Clinical trials: Diminished Pleasure
Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP)
French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy Controls
The goal of this study is to learn whether people living with severe psychiatric disorders can be grouped into more homogeneous subgroups, across usual diagnostic categories, based on two key dimensions: social withdrawal and…
- Conditions
- Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP), Bipolar Disorder (BD), Major Depressive Disorder (MDD
- Trial name
- FRENCH-MINDS (NCT07881016)
- Testing
- 3T Brain MRI, Biological Sampling, Clinical, Cognitive and Digital Assessments
- Where
- 17 sites in France
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fondation FondaMental
ASD
Proof of Mechanism Study for the Treatment of Social Anhedonia in ASD
This project will use the experimental medicine approach of a Phase IIa Proof of Mechanism 16-week, randomized, double-blind, controlled trial of L-DOPA versus placebo administration in combination with a 16 week social skills…
- Trial name
- ACEP4 (NCT03243552)
- Testing
- Social Skills Training
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Anhedonia
Examining Reward-Related Predictors and Mechanisms of Change in BA Treatment for Anhedonic Adolescents
The prevalence of major depressive disorder (MDD) is relatively low in childhood (i.e., 1-3%), but increases substantially during adolescence.
- Trial name
- NCT02498925
- Testing
- Behavioral Activation
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Anhedonia, Stress Response
Stress Trajectories and Anhedonia in Adolescence Research Study
This project will examine how multiple biological measures from the brain and the body's stress response system contribute to anhedonia (the loss of pleasure) in adolescence.
- Conditions
- Anhedonia, Stress Response, Adolescent Development
- Trial name
- STAARS (NCT07040449)
- Testing
- Montreal Imaging Stress Task, Trier Social Stress Test for Children
- Where
- United States
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Conduct Disorder, Depression
Anhedonia Beyond Depressive Symptoms in Children and Adolescents With Conduct Disorder
Conduct Disorder (CD) is a common psychiatric disorder among children and adolescents and is characterized by a persistent pattern of behaviors that violate the rights of others or major age-appropriate social norms and rules.
- Trial name
- NCT07849985
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University