Clinical trials: Dexmedetomidine
Emergence Agitation
Comparison of Effect of Dexmedetomidine and Midazolam on Emergence Agitation
Since the frequency of emergence agitation (EA) is relatively high in children while undergoing nasal surgery, and there is not much data available in Pakistan regarding EA in adults undergoing functional endoscopic sinus surgery…
- Trial name
- NCT07392983
- Testing
- Dexmedetomidine, Midazolam
- Where
- 2 sites in Pakistan
- Volunteers
- 146 people
- Sponsor
- Muhammad Aamir Latif
ICU Sedation
Study of DA-9501 In Pediatric Subjects In The Intensive Care Unit
To evaluate the efficacy, safety, and pharmacokinetics of dexmedetomidine given as continuous IV infusion in pediatric subjects [≥ 45 weeks CGA (corrected gestational age) to <17 years old] requiring sedation under intensive care…
- Trial name
- NCT02757625
- Testing
- Dexmedetomidine hydrochloride
- Where
- 12 sites in Japan
- Volunteers
- 63 people
- Sponsor
- Pfizer
Dexmedetomidine
Dexmedetomidine and Sufentanil Effect in PCA on Pediatric Patients Undergoing Scoliosis Surgery
The primary purpose of this three-arm single center, randomized, subject and assessor blind, controlled clinical study is to evaluate the effect of dexmedetomidine on patient-controlled intravenous analgesia after pediatric…
- Trial name
- DEX (NCT05249153)
- Testing
- low dose of dexmedetomidine with sufentanil, high dose of dexmedetomidine with sufentanil
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Peking Union Medical College Hospital
Pain
Caudal Versus Intravenous Dexmedetomidine for Caudal Analgesia in Children
The aim of this prospective randomized double-blind study was to compare the analgesic efficacy and the side effects of dexmedetomidine (1 µg.kg-1) co-administered with bupivacaine for caudal analgesia or intravenously in…
- Trial name
- NCT02416063
- Testing
- Caudal Dexmedetomidine, Intravenous dexmedetomidine
- Volunteers
- 75 people
- Sponsor
- University of Jordan
Sleep Disordered Breathing, Drug Induced Sleep Disorder
DISE in Pediatric Sleep Disordered Breathing
Adenotonsillar hypertrophy is the most common reason for children to have sleep disordered breathing (SDB). Even though adenotonsillectomy improves sleep apnea in children, 20-40% of children will still have persistent SDB.
- Trial name
- NCT06756971
- Testing
- Propofol, Dexmedetomidine
- Sponsor
- University of Iowa
Patients Undergoing External Dacrocystorhinostomy Operations, Assess Decreased Anesthetic Requirements Intraoperative
Dexmedetomidine an Effective Drug in Reducing Anesthetic Requirements in External Dacrocystorhinostomy (DCR) Patients
Assessing the intra and postoperative hemodynamic stability in patients undergoing external dacrocystorhinostomy under general anesthesia using Dexmedetomidine as a preoperative sedation compared to traditional technique with…
- Trial name
- DCR (NCT06808295)
- Testing
- Dexmedetomidine Hydrochloride
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Research Institute of Ophthalmology, Egypt
Pharmacogenetic Study, Procedural Anxiety
Determining the Pharmacogenetic Basis of Non-responsiveness to the Sedative Effects of Dexmedetomidine in Children
Intranasal Dexmedetomidine is one of the sedative drugs of choice commonly used as an anxiolytic premedication for children for diagnostic or therapeutic procedures.
- Conditions
- Pharmacogenetic Study, Procedural Anxiety, Dexmedetomidine
- Trial name
- NCT04471402
- Testing
- Precedex
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Hong Kong Children's Hospital
Sedation, Preoperative Anxiety Experienced by the Pediatric Patient
Children of Age 2-6years Undergoing Elective Surgery Will be Divided Into Two Groups Randomly. This Study Aims to Evaluate if Intranasal Dexmedetomidine is Better Than Intranasal Ketamine in Producing Sedation and Reducing Parent Separation Anxiety Before Surgery.
This study aims to compare intranasal dexmedetomidine versus intranasal ketamine as a premedication in children undergoing surgery in our population.
- Conditions
- Sedation, Preoperative Anxiety Experienced by the Pediatric Patient, Anxiolytic Effect, Sedation and Analgesia
- Trial name
- DREAM-Kids (NCT07180095)
- Testing
- Intranasal dexmedetomidine, Intranasal ketamine
- Volunteers
- 60 people
- Sponsor
- Liaquat National Hospital & Medical College
Emergence Delirium, Anesthesia
Effect of Different Drugs on Emergency Delirium in Preschool Age Patient
Emergence delirium (ED) was first described by Eckenhoff and colleagues in the 1960s and is defined in pediatric anesthesia as 'dissociated state of consciousness in which child is irritable, uncompromising, uncooperative…
- Trial name
- NCT07057193
- Testing
- Dexmedetomidine group (D group), Ketamine group (K group), Midazolam group (M group)
- Where
- Egypt
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Procedural Anxiety, Emergencies
Comparing in Dexmedetomidine With po/pr Midazolam for Procedural Sedation in the Pediatric Emergency Department
This study aims to compare efficacy of Procedural Sedation with Dexmedetomidine as compared to Midazolam in the pediatric Emergency Department.
- Trial name
- PedINDEX (NCT03399838)
- Testing
- Dexmedetomidine, Midazolam
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Anti-anxiety Agents, Moderate Sedation
Sublingual Versus Intranasal Administration of Dexmedetomidine for Sedation of Children Undergoing Dental Treatment
The aim of this study is to assess the efficacy of Dexmedetomidine drug either used sublingually or intranasally in managing healthy children during dental treatment
- Trial name
- NCT04237532
- Testing
- Intranasal Dexmedetomidine, Sublingual Dexmedetomidine
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Nourhan M.Aly
Delirium on Emergence
Sevoflurane/Dexmedetomidine vs. Isoflurane for Pediatric Emergence Delirium
The purpose of this study is to measure the incidences of pediatric emergence delirium between the group receiving Isoflurane and the group receiving Sevoflurane plus intravenous push dexmedetomidine.
- Trial name
- NCT06624592
- Testing
- Sevoflurane, Isoflurane
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Mayo Clinic
Anesthesia
Intranasal Dexmedetomidine Versus Intranasal Midazolam as a Premedication in Pediatrics Undergoing Upper GI Endoscopy
compare the effectiveness of intranasal dexmedetomidine and midazolam as a premedication in sedation of preschool children in GI endoscopy
- Trial name
- NCT06181682
- Testing
- Dexmedetomidine, Midazolam
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Cranitomy Surgery
Comparison of Propofol to Precedex With Propofol for Emergence and Recovery in Patients Having Craniotomy Surgery
Primary Hypothesis: The use of a Precedex infusion, in addition to propofol during surgery, will improve patient management through the anesthesia postoperative recovery period determined by improvement in patients? tolerance of…
- Trial name
- NCT00848991
- Testing
- Precedex, Propofol
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Cooper Norcross Health
Procedural Sedation and Analgesia, Pediatric ALL
Study of the Efficacy of Moderate Sedation With Intra-NAsal Dexmedetomidine Monitored by EEG MOnitoring
This is a prospective, monocentric diagnostic study aiming to evaluate whether a sedation score obtained by a per-procedural electroencephalogram (EEG), the PSI score, could identify patients for whom a 2 μg/kg dose of DEX would…
- Trial name
- DINAMO (NCT06867289)
- Testing
- EEG
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Elective Bilateral Myringotomy
Sublingual Ketorolac Compared to Intranasal Dexmedetomidine for Postoperative Analgesia in Pediatric Patients Undergoing Bilateral Myringotomy
The investigators aim to compare intranasal dexmedetomidine in a dose of 1ug.kg-1 with sublingual ketorolac in a dose of 1mg.kg-1 on postoperative behaviour in those children undergoing BMT during their PACU stay
- Trial name
- NCT03742180
- Testing
- intranasal dexmedetomidine, sublingual ketorolac
- Where
- Egypt
- Sponsor
- Mansoura University
MRI Sedation
The Pharmacokinetics of Dexmedetomidine in Children
This study is designed to identify the plasma concentrations which are required to achieve adequate sedation, using a Ramsay Sedation Scale.
- Trial name
- NCT00909935
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Children's Hospital
Cardiac Output, Sedation
Assess the Ability of Electrical Cardiometry to Trend Hemodynamic Variables During Dexmedetomidine Sedation
The aim of the study is to investigate the use of a new FDA-approved non-invasive bio-impedance cardiac monitor, ICON, to detect hemodynamic effects during sedation in children undergoing radiology procedures.
- Trial name
- DEX-CO (NCT01001533)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Boston Children's Hospital
Hemodynamic Instability
Role of Nebulized Dexmedetomidine in Blunting the Effects of Direct Laryngoscopy and Endotracheal Tube on Heart Rate and Blood Pressure.
The goal of this interventional study is to check the effectiveness of nebulized Dexmedetomidine in preventing the rise in blood pressure and heart rate in patients undergoing General Anesthesia.
- Trial name
- NCT06103721
- Testing
- Dexmedetomidine Injection [Precedex], Normal Saline
- Where
- Pakistan
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Muhammad Haroon Anwar
Inadequate; Pulmonary Function, Newborn
Use of ICON™ to Detect Hemodynamic Variables During Dexmedetomidine Sedation in Children Undergoing Pulmonary Function Test
To collect and analyze the physiologic data of the ICON™ during dexmedetomidine (DEX) sedation for neonatal pulmonary function testing.
- Trial name
- NCT03205943
- Sponsor
- Boston Children's Hospital