Clinical trials: Digestive System Cancer
Colorectal Carcinoma
Clinicopathological Value of p16 Expression in Colorectal Carcinoma
Evaluation of the immunohistochemical expression of p16 in colorectal carcinoma and correlate its expression to different clinical and pathological parameters as patients' ages, sexes, tumor location, histopathological phenotype…
- Trial name
- NCT07047482
- Testing
- Immunohistochemical staining
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
H.Pylori, Gastric Cancer
Helicobacter Pylori Infection and Gastric Disease in Bhutan: First Community-Wide, Population-Based Study
Background: Helicobacter pylori is a major risk factor for gastric cancer, yet in many developing countries, including Bhutan where gastric cancer incidence is high, access to screening and eradication is limited.
- Conditions
- H.Pylori, Gastric Cancer, H Pylori Eradication
- Trial name
- NCT07211880
- Testing
- Rabeprazole Sodium, Amoxicillin Hydrate, Clarithromycin, Upper gastrointestinal endoscopy for the H. pylori and serum pepsinogen positive individuals (high risk group of gastric cancer), Urea Breath Test for the prevalence of H pylori
- Where
- Bhutan
- Volunteers
- 1,043 people, healthy volunteers welcome
- Sponsor
- Zero Helicobacter IGAN Network
Gastric Neoplasm
A Trial to Evaluate Para-aortic Lymphadenectomy for Gastric Cancer
To evaluate the survival benefit of para-aortic lymphadenectomy in potentially curative gastrectomy
- Trial name
- NCT00149279
- Testing
- Surgery: D2 dissection, Surgery: D2+paraaortic dissection
- Where
- Japan
- Volunteers
- 520 people
- Sponsor
- Japan Clinical Oncology Group
Colon Cancer
Cancer Control Following Polypectomy
This study evaluates strategies for the surveillance of post-polypectomy patients for the control of bladder cancer
- Trial name
- NCT00591279
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Neuroendocrine Tumors, Progression
Everolimus 5 mg vs 10 mg/Daily for Patients With Neuroendocrine Tumors
Everolimus is approved in many countries to treat patients with advanced/metastatic well-differentiated neuroendocrine tumors (NET), providing median progression-free survival times of approximately 12 months across different…
- Conditions
- Neuroendocrine Tumors, Progression, Neuroendocrine Tumor Grade 1, Neuroendocrine Tumor Grade 2
- Trial name
- EVENET (NCT06472388)
- Testing
- Everolimus 5 MG
- Where
- 2 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- AC Camargo Cancer Center
Ulcerative Colitis, Anti TNF Therapy
The Influence of Biologcal Treatment on the Short-Term Complications of Surgery in Patients With Inflematory Bowel Disease.
BACKGROUND: Previous studies of short-term surgical outcomes after preoperative exposure to anti-TNF therapy in ulcerative colitis (UC) patients who have undergone IPAA have been conflicting.
- Conditions
- Ulcerative Colitis, Anti TNF Therapy, Ileal Pouch Anal Anastomosis (IPAA)
- Trial name
- NCT03747068
- Testing
- Anti-TNF Drug
- Volunteers
- 130 people
- Sponsor
- HaEmek Medical Center, Israel
Congenital Biliary Dilatation
Congenital Biliary Dilatation Diagnosis Based on 3D Morphological Characteristics
Congenital biliary dilatation necessitates timely intervention owing to potential complications. This study endeavors to enhance diagnostic precision using quantitative three-dimensional morphological characteristics.
- Trial name
- NCT06162520
- Testing
- Contrast-enhanced computed tomography (CECT) and 3D morphological analysis
- Where
- China
- Volunteers
- 550 people
- Sponsor
- Tsinghua University
Zhejiang University
Split or Whole Liver Transplantation? A Multicenter Retrospective Cohort Study of Patients With Benign and Malignant Liver Disease
The primary objective of this study was to assess the safety and feasibility of split liver transplantation(SLT) for adult hepatocellular carcinoma (HCC) patients, while comparing the prognostic disparities between adult SLT and…
- Trial name
- NCT06359496
- Testing
- No intervention factor
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Liver Cancer, Recurrence
Factors Influencing the 3-Year Recurrence of Liver Carcinoma After Surgery
Objective: 1. To study the factors that influence the 3- year recurrence of liver carcinoma after surgery 2. To study the related factors affecting recurrence of liver carcinoma after surgery
- Trial name
- NCT02941861
- Testing
- Recurrence Rate of HCC after surgery, Recurrence Rate of CCA after surgery
- Volunteers
- 67 people
- Sponsor
- Ruechuta Molek
Liver Neoplasms, Adenoma
Liver MRI With Primovist/Eovist in Pediatric Subjects Who Are Suspected or Have Focal Liver Lesions.
Medical records are reviewed to obtain information about the use of a MRI diagnostic imaging agent (contrast agent) called Primovist/Eovist in children older than 2 months and less than 18 years.
- Conditions
- Liver Neoplasms, Adenoma, Carcinoma, Liver Abscess
- Trial name
- NCT01043523
- Testing
- Gadoxetic Acid Disodium (Eovist, BAY86-4873)
- Where
- 9 sites in United States, Italy and 3 more
- Volunteers
- 52 people
- Sponsor
- Bayer
Gastrointestinal Stromal Tumor
Imatinib Mesylate in Treating Patients With Gastrointestinal Stromal Tumor That Has Been Completely Removed During Surgery
This phase II trial is studying how well imatinib mesylate works in treating patients with gastrointestinal stromal tumor that was completely removed during surgery.
- Trial name
- NCT00025246
- Testing
- imatinib mesylate, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- National Cancer Institute (NCI)
Esophageal Neoplasms
Angiogenesis Inhibitor Plus Anti-PD-1/PD-L1 Antibody in Advanced Esophageal Cancer
The combination of an anti-PD-1/PD-L1 antibody with an angiogenesis inhibitor has shown efficacy in many cancers.The purpose of this study is to confirm that the combination of these two drugs can benefit patients with advanced…
- Trial name
- AIPAAIAEC (NCT05349045)
- Testing
- an anti-PD-1/PD-L1 antibody plus an angiogenesis inhibitor
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Gastric Cancer
A Novel Online Calculator to Predict Long-term Survival and Recurrence Risk of Patients With Gastric Adenocarcinoma
This study aimed to develop a novel Prognostic Oxidative Stress-Immune-Inflammatory Score (POSII Score) and introduce an innovative online calculator designed to predict long-term survival and assess the recurrence risk of…
- Trial name
- NCT06337266
- Where
- China
- Volunteers
- 3,622 people
- Sponsor
- Fujian Medical University
Eosinophilic Esophagitis (EoE)
BURDEN OF ESOPHAGEAL CANCER IN EOSINOPHILIC ESOPHAGITIS (ESCAPE STUDY)
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated inflammatory disorder of the esophagus that can lead to symptoms such as dysphagia and food impaction.
- Trial name
- ESCAPE (NCT07102329)
- Where
- Italy
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Esophageal Cancer
Adjuvant Radiotherapy for pT1b Esophageal Cancer After Submucosal Endoscopic Resection
Endoscopic Resection (ER) is a crucial therapeutic and diagnostic method for superficial esophageal cancer. However, lymph node metastasis rate in pT1b patients is relatively high.
- Trial name
- NCT05499195
- Where
- China
- Volunteers
- 159 people
- Sponsor
- Chinese Academy of Medical Sciences
Duodenal, Gastrointestinal Stromal Tumors
Development and External Validation of a Prognostic Model for DFS After Curative Resection of Duodenal GIST
Gastrointestinal stromal tumour (GIST) is the most common mesenchymal neoplasm of the digestive tract, originating from the interstitial cells of Cajal.
- Trial name
- NCT07837271
- Where
- 2 sites in China
- Volunteers
- 288 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Colorectal Cancer
Translation of Colorectal Cancer Screening Guidelines to Practice: A System Intervention
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the United States. Results from randomized clinical trials and intervention studies have suggested that implementation of a CRC screening program for…
- Trial name
- NCT00122187
- Testing
- Electronic Consult System
- Where
- 9 sites in United States
- Volunteers
- 8 people
- Sponsor
- US Department of Veterans Affairs
Early Gastric Cancer
Gastric Cancer Screening and Alarm Symptoms in Early Gastric Cancer
Most of the early gastric cancer are asymptomatic. Symptoms of advanced gastric cancer are weight loss, abdominal pain, nausea, vomiting, anorexia dysphagia, gastrointestinal bleeding.
- Trial name
- NCT01659632
- Where
- South Korea
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Familial Adenomatous Polyposis
Small Bowel Endoscopic Evaluation in Familial Adenomatous Polyposis (FAP)
Background and study aim The relative risks of duodenal adenocarcinoma and ampullary carcinoma in Familial Adenomatous Polyposis (FAP) have been estimated 100 to 330 times higher than in general population.
- Trial name
- NCT02656134
- Testing
- Duodenoscopy and enteroscopy, Molecular analysis.
- Where
- Brazil
- Volunteers
- 55 people
- Sponsor
- University of Sao Paulo
Adenomatous Polyposis Coli
Influence of Sulindac and Probiotics on the Development of Pouch Adenomas in Patients With Familial Adenomatous Polyposis
The purpose of this study is to determine whether sulindac and VSL#3 - inulin, either combined or alone, are effective in treating or preventing adenoma development in the ileal anal pouch in patients with familial adenomatous…
- Trial name
- NCT00319007
- Testing
- Sulindac (drug), VSL#3 (probiotic), Inulin (probiotic)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
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