Clinical trials: Digestive Disorders
Crohn's Disease
Eating Behaviour in Crohn's Disease
Food intake is mainly controlled through interactions between the gut and brain (the homeostatic control) and through our environment, with food exposure, mood and past experiences (the hedonic control) playing a major role.
- Trial name
- NCT02379117
- Where
- United Kingdom
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
HIV, Hepatitis C
Effects of Motivational Interviewing on Risky Injecting Practices Among Injecting Drug Users (IDUs)
The purpose of this study is to evaluate the effects of a brief motivational intervention in reducing risky injection practices among injecting drug users (IDUs).
- Trial name
- NCT00794391
- Testing
- Motivational interviewing, Educational intervention
- Where
- Canada
- Volunteers
- 219 people
- Sponsor
- Université de Sherbrooke
Helicobacter Pylori Infection, Peptic Ulcer
Treatment Efficacy of Regimens With and Without Bismuth in Children With Helicobacter Pylori-Associated Peptic Ulcer Disease
The goal of this clinical trial is to learn if including bismuth in the treatment helps heal stomach and duodenal ulcers caused by Helicobacter pylori (H. pylori) in children.
- Trial name
- NCT07260006
- Testing
- Bismuth quadruple therapy, Triple therapy with PPI + Amoxicillin + Metronidazole
- Where
- Vietnam
- Volunteers
- 80 people
- Sponsor
- Can Tho University of Medicine and Pharmacy
Eosinophilic Esophagitis
A Study of Lirentelimab (AK002) in Patients With Active Eosinophilic Esophagitis
This is a Phase 2/3, multi-center, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of lirentelimab (AK002) given monthly for 6 doses in adult and adolescent patients with active eosinophilic…
- Trial name
- KRYPTOS (NCT04322708)
- Testing
- lirentelimab (AK002)
- Where
- 78 sites in United States, Australia and 1 more
- Volunteers
- 277 people
- Sponsor
- Allakos Inc.
Eosinophilic Gastritis (EoG), Eosinophilic Duodenitis (EoD)
A Study to Learn How Well Dupilumab Works in Adult and Adolescent Participants With Eosinophilic Gastritis With or Without Eosinophilic Duodenitis and the Side Effects it May Have
This study is researching an experimental drug called dupilumab. The study is focused on participants with active eosinophilic gastritis (EoG) with or without eosinophilic duodenitis (EoD).
- Conditions
- Eosinophilic Gastritis (EoG), Eosinophilic Duodenitis (EoD), Eosinophilic Gastrointestinal Disease (EGID), Eosinophilic Gastroenteritis
- Trial name
- ENGAGE (NCT05831176)
- Testing
- Dupilumab
- Where
- 53 sites in United States, Canada and 2 more
- Volunteers
- 22 people
- Sponsor
- Regeneron Pharmaceuticals
Ulcerative Colitis
A Study to Evaluate Etrasimod Treatment in Adolescents With Ulcerative Colitis
The purpose of this study is to determine the safety, efficacy, and pharmacokinetics (PK) of etrasimod for the treatment of moderately to severely active ulcerative colitis in adolescents (≥ 12 years up to < 18 years of age).
- Trial name
- NCT05287126
- Testing
- Etrasimod
- Where
- 47 sites in United States, Japan and 3 more
- Volunteers
- 36 people
- Sponsor
- Pfizer
Lupus Erythematosus, Scleroderma
Clinico-biological Collection to Investigate the Physiopathology of Systemic Autoimmune Diseases
The aim of this project is to start a biological and clinical collection of patients presenting systemic autoimmune disease. This collection will provide appropriate biological samples to identify new biomarkers and to be…
- Conditions
- Lupus Erythematosus, Scleroderma, Myositis, Vasculitis
- Trial name
- ESSAi (NCT05251415)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- University Hospital, Toulouse
Cholestasis, Psychomotor Disorders, Developmental
Preventing Cholestasis Using SMOFLipid®
Preterm infants of extreme low birth weight (ELBW, < 1000 gram birth weight) cannot immediately be nourished with mother´s or formula milk and are typically dependent on parenteral nutrition (PN) for a prolonged period of time.
- Trial name
- NCT01585935
- Testing
- SMOFLIPID, INTRALIPID
- Where
- Austria
- Volunteers
- 230 people
- Sponsor
- Medical University of Vienna
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
Ixabepilone in Treating Young Patients With Solid Tumors or Leukemia That Haven't Responded to Therapy
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: This phase I trial is studying the side effects and best dose of ixabepilone in treating young…
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Kidney Cancer
- Trial name
- NCT00030108
- Testing
- ixabepilone
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Irritable Bowel Syndrome, Food Allergy
Endomicroscopic Evaluation of Food-induced Gastrointestinal Mucosal Alteration
The overarching goal of this study is to establish a first ever registry in the U.S. to collect outcomes data to evaluate changes in the gastrointestinal (GI) mucosa following direct food application utilizing Confocal Laser…
- Trial name
- NCT06792838
- Testing
- Confocal Laser Endomicroscopy
- Volunteers
- 200 people
- Sponsor
- Cook Children's Health Care System
Crohn Disease
A Study to Evaluate the Efficacy, Safety, and Drug Levels of Oral Ozanimod in Pediatric Participants With Moderately to Severely Active Crohn's Disease With an Inadequate Response to Conventional Therapy
The purpose of this study is to evaluate the efficacy, safety, drug levels, and drug effects of ozanimod in pediatric participants with moderately to severely active Crohn's Disease.
- Trial name
- NCT05470985
- Testing
- Ozanimod
- Where
- 46 sites in United States, Australia and 7 more
- Volunteers
- 5 people
- Sponsor
- Bristol-Myers Squibb
Cholestasis, Children
Retrospective Review of CT and MR in Pediatric Patients With Cholestasis
The investigators will try to predict the risk of esophageal varices (EVs) in long-term BA survivors using noninvasive computed tomography (CT) or magnetic resonance (MR) indices and the measurement of transverse diameters of…
- Trial name
- NCT01252043
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Liver Cirrhosis
Dynamic Preload Parameters During Liver Transplantation
The arterial system compliance is compromised in liver cirrhotic patients. Dynamic preload variables are either pressure-based (e.g.pulse pressure variation; PPV), flow-based (e.g.
- Trial name
- NCT01971333
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Gastric Cancer, EBV Infection
Relationship of EBV-positive Gastric Cancer and Multiple Genes Associated With Gastric Carcinogenesis
The data of 460 gastric cancer patients who underwent curative gastrectomy with D2 lymph node dissection between January 2017 and February 2022 were analyzed.
- Conditions
- Gastric Cancer, EBV Infection, MSI
- Trial name
- NCT05604378
- Testing
- Gastrectomy
- Where
- South Korea
- Volunteers
- 460 people
- Sponsor
- Saint Vincent's Hospital, Korea
Non-Alcoholic Fatty Liver Disease
Measuring Fatty Liver With Ultrasound and MRS in Children With Overweight or Obesity
Obesity is associated with a variety of comorbidities, amongst which non-alcoholic fatty liver disease (NAFLD). A recent meta-analysis has shown that the prevalence of NAFLD in obese pediatric populations is around 35%, compared…
- Trial name
- NCT03787108
- Testing
- Magnetic resonance spectroscopy measurement
- Where
- Netherlands
- Volunteers
- 53 people
- Sponsor
- Maastricht University Medical Center
Rotavirus Infection, Viral Gastroenteritis Due to Rotavirus
Efficacy Study of Nitazoxanide Suspension in the Treatment of Rotavirus Disease in Children
The purpose of this study is to determine the effectiveness of nitazoxanide suspension compared to placebo in treating rotavirus disease in pediatric patients less than 6 years of age.
- Trial name
- NCT01328925
- Testing
- Nitazoxanide
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Romark Laboratories L.C.
Diarrhea, Gastrointestinal Infection
Wells and Enteric Disease Transmission
Approximately 40 million people in the US are served by private, and frequently untreated, wells. Our best estimate is that 1.3 million cases of gastrointestinal illnesses (GI) per year are attributed to consuming water from…
- Conditions
- Diarrhea, Gastrointestinal Infection, Respiratory Viral Infection, Waterborne Diseases
- Trial name
- WET (NCT04826991)
- Testing
- Active UV Device, Inactive UV Device
- Where
- United States
- Volunteers
- 908 people, healthy volunteers welcome
- Sponsor
- Temple University
Acute Appendicitis, Abscess
Water And Saline Head-to-head In The Blinded Evaluation Study Trial
Patients who are diagnosed with acute appendicitis consented and then randomized into two arms of the trial. In one arm, patients receive irrigation of the abdomen during surgery with normal saline, or salt water.
- Trial name
- WASHITBEST (NCT02714023)
- Testing
- Normal Saline, Sterile Water
- Where
- United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Non-Alcoholic Fatty Liver Disease
Fish Oil and Nonalcoholic Fatty Liver Disease (NAFLD) Study
Over the past 30 years, the prevalence of childhood obesity in the United States has tripled from 5% to 15%. Major consequences of obesity include insulin resistance, type- 2 diabetes, cardiovascular disease and nonalcoholic…
- Trial name
- NCT01285362
- Testing
- Fish Oil Supplementation
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Columbia University
Functional Gastrointestinal Disorders
Internet-delivered CBT for Children With Functional Gastrointestinal Disorders - an Open Pilot Study
This pilot-study aims to evaluate the effect size and feasibility of internet-delivered cognitive behavior therapy (ICBT) for children (age 8-12 years) with pain-predominant functional gastrointestinal disorders (e.g.
- Trial name
- NCT02475096
- Testing
- Internet-delivered CBT
- Where
- 2 sites in Sweden
- Volunteers
- 31 people
- Sponsor
- Karolinska Institutet
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