Clinical trials: Digestive Tract Diseases
Cystic Fibrosis
Air Pollution and Children With Cystic Fibrosis
1. To determine personal exposure to air pollution in children with cystic fibrosis; 2. To determine airway macrophage uptake of inhaled particulate matter in cystic fibrosis children; 3.
- Trial name
- NCT03853629
- Testing
- None. Not applicable
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Gastrointestinal Disease, Esophageal Cancer
PMRR-NO: Pulmonary Metabolic Radiation Response Versus Exhaled Nitric Oxide
The goal of this clinical research study is to use a new breathing test that measures the amount of nitric oxide (NO) you exhale.
- Conditions
- Gastrointestinal Disease, Esophageal Cancer, Lung Cancer
- Trial name
- NCT00867477
- Testing
- Breathing Test, Respiratory Symptoms Questionnaire, Pet Scan
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- M.D. Anderson Cancer Center
Progressive Familial Intrahepatic Cholestasis (PFIC)
A Study to Evaluate the Efficacy and Safety of Maralixibat in Subjects With Progressive Familial Intrahepatic Cholestasis (MARCH-PFIC)
The purpose of this study is to determine whether the investigational treatment (maralixibat) is safe and effective in pediatric participants with Progressive Familial Intrahepatic Cholestasis (PFIC).
- Trial name
- MARCH-PFIC (NCT03905330)
- Testing
- Maralixibat
- Where
- 31 sites in United States, Argentina and 15 more
- Volunteers
- 93 people
- Sponsor
- Mirum Pharmaceuticals, Inc.
Pregnancy Related, Cystic Fibrosis
Prospective Study of Pregnancy in Women With Cystic Fibrosis
In this study, the investigators aim to evaluate changes in lung function in women with cystic fibrosis (CF) during pregnancy and for 2 years after pregnancy based on exposure to highly effective cystic fibrosis transmembrane…
- Trial name
- MAYFLOWERS (NCT04828382)
- Where
- 40 sites in United States
- Volunteers
- 285 people
- Sponsor
- Amalia Magaret
Alpha-1-antitrypsin Deficiency
Czech AATD Registry
Alpha-1-antitrypsin deficiency is the most common congenital disease of the respiratory system, leading to early pulmonary emphysema or bronchiectasis. Pulmonary involvement significantly accelerates active cigarette smoking.
- Trial name
- NCT05178277
- Where
- Czechia
- Volunteers
- 300 people
- Sponsor
- Thomayer University Hospital
Cholangitis, Secondary Biliary, Treatment Compliance
Antibiotics Treatment of Cholangitis Post-Kasai Portoenterostomy
Application of multi-center, prospective study on the severity of postoperative cholangitis biliary atresia classification, according to the degree of cholangitis targeted therapy, to improve the therapeutic effect of…
- Conditions
- Cholangitis, Secondary Biliary, Treatment Compliance, Antibodies Drug Specific
- Trial name
- NCT04370145
- Testing
- Sulperazon, Teicoplanin, Meropenem Injection
- Where
- 2 sites in China
- Volunteers
- 160 people
- Sponsor
- Tongji Hospital
Cystic Fibrosis
Natural History Study of Exocrine Pancreatic Function in Infants With Cystic Fibrosis (CF)
The purpose of the study is to evaluate the natural history of exocrine pancreatic function by assessing Fecal elastase-1 (FE-1) in infants with CF during their first year of life.
- Trial name
- NCT06506773
- Where
- 50 sites in United States, Australia and 9 more
- Volunteers
- 79 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Alagille Syndrome
Characterization of Pulmonary Artery Stenoses in Alagille Syndrome - a Medical Record Review
Patients who have Alagille Syndrome (AGS) also frequently have blockages (or "stenoses") of their pulmonary arteries. Little is known about the degree or variability of these stenoses, or the effect of this disease on the right…
- Trial name
- NCT01515631
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Stanford University
Colitis, Ulcerative, Crohn Disease
Unraveling a Potential Connection Between Bilirubin Metabolism, Gut Microbiota and Inflammatory Bowel Diseases
Inflammatory Bowel Diseases (IBDs) are a set of recurrent inflammatory conditions that include the colon and small intestine. The two principal conditions include Crohn's disease (CD) and ulcerative colitis (UC).
- Trial name
- NCT03841045
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Diphtheria, Tetanus
Study of the Booster Effect of DTaP-IPV-Hep B-PRP~T Combined Vaccine or Infanrix Hexa™ and Prevenar™ in Healthy Infants
This is a follow-up of the primary series vaccination schedule in Study A3L24 (NCT01177722). The objectives are: To describe the antibody persistence to any antigen contained in the investigational DTaP-IPV-Hep B-PRP-T vaccine…
- Conditions
- Diphtheria, Tetanus, Whooping Cough, Hepatitis B
- Trial name
- NCT01444781
- Testing
- DTaP-IPV-Hep B-PRP~T combined vaccine + Pneumococcal polysaccharide, DTaP-Hep B-IPV // Hib Vaccine + Pneumococcal polysaccharide, DTaP-IPV-Hep B-PRP~T + Pneumococcal polysaccharide vaccine
- Where
- 2 sites in Colombia, Costa Rica
- Volunteers
- 1,106 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Obesity, Intestinal Bacteria Flora Disturbance
Study on Dietary Nutrition Intervention Techniques for Children Obesity
With the rapid development of society and economy, children's simple obesity is the rising in the world and has become a chronic disease which is one of the biggest public health challenges in the world.
- Conditions
- Obesity, Intestinal Bacteria Flora Disturbance, Body Weight
- Trial name
- NCT02539836
- Testing
- Dietary nutrition based on plant fermentation extract, MRI in quantifying liver fat with MRS
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
Thymoma, Stomach Neoplasms
Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma
Background: Malignant mesothelioma is a malignancy arising from the mesothelial cells of the pleura, peritoneum, pericardium, or tunica vaginalis. Mesothelioma accounts for 0.10% of deaths annually in the United States.
- Conditions
- Thymoma, Stomach Neoplasms, Pancreatic Neoplasms, Mesothelioma
- Trial name
- NCT01950572
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Cancer Institute (NCI)
Probiotics Infant Formula, Infants Health
The Impact of Infant Formula With Probiotics on Infants Health
The trial will be divided into three groups, the experimental group: (I) probiotic A formula, (II) probiotic B formula; control group: (III) regular formula (Youluck infant formula).
- Trial name
- NCT03993301
- Testing
- Probiotic A formula, Probiotic B formula, Regular formula
- Where
- Taiwan
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Cholestasis, Cholestasis of Parenteral Nutrition
Compassionate Use of an Intravenous Fish Oil Emulsion in the Treatment of Liver Injury in Infants
To provide a mechanism for critically ill infants with parenteral nutrition (PN) associated cholestasis to receive Omegaven for compassionate use situations for which there are no satisfactory alternative treatments.
- Trial name
- NCT00738101
- Testing
- Omegaven
- Where
- 2 sites in United States
- Volunteers
- 293 people
- Sponsor
- Baylor College of Medicine
Cystic Fibrosis
Safety, Tolerability and Pharmacokinetics of Tiotropium in Cystic Fibrosis Patients
Study to obtain information about the safety and tolerability of tiotropium bromide administered via the Respimat® inhalation device in pediatric (≤11 y.o.) and adolescent/adult (≥12 y.o.) cystic fibrosis (CF) patients after…
- Trial name
- NCT02172534
- Testing
- Tiotropium bromide low, Tiotropium bromide medium, Tiotropium bromide high
- Volunteers
- 113 people
- Sponsor
- Boehringer Ingelheim
Chronic Respiratory Disease, Cystic Fibrosis
The Effect of Proprioceptive Neuromuscular Facilitation (PNF) Technique for Children With Chronic Pulmonary Diseases.
Cystic fibrosis and bronchiectasis are the most seen problems in children with chronic pulmonary diseases. İt is a genetic, chronic system disease that reduces life expectancy, and life quality as well.
- Conditions
- Chronic Respiratory Disease, Cystic Fibrosis, Bronchiectasis
- Trial name
- NCT03420209
- Testing
- Group applying PNF technique
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul University
Cystic Fibrosis
A Study Evaluating the Efficacy and Safety of VX-445/Tezacaftor/Ivacaftor in Cystic Fibrosis Subjects, Homozygous for F508del
This study will evaluate the efficacy, safety, and pharmacodynamics of elexacaftor (ELX, VX-445) in triple combination (TC) with tezacaftor (TEZ) and ivacaftor (IVA) in subjects with cystic fibrosis (CF) who are homozygous for…
- Trial name
- NCT04105972
- Testing
- ELX/TEZ/IVA, TEZ/IVA, IVA
- Where
- 35 sites in Australia, Belgium and 2 more
- Volunteers
- 176 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Cystic Fibrosis, Healthy Subjects
Evaluation of Nebulization and Positive Expiratory Pressure Combination
The purpose of this study is to compare the efficiency of nebulization and positive expiratory pressure combination
- Trial name
- NCT02535130
- Testing
- Positive expiratory pressure, amikacine nebulization
- Where
- Belgium
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Cystic Fibrosis
Nasal Potential Difference (NPD) for the Diagnosis of Cystic Fibrosis
The purpose of this research study is to provide a novel method for the diagnosis of Cystic Fibrosis (CF). This protocol is designed to test the ability of the cells to regulate the movement of salt and water in people with…
- Trial name
- NCT00589745
- Testing
- Nasal potential difference measurement
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Children's Hospital of Philadelphia
ALS, Amyotrophic Lateral Sclerosis
A Study to Explore the Role of Gut Flora in ALS
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding ALS
- Conditions
- ALS, Amyotrophic Lateral Sclerosis, Motor Neuron Disease
- Trial name
- NCT04150809
- Testing
- No intervention
- Where
- United States
- Sponsor
- ProgenaBiome
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