Clinical trials: Drug Use Disorders
Acute Kidney Injury, Drug Use
A Big Data Approach to Predict NEOnatal Acute Kidney Injury in Newborns expoSed to nephroTOxic Drugs (NeoAKI STOP)
This observational retrospective study aims to learn about the incidence of acute kidney (AKI) injury in newborns in infants exposed to nephrotoxic drugs with a big data approach.
- Conditions
- Acute Kidney Injury, Drug Use, Drug Interaction, Drug Toxicity
- Trial name
- NeoAKISTOP (NCT05851222)
- Where
- Italy
- Volunteers
- 4,200 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Lupus Nephritis
LUPKYNIS Drug-use Results Survey
The purpose of this study is to survey the safety of LUPKYNIS in patients with lupus nephritis under actual use conditions. In addition, information on efficacy will be collected.
- Trial name
- NCT07053891
- Testing
- Voclosporin (LUPKYNIS)
- Where
- Japan
- Volunteers
- 400 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Adolescent Obesity
SMART Use of Medication for the Treatment of Adolescent Severe Obesity
This study will examine the timing and sequence of using adjunct obesity pharmacotherapy for adolescents with severe obesity who do not respond to lifestyle modification therapy alone.
- Trial name
- SMART (NCT04007393)
- Testing
- Lifestyle Modification Therapy (LSMT), Phentermine Pill, Topiramate Pill
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Minnesota
Lymphoma, T-Cell, Peripheral
ISTODAX® for Intravenous Infusion Drug Use Results Survey- Relapsed or Refractory Peripheral T-Cell Lymphoma
To ascertain the safety and efficacy of Istodax® in actual clinical settings in patients with relapsed or refractory peripheral T-cell lymphoma (PTCL) who receive Istodax. 1. Planned registration period 4 years 2.
- Trial name
- NCT03742921
- Testing
- Istodax
- Where
- Japan
- Volunteers
- 150 people
- Sponsor
- Celgene
Chronic Kidney Disease
Post-marketing Surveillance of Bixalomer in Patients With Pre-dialysis Chronic Kidney Disease
The objective of this study is to assess the long-term safety and efficacy of bixalomer under post-marketed setting.
- Trial name
- NCT02805348
- Testing
- Bixalomer
- Where
- 14 sites in Japan
- Volunteers
- 144 people
- Sponsor
- Astellas Pharma Inc
Breast Cancer
LYNPARZA Breast Cancer in the Adjuvant Setting Japan Post-Marketing Surveillance (PMS)
To evaluate the frequency of bone marrow suppression Adverse Drug Reactions (ADRs) in patients with BRCA mutated HER2 negative high recurrent risk breast cancer treated with LYNPARZA for adjuvant treatment in the actual…
- Trial name
- NCT05677308
- Where
- 38 sites in Japan
- Volunteers
- 61 people
- Sponsor
- AstraZeneca
Molar Incisor Hypomineralization, Dental Caries
Silver Diamine Fluoride and Papain-Based Gel for Management of MIH-affected Molar in Paediatric Patients
Molar incisor hypomineralization (MIH) is a developmental defect of enamel affecting the first permanent molar and frequently the incisors with a prevalence of 16-16.9% in Malaysia.
- Conditions
- Molar Incisor Hypomineralization, Dental Caries, Hypomineralization of Enamel
- Trial name
- NCT04710927
- Testing
- Silver Diamine Fluoride, Papain-Based Gel, High Viscosity Glass Ionomer Cement (HVGIC)
- Where
- Malaysia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Gastric/Duodenal Ulcer, Gastric MALT Lymphoma, Idiopathic Thrombocytopenic Purpura, or H. Pylori Gastritis, and Other
Drug Use Surveillance of Takecab for "Supplement to Helicobacter Pylori Eradication"
The purpose of this study is to evaluate the safety and efficacy on participants receiving first-line eradication and second-line eradication including vonoprazan (Takecab) tablets (triple therapy) in the routine clinical setting.
- Trial name
- NCT03219723
- Testing
- Vonoprazan, Amoxicillin hydrate, Clarithromycin
- Where
- Japan
- Volunteers
- 560 people
- Sponsor
- Takeda
Substance Use Disorder (SUD), Drug Abuse
Adapted RPM-08 for Substance Use Disorder in Pakistan
The goal of this clinical trial is to learn if a culturally adapted Relapse Prevention Module (RPM-08) can reduce relapse risk in people with substance use disorders in Pakistan.
- Conditions
- Substance Use Disorder (SUD), Drug Abuse, Relapse
- Trial name
- NCT07552623
- Testing
- Adapted Relapse Prevention Module (RPM-08), Treatment as Usual (TAU)
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Universiti Sains Malaysia
HIV, Hepatitis C
Ending Transmission of HIV, HCV, and STDs and Overdose in Rural Communities of People Who Inject Drugs (ETHIC)
This study will evaluate the referral to harm reduction services (HRS) including syringe services, naloxone overdose prevention, substance use treatment referral, HIV, HCV, and STD testing and referral and linkage to care through…
- Conditions
- HIV, Hepatitis C, Opioid-use Disorder, Injection Drug Use
- Trial name
- ETHIC (NCT04427202)
- Testing
- Referral to harm reduction services
- Where
- 2 sites in United States
- Volunteers
- 306 people
- Sponsor
- University of Chicago
Choroidal Neovascularization
Special Drug Use Investigation of EYLEA for Myopic Choroidal Neovascularization
The objectives of this study are to investigate the safety and effectiveness of EYLEA.
- Trial name
- NCT02260687
- Testing
- Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
- Where
- Japan
- Volunteers
- 353 people
- Sponsor
- Bayer
Condomless Sex, Human Immunodeficiency Virus (HIV)
Cape Town Young Women's Health CoOp
This two-arm cluster randomized trial tested a gender-focused comprehensive HIV testing and counselling (HTC) program, the Young Women's Health CoOp (YWHC) with a standard HTC program and targeted female adolescents (aged 16-19)…
- Conditions
- Condomless Sex, Human Immunodeficiency Virus (HIV), Sexually Transmitted Infections (STIs), Alcohol and Drug Use
- Trial name
- NCT02974998
- Testing
- Young Women's Health CoOp (YWHC), Standard HTC
- Where
- South Africa
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- RTI International
Infections, Rotavirus
Drug Use Investigation for ROTARIX®
This study aims to assess the safety of Oral Rotarix® under clinical practice; and collect information regarding typical symptoms of intussusceptions and bloody stool in Japan.
- Trial name
- NCT01636193
- Testing
- Oral Rotarix®, Data collection
- Volunteers
- 1,607 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dysphonia
BOTOX® Drug Use Investigation (Spasmodic Dysphonia)
This study is a drug use investigation program of BOTOX. The objective of this investigation is to collect and assess information on the safety and efficacy of BOTOX injections in subjects with a diagnosis of spasmodic dysphonia…
- Trial name
- NCT03543150
- Testing
- BOTOX
- Where
- Japan
- Volunteers
- 400 people
- Sponsor
- GlaxoSmithKline
Opioid-use Disorder
Evaluating a Novel Medication Device for Methadone Dosing
This study will evaluate whether a commercially available, secure, electronic pill box is a feasible, acceptable, and satisfactory method to manage take-home dosing of methadone for both methadone clinic patients and staff…
- Trial name
- NCT03254043
- Testing
- Take-home Dosing Procedures
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Johns Hopkins University
Schizophrenia
Treatment for First-Episode Schizophrenia
This 3-year study will determine if the antipsychotic medications olanzapine (Zyprexa®) and risperidone (Risperdal®) can help patients with first-episode schizophrenia.
- Trial name
- NCT00000374
- Testing
- Olanzapine, Risperidone
- Where
- 2 sites in United States
- Volunteers
- 125 people
- Sponsor
- Northwell Health
Primary Hypercholesterolemia and Homozygous Familial Hypercholesterolemia (HoFH)
Vytorin Reexamination Study (0653A-174)
This survey is conducted for preparing application material for re-examination under the Pharmaceutical Affairs Laws and its Enforcement Regulation, its aim is to reconfirm the clinical usefulness of VYTORIN through collecting…
- Trial name
- NCT01070966
- Volunteers
- 2,089 people
- Sponsor
- Organon and Co
Point of Care Ultrasound
Point of Care Ultrasound Use by General Practitioners in France (Echo-MG)
This study explores how Point of Care Ultrasound (POC-US) is used in general practice in France and how it affects the diagnostic process and treatment of patients.
- Trial name
- Echo-MG (NCT04583670)
- Where
- 17 sites in France
- Volunteers
- 655 people
- Sponsor
- Sorbonne University
Cannabis Use, Cannabis Dependence
Neuroimaging of Adolescent Cannabis Use Treatment
This study is testing whether brain activity related to learning can help predict how well teens respond to a treatment program designed to reduce cannabis use.
- Conditions
- Cannabis Use, Cannabis Dependence, Cannabis Use Disorder, Cannabis Abuse
- Trial name
- ACT (NCT07340554)
- Testing
- Contingency Management, Elastic Net Regression
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Indiana University
Rheumatoid Arthritis (RA)
Japan Post-Marketing Surveillance for Peficitinib to Assess Safety and Effectiveness in the Patients With Rheumatoid Arthritis
The objective of this study is to investigate the safety and effectiveness in routine clinical practice and actual clinical setting for all patients with rheumatoid arthritis (RA) treated with peficitinib.
- Trial name
- NCT03971253
- Testing
- Peficitinib
- Where
- 47 sites in Japan
- Volunteers
- 3,000 people
- Sponsor
- Astellas Pharma Inc