Clinical trials: Down Syndrome
Down Syndrome, Cognitive Dysfunction
Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 6 To 10
The purpose of this study is to determine the efficacy and safety of donepezil hydrochloride (Aricept) in the treatment of cognitive dysfunction shown by children with Down syndrome, aged 6 to 10 years.
- Trial name
- NCT00754013
- Testing
- Aricept (Donepezil hydrochloride)
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Eisai Inc.
Down Syndrome
Effects of Powerball in Children With Down Syndrome
This randomised clinical trial investigates the effects of powerball using static and dynamic surface on upper limb Endurance and coordination in children with Down Syndrome.
- Trial name
- NCT07244133
- Testing
- Power ball with static surface, Powerball with dynamic surface
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- Riphah International University
Down Syndrome
Visual Perception Intervention Programmes Impact on Down Syndrome Affiliate Children's Fine Motor and Visual Perception.
A second copy of chromosome 21 results in Trisomy 21, a genetic disorder commonly referred to as Down syndrome. In addition to physical traits like low muscular tone, upward-slanting eyes, and a flat facial profile, this extra…
- Trial name
- NCT06531213
- Testing
- experimental, controlled
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Down Syndrome
Effect of Neuro Developmental Therapy in Infants With Down Syndrome
Neurodevelopmental treatments are a progressive therapeutic method experienced thru qualified therapists for the improvement in affected ones.
- Trial name
- NCT04816409
- Testing
- conventional therapy, Neurodevelopmental therapy
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Riphah International University
Down Syndrome
TheraTogs Versus Reciprocal Electrical Stimulation on Children With Diplegic Cerebral Palsy: a Randomized Controlled Trial
Children with diplegic cerebral palsy exhibit postural restrictions as a result of both primary and secondary brain damage impairments. One of the main goals of cerebral palsy rehabilitation is to improve balance and stability.
- Trial name
- NCT05702632
- Testing
- 1- Reciprocal electrical stimulation, TheraTogs orthotic treatment, traditional physical therapy program
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Cairo University
Down Syndrome, Autism Spectrum Disorder
Neuro-Nutrition to Support Physiological Function and Cognitive Skills in People With Down Syndrome, Autism Spectrum Disorder, and ADHD
This study aimed to evaluate the impact of a specialized nutritional intervention on physiological performance, sleep quality, and cognitive abilities in individuals with neurodevelopmental disorders, specifically Down syndrome…
- Conditions
- Down Syndrome, Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder (ADHD)
- Trial name
- NEURODIET-DSAA (NCT07165509)
- Testing
- T-2 Nutritional Supplement, Structured Dietary Program
- Where
- Mexico
- Volunteers
- 76 people
- Sponsor
- Elizabeth Guadalupe Ibarra Coronado
Atopic Dermatitis, Alopecia Areata
Treatment of Atopic Dermatitis and Alopecia Areata With Abrocitinib in Individuals With Down Syndrome
This is a single-center, open-label, basket phase 2b trial that will enroll Down Syndrome (DS) participants with at least one inflammatory skin condition (Atopic Dermatitis (AD) and/or Alopecia Areata (AA)).
- Trial name
- NCT07242638
- Testing
- Abrocitinib
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Down Syndrome
Oral Language in Children With Down Syndrome
The objective of this research is to verify the language of children with Down syndrome concerning lexical, syntactic and semantic aspects using MLU.
- Trial name
- NCT00952354
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Down Syndrome, Healthy
Clinical Validation of the Bordeaux Maze Test
Currently, the instruments used in translational studies related to cognition have proved to be inaccurate. For this reason, the objective of this study is to evaluate whether the Bordeaux Maze Test has adequate psychometric…
- Trial name
- BORMATE (NCT04241042)
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Down Syndrome
Promoting Health Through Parent Empowerment and the Activation of Routines (PrO-PEAR)
This study will examine the feasibility of the Promoting Health through Parent Empowerment and the Activation of Routines (Pro-PEAR) intervention using a open case-series for intervention optimization followed by a pilot RCT in…
- Trial name
- Pro-PEAR (NCT05020366)
- Testing
- Promoting Health through Parent Empowerment and the Activation of Routines, Enhanced Usual Care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pittsburgh
Down Syndrome
Effect of Whole Body Vibration on Down Syndrome
A congenital condition known as Down syndrome is typified by an excess of genetic material from chromosome 21, making 47 chromosomes in total. Development of the body and brain may be impacted.
- Trial name
- NCT06838754
- Testing
- Whole body vibration therapy, Routine physical therapy
- Where
- Pakistan
- Volunteers
- 16 people
- Sponsor
- Riphah International University
Down Syndrome
Effects of Stretch-shortening Cycle Exercises Postural Control in Down Syndrome
To investigate the effect of a 3-month, trampoline-based stretch-shortening cycle (SSC) exercises on muscle strength and postural control in children with Down syndrome.
- Trial name
- NCT04966403
- Testing
- Standard physical therapy, trampoline-based stretch-shortening cycle exercises
- Where
- Saudi Arabia
- Volunteers
- 32 people
- Sponsor
- Qassim University
Down Syndrome
Effects of Lower Limb Fitness Program in Children With DS
Down Syndrome is a congenital disorder resulting from the trisomy of the human chromosome 21, which will determine, among other characteristics, intellectual disability and growth retardation.
- Trial name
- NCT06407895
- Testing
- Lower Limb Fitness Program, Routine Therapy
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- Riphah International University
Obstructive Apnea
Comparison of a Demand Oxygen Delivery
Conducting a randomized control trial of oxygen in children with Down syndrome to treat moderate to severe obstructive sleep apnea.
- Trial name
- DOSA (NCT06609694)
- Testing
- Portable oxygen concentrator Inogen G5 model
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Down Syndrome
Effect Of Pilates On Postural Control And Balance In Children With Down's Syndrome
Down's syndrome (DS) is a genetic condition characterized by the presence of an extra chromosome 21, leading to various clinical symptoms.
- Trial name
- NCT05969873
- Testing
- Pilates exercise, Balance training
- Where
- Pakistan
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Down Syndrome
Effect of Sensory Integration on Gross and Balance on Children With Down Syndrome
To investigate the effect of sensory integration on gross motor function in children with Down syndrome. To investigate the effect of sensory integration on balance in children with Down syndrome.
- Trial name
- NCT07785011
- Testing
- BALANCE AND SENSORY INTEGRATION
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Raheel Sanad
Obstructive Sleep Apnea, Down Syndrome (Trisomy 21)
Oro-myofunctional Characteristics and Obstructive Sleep Apnea in Infants With Down Syndrome
Obstructive Sleep Apnea (OSA) is characterised by repetitive collapse of the upper airway during sleep, inducing breathing disturbances that can result in oxygen desaturation and frequent arousals.
- Trial name
- OMF21 (NCT07195253)
- Testing
- Polysomnography (PSG) to explore OSA, Oro-myo-functional clinical evaluation, Sleep Disturbance Scale for Children
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Down Syndrome, Hemiparesis
Kinematic Analysis of Manual Dexterity
The following study aims to standardize the instrumented BBT for the objective evaluation of upper limb joint kinematics using MoCap on a population of healthy subjects between 4 and 18 years of age.
- Conditions
- Down Syndrome, Hemiparesis, Healthy Subjects
- Trial name
- SUPERFUN (NCT07875127)
- Testing
- Inertial Measurement Unit and Box and Block test
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Down Syndrome
Aerobic Exercise With and Without Low Calorie Diet on Adiposity and BMI of Down Syndrome
Down syndrome (DS) is caused by trisomy 21, or the presence of an extra copy of chromosome 21. A calibrated weight scale is used to measure participants' weight accurately.
- Trial name
- NCT06943170
- Testing
- Aerobic Exercise and Low Calorie Diet
- Where
- Pakistan
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Down's Syndrome
Eyelash Line Resection for Entropion Associated With Down's Syndrome
Surgical outcome of entropion associated with Down's syndrome was evaluated. Grading scale of superficial punctate keratopathy and score of wearing glasses to correct refractive errors were measured.
- Trial name
- NCT01758718
- Testing
- Eyelash line resection
- Where
- Japan
- Volunteers
- 24 people
- Sponsor
- Kyorin University