Clinical trials: Disease Prevention
Acidosis, Lactic, Chronic Disease
Prevention of Dichloroacetate Toxicity
This is a study to determine the safety of dichloroacetate (DCA) with a low-tyrosine diet given with or without nitisinone (NTBC) in children with chronic lactic acidosis (CLA).
- Trial name
- NCT00031161
- Testing
- Nitisinone (NTBC), Dichloroacetate, Low-tyrosin diet
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Infant, Newborn, Diseases, Sepsis
Prevention of Perinatal Sepsis (PoPS): Evaluation of Chlorhexidine Wipes of Birth Canal and Newborn
The purpose of this study is to evaluate whether use of the disinfectant chlorhexidine administered to the birth canal during labour and newborn at delivery can protect a woman and her baby from bacterial infections after birth.
- Conditions
- Infant, Newborn, Diseases, Sepsis, Puerperal Infection
- Trial name
- NCT00136370
- Testing
- Chlorhexidine, Birth canal wipe, sterile water external genital wipe
- Where
- South Africa
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Dental Caries, Child Behavior
Fluoride vs Probiotic Toothpaste for Caries Prevention
This clinical trial had two objectives. The first was to compare the effectiveness of 950 ppm fluoride toothpaste versus probiotic toothpaste in preventing dental caries in 4- to 5-year-old children.
- Trial name
- NCT07579403
- Testing
- Fluoride toothpaste, Probiotic Toothpaste, Control Toothpaste
- Where
- China
- Volunteers
- 508 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital of Qingdao University
Colon Ischemia, Aortic Aneurysm
Prevention of Colon Ischemia During Aortic Aneurysm (AAA) Repair
Patients undergoing surgery on their Aorta can get ischemia, a lack of blood flow, to their intestines and colon. This is very serious, as 2 out of 3 patients who have this problem die before leaving the hospital.
- Trial name
- NCT00671203
- Testing
- Reestablish colon blood flow
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Spectros Corporation
Influenza
Study to Assess the Efficacy and Safety of GP681 Versus Placebo for Postexposure Prophylaxis Against Influenza
Index patients who are infected with influenza virus (Q-PCR positive) can be treated with anti-influenza drugs if their influenza symptoms onset was within 48 hours of screening.
- Trial name
- NCT06574503
- Testing
- GP681 40mg, GP681 Simulant
- Where
- China
- Volunteers
- 748 people, healthy volunteers welcome
- Sponsor
- Jiangxi Qingfeng Pharmaceutical Co. Ltd.
Obesity & Overweight, Eating Disorders
Lifestyle Intervention for Obesity and Eating Disorder Prevention in Transgender Adolescents
Transgender and gender-diverse adolescents are at increased risk for obesity, disordered eating behaviors, body dissatisfaction, and reduced quality of life due to minority stress and structural inequities.
- Conditions
- Obesity & Overweight, Eating Disorders, Body Image Disturbance, Gender Diverse Populations
- Trial name
- NCT07466069
- Testing
- TransForm Health Program
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo
Dental Caries
Early Childhood Caries Prevention at a Pediatric Clinic
This purpose of this study was to evaluate effectiveness of a risk-based dental caries prevention program conducted by dental personnel at an urban pediatric primary care clinic serving largely low-income residents of Baltimore…
- Trial name
- NCT00497029
- Testing
- fluoride varnish, patient education
- Where
- United States
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Hepatitis B, Vertical Transmission of Infectious Disease
The COMBAT HBV Feasibility Trial
This is a double-blind, randomized placebo-controlled trial (RCT) of a prophylaxis-for-all approach to prevention of mother-to-child transmission (PMTCT) of hepatitis B virus (HBV) in the Democratic Republic of Congo (DRC).
- Trial name
- COMBAT-HBV (NCT05705427)
- Testing
- Tenofovir Disoproxil Fumarate 300 MG, Hepatitis B monovalent vaccine
- Where
- Democratic Republic of the Congo
- Volunteers
- 317 people
- Sponsor
- University of North Carolina, Chapel Hill
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
Methods of T Cell Depletion Trial (MoTD)
A multi-centre phase II trial of GvHD prophylaxis following unrelated donor stem cell transplantation comparing Thymoglobulin vs. Calcineurin inhibitor or Sirolimus-based post-transplant cyclophosphamide.
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelomonocytic Leukemia, Myelodysplastic Syndromes
- Trial name
- MoTD (NCT04888741)
- Testing
- Thymoglobulin, Cyclophosphamide, Cyclosporine
- Where
- 17 sites in United Kingdom
- Volunteers
- 400 people
- Sponsor
- University of Birmingham
Catheter Related Infections, Short Bowel Syndrome
Trial of 70% Ethanol Versus Heparin to Reduce the Rate of Central Line Infections in Children With Short Bowel Syndrome
This study is designed to determine if the use of 70% ethanol lock solution in central lines decreases the rate of central line infections in children with short bowel syndrome.
- Trial name
- NCT01263574
- Testing
- 70% ethanol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Obesity, Diabetes Mellitus
Type 2 Diabetes Primary Prevention for At Risk Girls
Purpose: To evaluate two approaches to prevent obesity and type 2 diabetes in young girls. The Need: We are experiencing an epidemic of childhood obesity.
- Conditions
- Obesity, Diabetes Mellitus, Pre Diabetes
- Trial name
- NCT00063674
- Testing
- Nutrition Education, After-school dance class
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Anal Cancer, Anal Squamous Intraepithelial Neoplasia
Anal Intraepithelial Neoplasia and Anal Squamous Cell Carcinoma
This is a study involving exome sequencing and immune profiling of matched tissue and blood samples from patients with both high-grade squamous intraepithelial lesions and anal squamous cell carcinoma.
- Trial name
- NCT05835960
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Imperial College London
Mycoses
Itraconazole for the Prevention of Fungal Infections in Chronic Granulomatous Disease
This protocol describes a prospective, randomized study examining the safety and efficacy of Itraconazole for preventing fungal infections in patients with Chronic Granulomatous Disease (CGD).
- Trial name
- NCT00001280
- Testing
- itraconazole
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bronchopulmonary Dysplasia
Safety and Efficacy of MSC-EVs in the Prevention of BPD in Extremely Preterm Infants
The phase 1/2 trial aims to evaluate the safety and efficacy of EXOB-001 consisting of extracellular vesicles derived from umbilical cord mesenchymal stromal cells in the prevention of bronchopulmonary dysplasia (BPD) in…
- Trial name
- EVENEW (NCT06279741)
- Testing
- Endotracheopulmonary Instillation, Suspension
- Where
- 8 sites in Belgium, Italy
- Volunteers
- 265 people
- Sponsor
- EXO Biologics S.A.
Allogeneic Transplantation (Non T-cell Depleted)
Phase I Clinical Trial to Assess Safety of UV Phototherapy for the Prevention of GVHD Post Allogeneic SCT
The primary goal of thos study is to assess safety of Ultraviolet (UV) Phototherapy for the Prevention of Graft versus Host Disease after allogeneic stem cell transplantation (Phase I - Clinical trial).
- Trial name
- NCT00524953
- Testing
- EUMATRON - EN 600 NT
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
Beta-Thalassemia Major, Graft-versus-host Disease (GVHD)
Efficacy of Basiliximab in the Prevention of Acute Graft-versus-host Disease in Unrelated Allogeneic Hematopoietic Stem Cell Transplantation Therapy for Thalassemia Major
The purpose of this study is to evaluate the basiliximab for prevention of graft-versus-host disease in unrelated allo-genetic hematopoietic stem cell transplantation for thalassemia major.
- Trial name
- NCT02342145
- Testing
- Basiliximab,, Tacrolimus, Methotrexate
- Where
- 3 sites in China
- Volunteers
- 205 people
- Sponsor
- Zhongming Zhang
Acute Lower Respiratory Illness
Cookstove Replacement for Prevention of ALRI and Low Birthweight in Nepal
At our field site in southern Nepal, acute respiratory illness (ARI) has been a leading cause of mortality among young children.
- Trial name
- NCT00786877
- Testing
- Improved biomass cookstove with exterior ventilation, Phase 2 intervention arm (LPG stove)
- Where
- Nepal
- Volunteers
- 4,678 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Bipolar Disorder, Mood Disorders
Delivering Telemetry-Triggered Educational Content Using MyChart in Mood Disorders
Mood disorders - principally major depressive disorder and bipolar disorder - are a significant public health issue affecting one in four people during their lives in total, over 8 million Canadians are affected by mood…
- Trial name
- NCT03575728
- Testing
- MyChart-MHT
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- Sunnybrook Health Sciences Centre
Acute Stress Disorder
Psychological Interventions in Children After Road Traffic Accidents or Burns
Within a randomized controlled design the effects of a brief early psychological intervention (child, parents) after road traffic accidents or burns shall be examined in a sample of 120 children and adolescents (aged 2 to 16…
- Trial name
- PICARTA-B (NCT01085370)
- Testing
- Early psychological intervention
- Where
- Switzerland
- Volunteers
- 108 people
- Sponsor
- University Children's Hospital, Zurich
Injuries, Dancing
"The Show Must go on" : The Experience of Injuries Among Dancers: Fears, Thoughts, and Beliefs. A Qualitative Study
This qualitative, cross-sectional study aims at describing the experience of Italian dancers with injury. Dancers face a high risk of sustaining one or more injuries during their career (87-94%), which may lead to physical…
- Conditions
- Injuries, Dancing, Injury;Sports, Stress, Psychological
- Trial name
- NCT06349928
- Testing
- Focus group or interview
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Siena
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