Clinical trials: Digestive Disorders
Anorexia Nervosa
Anorexia Nervosa and Its Effects on Brain Function, Body Metabolism and Their Interaction in Adolescents
The aim of the research project is to investigate the neurological, physiological and behavioral underpinnings associated with the development of anorexia nervosa in adolescents.
- Trial name
- AVAIN_JR (NCT05357053)
- Where
- Finland
- Volunteers
- 33 people
- Sponsor
- Turku University Hospital
Irritable Bowel Syndrome, Functional Abdominal Pain Syndrome
Peppermint Oil for the Treatment of Irritable Bowel Syndrome or Functional Abdominal Pain in Children: the MINT Study
Peppermint oil has shown to be effective in the treatment of Irritable Bowel Syndrome (IBS) symptoms in adults. Few studies of low quality are performed in an paediatric setting.
- Conditions
- Irritable Bowel Syndrome, Functional Abdominal Pain Syndrome, Child, Adolescent
- Trial name
- MINT (NCT05799053)
- Testing
- Small intestinal release peppermint oil, Peppermint sweets
- Where
- 3 sites in Netherlands
- Volunteers
- 228 people
- Sponsor
- St. Antonius Hospital
Gastrointestinal Disease, Gastrointestinal Bleeding
Blood Pressure During ESD is Related With the Postoperative Bleeding
Endoscopic submucosal dissection(ESD) is a prominent minimally invasive operation technique for treating early gastrointestinal tumor.
- Trial name
- NCT03070665
- Testing
- Norepinephrine
- Where
- China
- Volunteers
- 296 people
- Sponsor
- Shanghai Zhongshan Hospital
Lactation, Inflammatory Bowel Disease
A Study to Measure Mirikizumab Levels in Breast Milk of Lactating Participants Receiving Mirikizumab Therapeutically for an Approved Indication
The main purpose of this study is to assess the amount of mirikizumab in breast milk in women who are breastfeeding who are receiving stable maintenance doses of mirikizumab for an approved indication.
- Trial name
- NCT07612267
- Testing
- Mirikizumab
- Where
- 20 sites in United States, Canada and 5 more
- Volunteers
- 14 people
- Sponsor
- Eli Lilly and Company
Colorectal Cancer, Metastatic Cancer
Intravenous Compared With Intrahepatic Chemotherapy in Treating Patients With Colorectal Cancer Metastatic to the Liver
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00002692
- Testing
- fluorouracil, isolated perfusion, leucovorin calcium
- Where
- United Kingdom
- Volunteers
- 312 people
- Sponsor
- Medical Research Council
Pancreatitis
Non-inferiority of Pharmacological Prevention Alone Versus Pancreatic Stents to Prevent Post-ERCP Pancreatitis
Pancreatitis is the most important complication of ERCP. The severity of this condition varies from mild to severe and can lead to prolonged hospitalization, surgical interventions, and even death.
- Trial name
- NCT02368795
- Testing
- Pancreatic Stent, Indomethacin, Isosorbide Dinitrate
- Where
- Iran
- Volunteers
- 400 people
- Sponsor
- Tehran University of Medical Sciences
Non Alcoholic Fatty Liver Disease
Serum Pentraxin-3 in Non-alcoholic Fatty Liver Disease With or Without Hepatitis C Virus
This study included 70 subjects divided into 3 groups. Group I included 25 patients with NAFLD. Group II included 25 patients with NAFLD and chronic HCV. Group III: included 20 controls.
- Trial name
- NCT03276039
- Testing
- plasma pentraxin-3
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Infections, Rotavirus
Study of 2 Doses of HRV Vaccine Given Concomitantly or Separately With Routine Vaccinations in Healthy Infants in USA
The aim of this this study is to confirm absence of immune interference between HRV vaccine and routine infant vaccinations currently in use in the USA.
- Trial name
- NCT00334607
- Testing
- 2-dose oral live attenuated G1P[8] human rotavirus vaccine
- Where
- 42 sites in United States
- Volunteers
- 484 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Gastroenteritis
Triage Administration of Ondansetron for Gastroenteritis in Children
The investigators aim to assess whether ondansetron given at triage can reduce the number of patients requiring emergency department observation in children with acute gastroenteritis.
- Trial name
- NCT03052361
- Testing
- Ondansetron
- Where
- Canada
- Volunteers
- 81 people
- Sponsor
- St. Justine's Hospital
Decompensated Cirrhosis, Acute-On-Chronic Liver Failure
Albumin Infusion in Inpatients With Decompensated Cirrhosis
Albumin infusion in patients with hospitalized decompensated, even in short-term period use, could improve survival through the reduction of systemic inflammation, which is the main driver of acute-on-chronic liver failure in…
- Trial name
- NCT05719051
- Testing
- Albumin infusion
- Where
- China
- Volunteers
- 564 people
- Sponsor
- Ruijin Hospital
Pelvic Floor Disorders
Pelvic Floor Function Evaluation of Singleton Primiparae After Vaginal Delivery and Cesarean Section
Objective of this longitudinal observational cohort study was to analyze incidence of pelvic floor dysfunction (PFD) symptoms, including pelvic organ prolapse (POP), urinary incontinence (UI), and fecal incontinence (FI), seven…
- Trial name
- NCT02661867
- Testing
- delivery
- Volunteers
- 865 people
- Sponsor
- Brno University Hospital
Coeliac Disease
Interest of Urinary Measurement of Immunogenic Gluten Peptides (GIP) in the Follow-up of Pediatric Celiac Patients.
The main reason for insufficient control of celiac disease is non-adherence to the gluten-free diet (GFD), whether voluntary or involuntary. In children, involuntary exposures are common (canteens, snacks, restaurants).
- Trial name
- GIped (NCT07578038)
- Testing
- Urinary measurement of GIP, Usual follow-up and measurement of urinary GIP.
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Fondation Lenval
Eating Disorders, Binge Eating
Naltrexone Neuroimaging in Teens With Eating Disorders
Using a randomized, placebo-controlled, crossover study, this study will evaluate functional magnetic resonance imaging (fMRI) as a pharmacodynamic biomarker of opioid antagonism in adolescents with eating disorders.
- Conditions
- Eating Disorders, Binge Eating, Purging (Eating Disorders), Bulimia Nervosa
- Trial name
- NN-RCT (NCT05509257)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Mercy Hospital Kansas City
Celiac Disease
Comparison of Engerix B Vaccine Versus Sci-B-Vac Vaccine in Celiac Patients
Celiac disease and infection with hepatitis B virus (HBV) are very prevalent worldwide and carry a high morbidity rate. It has been recently shown that patients with celiac disease very often fail to develop immunity after…
- Trial name
- NCT01159457
- Testing
- Hepatitis B vaccination (Sci-B-Vac), Hepatitis B vaccination (EngerixB)
- Where
- Israel
- Volunteers
- 210 people
- Sponsor
- Shaare Zedek Medical Center
Brain and Central Nervous System Tumors, Kidney Cancer
Early Enteral Tube Feedings in Children Receiving Chemo for AML/MDS & High Risk Solid Tumors
RATIONALE: Tubefeeding may help maintain good nutrition and lessen weight loss in younger patients receiving chemotherapy for cancer.
- Conditions
- Brain and Central Nervous System Tumors, Kidney Cancer, Leukemia, Liver Cancer
- Trial name
- NCT00624962
- Testing
- nutritional intervention, therapeutic nutritional supplementation
- Sponsor
- Vanderbilt University
Cystic Fibrosis
Tissue Bank for Pulmonary Diseases
The aim of this research study is to collect and store the specimens that are left over after patients undergo tests ordered by their physicians.
- Trial name
- NCT00546962
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Boston Children's Hospital
Colitis, Ulcerative, Crohn Disease
Inflammatory Bowel Disease in South Eastern Norway
The IBSEN III study will investigate the incidence of inflammatory bowel disease in South Eastern Norway and describe the clinical course of the disease.
- Conditions
- Colitis, Ulcerative, Crohn Disease, Inflammatory Bowel Disease
- Trial name
- IBSENIII (NCT02727959)
- Where
- Norway
- Volunteers
- 2,286 people
- Sponsor
- Oslo University Hospital
Ulcerative Colitis
ABTECT-1 - ABX464 Treatment Evaluation for Ulcerative Colitis Therapy -1
This is a multicenter, randomized, placebo controlled study to evaluate the efficacy and safety of ABX464 given at 25 or 50 mg QD in inducing clinical remission in subjects with moderately to severely active ulcerative colitis…
- Trial name
- NCT05507203
- Testing
- ABX464
- Where
- 264 sites in United States, Argentina and 22 more
- Volunteers
- 639 people
- Sponsor
- Abivax S.A.
Hepatic Encephalopathy
S. Endotoxin, Inflammatory Mediators and MRS Before and After Treatment in MHE
The purpose of this study is to examine S.endotoxins , inflammatory mediators and Magnetic Resonance Spectroscopy (MRS) before and after treatment in patients of cirrhosis and minimal hepatic encephalopathy.
- Trial name
- endtxninHE (NCT01446523)
- Testing
- Lactulose
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Govind Ballabh Pant Hospital
Colorectal Cancer, Colorectal Adenoma
A Study on a Blood-based Dual-target Test for CRC Detection
To evaluate the effectiveness and accuracy of the ctDNA dual-target test kit in a large case-control cohort for the detection of colorectal cancer and advanced adenomas.
- Trial name
- NCT05508503
- Testing
- Test of methylated NTMT1 and MAP3K14-AS1, FIT
- Where
- China
- Volunteers
- 1,378 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
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