Clinical trials: Drug Abuse
Medical Education
Online Primary Care Physician (PCP) Training in Screening, Brief Intervention, Referral, and Treatment
This project seeks to develop a comprehensive, computer-based education program for primary care physicians that will improve their skills in structured substance abuse screening, brief interventions, and referral and treatment…
- Trial name
- NCT01326936
- Testing
- Online education
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical Directions, Inc
Drug Abuse
Brief Intervention for Drug Abusing Adolescents
The purpose of this clinical trail is to evaluate the efficacy of a brief, cognitive-behavioral therapeutic intervention for adolescents reporting mild or moderate drug abuse (MMDA).
- Trial name
- NCT00350909
- Testing
- brief intervention (cognitive-behavioral therapy)
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Depressive Disorder, Major
PRJ2215: Assessment of Buproprion Misuse/Abuse 2004-2011
Bupropion hydrochloride was first approved on 30 December 1985 in United States for depression and is currently approved in 80 countries.
- Trial name
- NCT02039960
- Testing
- Bupropion
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Bcenzodiazepines, Abuse, Retrospective Study, Focus Groups, Real-world Study
A Study of the Effectiveness of Electronic Interventions on the Standardized Prescription Benzodiazepines and Z-drugs
A retrospective surveys and group interviews focusing on the prescription and abuse of benzodiazepines will be carried out in China.
- Trial name
- NCT03724669
- Testing
- waiting list, benzodiazepines related knowledge intervention
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Shanghai Mental Health Center
Medication Abuse, Harm Reduction
Evaluation of Clinical Decision Support in Opioid Tapering
The 2022 Center for Disease Control and Prevention (CDC) clinical practice guideline for prescribing opioids for pain recommends that when tapering a patient's opioid dose, doses should be decreased at a slow rate to reduce the…
- Conditions
- Medication Abuse, Harm Reduction, Opioid Use Disorder, Opioid Prescribing
- Trial name
- NCT06527079
- Testing
- Observational study without a prospective intervention
- Volunteers
- 200,000 people
- Sponsor
- University of Colorado, Denver
Drug Use, Drug Abuse
Acute Intervention to Reduce Distress Following Sexual Assault
The purpose of this study was to evaluate whether a brief intervention in video format delivered in the post assault medical exam setting and including education about assault reactions and instruction in and modeling of…
- Conditions
- Drug Use, Drug Abuse, Posttraumatic Stress Disorder
- Trial name
- NCT01622855
- Testing
- PPRS
- Where
- United States
- Volunteers
- 442 people
- Sponsor
- Medical University of South Carolina
Prevention, Family Function
Familias Unidas: Preventing Substance Abuse in Hispanic Youth
The focus of this study will be to test the Familias Unidas Intervention program among Hispanic 8th graders in the Miami-Dade County Public School System.
- Conditions
- Prevention, Family Function, Substance Use, Sexual Behavior
- Trial name
- NCT01038206
- Testing
- Familias Unidas
- Where
- United States
- Volunteers
- 746 people, healthy volunteers welcome
- Sponsor
- University of Miami
Prevention Harmful Effects
Computerized Alcohol Screening for Children and Adolescents (cASCA) in Primary Care
The purpose of this study is to assess the psychometric properties of a brief screening questionnaire for alcohol problems among 9- to 18-year-old patients in pediatricians' offices, and to pilot test a personalized…
- Trial name
- cASCA (NCT02233946)
- Testing
- computer-facilitated brief intervention
- Where
- 5 sites in United States
- Volunteers
- 871 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Drug Resistant Epilepsy
CANnabinoids for Drug Resistant Epilepsy (DRE) in Adults and Children
Epilepsy is a neurological disorder affecting more than 50 million people globally, including more than 260,000 Canadians. Cannabidiol (CBD) reduces seizure frequency and improves quality of life for adults and children with Drug…
- Trial name
- CAN-DRE (NCT07023744)
- Testing
- CBD Isolate, CBD CHE
- Volunteers
- 90 people
- Sponsor
- University of Manitoba
Suicidal Ideation, Depression
Population Screening Using Smartphone in Milpa Alta
The objective of this study is to make a suicide screening in the entire population of Milpa Alta (approximately 150,000 inhabitants), taking into account other outcomes such as depression, anxiety, alcohol and drugs.
- Conditions
- Suicidal Ideation, Depression, Depressive Disorder, Anxiety
- Trial name
- Smart-screen (NCT04067063)
- Testing
- Self-administered evaluation questionnaire
- Where
- Mexico
- Volunteers
- 150,000 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Substance-Related Disorders
Motivational Incentives for Enhanced Drug Abuse Recovery: Drug Free Clinics - 1
The purpose of this study is to test the utilization of incentive values (considerably lower than those typically used in research clinics) to motivate clients to attend treatment and initiate and sustain abstinence.
- Trial name
- NCT00033007
- Testing
- Behavior Therapy
- Where
- 11 sites in United States
- Volunteers
- 440 people
- Sponsor
- Johns Hopkins University
Opioid-Related Disorders, Opiate Addiction
Study to Validate Coded Medical Terms Used to Identify Opioid-Related Overdose in Databases Used for PMR Study 1B
The purpose of this study is to determine reliability of codes and data from electronic medical records to predict and measure overdose and death in patients prescribed opioid analgesics.
- Conditions
- Opioid-Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02667197
- Testing
- Algorithm to determine overdose from opioid abuse
- Volunteers
- 2,701 people
- Sponsor
- Member Companies of the Opioid PMR Consortium
Well Being, Drug Addiction
Evaluation of Effectiveness of the LifeSkills Training - Lombardia - Primary Shool Program ( Val3P-LST )
Life Skills Training is a school-based prevention program aiming at promoting wellbeing and at preventig use of substances. It has a version for middle school and another for primary school students.
- Conditions
- Well Being, Drug Addiction, Tobacco Use, Alcohol Abuse
- Trial name
- Val3P-LST (NCT07858513)
- Testing
- life skills primary prevention
- Where
- Italy
- Volunteers
- 3,927 people, healthy volunteers welcome
- Sponsor
- Agenzia di Tutela della Salute della Città Metropolitana di Milano
Substance Use Disorders, Risk Behavior
Culturally Informed Family Based Treatment of Adolescents: A Randomized Trial
This Stage II randomized trial tests Culturally Informed \& Flexible Family Based Treatment for Adolescents (CIFFTA) developed as part of a Stage I treatment development effort and yielding promising preliminary findings.
- Conditions
- Substance Use Disorders, Risk Behavior, Psychiatric Disorders, Family Dysfunction
- Trial name
- CIFFTA (NCT01823250)
- Testing
- Family Therapy based on Structural Family Therapy, Group Therapy, Psychoeducational Sessions
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- University of Miami
Drug Abuse, HIV Infections
Neurobehavioral Model of HIV in Injection Drug Users
The purpose of this R01 study is to evaluate the association between neuropsychological executive dysfunction and HIV infection among young injection and non-injection drug users.
- Trial name
- NCT00198861
- Testing
- Injection and Non-Injection Drug Users
- Where
- United States
- Volunteers
- 836 people
- Sponsor
- The City College of New York
Opioid-related Disorders, Opioid Addiction
Surveillance Monitoring of Opioid Abuse in Poison and Drug Treatment Centers
To conduct surveillance for abuse, misuse, overdose, addiction, and death and to evaluate if the REMS meets its surveillance goals, and if it does not, to modify it appropriately based on the metrics.
- Conditions
- Opioid-related Disorders, Opioid Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02871232
- Testing
- Researched Abuse, Diversion and Addiction-Related Surveillance (RADARS) System of post-marketing surveillance of prescription medication abuse, misuse, and diversion
- Volunteers
- 26,500 people
- Sponsor
- ER/LA Opioid REMS Program Companies (RPC)
Adolescent
Development of a Community-based Network for Drug Abusers
Hidden drug abuse remains a significant concern for public health. An appropriate intervention is necessary to encourage hidden drug abusers to report their situations and seek professional help.
- Trial name
- NCT04400526
- Testing
- A video competition, A training workshop, A mass promotional campaign
- Where
- Hong Kong
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Substance-Related Disorders
Medical Office Intervention for Adolescent Drug Use
The goal of this study is to assess the efficacy of a new intervention based on motivational enhancement therapy among adolescents with a history of substance use.
- Trial name
- NCT00229983
- Testing
- Motivational Enhancement Therapy
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Boston Children's Hospital
Youths At-risk for Drug Use/Abuse
Neurological Influences on Drug Prevention Intervention
In this R01 study, a randomized clinical trial is proposed to evaluate the efficacy of a drug abuse prevention intervention for indicated middle school youth that coordinates family and teen-based components.
- Trial name
- NCT00198939
- Testing
- Integrated Family and Cognitive-Behavioral Drug Prevention Intervention, Psychoeducation
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University of Florida
Substance Abuse
Testing ALERT With GTO in Middle Schools
To test the efficacy of Project ALERT with the support enhancement tool, Getting To Outcomes.
- Trial name
- GTO-ALERT (NCT05219422)
- Testing
- Project ALERT, Getting to Outcomes
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- RAND