Clinical trials: Diagnostics
Melanoma, Skin Cancer
Artificial Intelligence Augmented Training in Skin Cancer Diagnostics for General Practitioners
Background: The worldwide incidence of skin cancer has been rising for 50 years, in particular the incidence of malignant melanoma has increased approx. 2-7% annually and is the most common cancer amongst Danes aged 15-34.
- Trial name
- AISC-GP (NCT04576416)
- Testing
- AI augmented training and clinical feedback
- Where
- Denmark
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Malaria
Sustainable Financial Incentives To Improve Prescription Practices For Malaria
This project aims to test an innovative, sustainable financial incentive designed to reduce the number of non-malarial fevers that are treated inappropriately with antimalarial drugs.
- Trial name
- NCT01809873
- Testing
- Performance based incentives
- Where
- Kenya
- Volunteers
- 14,862 people
- Sponsor
- Duke University
HIV Infections, Hepatitis B Infections
Rapid Diagnostics for HIV and Hepatitis
The purpose of this study is to determine the efficacy of two rapid diagnostic tests in plasma, venipuncture whole blood, and fingerstick whole blood.
- Conditions
- HIV Infections, Hepatitis B Infections, Hepatitis C Infections
- Trial name
- NCT02190305
- Testing
- Multiplo HBc/HIV/HCV and Reveal HBsAg
- Where
- 4 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- MedMira Laboratories Inc.
Melanoma, Skin Cancer
AI Augmented Training for Skin Specialists
Background: The worldwide incidence of skin cancer has been rising for 50 years, in particular the incidence of malignant melanoma has increased approx. 2-7% annually and is the most common cancer amongst Danes aged 15-34.
- Trial name
- AISC-SS (NCT04758988)
- Testing
- DermLoop Learn
- Where
- 2 sites in Denmark
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Ultrasound, Diagnostics
How Point-of-Care Ultrasound Affects the Diagnostic Process in General Practice.
This study explores how Point of Care Ultrasound (POC-US) is used in general practice in Denmark and how it affects the diagnostic process and treatment of patients.
- Conditions
- Ultrasound, Diagnostics, General Practice
- Trial name
- NCT03375333
- Where
- Denmark
- Volunteers
- 579 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Tuberculosis
Diagnostics and Pharmacotherapy for Severe Forms of TB (DMID 15-0100)
Major Research Aim: To study novel molecular diagnostics and the pharmacokinetic variability among a spectrum of TB disease states, including severe forms of TB like disseminated TB, TB meningitis and drug resistant TB, among…
- Trial name
- NCT03559582
- Volunteers
- 478 people
- Sponsor
- University of Virginia
Brain Injuries, Traumatic
Biochemical Diagnostics of Mild Traumatic Brain Injury (TBI) and Concussion in Children and Adolescents
The study will enroll children and adolescents (0 - 17 years) suspected of having concussion or mild traumatic brain injury (TBI).
- Trial name
- NCT04288167
- Testing
- Sample collection
- Where
- Finland
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Medicortex Finland Oy
Coronary Artery Disease, Atherosclerosis
CaRi-Heart Assessment of Risk and Evaluation of Inflammation in Coronary CT Angiography (CARE-CCTA)
This study evaluates the use of CaRi-Heart® analysis, an artificial-intelligence (AI) software tool that measures inflammation in the coronary arteries using images already captured during a standard Coronary CT Angiography…
- Conditions
- Coronary Artery Disease, Atherosclerosis, Cardiovascular Inflammation
- Trial name
- CARE-CCTA (NCT07220304)
- Testing
- CaRi-Heart® Analysis
- Where
- 18 sites in United States
- Volunteers
- 15,000 people
- Sponsor
- Corazon Medical PC
Respiratory Infections in Children
Trial of an AI-enabled Digital Stethoscope to Improve Antibiotic Stewardship
Antibiotics are a mainstay of the treatment of lower respiratory infections in young children even though most episodes are caused by self-limiting viruses.
- Trial name
- BLAAAST (NCT07362433)
- Testing
- Automated digital stethoscope
- Where
- Bangladesh
- Volunteers
- 2,500 people
- Sponsor
- Johns Hopkins University
Sexually Transmitted Infection, Chlamydia
Investigating Point-of-care Diagnostics for Sexually Transmitted Infections and Antimicrobial Resistance in Primary Care in Zimbabwe
A prospective interventional study to evaluate a strategy of point-of-care testing for sexually transmitted infections including chlamydia, gonorrhoea, trichomoniasis, syphilis, and Hepatitis B with comprehensive case management…
- Conditions
- Sexually Transmitted Infection, Chlamydia, Gonorrhea, Trichomoniasis
- Trial name
- IPSAZ (NCT05541081)
- Testing
- Point-of-care STI testing
- Where
- Zimbabwe
- Volunteers
- 1,005 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Viral Infection, Bacterial Infections
A Controlled, Blinded Study to Validate the Diagnostic Accuracy and Assess the Clinical Utility of a Host-response Based Diagnostic Tool for Distinguishing Between Bacterial and Viral Etiologies in Pediatric Patients Presenting to the ED With Suspicion of Acute Infection
To externally validate the diagnostic accuracy and assess the clinical utility of a host-response based diagnostic tool called ImmunoXpert™, for differentiating between bacterial and viral etiologies in pediatric patients >3…
- Conditions
- Viral Infection, Bacterial Infections, Antibiotic Misuse, Host Response Diagnostics
- Trial name
- ROSETTA (NCT04254991)
- Testing
- ImmunoXpert™
- Volunteers
- 525 people
- Sponsor
- MeMed Diagnostics Ltd.
Wounds
A Retrospective Study of the Effects of Molecular Diagnostics on Wound Care Outcomes
A retrospective molecular diagnostic review on wound care outcomes between two time periods. The time periods include June, July, August of 2008 and June, July, August of 2009.
- Trial name
- NCT01089673
- Testing
- data collection
- Volunteers
- 600 people
- Sponsor
- Southwest Regional Wound Care Center
Respiratory Virus Infection, Fever of Unknown Origin
Rapid Viral Diagnostics in Adults to Reduce Antimicrobial Consumption and Duration of Hospitalization
Viral respiratory infections are common and often require use of health care resources. Patients receive inappropriate bacterial antibiotics, which has many problems including side-effects, development of resistance and costs.
- Conditions
- Respiratory Virus Infection, Fever of Unknown Origin, Dyspnea, Chest Pain
- Trial name
- NCT02538770
- Testing
- Rapid diagnostics using Anyplex TMII RV16 Detection, Delayed diagnostics Anyplex TMII RV16 Detection
- Where
- 2 sites in Finland
- Volunteers
- 900 people
- Sponsor
- University of Oulu
Acid Base Disorder
Rapid Diagnostics for Genetic Disorders in Neonates
The goal of this study is to test a prototype genomic blood analysis for identifying rare diseases in infants hospitalized in the neonatal intensive care unit (NICU).
- Trial name
- NCT07005700
- Testing
- Targeted genomic sequencing
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Sharp HealthCare
Whole Exome Sequencing, Rare Diseases
PREcision Diagnostics in Rare genetIC Diseases and Tumors - Long Read Sequencing
Using long-read sequencing (LRS) technology to achieve molecular diagnosis in patients with rare genetic diseases who have already been tested by state-of-the-art genetic analysis with ambiguous or negative results.
- Trial name
- PREDICT-LRS (NCT06796751)
- Testing
- DNA/RNA sequencing and bioinformatic data analysis
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Clostridium Difficile
C Difficile Near-patient Diagnostics
The investigators will conduct a two-period, two-intervention, cluster randomized crossover (CRXO) designed study at Foothills Hospital in Calgary, Alberta.
- Trial name
- NCT03857464
- Testing
- Near Patient Testing, SOP for C. difficile diagnostics
- Where
- 2 sites in Canada
- Volunteers
- 3,816 people
- Sponsor
- University of Calgary
Movement Disorder, Cognitive Decline
Next Generation Sequencing Diagnostics - On the Road to Rapid Diagnostics for Rare Diseases
In the study, NextGen SE are on-hand a cohort comprising each 50 pediatric and 50 adult patients, and in which there are an unclear movement disorder or an unclear cognitive disorder, examines the following questions : Primary…
- Trial name
- NextGen-SE (NCT02588638)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital Tuebingen
Kidney Transplantation
Performances of Large Language Models in Kidney Allograft Diagnostics
Kidney allograft rejection diagnosis relies on the complex Banff classification, but its application is limited by variability and workload.
- Trial name
- NCT07004660
- Volunteers
- 240 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
HIV Infections
Evaluation of the Performance of Chembio Diagnostics Systems, Inc. DPP® HIV 1/2 Rapid Test
This study has been designed to evaluate the performance of the Chembio Diagnostics Systems, Inc. DPP® HIV 1/2 rapid test. The device is intended to qualitatively detect the presence of antibodies against HIV-1/2 in oral fluid…
- Trial name
- NCT01032902
- Testing
- In Vitro Diagnostic Device
- Where
- 5 sites in United States
- Volunteers
- 2,808 people, healthy volunteers welcome
- Sponsor
- Chembio Diagnostic Systems, Inc.
Venous Leg Ulcer
Diagnostics in the Leg Ulcer Pathway
This project aims to investigate 'The minimum diagnostic requirements for patients presenting to primary care with suspected venous ulcers.' In order to do this, the investigators intend to run a series of questionnaires with…
- Trial name
- NCT06181708
- Testing
- N/A - Questionnaire based study
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Imperial College London