Clinical trials: Digestive Disorders
Cystic Fibrosis
Effectiveness of CFTR Modulators According to Co-therapy
Unless CFTR modulators are highly effective, the introduction of CFTR (Cystic fibrosis transmembrane conductance regulator) modulators could lead to concomitant reduction or discontinuation of respiratory co-therapies in…
- Trial name
- MODUCO (NCT05663255)
- Testing
- Discontinuation of respiratory co-therapy (azithromycin, RhDNase, or inhaled antibiotics)
- Volunteers
- 1,990 people
- Sponsor
- Hospices Civils de Lyon
Rectal Cancer
Flexible Colonoscope Assisted Hybrid Transanal Total Mesorectal Resection (taTME)
The investigators propose to use flexible endoscopy combined with transanal total mesorectal resection to further reduce anal injury.
- Trial name
- NCT06380855
- Testing
- Flexible colonoscope assisted hybrid transanal total mesorectal resection
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Sun Yat-sen University
Thymidine Kinase 2 (TK2)
A RETROspective Study of Patients With TK2d
This is a medical chart review study to collect information for patients who have been taking pyrimidine nucleosides for treatment of TK2 deficiency.
- Trial name
- RETRO (NCT03701568)
- Testing
- dC/dT
- Where
- 8 sites in United States, Israel and 1 more
- Volunteers
- 38 people
- Sponsor
- Zogenix MDS, Inc.
Hepatitis B
Anti-Hep B Antibodies at Age 9 to 10 Years After Hep B Vaccine at Birth and DTaP-IPV-Hep B-PRP-T Hexavalent Vaccine.
The aim of the study is to assess the persistence of anti-Hep B antibody at 9 to 10 years of age after the last priming dose in subjects who completed study A3L12 (NCT00401531), and also evaluate the immune response against…
- Trial name
- NCT02697474
- Testing
- Euvax B®: Hepatitis B vaccine
- Where
- 2 sites in Thailand
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Extraesophageal Reflux
Extraesophageal Reflux - Feasibility of Measurement of Pepsin in Saliva as a Diagnostic Option
The diagnostics of extraesophageal reflux (EER) is challenging. Currently, 24-h dual-probe esophageal pH monitoring or impedance is considered the best diagnostic method for EER.
- Trial name
- NCT03904758
- Testing
- Pepsin in saliva test
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- University Hospital Ostrava
Cystic Fibrosis
Treatment of Aspergillus Fumigatus (a Fungal Infection) in Patients With Cystic Fibrosis
This clinical trial will attempt to determine whether we can improve clinical outcomes for patients with cystic fibrosis who are infected with a fungus called Aspergillus fumigatus.
- Trial name
- NCT00528190
- Testing
- Itraconazole
- Where
- 2 sites in Canada
- Volunteers
- 35 people
- Sponsor
- Ottawa Hospital Research Institute
Diphtheria, Hepatitis B
Safety Study of a Vaccine Against Meningitis in Infants ( 2,4 & 6 Months Age) After a Birth Dose of Hepatitis B.
The purpose of this study is to compare the reactogenicity \& safety of Tritanrix™-HepB/Hib-MenAC vaccine to the international standard of care, Tritanrix™-HepB/Hiberix™.
- Conditions
- Diphtheria, Hepatitis B, Whole Cell Pertussis, Haemophilus Influenzae Type b
- Trial name
- NCT00317135
- Testing
- Tritanrix-HepB/Meningitec conjugate vaccine, Tritanrix/Hiberix vaccine
- Where
- Philippines
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Infantile Hypertrophic Pyloric Stenosis, Pyloromyotomy
Per-oral Pyloromyotomy for Treating Infantile Hypertrophic Pyloric Stenosis
Infantile hypertrophic pyloric stenosis (IHPS) is the most common condition for surgical treatment in infant. Traditionally, laparoscopic or open pyloromyotomy are the standard treatments.
- Trial name
- NCT04148040
- Testing
- G-POEM
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Zhongshan Hospital
Cholera (Disorder)
Ondansetron to Prevent Oral Rehydration Failure in Children With Cholera
This Phase IIa randomized controlled trial will evaluate whether a single oral dose of ondansetron can reduce oral rehydration failure in children and adolescents with suspected or confirmed cholera and active vomiting.
- Trial name
- NCT07795060
- Testing
- Ondansetron, Standard Cholera Care
- Where
- Republic of the Congo
- Volunteers
- 120 people
- Sponsor
- Public Interest Science Center
Hepatitis C
History of Hepatitis C in Volunteer Blood Donors
Hepatitis C is a disease of the liver caused by the Hepatitis C Virus (HCV). Patients with hepatitis C may feel well and show no signs or symptoms of being ill.
- Trial name
- NCT00001982
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Esophageal Achalasia
Quality of Life After POEM for Achalasia
Achalasia is an esophageal motility disorder, characterized by insufficient lower esophageal sphincter relaxation and loss of esophageal peristalsis.
- Trial name
- NCT05010889
- Testing
- Peroral endoscopic myotomy (POEM)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Colorectal (Colon or Rectal) Cancer, Pelvic Malignancies
Utero-ovarian Transposition in Patients With Pelvic Malignancies Undergoing Whole Pelvic Radiotherapy
This study is designed as a Phase I clinical trial enrolling female patients aged 18-40 years who have been diagnosed with pelvic malignancies requiring whole pelvic external radiation therapy (WPXRT) and who express interest in…
- Conditions
- Colorectal (Colon or Rectal) Cancer, Pelvic Malignancies, Oncofertility
- Trial name
- UOT WPXRT (NCT07419490)
- Testing
- Uteroovarian transposition
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of South Florida
Hepatitis B
Hepatitis B Antibody Persistence and Immune Response to Hepatitis B Vaccine Challenge in Previously Vaccinated Children
This study will evaluate the persistence of immunity to hepatitis B in healthy children aged 7 to 8 years, after previous vaccination with Infanrix hexa™ in the first two years of life, and also their ability to mount an immune…
- Trial name
- NCT01333813
- Testing
- Engerix-B™ Kinder
- Where
- 12 sites in Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Quality of Life (QOL), Tracheostomy
Feeding Difficulties and Quality of Life in Children With Tracheal Cannula
The over all goal of this observational study is to study if there is an association between the presence of feeding difficulties and self-assessed quality of life in children with tracheal cannula.
- Conditions
- Quality of Life (QOL), Tracheostomy, Children in the Pediatric Intensive Care Unit or General Pediatric Care Unit Requiring a Central Venous Catheter, Feeding Difficulties
- Trial name
- NCT06893458
- Where
- 2 sites in Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Prematurity of Fetus, Postnatal Growth Disorder
Early Versus Late Initiation of Feeding in Premature Growth Restricted Newborns With Absent or Reversed End Diastolic Flow On Umbilical Artery Doppler (AREDF)
The purpose of the study is to compare early versus late initiation of enteral feeding in premature growth restricted babies below the gestational age of 35 weeks born to mothers with prenatal absent or reversal of end diastolic…
- Trial name
- AREDF (NCT01367015)
- Testing
- Early Feeding, Late Feeding
- Where
- India
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences
Cystic Fibrosis
Evaluation of Patient Access to People With Cystic Fibrosis (CF) and Healthcare Professionals
Cystic fibrosis (CF) is one of the most common inherited conditions in the United Kingdom (UK). There are 10,810 people living with CF in the UK, with median predicted survival now 47 years old.
- Trial name
- NCT06122025
- Testing
- Patient Access
- Where
- United Kingdom
- Volunteers
- 102 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Cystic Fibrosis
Microbiome Acquisition and Progression of Inflammation and Airway Disease in Infants and Children With Cystic Fibrosis
Cystic Fibrosis (CF) is a fatal, recessive genetic disorder characterized by progressive inflammation and lung damage. It is unclear whether current treatment strategies, which focus on detection and eradication of pathogenic…
- Trial name
- NCT01661491
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yale University
GERD, Gastroesophageal Reflux
Compassionate Use of Domperidone for Refractory Gastroparesis
The purpose of this program is to allow the use of domperidone in children from 12 to 21 years of age with symptoms related to motility disorders and Gastroesophageal reflux disease (GERD) who have failed all the standard…
- Conditions
- GERD, Gastroesophageal Reflux, Gastroparesis
- Trial name
- NCT04699591
- Testing
- Domperidone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Jose Cocjin
Impaired Glucose Tolerance, Pre-diabetes
Study to Investigate the Pathophysiology of Type 2 Diabetes in Youth
The purpose of the study is to determine the role of beta-cell function and insulin resistance in the development of impaired glucose tolerance (IGT) and type 2 diabetes in children and adolescents who have an increased risk of…
- Conditions
- Impaired Glucose Tolerance, Pre-diabetes, Childhood Obesity, Insulin Resistance
- Trial name
- NCT00536250
- Where
- United States
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Yale University
Progressive Familial Intrahepatic Cholestasis (PFIC)
Open Label Study to Evaluate Efficacy and Long Term Safety of LUM001 (Maralixibat) in the Treatment of Cholestatic Liver Disease in Patients With Progressive Familial Intrahepatic Cholestasis
This is an open label study in children with Progressive Familial Intrahepatic Cholestasis (PFIC) designed to evaluate the safety and efficacy of LUM001, also known as Maralixibat (MRX).
- Trial name
- INDIGO (NCT02057718)
- Testing
- LUM001 (Maralixibat)
- Where
- 10 sites in United States, France and 2 more
- Volunteers
- 33 people
- Sponsor
- Mirum Pharmaceuticals, Inc.
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