Clinical trials: Drug Overdose
Acetaminophen Overdose
Safety and Efficacy Study of a New Formulation of Acetylcysteine Injection
The primary purpose of this study is determine if a new formulation of Acetadote is at least as effective as the current formulation in the prevention and treatment of acetaminophen overdose related liver injury.
- Trial name
- NCT01118663
- Testing
- Acetadote EF (Ethylenediaminetetraacetic Acid (EDTA) - Free), Acetadote
- Where
- 14 sites in United States
- Volunteers
- 17 people
- Sponsor
- Cumberland Pharmaceuticals
Opioid Use Disorder, Opioid Overdose
Health Insurance Instability and Mortality Among Patients Receiving Bup Tx for OUD
The goal of this multi-site observational cohort study is to link electronic health records (EHR) with novel data sources to examine insurance instability and its association with all-cause and overdose mortality in adult…
- Conditions
- Opioid Use Disorder, Opioid Overdose, Death
- Trial name
- NCT05944133
- Testing
- No intervention, observational retrospective study
- Where
- United States
- Volunteers
- 27,257 people
- Sponsor
- Kaiser Permanente
Acetaminophen, Drug Overdose
Evaluation of the Efficacy of Fomepizole in the Treatment of Acetaminophen Overdose
This study is a randomized, placebo-controlled double-blinded clinical trial of patients presenting with acetaminophen poisoning who are at increased risk of developing liver injury.
- Conditions
- Acetaminophen, Drug Overdose, Acetaminophen Overdose, Acetaminophen Poisoning
- Trial name
- NCT05517668
- Testing
- Intravenous infusion of N-acetylcysteine, Intravenous infusion of Fomepizole (4-MP)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Richard Dart, MD, PhD
Paracetamol Overdose
The Markers and Paracetamol Poisoning Study 2
Paracetamol overdose is one of the most common medical emergencies. Annually in the UK, 100,000 people seek medical attention and 50,000 need hospital admission.
- Trial name
- MAPP2 (NCT03497104)
- Testing
- Surplus blood tests
- Where
- United Kingdom
- Volunteers
- 464 people
- Sponsor
- NHS Lothian
Drug Toxicity
Cytokines Polymorphisms and Acetaminophen Toxicity
Genotyping assays for polymorphisms in the interleukin 10(IL10)gene and the inducible nitric oxide synthase (iNOS) gene will be performed. Genotypes will be compared to the severity of toxicity following overdose.
- Trial name
- NCT00166608
- Testing
- Blood sampling
- Where
- 7 sites in United States
- Volunteers
- 111 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Sedative Overdose
Local Anesthesia Impact on Dental Sedation
The goal of this observational study is to investigate the impact of local anesthesia in health children who were sedated for dental procedures.
- Trial name
- NCT06218173
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ankara University
Overdose
Prospective Cohort Study of Intravenous Lipid Emulsion for Resuscitating Critically-ill Poisoned Patients
The purpose of this project is to evaluate the case characteristics of patients who receive intravenous lipid emulsion therapy. Previous literature to date has focused on animal studies or has been primarily limited to case…
- Trial name
- NCT03107689
- Testing
- administration of intravenous lipid emulsion
- Where
- 2 sites in United States
- Volunteers
- 134 people
- Sponsor
- University of Southern California
Drug Overdose
Nasal Naloxone for Narcotic Overdose
The goal of this study is to determine if nasal naloxone is inferior to standard care for naloxone administration in a pre-hospital setting.
- Trial name
- NCT01912573
- Testing
- Intranasal (IN) naloxone, Intravenous (IV) naloxone, Intramuscular (IM) naloxone
- Where
- 3 sites in United States
- Volunteers
- 236 people
- Sponsor
- Judith Feinberg
Anesthesia
Decision Support System for Anesthetists
The balanced anesthesia process contains three main parts: the control of hypnosis, analgesia, and neuromuscular blockade. For the induction phase, the anesthesiologist performs protocols based on prior planning specific to each…
- Trial name
- Serenity (NCT04079036)
- Where
- Brazil
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Substance Use, Substance-Related Disorders
Clinician Practice Companion to Address Youth Substance Use
Substance use, including the use of opioids, cannabis, and other drugs, is common among adolescents and young adults, and overdose has become a leading cause of death among youth in Canada and the United States.
- Conditions
- Substance Use, Substance-Related Disorders, Adolescent Substance Use, Cannabis Use
- Trial name
- NCT07725289
- Testing
- Practice Companion
- Where
- 5 sites in United States, Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Baseline Epidemiologic Assessment
Baseline Epidemiologic Assessment of Abuse-Deterrence of MorphaBond Extended Release (BEAD-MB)
The main objectives of this study are to provide surveillance/descriptive data to (a) assess utilization of MorphaBond ER and selected comparators overall and by age group and census regions using nationally-projected quarterly…
- Trial name
- BEAD-MB (NCT04033094)
- Testing
- MorphaBond ER, Comparator Drug
- Where
- United States
- Volunteers
- 17,566 people
- Sponsor
- Daiichi Sankyo
Substance Abuse, Opioid Abuse (Disorder)
Youth Overdose & Use Reduction in Rural Systems
The goal of this study is to conduct a clinical trial to understand effects of providing multilevel intervention to young people in the legal system.
- Conditions
- Substance Abuse, Opioid Abuse (Disorder), Overdose Prevention, Substance Use Disorder (SUD)
- Trial name
- YOURS (NCT07846735)
- Testing
- Navigator - Flexible Care Management
- Volunteers
- 550 people
- Sponsor
- Seattle Children's Hospital
Neurotoxicity, Unspecified Adult Solid Tumor, Protocol Specific
Carboxypeptidase-G2 in Treating Nervous System Toxic Effects in Patients Given an Overdose of Intrathecal Methotrexate
RATIONALE: Chemoprotective drugs such as carboxypeptidase-G2 may protect normal cells from the toxic effects of chemotherapy. PURPOSE: Clinical trial to study the effectiveness of carboxypeptidase-G2 in treating nervous system…
- Conditions
- Neurotoxicity, Unspecified Adult Solid Tumor, Protocol Specific, Unspecified Childhood Solid Tumor, Protocol Specific
- Trial name
- NCT00018967
- Testing
- glucarpidase
- Where
- 103 sites in United States, Australia and 2 more
- Volunteers
- 10 people
- Sponsor
- National Cancer Institute (NCI)
Overdose
A Universal Primary Care Based Intervention to Reduce Youth Overdose Risk Aim 3
Between 2015 and 2019, overdose deaths translated to 1.25 million years of life lost among adolescents and young adults (youth) aged 12 to 24 years, and the percent change in fatal overdose rates among adolescents ages 14 to 18…
- Trial name
- NCT07797933
- Testing
- Brief youth overdose prevention education, Usual Standard of Care
- Where
- United States
- Volunteers
- 648 people
- Sponsor
- Boston Medical Center
Feeding Intolerance, Premature Birth
Multi-Center Study of Different Doses Domperidone in Feeding Intolerance
The purpose of this clinical multi-center study is to determine whether different doses of domperidone are effective in the treatment of feeding intolerance in premature infant
- Conditions
- Feeding Intolerance, Premature Birth, Domperidone Overdose, Gastric Retention
- Trial name
- MCSDDDFI (NCT02980250)
- Testing
- Low dose, normal dose, over dose
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Toxicity Due to Chemotherapy
Uridine Triacetate as Antidote for Patients at Excess Risk of 5-FU Toxicity Due to Overdosage or Impaired Elimination
The purpose of this study is to provide emergency treatment of adult and pediatric patients: Following a fluorouracil or capecitabine overdose regardless of the presence of symptoms or Who exhibit early-onset, severe or…
- Trial name
- NCT01432301
- Testing
- uridine triacetate
- Sponsor
- Wellstat Therapeutics
Paracetamol Overdose
PP100-01 (Calmangafodipir) for Overdose of Paracetamol
Investigate the safety and tolerability of PP100-01 add-on treatment to the 12hr NAC treatment regime in patients treated for paracetamol/acetaminophen overdose (POD) when NAC treatment is initiated before 24hours post POD.
- Trial name
- POP (NCT03177395)
- Testing
- PP100-01 (calmangafodipir), Acetylcysteine
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Egetis Therapeutics AB (publ)
Opioid Overdose, Drug Overdose
Preventing Overdose Using Information and Data From the Environment
The objectives of this project are to leverage surveillance data to predict future overdose outbreaks, and to evaluate the impact of a randomized, statewide, community-level intervention trial to target overdose prevention…
- Trial name
- PROVIDENT (NCT05096429)
- Testing
- PROVIDENT
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Brown University
Mental Disorders, Metabolism Medication Toxicity
Pharmacogenomic Profiling of Pediatric Patients
The purpose of this study is to determine the proportion of children presenting to a pediatric emergency department with an acute mental health/behavioral crisis or clinical drug toxicity who have a "match" or "mismatch" between…
- Conditions
- Mental Disorders, Metabolism Medication Toxicity, Pediatric Disorder
- Trial name
- NCT02770339
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Osteoarthritis of Knee
Effect of Overdose Ultrasound on Osteoarthritic Knee in Adult Albino Rat: a Histological Study
The purpose of this study is to investigate the effect of overdose ultrasound on the articular cartilage of the osteoarthritic knee in adult albino rate.
- Trial name
- NCT06774469
- Testing
- assigned, Injection, Solution, ultrasound
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University