Clinical trials: Diaphragms
Neonatal Respiratory Distress
DIaphragmatic Swing According to Cpap Flow Output in NEOnates (DISCONEO)
The hypothesis behind the study is that the performance of constant flow CPAP (Continuous Positive Airway Pressure) devices (CF-CPAP) is not inferior to that of variable flow CPAP devices (VF-CPAP) in terms of respiratory efforts…
- Trial name
- NCT07513051
- Testing
- CF-CPAP; CF-CPAP; VF-CPAP; VF-CPAP, VF-CPAP; VF-CPAP; CF-CPAP; CF-CPAP, CF-CPAP; VF-CPAP; VF-CPAP; CF-CPAP
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Mechanical Ventilation Complication, Congenital Heart Disease
Application of Neurally Adjusted Ventilatory Assist to Children After Congenital Cardiac Surgery
Neurally adjusted ventilatory assist (NAVA) is a new mode of mechanical ventilation that delivers ventilatory assist in proportion to neural effort.
- Trial name
- NCT01662011
- Testing
- mode of neurally adjusted ventilatory assist, Mode of pressure support ventilation
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Preterm Birth, Premature Lungs
Effect of Nasal CPAP Versus NIPPV On Diaphragm Electrical Activity (Edi) In VLBW Preterm Infants
Background: In premature babies, many organ systems are not fully grown and developed, including the lungs and respiratory muscles, so they will need breathing support to help them to breathe by preventing their tiny air sacs to…
- Conditions
- Preterm Birth, Premature Lungs, Respiratory Distress Syndrome in Premature Infant
- Trial name
- NCT06295484
- Testing
- Alternating traditional CPAP, NIPPV, and high CPAP
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Sunnybrook Health Sciences Centre
Respiratory Support
The ACCESSIT Study
The study is designed to characterize and monitor the structure, degree of activation and function of the different respiratory muscles during mechanical ventilation after spine trauma and spinal cord injury.
- Trial name
- ACCESSIT (NCT05207046)
- Testing
- Mechanical Ventilation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Hernia, Diaphragmatic
Early Childhood Follow-up of Congenital Diaphragmatic Hernia Survivors
The primary objective of this study is to determine the medical and neurodevelopmental outcomes of congenital diaphragmatic hernia (CDH) survivors at school-age (4-6 years) follow-up.
- Trial name
- CDH (NCT01029665)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Hernia, Incisional Hernia
"Nanotechnologies Applied to General Surgery and Emergency Surgery: Buckypaper as a New Fixing Method for Prosthetic Materials for the Treatment of Hernia and Incisional Hernia in Laparotomy and Laparoscopic
"Nanotechnologies applied to General Surgery and Emergency Surgery: The Buckypaper as a new fixing method for prosthetic materials in the treatment of abdominal wall hernias, diaphragmatic hernias, diaphragmatic rupture…
- Trial name
- 36P (NCT02137018)
- Testing
- PPL fixation by BP, PPL mesh
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Inadequate; Pulmonary Ventilation, Newborn, Infant, Very Low Birth Weight
Nasal Noninvasive NAVA in the Very Low Birth Weight Infant
The purpose of this study is to determine if a new type of mechanical ventilation, or breathing machine (called neurally adjusted ventilatory assist or NAVA), will provide additional support to infants who were born prematurely.
- Trial name
- NCT01785563
- Testing
- Nasal NIV-NAVA
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Tarah T Colaizy
Bronchopulmonary Dysplasia
Ultrasound Assessment of Diaphragmatic Function in Infants With BPD
Preterm infants have high and prolonged exposure to positive pressure ventilation, which contributes to acute lung injury and the development of bronchopulmonary dysplasia (BPD).
- Trial name
- NCT04941963
- Testing
- Chest ultrasound
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Mount Sinai Hospital, Canada
Obstructive Sleep Apnea of Child
Diaphragm Ultrasound İn Children With OSAS
This is a prospective observational study evaluating perioperative diaphragmatic function by ultrasonography in children aged 1-12 years undergoing elective surgery under general anesthesia.
- Trial name
- NCT07380321
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Hernia, Diaphragmatic, Hypertension, Pulmonary
Chronic Sildenafil for Severe Diaphragmatic Hernia
The purpose of this study is to test if sildenafil is effective in the treatment of infants with severe congenital diaphragmatic hernia (determined by the presence of prolonged pulmonary hypertension or prolonged oxygen…
- Conditions
- Hernia, Diaphragmatic, Hypertension, Pulmonary, Hypoplasia, Pulmonary
- Trial name
- NCT00133679
- Testing
- sildenafil
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- University of California, San Francisco
Respiratory Insufficiency in Children, Newborn Rds
Diaphragmatic Work During HFNC and CPAP Support
The goal of this randomised controlled, cross-over clinical trial is to compare High Flow Nasal Cannulas (HFNC) and Continuous Positive Airways Pressure (CPAP) in neonates over 34 weeks' amenorrhoea (SA) up to children weighing…
- Conditions
- Respiratory Insufficiency in Children, Newborn Rds, Nasal Cannula, CPAP Ventilation
- Trial name
- DiaWorkHFNC (NCT06249009)
- Testing
- Non invasive ventilation
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Congenital Diaphragmatic Hernia
Delayed Cord Clamping for Congenital Diaphragmatic Hernia
Congenital diaphragmatic hernia (CDH) is a congenital anomaly associated with a high risk of mortality and need for life-saving interventions such as extracorporeal membrane oxygenation (ECMO), nitric oxide, and vasopressor…
- Trial name
- DING (NCT03314233)
- Testing
- DING
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Children's Hospital of Philadelphia
Obesity, Asthma
Obesity-asthma Endophenotype and Diaphragm Mobility in Adolescence
Obesity and asthma share changes that may begin in the fetal development phase. The endophenotype obesity-asthma presents as main characteristic a pattern of inflammatory response different from the habitual Th2 profile of…
- Trial name
- NCT03029936
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Pediatric Asthma, Chronic Respiratory Diseases
Clinical and Autonomic Efficacy of Digital-Gamified Diaphragmatic Training in Pediatric Pulmonary Rehabilitation
Adherence to traditional pediatric pulmonary rehabilitation exercises is often low due to their repetitive nature, leading to poor respiratory outcomes.
- Conditions
- Pediatric Asthma, Chronic Respiratory Diseases, Obstructive Airway Disease
- Trial name
- NCT07765264
- Testing
- Digital-Gamified Diaphragmatic Training (DGDT), Standard Mechanical Incentive Spirometer
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Delta University for Science and Technology
Premature Birth
Changes in Respiratory Effort in Preterm Infants
Continuous Positive Airway Pressure (CPAP) is used to treat preterm infants with an immature respiratory center and having respiratory distress. CPAP requires intensive care monitoring and special qualified staff.
- Trial name
- NCT02014493
- Testing
- High Flow Nasal Cannulae (HFNC), Continuous Positive Airway Pressure (CPAP)
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- St. Olavs Hospital
Virtual Reality, Congenital Diaphragmatic Hernia
Virtual Reality and Congenital Diaphragmatic Hernia
The study has been designed to investigate the effect of 12 weeks of using virtual reality based exercises on pulmonary functions, exercise capacity, functional performance, and quality of life in children with…
- Conditions
- Virtual Reality, Congenital Diaphragmatic Hernia, Children
- Trial name
- NCT05612503
- Testing
- Traditional physical therapy program, Virtual reality-based exercises
- Where
- Saudi Arabia
- Volunteers
- 52 people
- Sponsor
- Qassim University
Patient With Radiotherapy (Linac MRI), Mobile Cancerous Lesion
Impact of Non-magnetic Screen Respiratory Self-guidance During MRI-guided Radiotherapy Sessions for Mobile Lesions
The patients eligible for the study are those treated by radiotherapy on Linac MRI for a mobile cancerous lesion (pancreas, liver, kidneys, adrenals, lung, adenopathy above or below the diaphragm ...).
- Trial name
- RespEcran (NCT05783908)
- Testing
- With non-magnetic screen
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Georges Francois Leclerc
Respiratory Distress Syndrome, Newborn, Infant, Premature
Neural Control of Non-invasive Ventilation in the Preterm
The present study will use a new type of respirator in premature babies who need help with their breathing. This new respirator uses signals from the baby's diaphragm - the most important breathing muscle - to control the timing…
- Trial name
- NCT00368485
- Testing
- Neurally Controlled Mechanical Ventilation
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
PEEP by Lung Ultrasound, PEEP With Dynamic Compliance
Postoperative Diaphragm Function in Pediatric Laparoscopic Abdominal Surgery Using Compliance and PEEP Guided by Lung Ultrasound
Protective ventilation strategies and alveolar recruitment maneuvers (ARM) are employed in patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) to improve oxygenation, prevent alveolar collapse…
- Trial name
- NCT07126067
- Testing
- Lung Ultrasound and PEEP Application, Application of PEEP with Dynamic Compliance
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Konya City Hospital
Spine Deformity, Scoliosis
The Effect of Three-dimensional Exercise (Schroth Exercise) on Diaphragm Thickness in Adolescent Idiopathic Scoliosis Patients
Spinal deformity is common in childhood and adolescence, and can often present as scoliosis or increased thoracic kyphosis deformity with various etiologies.The diaphragm is the main respiratory muscle, and diaphragm contraction…
- Conditions
- Spine Deformity, Scoliosis, Scoliosis Idiopathic, Scoliosis; Adolescence
- Trial name
- NCT06417944
- Testing
- Scoliosis study form, Scoliosis X-ray (orthorontgenogram), Pulmonary function test
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital