Clinical trials: Disabilities, Intellectual
Down Syndrome
A Study of RO5186582 in Down Syndrome Among Children 6 to 11 Years of Age
This study will evaluate the safety, tolerability, efficacy, and pharmacokinetic and pharmacodynamic activity of 3 different dosages of RO5186582 compared with placebo.
- Trial name
- NCT02484703
- Testing
- RO5186582
- Where
- 9 sites in United States
- Volunteers
- 45 people
- Sponsor
- Hoffmann-La Roche
Down Syndrome, Intellectual Disability
Down Syndrome Memantine Follow-up Study
The purpose of this research study is to learn if the medication Memantine Hydrochloride (the study medication) can help adolescents and young adults with Down syndrome. Dr.
- Trial name
- NCT02304302
- Testing
- Memantine
- Where
- 2 sites in United States, Brazil
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Down Syndrome,Auxological Indexes, Auxological Parametars, Intrauterine Growth Restriction
Indicators of Growth, Nutritional Status and Comorbide Disorders of Newborns With Down Syndrome
Objective To access predictive values of the auxological parameters and indexes for risk of comorbid malformations in newborns with Down syndrome (DS) Study design In this cohort retrospective study, 141 newborns with proven…
- Trial name
- DownSy (NCT03553706)
- Where
- Croatia
- Volunteers
- 141 people
- Sponsor
- University Hospital of Split
Fragile X Syndrome
A Randomized Study of BPN14770 in Male Adolescents (Aged 9 to < 18 Years) With Fragile X Syndrome
This is a 2-part study, with each part having a unique set of objectives for male adolescents aged 9 to < 18 years with fragile X syndrome (FXS).
- Trial name
- NCT05163808
- Testing
- zatolmilast
- Where
- 17 sites in United States
- Volunteers
- 163 people
- Sponsor
- Tetra Discovery Partners
Down Syndrome
Impact of an Orthotic Garment on Gross Motor Skills for Infants With Down Syndrome
Infants with Down syndrome (DS) develop slower than their typically developing peers. Physical therapist (PT) supervised home programs have the potential to optimize gross motor development in a financially feasible way.
- Trial name
- NCT04603352
- Testing
- Hip Helpers home program
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of St. Augustine for Health Sciences
Down Syndrome
the Effect of Cerebrolysin on Physical and Mental Functions of Down Syndrome
Down syndrome is a genetic disorder that causes delay in both physical growth and mental development. It is the most frequently reported chromosomal abnormality and the most common genetic syndrome.
- Trial name
- NCT04751136
- Testing
- cerebrolysin
- Where
- Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Mansoura University Children Hospital
X-Linked Adrenoleukodystrophy
A Study to Prospectively Assess Disease Progression in Male Children With X-ALD
This is a non-interventional, multi-center study that follows general principles of periodic assessment of X-ALD patients in routine practice.
- Trial name
- NCT03278899
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- NeuroVia, Inc.
Abnormalities, Failure to Thrive
Evaluation of Patients With Unresolved Chromosome Abnormalities
The purpose of this research is to study a new way to test for chromosome abnormalities. Chromosomes are strands of DNA (the genetic material in the cell nucleus) that are made up of genes-the units of heredity.
- Conditions
- Abnormalities, Failure to Thrive, Mental Retardation, Microcephaly
- Trial name
- NCT00001639
- Where
- United States
- Volunteers
- 263 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Down Syndrome
Effects of Dohsa Hou Exercises on Functional Mobility
Trisomy 21 is a condition where there's an extra chromosome 21, which leads to a set of clinical signs called Down syndrome. Down syndrome is one of the most complicated genetic conditions that can occur post-term and is the most…
- Trial name
- NCT06131099
- Testing
- Dohsa hou exercises, Standard treatment protocal
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Dyslexia, Developmental, Developmental Language Disorder
Intervention Effectiveness Study of BEtter AT LEarning (BEATLE)- Digital Neuropsychological Rehabilitation Program
The purpose of this study is to evaluate the effectiveness of BEATLE with clinical samples of patients diagnosed with Developmental Language Disorder (DLD), Dyslexia, and Mixed Specific Developmental Disorder.
- Conditions
- Dyslexia, Developmental, Developmental Language Disorder, Specific Learning Disorder, Borderline Intellectual Functioning
- Trial name
- BEATLE (NCT06713863)
- Testing
- BEtter AT LEarning (BEATLE)- Digital Care Pathway
- Where
- 2 sites in Finland
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Down Syndrome
Effects of Core Stability Exercises With and Without Treadmill Training on Balance in Children With Down Syndrome
To find the effects of core stability exercises with and without treadmill training on balance in children with down syndrome
- Trial name
- NCT05460910
- Testing
- core stability exercises with treadmill, core stability exercise without treadmill
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- Riphah International University
Down Syndrome
Visual Perception Intervention Programmes Impact on Down Syndrome Affiliate Children's Fine Motor and Visual Perception.
A second copy of chromosome 21 results in Trisomy 21, a genetic disorder commonly referred to as Down syndrome. In addition to physical traits like low muscular tone, upward-slanting eyes, and a flat facial profile, this extra…
- Trial name
- NCT06531213
- Testing
- experimental, controlled
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Mild Intellectual Disability
Comparison of Orthodontic Aligner Treatment Protocols Managed Through Remote Monitoring Versus In-Person Care
This study aims to assess patient adherence to orthodontic treatment with dental aligners delivered through remote monitoring compared with in-person care.
- Trial name
- NCT07413003
- Testing
- Remotely monitored orthodontic aligner treatment, In-person monitored orthodontic aligner treatment
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Oasi Research Institute-IRCCS
Intellectual Disability, Speech and Language Disorder
Early Augmentative and Alternative Communication (AAC) Intervention Delivered Via Hybrid Telehealth
The goal of this mixed methods study aims to develop and pilot test an augmentative and alternative communication (AAC) intervention for toddlers with intellectual and developmental disabilities (IDD) and their families.
- Trial name
- NCT05743439
- Testing
- Early Augmentative and Alternative Communication (AAC) Intervention
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Mucopolysaccharidosis Type I, Mucopolysaccharidosis Type II
Longitudinal Studies of Brain Structure and Function in MPS Disorders
Neurobehavioral function and quality of life are compromised in many patients with mucopolysaccharidosis (MPS) disorders. The long-term goals of this research are to: 1) more accurately inform patients/parents regarding potential…
- Conditions
- Mucopolysaccharidosis Type I, Mucopolysaccharidosis Type II, Mucopolysaccharidosis Type VI, Mucopolysaccharidosis Type IV
- Trial name
- NCT01870375
- Where
- 4 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- University of Minnesota
Down Syndrome
Assessing Malleability of Spatial Abilities in Down Syndrome
Based on available literature and our own preliminary research, the researchers have concluded that persons with Down syndrome (DS) exhibit difficulties in utilizing the specific spatial abilities of mental rotation and…
- Trial name
- NCT05332912
- Testing
- Spatial Ability Experience
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa
Rett Syndrome
Effects of Creatine Supplementation in Rett Syndrome
Creatine supplementation in RTT: a randomized controlled trial Rett Syndrome (RTT) is a neurodevelopmental disorder characterised by apparently normal early development (stage 1 of RTT) followed by loss of purposeful hand use…
- Trial name
- NCT01147575
- Testing
- Creatine monohydrate
- Where
- Austria
- Volunteers
- 21 people
- Sponsor
- Medical University of Vienna
Intellectual Disability, Variable, Autism Spectrum Disorder (ASD)
School-Based Sensory Processing and Daily Living Skills-Focused Occupational Therapy Program
This study aims to develop and evaluate a school-based occupational therapy program focused on sensory processing and activities of daily living for children with Autism Spectrum Disorder and Intellectual Disability.
- Trial name
- NCT07326267
- Testing
- Individual School-Based Occupational Therapy Sessions, Sensory Preparation Using Proprioceptive, Vestibular, and Tactile Input, Task-Oriented Activities of Daily Living Training
- Volunteers
- 40 people
- Sponsor
- Çankırı Karatekin University
Lysosomal Storage Disease, Peroxisomal Disorder
Reduced-Intensity Hematopoietic Stem Cell Transplant for High Risk Lysosomal and Peroxisomal Disorders
This study is designed to test the ability to achieve donor hematopoietic engraftment while maintaining low rates of transplant-related mortality (TRM) in patients with high-risk lysosomal and peroxisomal disorders using a novel…
- Trial name
- NCT01626092
- Testing
- Campath-1H, Clofarabine, Melphalan
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Intellectual Disabilities (F70-F79)
North Health in Intellectual Disability
Intellectual disability (ID) is a diagnosis characterized by significant limitations both in intellectual functioning and in adaptive behavior as expressed in conceptual, social and practical adaptive skills.
- Trial name
- NOHID (NCT03889002)
- Where
- Norway
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway