Clinical trials: Diabetes
Type 1 Diabetes Mellitus
Rituximab in New Onset Type 1 Diabetes
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks the insulin-producing beta cells in the pancreas.
- Trial name
- TN05 (NCT00279305)
- Testing
- Anti-CD20 (rituximab)
- Where
- 16 sites in United States, Australia and 2 more
- Volunteers
- 87 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Childhood, Diabetes Mellitus, Type 2
The QUebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) Cohort
The QUebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) Cohort study is a unique and comprehensive longitudinal study of 630 Caucasian children and their parents that was designed to investigate the natural history and…
- Conditions
- Obesity, Childhood, Diabetes Mellitus, Type 2, Cardiovascular Risk Factor, Pediatric ALL
- Trial name
- QUALITY (NCT03356262)
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Cardiovascular Diseases, Diabetes Mellitus, Type 2
Healthy Lifestyle Promotion Program in Communities From the Yaqui Valley
The aim is to evaluate the change in indicators of lifestyle and its effect on cardiometabolic biomarkers as a response to an integrative mother-child intervention to promote healthy lifestyles and prevent food insecurity and…
- Trial name
- NUTRIGANDO (NCT05945862)
- Testing
- NUTRIGANDO
- Where
- Mexico
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Instituto Tecnologico de Sonora
Type 1 Diabetes
Happy Bob App: A Preliminary Evaluation of Its Use in Youth With Diabetes
The goal of this clinical trial is to evaluate the impact of peer support via the Happy Bob phone app in youth with Type 1 Diabetes.
- Trial name
- NCT06412601
- Testing
- RPM, app
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Diabetes Mellitus, Type 1
Interventions to Prevent Adolescents With Type 1 Diabetes From Long-term Complications
The purpose of this study is to evaluate the effectiveness of diabetes management training combined with the method of Motivational Interviewing with elements of Cognitive Behaviour Therapy and E-mail support in the treatment of…
- Trial name
- NCT01520428
- Testing
- Motivational Interviewing, CBT and E-mail support
- Where
- Austria
- Volunteers
- 120 people
- Sponsor
- Medical University of Vienna
LRBA Deficiency, CTLA4 Haploinsufficiency
New Biomarkers for Diagnosis and Follow-up of Patients With LRBA or CTLA4 Deficiencies
Primary immune deficiencies (PID) are a group of chronic diseases characterized by recurrent infections. Apart from recurrent infections, in some of PIDs autoimmunity, allergy or malignancy could be accompanied to the diseases.
- Trial name
- NCT04377867
- Testing
- Abatacept Injection [Orencia]
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Marmara University
Type 1 Diabetes
Technology Knowledge Optimization in Type 1 Diabetes (TeKnO T1D): Parents
This study aims to identify the unmet psychoeducational needs of parents of children 8-12 years of age using insulin pump and CGM for pediatric T1D management and to leverage that information to develop an innovative app-based…
- Trial name
- TeKnO T1D (NCT05300022)
- Testing
- TeKnO T1D: Parents
- Where
- United States
- Sponsor
- Children's Hospital of Philadelphia
Type 1 Diabetes
Healthy And Positive Pathways for Young People With Type 1 Diabetes (HAPPY T1D)
In this 2-year randomized clinical trial, we will implement and assess the impact of a behavioral/psychoeducational intervention to reduce diabetes distress and improve glycemic outcomes in adolescents and young adults, aged…
- Trial name
- NCT05413239
- Testing
- Psychoeducation to reduce diabetes distress and improve glycemic outcomes
- Where
- 2 sites in United States
- Volunteers
- 217 people
- Sponsor
- Joslin Diabetes Center
Type1 Diabetes
Yale-Harvard Hotel-based Closed-Loop Studies in Children (HY-GRAID)
The aim of this clinical study is to determine the feasibility, safety, and preliminary effectiveness of the Zone-Model Predictive Control Artificial Pancreas (ZMPC_AP) system in pediatric subjects with type 1 diabetes in an…
- Trial name
- HY-GRAID (NCT04255381)
- Testing
- Zone-Model Predictive Control Artificial Pancreas (ZMPC_AP)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Educational Problems
Educational Intervention Using SMS to Evaluate Clinical Effects and Satisfaction in Patients With Diabetes Mellitus
The investigators evaluated the satisfaction of these patients with the health service and their self-care. The study included patients diagnosed with DM, respecting the established inclusion and exclusion criteria.
- Trial name
- SMS (NCT04191902)
- Testing
- orientation
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Type 1 Diabetes
Glucose Variability in Type 1 Diabetes (T1D) and Glycaemic Responses to Food Composition.
The study proposed to recruit approximately 435 children and young people who have T1D and who regularly use Dexcom continuous glucose monitoring (CGM). Recruitment was be via their local dietitian.
- Trial name
- NCT06546657
- Testing
- Breakfast
- Where
- United Kingdom
- Volunteers
- 96 people
- Sponsor
- University of Stirling
Diabetes Mellitus, Type 1
Joint Application of Human Insulin and Rapid Insulin Analogue in Control of Postprandial Glycemia
Postprandial glycemic control is essential for diabetes compensation. Insulin pump therapy control blood glucose released in response to both high and low glycemic index carbohydrates in a mixed diet using normal, square and…
- Trial name
- CPIT (NCT01088451)
- Testing
- Combined prandial insulin therapy (CPIT)
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- University Hospital Hradec Kralove
Diabetes Mellitus
Evaluation of a Diabetes Treatment and Education Program for Insulin Pump Therapy (INPUT)
This study is a randomized, controlled, prospective trial with a 6-month follow-up. A newly developed treatment and education programme for diabetic patients with an insulin pump therapy (INPUT) will be tested compared to a…
- Trial name
- INPUT (NCT02868931)
- Testing
- INPUT
- Where
- Germany
- Volunteers
- 268 people
- Sponsor
- Norbert Hermanns
Type1 Diabetes Mellitus
The International Diabetes Closed Loop (iDCL) Trial: Protocol 1
The objective of the study is to assess the efficacy and safety of home use of a Control-to-Range (CTR) closed-loop (CL) system.
- Trial name
- iDCL (NCT02985866)
- Testing
- Artificial Pancreas, Sensor Augmented Therapy
- Where
- 7 sites in United States
- Volunteers
- 127 people
- Sponsor
- University of Virginia
ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION, Diabetes Mellitus
Abnormal Glucose Tolerance in Allogeneic Hematopoietic Stem Cell Transplantation
To investigate the impact of abnormal glucose tolerance in hematopoietic stem cell transplantation donors on patients' post-transplant survival outcomes.
- Conditions
- ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION, Diabetes Mellitus, Impaired Fasting Glucose
- Trial name
- NCT06704542
- Where
- 6 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Ruijin Hospital
Celiac Disease in Children, Diabetes Mellitus, Type I
Auto-antibody Dosage From Blood Spots for Diagnosis of Type 1 Diabetes and Celiace Disease
Early diagnosis of type 1 diabetes and celiac disease is very useful, allows early therapy and prevents deaths from the onset of diabetic ketoacidosis.
- Conditions
- Celiac Disease in Children, Diabetes Mellitus, Type I, Screening
- Trial name
- CELDI (NCT06849622)
- Testing
- Test on blood sample, Test on dried blood sample
- Where
- Italy
- Volunteers
- 1,500 people
- Sponsor
- Meyer Children's Hospital IRCCS
Respiratory Disorder, Cardiovascular Diseases
Study of RE.DOCTOR Vitals® Software Accuracy
The purpose of this observational trial is to advance digital health monitoring through the analysis of Photoplethysmography (PPG) waveforms collected via RE.DOCTOR Vitals software.
- Conditions
- Respiratory Disorder, Cardiovascular Diseases, Diabetes, Pre-Diabetes
- Trial name
- RE-VITAL (NCT06237322)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- RE.DOCTOR LLC
Type 1 Diabetes
Closed-loop Control of Glucose Levels (Artificial Pancreas) for 15 Weeks in Adolescents and Adults With Type 1 Diabetes
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT02846857
- Testing
- 15-week intervention with sensor-augmented pump, 15-week intervention with single-hormone closed-loop, 15-week intervention with dual-hormone closed-loop
- Sponsor
- Institut de Recherches Cliniques de Montreal
Diabetes, Diabetes Mellitus, Type 1
A Survey on Low Blod Sugar Among Insulin-treated Patients With Diabetes
This study is conducted globally. The aim of this study is to describe the proportion of patients with hypoglycaemic episodes and estimate the incidence of various types of hypoglycaemia in the retrospective and prospective…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT02306681
- Testing
- No treatment given
- Where
- 8 sites in Bangladesh, Colombia and 6 more
- Volunteers
- 7,315 people
- Sponsor
- Novo Nordisk A/S
Diabetes, Type 1 Diabetes
Predictive and Protective Factors in the Cause of Diabetes - A Study in Twins
This study, conducted at St. Bartholomew's Hospital, London, England, will determine whether cells passed from mother to offspring during pregnancy increase or decrease the child's risk of developing type 1 diabetes.
- Trial name
- NCT00339781
- Where
- United Kingdom
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
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