Clinical trials: Disability Evaluation
Developmental Disabilities
The Investigation of Children With Developmental Delay and Children's Rehabilitation Common Case
Children with developmental disabilities and children's rehabilitation common case investigation: Long-term follow-up study.
- Trial name
- NCT02686931
- Where
- Taiwan
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Shoulder Pain, Shoulder Mobility Impairment
Burden and Outcome of Shoulder Disorders in Primary Health Care
Consumption of medical care and outcome of shoulder pain and disability in primary care.
- Trial name
- NCT01300091
- Where
- Finland
- Sponsor
- Central Finland Hospital District
Quality of Life
Assessment of Oral Health Related Quality of Life After Full Mouth Rehabilitation Under GA
To assess Oral health related quality of life (OHRQOL) after full mouth rehabilitation under GA in a group of Egyptian children with special healthcare need.
- Trial name
- NCT03497312
- Testing
- full mouth rehabilitation
- Volunteers
- 14 people
- Sponsor
- Cairo University
Autism Spectrum Disorder, Autism
Treatment Monitoring in Autism Spectrum Disorder (ASD) in Children
The goal of this clinical study is to learn about the utility and performance of the EarliPoint(™) System: Evaluation for Autism Spectrum Disorder to monitor changes in a child's verbal ability, non-verbal learning, and social…
- Conditions
- Autism Spectrum Disorder, Autism, Developmental Delay, Autism, Early Infantile
- Trial name
- MEASURE-ASD1 (NCT05675371)
- Testing
- Assessment by Expert Clinician During Behavioral Intervention (ABA or similar), Assessment by the EarliPoint Assessment For Autism Spectrum Disorder
- Where
- 9 sites in United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- EarliTec Diagnostics, Inc
Physical Activity, Social Responsibility
Imitation-based Dog Assisted Intervention, for Children With Developmental Disabilities.
This R21 application will provide a multidisciplinary One Health approach to DAID physical activity intervention for adolescents with developmental disabilities and their family dog.
- Trial name
- NCT03462407
- Testing
- DAID, Dog walking
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Oregon State University
Down Syndrome, Chromosome Abnormalities
Down Syndrome - Comparison of Screening Methods in the 1st and 2nd Trimesters
Too much or too little genetic information (chromosome material) can cause abnormal development of the fetus or death. Each year approximately 2.5 million pregnant women are screened for Down Syndrome using invasive screening…
- Trial name
- NCT00006445
- Testing
- Ultrasound, Serum screen
- Where
- 10 sites in United States
- Volunteers
- 38,000 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Dyslexia
Evaluation of Speech Rhythm Training in Dyslexic Readers Aged 7 to 9 Years
Studies of dyslexia have shown altered oscillatory activity in the low gamma band (~25-35 Hz) in the left auditory cortex. Neural oscillations around 30 Hz constitute the basic sampling rate of speech, from which the ability to…
- Trial name
- RnDys (NCT05996497)
- Testing
- behavioral measures, Electrophysiological measures, Training 1
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Institut Pasteur
Multiple Sclerosis, Pathologic Processes
Disability, MRI Lesions and Thickness of Retinal Fibers: Evaluation 15 Years After a First Episode of Demyelination
Knowledge of the evolution of multiple sclerosis (MS) and its long-term prognostic factors is essential to guide the therapeutic management.
- Conditions
- Multiple Sclerosis, Pathologic Processes, Tomography, Optical Coherence, Magnetic Resonance Imaging
- Trial name
- DB-SEP15 (NCT03268096)
- Testing
- Cerebral MRI and Optical Coherence Tomography
- Where
- France
- Volunteers
- 182 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
FOXP1, Mental Retardation With Language Impairment and With or Without Autistic Features
FOXP1 Syndrome: The Seaver Autism Center for Research and Treatment is Characterizing FOXP1-related Neurodevelopmental Disorders Using Genetic, Medical, and Neuropsychological Measures.
FOXP1, also known as Forkhead-box Protein P1, is a transcription factor protein belonging to the FOX gene family. Disruptions in the FOXP1 gene cause a phenotype characterized by global developmental delay, speech deficits, mild…
- Conditions
- FOXP1, Mental Retardation With Language Impairment and With or Without Autistic Features, Autism Spectrum Disorder
- Trial name
- NCT03718923
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Down Syndrome, Patau Syndrome
Clinical Evaluation of the IONA Test for Non-invasive Pre Natal Screening in Twin Pregnancies
The purpose of this study is to evaluate the performance of the IONA® test which is a non-invasive prenatal test (NIPT) for Down's syndrome and other chromosomal abnormalities in twin pregnancies, from a maternal blood sample.
- Conditions
- Down Syndrome, Patau Syndrome, Edward's Syndrome
- Trial name
- TWIN (NCT03200041)
- Testing
- Blood sample
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Premaitha Health
Neurodevelopmental Disorders, Intellectual Disability
Multi-Omics Genetic Investigation Strategies to Enhance the Diagnostic Workflow for Rare Diseases
LEOPARD is a multicenter study aimed at improving the genetic diagnosis of patients with neurodevelopmental disorders (NDDs) of unknown etiology, particularly those with moderate-to-severe intellectual disability.
- Conditions
- Neurodevelopmental Disorders, Intellectual Disability, Autism Spectrum Disorder, Genetic Diseases, Inborn
- Trial name
- LEOPARD (NCT07884227)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Giannina Gaslini
Hearing Loss, Noise-Induced
The Growing Burden of Hearing-Related Disability.
Hearing loss and tinnitus can affect communication, employment, daily functioning, and long-term disability. This study will examine hearing-related disability claims recorded by the National Insurance Institute of Israel between…
- Trial name
- Hearing (NCT07798687)
- Where
- Israel
- Volunteers
- 150,000 people
- Sponsor
- Assuta Medical Center
Motor Dysfunction
To Advance the New Disability Evaluation System in Taiwan
Before 2007, the disability evaluation was based on the medical model in Taiwan. According to the People with Disabilities Rights Protection Act announced on 11 July 2007, the assessment of a person's eligibility for disability…
- Trial name
- NCT02614677
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- Changhua Christian Hospital
Smith-Lemli-Opitz Syndrome
Simvastatin Therapy in Smith-Lemli-Opitz Syndrome
This study will evaluate the safety and effectiveness of simvastatin in treating children with Smith-Lemli-Opitz syndrome (SLOS).
- Trial name
- NCT00064792
- Testing
- Simvastatin Susp., OraPlus
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Forbes Porter, M.D.
Learning Disabilities
Assessment of a Drama Workshop Program for Immigrant and Refugee Adolescents
The purpose of this study is to determine whether a drama workshop program for immigrant and refugee youth is effective in reducing impairment in high school students presenting learning difficulties.
- Trial name
- NCT01426451
- Testing
- Group tutoring program, Theatre workshops
- Where
- 5 sites in Canada
- Volunteers
- 464 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Health Knowledge, Intellectual Developmental Disorder
Easy-to-Read Content Effectiveness Evaluation
Individuals with intellectual disabilities face challenges in accessing medical services and health education due to communication barriers and limited support tools.
- Conditions
- Health Knowledge, Intellectual Developmental Disorder, Visual Impairment
- Trial name
- NCT07036575
- Testing
- Standard Visual Health Education, Easy-Read Instructor-Guided Education, Easy-Read Audio-Based Self-Learning
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- National Taiwan University Hospital
Rett Syndrome
Lamivudine as a Novel Clinical Effort for Rett Syndrome
Rett syndrome (RTT) is a rare genetic neurodevelopmental disorder caused primarily by mutations in the MECP2 gene, leading to progressive impairments in motor function, communication, and behavior following an initial period of…
- Trial name
- LANCE (NCT07640503)
- Testing
- Lamivudine
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Maria Denise Fernandes Carvalho de Andrade
Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome
ATTUNE: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION440 in Participants With Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome (MDS)
The primary purpose of this study is to evaluate the safety and tolerability of ION440.
- Trial name
- NCT06430385
- Testing
- ION440
- Where
- 12 sites in United States, Austria and 3 more
- Volunteers
- 48 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Dental Phobia, Disabilities Multiple
Evaluation of Implant Therapies Performed Under General Anesthesia in Patients With Specific Dental Needs
Implant placement is the solution of choice for replacing missing teeth in a fixed way. However, dental practitioners and surgeons are reluctant to place implants in the population of patients with special needs.
- Conditions
- Dental Phobia, Disabilities Multiple, Complex Medical Health Condition
- Trial name
- NCT05153538
- Where
- France
- Volunteers
- 57 people
- Sponsor
- University Hospital, Clermont-Ferrand
Disability Physical
Evaluation of ORTHOPUS Partner Arm in People With Disabilities Needing for Robotic Assistance to Compensate for Upper Limb Deficiency
The study is a prospective, multicenter, interventional, open clinical trial, in Single Case Experimental Design (SCED) in multiple introduction withdrawal, controlled, randomized.
- Trial name
- MS PARTNER (NCT06828510)
- Testing
- With device
- Volunteers
- 12 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris