Clinical trials: Doxycycline
Healthy Volunteers, Fungal Infections
A Pilot of Pediatric/Adult Study of Gene Expression Profiling and Clinical Characterization of Phototoxicity
This study will examine the phototoxicity, a reaction to light that is like exaggerated sunburn, which occurs in people who take medications such as voriconazole, a medication used to fight fungus.
- Conditions
- Healthy Volunteers, Fungal Infections, Bacterial Infections
- Trial name
- NCT00353158
- Testing
- Doxycycline, Voriconazole
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Fever
Comparative Efficacy of Single-dose Doxycycline Versus Standard 5- Day Amoxicillin Treatment
Abstract: Background The current practice in Senegal is to use broad-spectrum antibiotics including amoxicillin and/or cotrimoxazole in case of non-malarial fevers. First-line treatment with doxycycline has cured such patients.
- Trial name
- NCT03765931
- Testing
- Doxycycline, Amoxicillin
- Where
- Senegal
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche pour le Developpement
COVID-19
Retrospective Study for Identificatiopn of a Link Between Doxycycline and COVID-19 Treatment
A new coronavirus, the third documented animal-to-human passage, emerged in Wuhan , China in the last quarter of 2019. Acne patients on doxycycline escaped seasonal viruses, showing the interest of this antibiotic as a possible…
- Trial name
- DOXY-COVID (NCT05445479)
- Testing
- Doxycycline
- Sponsor
- Nantes University Hospital
Chlamydial Infection
Treatment Failure of Chlamydial Infection in Males and Females in Youth Correctional Facilities
Chlamydia is a common infection among youth and can be given from one person to another during sex. Many people who have chlamydia have no signs of infection at all, but can pass the infection to anyone they have sex with.
- Trial name
- NCT00980148
- Testing
- Azithromycin, Doxycycline
- Where
- 2 sites in United States
- Volunteers
- 567 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Brucellosis, Osteoarticular Brucellosis
All-Oral Fluoroquinolone-Based Triple Therapies for Adults With Imaging-Confirmed Osteoarticular Brucellosis
Brucellosis is a globally distributed zoonosis with persistent clinical management challenges. The World Health Organization (WHO)-recommended doxycycline-rifampin (DOX-RIF) dual regimen may drive rifampin-associated…
- Trial name
- BRUCE-O (NCT07887152)
- Testing
- Doxycycline + Rifampicin + Ceftriaxone (intravenous therapy for 4 weeks), Triple oral regimen (Doxycycline + Rifampicin + Levofloxacin), Triple oral regimen (Doxycycline + Rifampicin + Moxifloxacin)
- Volunteers
- 150 people
- Sponsor
- The First Affiliated Hospital of Shihezi University
Lymphedema, Lymphatic Filariasis
A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali
Current lymphedema management protocols are based on the use of simple measures of hygiene (regular washing with soap and water, skin and nail care), use of topical antibiotics or antifungal agents, exercise and footwear.
- Conditions
- Lymphedema, Lymphatic Filariasis, Filariasis
- Trial name
- LeDoxy-Mali (NCT02927496)
- Testing
- Doxycycline
- Where
- Mali
- Volunteers
- 220 people
- Sponsor
- The Task Force for Global Health
Acne Vulgaris
Aczone 5% Gel as Maintenance Treatment of Acne Vulgaris Following Completion of Oral Doxycycline and Aczone 5% Gel
This pilot study will explore if continuation of treatment of treatment with Aczone 5% gel following combination treatment with with doxycycline and Aczone 5% gel can maintain therapeutic response.
- Trial name
- NCT01885910
- Testing
- Doxycycline 100mg, Aczone 5% gel
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Derm Research, PLLC
Acne Vulgaris
A Treatment for Severe Inflammatory Acne Subjects
Demonstrate that a daily treatment regimen of adapalene 0.3%/benzoyl peroxide 2.5% gel + oral Doxycycline 200 mg is effective and safe in severe inflammatory acne with 3 or fewer nodules or cysts (non-nodulocystic) during a…
- Trial name
- NCT02899000
- Testing
- Adapalene 0.3% / benzoyl peroxide 2.5% emulsion gel, Oral doxycycline hyclate
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Galderma R&D
Acne Vulgaris
Treatment of Moderate to Severe Facial Acne Vulgaris
Randomized, multi-center, double-blind, placebo-controlled 12-week study to assess the safety and efficacy of 3 doses of an oral formulation of Doxycycline oral tablets using the Investigator's Global Assessment (IGA) score and…
- Trial name
- NCT00612573
- Testing
- Doxycycline 0.6 mg/kg/day, Doxycycline 1.2 mg/kg/day, Doxycycline 2.4 mg/kg/day
- Where
- 23 sites in United States
- Volunteers
- 257 people
- Sponsor
- Warner Chilcott
Gonorrhea, Chlamydia
Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections
The goal of this open-label, randomized trial is to assess the efficacy of doxycycline prophylaxis in reducing incidences of bacterial sexually transmitted infections (STIs) among adolescent and young adult females while also…
- Conditions
- Gonorrhea, Chlamydia, Syphilis, Sexually Transmitted Infections (STIs)
- Trial name
- NCT06738407
- Testing
- Doxycycline hyclate delayed released 200 mg, Doxycycline hyclate delayed released 200 mg weekly, Per standard of care with quarterly STI testing/treatment and sexual health counseling
- Where
- 13 sites in United States
- Volunteers
- 760 people
- Sponsor
- Westat
Sexually Transmitted Infection (STI), Gonorrhea
A Clinical Study to Assess the Efficacy of Weekly Doxycycline Prophylaxis to Reduce Bacterial Sexually Transmitted Infections (STI) in Young African Women
This study is for people who may get sexually transmitted infections (STIs). Approximately 580 African adolescent and young adult women ages 13-34 in Africa will be included in this study.
- Conditions
- Sexually Transmitted Infection (STI), Gonorrhea, Syphilis, Chlamydia
- Trial name
- NCT07884240
- Testing
- Doxycycline hyclate, Standard of Care for STI prevention
- Where
- 4 sites in Botswana, Eswatini and 2 more
- Volunteers
- 580 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Abortion
Side Effects and Adherence Associated With Doxycycline Use Following Medical Abortion
The effectiveness of antibiotic treatment at reducing post-abortion infection is unclear. The experiences of women prescribed routine antibiotics after medical abortion is missing from the existing evidence.
- Trial name
- NCT01799252
- Where
- 7 sites in United States
- Volunteers
- 582 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Syphilis Infection, Gonorrhea
The Efficacy of Doxycycline Post Exposure Prophylaxis for Preventing STIs Among MSM in Bangkok, Thailand.
The objective of this research is to evaluate the efficacy and safety of doxycycline in MSM for preventing sexually transmitted infections (gonorrhea, chlamydia, and syphilis) in Thailand Participation in this study will last…
- Conditions
- Syphilis Infection, Gonorrhea, Chlamydia
- Trial name
- ThaiDoxyPEP (NCT07397403)
- Testing
- Doxycycline (200mg/day)
- Where
- Thailand
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Bangrak STIs Center
Methicillin-resistant Staphylococcus Aureus, Skin Infection
Short and Long Term Outcomes of Doxycycline Versus Trimethoprim-Sulfamethoxazole for Skin and Soft Tissue Infections Treatment
The purpose of this study is to compare how well two different antibiotics, doxycycline (DOXY) and trimethoprim/sulfamethoxazole (TMP/SMX), work at curing uncomplicated skin and soft tissue infection (uSSTI) such as 1.Boils (pus…
- Trial name
- TODOS (NCT03637400)
- Testing
- TMP-SMX, DOXY
- Where
- 3 sites in United States
- Volunteers
- 269 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Exacerbation of Ulcerative Colitis, Ulcerative Colitis, Active Severe
Manipulating the Microbiome in IBD by Antibiotics and FMT
the etiology of Inflammatory Bowel Diseases (IBD) is closely associated with the gut microbiome. The results of previous studies on the effectiveness of antibiotics and fecal macrobiota transplantation (FMT) are contradicting.
- Conditions
- Exacerbation of Ulcerative Colitis, Ulcerative Colitis, Active Severe, Crohn's Colitis
- Trial name
- FMT (NCT02033408)
- Testing
- AB (antibiotics), CS (corticosteroids) Only
- Where
- 12 sites in Canada, Finland and 4 more
- Volunteers
- 28 people
- Sponsor
- Shaare Zedek Medical Center
Umbilical Granuloma
Comparison Of Doxycycline And Common Salt For Treatment Of Umbilical Granuloma: A Randomised Control Trial
it is the study for the disease called umbilical granuloma to look for the better treatment option which can be performed by healthcare physicians and local nurses and even parents
- Trial name
- NCT05545462
- Testing
- Doxycyclin, COMMON SALT
- Where
- Pakistan
- Volunteers
- 196 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Acne Vulgaris
Comedone Extraction and Oral Doxycycline In The First Line Treatment of Moderate Acne Vulgaris
The objective of the study was to evaluate the effectiveness of comedone extraction compared to oral antibiotics as the main therapy of moderate acne vulgaris (MAV); and to determine the expression of HIF-1 alpha by examining the…
- Trial name
- NCT04206631
- Testing
- Doxycycline Capsule, Comedone extraction
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Acne Vulgaris on the Face, Acne Vulgaris
Efficacy of Oral Metformin vs Oral Doxycycline in Treating Acne Vulgaris
The goal of the clinical trial is to learn if oral metformin works to treat moderate to severe acne vulgaris. Investigators will compare this drug to oral doxycycline to see if this drug works to treat acne.
- Trial name
- NCT07357337
- Testing
- oral metformin, Oral doxycycline
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- Ghurki Trust and Teaching Hospital
Acne
Comparative Effectiveness Study of Spironolactone Versus Doxycycline for Acne
Acne is common illness of adolescents and young adults which is associated with substantial morbidity. While topical treatments are often sufficient for mild acne, moderate to severe acne often requires treatment with systemic…
- Trial name
- SD-ACNE (NCT04582383)
- Testing
- Spironolactone, Doxycycline Hyclate
- Where
- 18 sites in United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Acne
The Use of Oracea and Epiduo Forte in Severe Acne Patients
This is a single-center, open label pilot study. The study is comprised of 5 study visits; Screening, Baseline, and weeks 4, 8, and 12. All subjects will receive Oracea once daily (QD) and Epiduo Forte at Baseline.
- Trial name
- NCT03457636
- Testing
- Doxycycline Anhydrous 40 MG, Adapalene/Benzoyl Peroxide Gel 0.3-2.5%
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Derm Research, PLLC