Clinical trials: Drug Interactions
Opioid-Related Disorders, Substance-Related Disorders
Effects of Combined Alcohol and Nitrous Oxide Intake - 15
The purpose of this study is to determine the effects of combined alcohol and nitrous oxide intake on mood, psychomotor performance, and the pain response in healthy volunteers.
- Trial name
- NCT00000263
- Testing
- 30% Nitrous oxide, 0.25 g/Kg ethanol, 0.5 g/KG ethanol
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Osteoporosis
A Study Of SB-751689, Atorvastatin, Ketoconazole, And Rosuvastatin In Health Postmenopausal Women.
The first purpose of this study is to determine if taking SB-751689 along with Rosuvastatin (CRESTOR) or Atorvastatin (LIPITOR) will change how Rosuvastatin or Atorvastatin are absorbed and eliminated from the body.
- Trial name
- NCT00388596
- Testing
- SB-751689
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy
Effects of Kava on the Body's Elimination of Caffeine and Dextromethorphan
This study will examine how kava-a widely used herbal remedy-may affect the body's elimination of other medicines. Many people take kava to reduce anxiety or cause sedation.
- Trial name
- NCT00009542
- Testing
- kava (Piper methysticum)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Cardiovascular Diseases, Cohort Studies
FAMILY INHERITANCE, GENE-GENE AND GENE-ENVIRONMENT INTERACTIONS IN THE FIELD OF CARDIOVASCULAR AND RENAL DISEASES. Fifth Visit of the STANISLAS Cohort
The Stanislas Cohort is a monocentric familial longitudinal cohort originally comprised of 1006 families consisting of two parents and at least two biological children and deemed healthy, recruited in 1993-1995 at the Centre for…
- Conditions
- Cardiovascular Diseases, Cohort Studies, Genotype, Risk Factors
- Trial name
- NCT05916287
- Testing
- Blood and urine samples, Blood samples, Cardiovascular assessment
- Where
- France
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Dystonia
Interactions Between Striatum and Cerebellum in ADCY5 and PRRT2 Dystonias
The investigators will study the relationship between the basal ganglia and the cerebellum in dystonia by associating cerebellar stimulations with functional magnetic resonance imaging analysis.
- Trial name
- AMEDYST (NCT03481491)
- Testing
- transcranial magnetic stimulation of the cerebellum
- Where
- France
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
HCV Infection
Drug-Drug Intercations and Direct Acting Antiviral Agents Against HCV
Background: Currently used direct-acting antivirals (DAA) share pharmacokinetic pathways with many comedications commonly used in patients with chronic hepatitis C virus (HCV) infection, therefore drug-drug interactions (DDI)…
- Trial name
- NCT06928259
- Where
- 4 sites in Spain
- Volunteers
- 728 people
- Sponsor
- University of Seville
Very Low Birthweight
Mother Sibling Interactions Following Very Low Birth Weight (VLBW) Infant Homecoming
The proposed study will explore longitudinally the impact of a very low birthweight (VLBW) infant on mother-sibling interactions and sibling adjustment.
- Trial name
- NCT01385254
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Duke University
Intellectual Disability
Support Staff-client Interactions With Augmentative and Alternative Communication
This exploratory and observational study focuses on adults with an intellectual disability (ID) and their support workers. Two groups of clients are observed: clients using Key Word Signing, and clients using aided Augmentative…
- Trial name
- NCT02099773
- Where
- 3 sites in Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
HIV Infections, Malaria
Relationship Between HIV and Malaria in Ugandan Children
HIV and malaria are two of the most important diseases to afflict children in sub-Saharan Africa. However, it is unknown what relationships exist between the two diseases.
- Trial name
- NCT00356824
- Testing
- Amodiaquine, Artesunate
- Where
- Uganda
- Volunteers
- 300 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sarcoma, Kaposi, HIV Infections
The Safety and Effectiveness of Interferon Alfa-2B Plus Didanosine in Patients With Kaposi's Sarcoma
Primary: To evaluate the safety, toxicity, and antitumor activity of two doses of interferon alfa-2b (IFN-alpha) combined with a fixed dose of didanosine (ddI) in patients with Kaposi's sarcoma associated with HIV infection.
- Trial name
- NCT00001114
- Testing
- Interferon alfa-2b, Didanosine
- Where
- 13 sites in United States, Puerto Rico
- Volunteers
- 90 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Urinary Tract Infections
Interactions Between Cranberry Juice and Antibiotics Used to Treat Urinary Tract Infections
The purpose of study is to determine whether cranberry juice interacts with antibiotics used to treat urinary tract infections (UTIs).
- Trial name
- NCT00084201
- Testing
- Cranberry juice, Amoxicillin
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Dysbiosis
Interactions Between Skincare Product Ingredients and the Skin Microbiome
This is a study of the influence of skincare products containing chemicals such as parabens and phthalates on the skin microbiome.
- Trial name
- NCT04476732
- Testing
- Paraben-free skincare product, Paraben-containing skincare product
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Respiratory Infections, Genetic Disorder
Molecular Typing of Community-acquired Pneumonia Based on Multiple-omic Data Analysis
Community-acquired pneumonia (CAP) is a heterogeneous disease causing great morbidity, mortality and health care burden globally.
- Conditions
- Respiratory Infections, Genetic Disorder, Community-Acquired Infections, Host-Pathogen Interactions
- Trial name
- NCT03093220
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Child Development, Child Behavior
The Infant- Toddler Climate of Healthy Interactions for Learning and Development (I-T CHILD)
The purpose of the study is to train New York-based early childhood mental health consultants (ECMHCs) who will apply the Infant-Toddler Climate of Healthy Interactions for Learning and Development (I-T CHILD) tool as part of…
- Conditions
- Child Development, Child Behavior, Social Skills, Infant Development
- Trial name
- I-T CHILD (NCT05132374)
- Testing
- I-T CHILD
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yale University
Autism Spectrum Disorder
Intelligent Robotic Interactions for Children With Autism Spectrum Disorders
For several years, studies have been developed on the contribution of social robots as a tool for interventions for children with autism spectrum disorders (ASD).
- Trial name
- I-ROBI (NCT05991791)
- Testing
- Early Start Denver Model (ESDM)
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Montpellier
Tuberculosis, HIV
Rifampin and Nevirapine Interactions in Young Children
Nevirapine is the preferred nonnucleoside reverse transcriptase inhibitor (NNRTI) for treatment of HIV in children younger than 3 years old who have tuberculosis (TB) coinfection.
- Trial name
- NCT01699633
- Where
- Ghana
- Volunteers
- 58 people
- Sponsor
- The Miriam Hospital
Coronary Heart Disease, Acute Coronary Syndrome
Cohort Study of Clopidogrel and Proton Pump Inhibitors
Patients who have experienced and survived non-ST segment elevation acute coronary syndromes are often prescribed a combination of aspirin and clopidogrel to thin the blood and prevent further acute coronary episodes.
- Conditions
- Coronary Heart Disease, Acute Coronary Syndrome, Drug Interactions, Clopidogrel
- Trial name
- NCT01231867
- Where
- United Kingdom
- Volunteers
- 24,471 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Diabetes type1
Simple Initiation of Advanced Hybrid Closed Loop System
Background and Aim. The new and advanced hybrid closed loop (AHCL) system MiniMed 780G automatically adjusts basal insulin delivery in addition to automated bolus corrections, based on continuous glucose monitoring (CGM)…
- Trial name
- 780GGS (NCT05069727)
- Testing
- Regular Protocol with advanced carbohydrate counting, Simplified Protocol with fixed carbohydrate content
- Where
- Qatar
- Volunteers
- 34 people
- Sponsor
- Sidra Medicine
Children
Reduction in MACbar of Sevoflurane by Dexmedetomidine in Children
The study was designed to define the interaction of intravenous infusion of dexmedetomidine, an a2-adrenergic agonist, and sevoflurane in children having surgery by using the minimum alveolar concentration which can block…
- Trial name
- NCT02261675
- Testing
- dexmedetomidine
- Volunteers
- 63 people
- Sponsor
- Cai Li
HIV
Polypharmacy and Clinically Significant Drug Interactions Among HIV-Infected Patients Receiving Antiretroviral Therapy
This will be a cross-sectional population-based study carried out in the region of Madrid (6,468,322 inhabitants according to current census) to quantify the number of Co-meds in HIV-infected individuals on ART in the region of…
- Trial name
- PODIUM (NCT03123575)
- Volunteers
- 1,000 people
- Sponsor
- Hospital General Universitario Gregorio Marañon