
- PmP-C App
- Where
- Taiwan
- Volunteers
- 538 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Autism Spectrum Disorder
Effectiveness of Social Skills Training Group for Children With Autism Spectrum Disorder
Socio-communicative impairments are core deficits in individuals with autism spectrum disorder (ASD). Individuals with ASD have difficulty understanding eye contact, facial expressions, body language, and different tones of voice…
- Trial name
- NCT04551313
- Testing
- social skill group
- Where
- 2 sites in Taiwan
- Volunteers
- 86 people
- Sponsor
- National Taiwan University Hospital
Autism Spectrum Disorder
Efficacy of Bumetanide in Children With Autism Spectrum Disorder Guided by Peripheral Blood Biomarkers and Machine Learning Models
The objective of this study is to learn if bumetanide could alleviate the clinical symptoms in children with autism spectrum disorder (ASD), who has been predicted as high responders to bumetanide via a cytokine-based predictive…
- Trial name
- NCT07005414
- Testing
- Bumetanide, Treatment as usual (TAU)
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Fei Li
Autism
Improving Working Memory of Children With Autism
Existing findings suggest that challenges in working memory (WM) of children with autism are common (Habib, Pollick, Melville, \& 2019).
- Trial name
- NCT04209452
- Testing
- Rehearsal strategy, Reinforcement, Rehearsal strategy and reinforcement
- Where
- 3 sites in China
- Volunteers
- 15 people
- Sponsor
- Arizona State University
Rare Disorders
Implementing Dynamic Consent for Rare Disease Patients
The study aims to test on a cohort of rare patients a digital innovative tool to support patients/parents in the informed consent and assent process and to keep up-to-date a lawful informed and dynamic consent and to use samples…
- Trial name
- ConsDinamico (NCT06656247)
- Testing
- Online consenting
- Volunteers
- 50 people
- Sponsor
- Istituto Ortopedico Rizzoli
Marfan Syndrome, Loeys-Dietz Syndrome
Genotypes and Craniofacial Phenotypes in Orthodontic Patients With Marfan and Loeys-Dietz Syndromes
The aim of this retrospective observational study is to investigate the association between genotype and craniofacial phenotype in orthodontic patients affected by Marfan and Loeys-Dietz syndromes.
- Trial name
- NCT07360704
- Testing
- Cephalometric analysis
- Where
- Italy
- Volunteers
- 39 people
- Sponsor
- Andrea Scribante
Molar Incisor Hypomineralization
Glass Ionomer Cement Sealant in the Prevention of Post-eruptive Fractures in Molars Affected by MIH
This trial will compare the application of Glass Ionomer Cement (GIC) sealant with no-intervention for the most clinically- and cost-effective strategy for managing MIH molars without post-eruptive breakdown, in a school setting…
- Trial name
- MIHMex (NCT03870958)
- Testing
- GIC sealant (GC Fuji TRIAGE®), Control
- Where
- Mexico
- Volunteers
- 195 people
- Sponsor
- Isabel Cristina Olegário da Costa
Pain, Pain, Postoperative
Prediction and Characterization of Acute and Chronic Postoperative Pain
Despite enormous progress insufficient postoperative pain management remains a frequent problem in the early postoperative phase after surgery.
- Conditions
- Pain, Pain, Postoperative, Funnel Chest
- Trial name
- NCT01308385
- Testing
- Conditioned pain modulation
- Where
- Denmark
- Volunteers
- 52 people
- Sponsor
- University of Aarhus
Autism Spectrum Disorder
pBFS Guided rTMS Over Cognitive Control Network for ASD
The aim of this trial is to assess the efficacy and safety of precision neuromodulation for alleviating core symptoms in patients with autism spectrum disorder (ASD) who also have intellectual or developmental delay.
- Trial name
- NCT06255535
- Testing
- active iTBS treatment
- Where
- 6 sites in China
- Volunteers
- 215 people
- Sponsor
- Changping Laboratory
Gait Analysis
An Ankle-foot Orthosis Improves Gait Performance and Satisfaction in Stroke Patients
All participants were at least 6-month post-stroke and had unilateral limb involvement (8 right/4 left). The main inclusion criteria in selection of the participants in this study were as follows :(1) First stroke (2) At least 6…
- Trial name
- NCT03965715
- Testing
- 3D printing AFO, anterior AFO, off-the-shelf AFO
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Cheng-Kung University Hospital
Pectus Excavatum, Autonomic Dysfunction
Autonomic Dysfunction in Patients With Pectus Excavatum.
Investigators conducted a pilot study to to evaluate the autonomic function in participants with pectus excavatum before and after Nuss surgery.
- Conditions
- Pectus Excavatum, Autonomic Dysfunction, Surgery
- Trial name
- ADPE (NCT03346876)
- Testing
- Nuss surgery
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Autism Spectrum Disorder
Evaluation of Behavioural Psycho & Physiological Responses in People With ASD During a Blood Test in Routine Care Practice
The project is a prospective study designed to characterize behaviour and its psycho-physiological correlates of participants with ASD (children and adults) in comparison with subjects without ASD matched in age during blood test…
- Trial name
- AUTICOPP (NCT04638452)
- Testing
- Video & movements recording, Questionnaires
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Charles Perrens, Bordeaux
Premature, Orogastric Tube
Development and Efficiency of Atraumatic Orogastric Tube Insertion Protocol with Combination of Wrapping, Fetal Position, Breastmilk, and Sucrose
This study aimed to reduce the pain and increase comfort during the orogastric tube insertion (OGT) procedure, which is routinely applied to feed these babies at 32-34 weeks of age, in preterm newborns with a sucking reflex.In…
- Conditions
- Premature, Orogastric Tube, Oral Sucrose
- Trial name
- OGT (NCT05180058)
- Testing
- Wrapping + Breastmilk Group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ayse Sonay Turkmen, Prof.Dr
Malaria, HIV
Antimalarial Pharmacology in Children and Pregnant Women in Uganda
The burden of malaria is greatest in children and pregnant women in sub-Saharan Africa. Malaria is one of the most important infectious diseases in the world.
- Trial name
- NCT01717885
- Where
- Uganda
- Volunteers
- 473 people
- Sponsor
- University of California, San Francisco
Turner Syndrome
The Effect of Growth Hormone in Very Young Girls With Turner Syndrome
This study investigated the effect of growth hormone on the growth of infants and toddlers with Turner syndrome during 2 years of treatment with growth hormone.
- Trial name
- NCT00406926
- Testing
- Somatropin
- Where
- 10 sites in United States
- Volunteers
- 100 people
- Sponsor
- Eli Lilly and Company
Hip Dysplasia
Treatment of Developmental Dysplasia of the HIp
Closed reduction is where the thigh bone is placed into the socket without any surgical incision being made. This is more likely to be performed in a child under the age of four year.
- Trial name
- NCT03193385
- Testing
- closed reduction
- Volunteers
- 20 people
- Sponsor
- Assiut University
Autistic Disorder
Design Of WELL Being Monitoring Systems, Application in Autism
The worldwide prevalence of autism is constantly increasing. People with autisms have difficulties in communication and social interaction resulting from atypical perceptual and information processing, leading to the accumulation…
- Trial name
- Do Well B (NCT02275455)
- Testing
- real life situations
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Spinal Deformity
AI-Powered Scoliosis Auto-Analysis System Multicenter Development and Validations
The investigators aim to use artificial intelligence (AI) to help clinicians in diagnosing and assessing spinal deformities.
- Trial name
- NCT05146193
- Testing
- Nude back photo
- Where
- Hong Kong
- Volunteers
- 2,500 people
- Sponsor
- The University of Hong Kong
Renal Function Disorder
Development and Validation of Creatinine-Based Estimates of the Glomerular Filtration Rate Equation
This study aim to recruit all Electronic Medical Record of patients who underwent for 51chromium ethylenediamine tetra acetic acid (51Cr-EDTA) imaging at the Nuclear Medicine Centre, University Malaya Medical Centre from…
- Trial name
- NCT05112393
- Testing
- Development of new estimating Glomerular Filtration Rate (eGFR) equation, Validation of new estimating Glomerular Filtration Rate (eGFR) equation
- Where
- Malaysia
- Volunteers
- 200 people
- Sponsor
- University of Malaya
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